Clinical trials: Investigation Time
Hypertension
Efficacy and Safety of Perindopril 5 mg / Indapamide 1.25 mg / Amlodipine 5 mg Fixed Combination in Hypertension
The purpose of this study is to investigate the efficacy and safety of a fixed-dose combination of perindopril 5 mg /indapamide 1.25 mg / amlodipine 5 mg compared to the free combination of the same components (perindopril 4 mg /…
- Trial name
- NCT05820880
- Testing
- Fixed [Per/Ind/Aml], Free [Per/Ind + Aml]
- Where
- 42 sites in China
- Volunteers
- 532 people
- Sponsor
- Institut de Recherches Internationales Servier
Non-Small Cell Lung Cancer
Osimertinib (AZD9291) in First-line Locally Advanced or Metastatic NSCLC Patients With EGFR and EGFR T790M
The primary goal is to evaluate the efficacy of osimertinib (AZD9291), in terms of the objective response rate in patients with advanced non-squamous NSCLC with EGFR mutations and the EGFR T790M mutation at diagnosis as defined…
- Trial name
- AZENT (NCT02841579)
- Testing
- Osimertinib
- Where
- 7 sites in Spain
- Volunteers
- 22 people
- Sponsor
- MedSIR
Neonatal Respiratory Distress, Very Low Birth Weight Infant
Evaluation of the Impact of SpO2 Averaging Time on Performance of an Automatic FiO2 Control System: a Randomized Study
The aim of the study is to determine the preferred oximeter averaging setting during automated control of FiO2 (A-FiO2) in infants receiving respiratory support and supplemental oxygen.
- Trial name
- NCT05274386
- Testing
- Fabian ventilator with PRICO system (Acutronic Medical Systems AG, Hirzel, Switzerland); SpO2 averaging time set to 4to6 s, Fabian ventilator with PRICO system (Acutronic Medical Systems AG, Hirzel, Switzerland); SpO2 averaging time set to 10 s, Fabian ventilator with PRICO system (Acutronic Medical Systems AG, Hirzel, Switzerland); SpO2 averaging time set to 16 s
- Where
- Czechia
- Volunteers
- 10 people
- Sponsor
- Czech Technical University in Prague
Breast Cancer, Surgery
Real Time Tissue Characterisation Using Mass Spectrometry REI-EXCISE iKnife Study
REI-EXCISE is a multicentre, prospective, non-randomised feasibility study, aimed to evaluate the diagnostic accuracy of rapid ionisation mass spectroscopy using an iKnife device.
- Trial name
- REI-EXCISE (NCT03432429)
- Testing
- REIMS iKnife
- Where
- 3 sites in United Kingdom
- Volunteers
- 158 people
- Sponsor
- Imperial College London
Hepatitis C, Chronic
A Study of RO5024048 in Combination With Pegasys and Copegus in Treatment-Naive Patients With Chronic Hepatitis C, Genotype 1 or 4
This 6-arm study will assess the efficacy and safety of RO5024048 (R7128) in combination with the approved doses of Pegasys (180micrograms sc weekly) + Copegus (1000/1200mg po daily) (SOC), versus SOC in treatment-naive patients…
- Trial name
- NCT00869661
- Testing
- Copegus, Pegasys, RO5024048
- Where
- 66 sites in United States, Australia and 8 more
- Volunteers
- 413 people
- Sponsor
- Hoffmann-La Roche
Dementia
Dementia Communication Training Program for Novice Home Care Workers
This study aims to evaluate the effects of a dementia communication training program using a real-time interactive virtual trainer among novice home care workers.
- Trial name
- NCT07244497
- Testing
- virtual trainer-based dementia communication training, scenario-based discussions dementia communication training
- Where
- Taiwan
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Tzu Chi University
Breastfeeding
Evaluation of Breastfeeding Support After Short Time Hospitalization
The purpose of this study is to evaluate if the developed theory and evidence based programme has a positive effect on mother's breastfeeding self efficacy, establishing an effective breastfeeding and breastfeeding duration after…
- Trial name
- NCT01620723
- Testing
- New Breastfeeding Counselling, Treatment as usual
- Where
- 9 sites in Denmark
- Volunteers
- 3,541 people
- Sponsor
- Danish Committee for Health Education
Cerebral Aneurysm Unruptured, Cerebral Aneurysm Ruptured
Surgical Theater's Surgery Rehearsal Platform
Objectives: The objective of this clinical study is to determine if the use of the SRP will lead to improved effort and time efficiency in cerebral aneurysm surgery.
- Trial name
- SRP (NCT02099318)
- Testing
- Active SRP cases, Control cases
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Gastric Retention, Healthy
Study to Evaluate Safety/Duration in Stomach of Extended Release Capsules in Healthy Adults
To assess how long extended release prototype capsule formulations stay in the stomach as determined by magnetic resonance imaging (MRI).
- Trial name
- NCT03718390
- Testing
- Formulation A, Formulation B, Formulation C
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lyndra Inc.
To Assess the Reduction in the Viral Load of SARS-CoV-2 in Patients Receiving Ivermectin Compared to Those Receiving Standard Care
Evaluation of the Impact of the Administration of Single Dose of Ivermectin in the Early Phase of COVID-19
The action of ivermectin in vitro on the viral replication of SARS-CoV-2 was demonstrated and published by an Australian team in June 2020.
- Trial name
- IVERCoV (NCT05040724)
- Testing
- Ivermectin
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Raincy Montfermeil Hospital Group
Chronic Kidney Disease
A Clinical Study to Evaluate the Safety, Tolerability and Activity of a New Phosphate Binder (SBR759) in Patients With Chronic Kidney Disease on Hemodialysis
The primary objective of this study is to assess the safety, tolerability and activity of escalating multiple doses of SBR759 in patients with chronic kidney disease on hemodialysis.
- Trial name
- NCT00750295
- Testing
- SBR759
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Novartis Pharmaceuticals
Systemic Lupus Erythematosus
A First Time in Human Study to Evaluate the Safety and Tolerability of GSK3996401 Following Dosing With GSK4347859 in Healthy Participants
This is a first time in human (FTiH) study which means that this is the first time that GSK4347859 is given to humans. The study is designed to investigate the safety, tolerability, and concentration of GSK3996401 (the activated…
- Trial name
- NCT06188507
- Testing
- GSK4347859
- Where
- 2 sites in United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Age-related Macular Degeneration
Global Atrophie Biomarker Evaluation Study (GABiE)
To investigate the use of microperimetry and SS-OCT in assessing the natural changes of retinal sensitivity and anatomy in the perilesional zone of geographic atrophy areas in patients with dry age-related macular degeneration.
- Trial name
- GABiE (NCT03935126)
- Testing
- Diagnostics
- Where
- 2 sites in United States, Switzerland
- Volunteers
- 3 people
- Sponsor
- Boehringer Ingelheim
Schizophrenia
First Time in Human Study (FTIH) With Positron Emission Tomography (PET)
This study described in the present protocol consists of two sections. Part A is the first administration into man to evaluate the safety, tolerability and pharmacokinetics of single ascending doses of GSK1144814.
- Trial name
- NCT01381419
- Testing
- GSK1144814
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Androgenetic Alopecia, Male Pattern Baldness
A Study to Evaluate and Compare Injections of Autologous Dermal and Epidermal Cells Into the Balding Scalp of Subjects With Hair Loss
Evaluate the ability of injections of Ji Gami(TM) and Ji Gami(TM) DO to induce hair growth in male and female subjects with hair loss.
- Conditions
- Androgenetic Alopecia, Male Pattern Baldness, Female Pattern Baldness
- Trial name
- NCT01451021
- Testing
- Autologous cultured dermal and epidermal cells
- Where
- 3 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Aderans Research Institute
Healthy Volunteers
Anesthetic Effect Duration Assessment
The purpose of this study is to evaluate the duration of anesthetic effect produced , Lidocaine7% + Tetracaine 7% cream when applied with 2 different application times on the face and thigh.
- Trial name
- NCT01545765
- Testing
- Lidocaine 7% + Tetracaine 7% cream
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Length of Stay, Emergency Departments
SurgeCon: An Emergency Department Surge Management Platform
Wait times and overcrowding are challenging emergency departments (EDs) around the world. Several countries with advanced healthcare systems cannot keep pace with patient demand, and Canada ranks among the longest wait times…
- Trial name
- SurgeCon (NCT04789902)
- Testing
- SurgeCon
- Where
- 4 sites in Canada
- Volunteers
- 436,052 people
- Sponsor
- Memorial University of Newfoundland
Umbilical Cord
Assessment of the Number of Umbilical Cord Vessels at the Time of Nuchal Translucency Screening
The primary objective of this study is to determine the detection rate of two- or three-vessel umbilical cord at the time of nuchal translucency screening between 11 and 13 6/7 weeks gestation.
- Trial name
- NCT01367132
- Testing
- Doppler ultrasound
- Where
- 2 sites in United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Heart Failure
Determining Optimal Dose and Duration of Diuretic Treatment in People With Acute Heart Failure (The DOSE-AHF Study)
Heart failure is a disorder in which the heart does not pump blood adequately. This can lead to several serious problems, including reduced blood flow throughout the body, congestion of blood in the veins and lungs, and fluid…
- Trial name
- NCT00577135
- Testing
- Furosemide-Q12 hour bolus, Furosemide-Continuous Infusion, Furosemide-Low Intensification
- Where
- 9 sites in United States, Canada
- Volunteers
- 308 people
- Sponsor
- Duke University
Drug Interactions
Study to Learn More About the Effect of Itraconazole (ITZ) Given Repeatedly by Mouth on the Way How the Study Drug BAY1902607 Given One Time by Mouth Acts in the Human Body of Healthy Male Participants
BAY1902607 is a new type of drug under clinical development for different conditions including the treatment of endometriosis, i.e. a condition where the tissue that usually grows inside the womb grows outside of the womb.
- Trial name
- NCT03789890
- Testing
- BAY1902607, Itraconazole
- Where
- Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Bayer
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