Clinical trials: Investigation Time
Hyperphosphatemia
To Evaluate the Patient Tolerance, Pharmacodynamics and Pharmacokinetics of Lanthanum Polystyrene Sulfonate Powder
The aim of the study is: To evaluate the tolerance of lanthanum polystyrene sulfonate powder in patients with end-stage renal disease (ESRD-HD) hyperphosphatemia with multiple doses and multiple doses； To evaluate the…
- Trial name
- NCT04440696
- Testing
- Lanthanum Polystyrene Sulphonate Powder, Lanthanum Carbonate 500 MG
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Grand Life Science (Liaoning) Co., Ltd.
Multiple Sclerosis
Effects Of Motor Imagery and Sensorimotor Training
Many types of pain can occur in Multiple Sclerosis (MS), one of the most common types is neuropathic pain. Neuropathic pain is directly related to the disease's demyelination process and is associated with dysesthetic pain…
- Trial name
- MS-MI-SM (NCT07710742)
- Testing
- Motor imagery, Sensorimotor Training, Conventional therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Uludag University
Chronic Obstructive Pulmonary Disease
pCO2 Oscillations During Exercise: Relation to Cerebral Blood Flow and to Cognitive Dysfunction in COPD
Investigators wish to identify a relationship between substantial changes in carbon dioxide partial-pressure (pCO2), which frequently occur during the transitions from rest to exercise (ΔpCO2 >4 millimeters of mercury [mmHg] from…
- Trial name
- NCT02660437
- Testing
- Pulmonary Rehabilitation program
- Where
- Germany
- Volunteers
- 91 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Knee Osteoarthritis
Stability of Contemporary Knee Arthroplasty
Total joint replacement is an efficacious treatment for osteoarthritis of hips and knees. Both total knee replacement (TKR) and total hip replacements (THR) have excellent implant survivorship.
- Trial name
- NCT02861794
- Testing
- Medacta International, GMK Sphere medially stabilized knee
- Where
- Norway
- Volunteers
- 44 people
- Sponsor
- Oslo University Hospital
Diabetes Mellitus, Non-Insulin-Dependent
Evaluation of the Effect on Glucose Control and the Safety and Tolerability of AC2993 in Patients With Type 2 Diabetes Mellitus
This is a multicenter, randomized, blinded, placebo-controlled, short-term, dose-response study to examine the effects on glucose control of AC2993 as compared to placebo in patients with type 2 diabetes.
- Trial name
- NCT00044694
- Testing
- AC2993 2.5 mcg
- Where
- 33 sites in United States
- Volunteers
- 156 people
- Sponsor
- AstraZeneca
Sprain of Ankle
Evaluation of the Effect of the Association of Proton Pump Inhibitor (PPIs) With Non-Steriodal Anti-Inflamatories (NSAIDs) in Work Leave Time.
Retrospective cohort study to evaluate the effect of the association of PPIs with NSAIDs in work leave time.
- Trial name
- NCT00717119
- Where
- Spain
- Volunteers
- 6,356 people
- Sponsor
- AstraZeneca
Herpes Simplex
A Study on the Reactogenicity, Safety, Immune Response, and Efficacy of a Targeted Immunotherapy Against HSV in Healthy Participants Aged 18-40 Years or in Participants Aged 18-60 Years With Recurrent Genital Herpes
The purpose of this first-time-in-human (FTiH) study is to evaluate the reactogenicity, safety, immune response, and efficacy of an investigational herpes simplex virus (HSV)-targeted immunotherapy (TI).
- Trial name
- NCT05298254
- Testing
- Non-adjuvanted HSV formulation 1, Non-adjuvanted HSV formulation 2, Non-adjuvanted HSV formulation 3
- Where
- 30 sites in United States, Australia and 6 more
- Volunteers
- 505 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Adolescent Behaviors
Grade Book Game Evaluation Among 6th Grade Students
School engagement is associated with children's long-term health and success. Students who are engaged in school have better academic outcomes and lower rates of risky health behaviors.
- Trial name
- GG (NCT03039894)
- Testing
- Gradebook Game
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Los Angeles
Invasive Fungal Infection, Aspergillosis
Evaluate Three Methods for Diagnosis of Invasive Fungal Infection in Chinese Patients After HSCT
The purpose of this study is to assess the cut-off value of GM/G test in Chinese patients after hematopoietic stem cell transplantation, and evaluate GM/G test and real-time PCR for diagnosis of IFI in Chinese patients.
- Conditions
- Invasive Fungal Infection, Aspergillosis, Fungemia, Hematopoietic Stem Cell Transplantation
- Trial name
- NCT00460330
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University
Heart Failure, Congestive, Renal Failure Acute Chronic
Effect of a Focused Point-of-care Ultrasonography Screening Protocol in Hospitalized Patients
This research project aims to establish a real-time focused ultrasound examination protocol for routine assessment of hospitalized patients, including evaluations of the inferior vena cava (IVC), pericardial effusion…
- Conditions
- Heart Failure, Congestive, Renal Failure Acute Chronic, Liver Cirrhosis, Sepsis
- Trial name
- NCT07656428
- Where
- Taiwan
- Volunteers
- 9,000 people
- Sponsor
- National Taiwan University Hospital
Glioma, Parietal Lobe Glioma
Evaluation of the Variation Over Time of Visuospatial Deficit in Patients With Parietal Lobe Glioma
The goal of modern neurooncological surgery is to obtain maximum tumor resection while preserving neurological function. Parietal lobe gliomas often cause attention deficits (hemineglect) that are difficult to differentiate from…
- Conditions
- Glioma, Parietal Lobe Glioma, Visuspatial Deficit, Unilateral Spatial Neglect (USN)
- Trial name
- neGLIO (NCT07286929)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Healthy
PK and PD of Single, Escalating Doses of PER977 Following Enoxaparin
PER977 administration following a single dose of enoxaparin
- Trial name
- PER977 (NCT02206100)
- Testing
- PER977, enoxaparin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Perosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc.
Irritable Bowel Syndrome
A Phase 1, First Time in Human (FTIH) Study to Evaluate GSK3352589, a REarranged During Transfection (RET) Growth Factor Receptor Tyrosine Kinase Inhibitor, in Healthy Volunteers
This FTIH study is designed to assess the safety, tolerability and pharmacokinetic (PK) of escalating single and repeat oral doses of GSK3352589 in normal healthy volunteers.
- Trial name
- NCT03154086
- Testing
- GSK3352589
- Where
- Australia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Turner's Syndrome, Human Growth Hormone Deficiency
Evaluation of Overall Compliance and Duration of Zomacton® Treatment With the Zomajet® Needle-free Device
The purpose of this strictly observational, prospective, longitudinal study is to evaluate with sufficient precision the rate of overall treatment compliance from one year to 3 years of follow-up of the patients.
- Trial name
- ZOMAJET (NCT01306357)
- Testing
- Somatropin
- Where
- 17 sites in France
- Volunteers
- 87 people
- Sponsor
- Ferring Pharmaceuticals
Peripheral Perfusion
Assessment of Peripheral Perfusion in the Critically Ill Patient
The purpose of this study is to evaluate PPI as a surrogate for clinical signs of peripheral perfusion in patients in septic shock and after cardiac surgery.
- Trial name
- CRTPPI (NCT02771002)
- Testing
- Peripheral Perfusion index by Carescape Patientenmonitor
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Phase 1, Single Dose
A First In Human Study In Healthy People To Evaluate Safety, Toleration And Time Course Of Plasma Concentration Of Single Inhaled Doses Of PF-05212372.
The purpose of this study in healthy people is to evaluate safety, toleration and time course of plasma concentration of single inhaled doses of PF-05212372.
- Conditions
- Phase 1, Single Dose, Safety, Toleration
- Trial name
- NCT01415102
- Testing
- PF-05212372
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Atrial Fibrillation (AF), Stroke
Comparative Evaluation of the Efficacy and Safety of High-Power Short-Duration Radiofrequency Ablation and Standard Low-Power Ablation in Catheter Treatment of Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia and represents one of the leading causes of cardiovascular morbidity and mortality.
- Conditions
- Atrial Fibrillation (AF), Stroke, Acute Cerebrovascular Accident, Atrial Fibrillation Recurrent
- Trial name
- NCT07728539
- Testing
- Technique of radiofrequency ablation using very high-power short-duration ablation parameters, Technique of radiofrequency ablation using low-power settings
- Where
- Russia
- Volunteers
- 196 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Physical Activity
Physical Activity and Daily Experiences Study
Lack of physical activity is associated with negative health outcomes, including obesity, diabetes, and cardiovascular disease. There are calls from NIH and medical organizations to integrate the use mobile devices, such as…
- Trial name
- NCT02005042
- Testing
- Feedback on smartphone
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Penn State University
Breast Neoplasms
Sienna+® Injection Time Study 4 Arms
Patients with breast cancer normally undergo a labelling with radioactive tracer typically 1 day before surgery, which enables the surgeon to localize the sentinel lymph node during surgery.
- Trial name
- Sentimag02 (NCT02612870)
- Testing
- Sienna+ retro, Sienna+ peri, Sienna+ retro 4-6
- Where
- 2 sites in Switzerland
- Volunteers
- 40 people
- Sponsor
- Kantonsspital Baden
Brain Tumor
Real-time Assessment of Frameless Intrafraction Motion
The purpose of this study is to assess the ability of a modified thermoplastic mask system in keeping an individual head stationary for a predefined amount of time.
- Trial name
- NCT01202539
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
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