Clinical trials: Involutional Osteoporosis
Osteoarthritis, Osteoarthritis (OA) of the Knee
A Clinical Study Evaluating the Dermal Safety of Soluble Denosumab Microneedle Patches
The goal of this clinical trial is to evaluate the skin safety of a soluble denosumab microneedle patch in participants with osteoporosis and osteoarthritis.
- Conditions
- Osteoarthritis, Osteoarthritis (OA) of the Knee, Osteoporosis, Osteoporosis (Senile)
- Trial name
- CSEDSSDMP (NCT07085520)
- Testing
- Microneedle with 0.24mg Denosumab, Saline Microneedle Patch, Microneedle with 1.2mg Denosumab
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Sarcopenia, Osteoporosis
The Bone-Myoregulation Reflex and Development of Sarcopenia in Osteoporosis
Bone and skeletal muscle are in a single unit that interacts with each other structurally and functionally. The aim of this study is to determine the contribution of bone myoregulation reflex as a neuronal crosstalk mechanism on…
- Trial name
- NCT06017245
- Testing
- whole-body vibration to Control
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Osteoporosis (Senile)
To Study the Efficacy and Safety of Doxercalciferol on Spinal and Femoral Density in Postmenopausal Osteopenic Women in a Long Term 2 Year Study
A clinical trial to compare the effect of doxercalciferol or placebo in preventing bone loss from the spine and femur in postmenopausal women
- Trial name
- NCT07660536
- Testing
- doxercalciferol capsules, Hectorol®
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Creighton University
Bone Diseases, Metabolic, Depression, Involutional
Use of Bone Biopsy to Better Understand the Causes of Decreased Bone Mineral Density in Depression
In this study researchers would like to learn more about the low levels of bone mineral density seen in approximately half of women in their forties diagnosed as currently having or previously had depression.
- Conditions
- Bone Diseases, Metabolic, Depression, Involutional, Osteoporosis
- Trial name
- NCT00001916
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Institute of Mental Health (NIMH)
Osteo Arthritis Knee, Age Related Osteoporosis
Low Frequency Ultrasound for Osteoarthritis Healing and Rehabilitation
The purpose of this study is to determine the safety and effectiveness (how well it works) of a new experimental ultrasound bath device that uses low frequency ultrasound (LFU) that may or may not help healing.
- Conditions
- Osteo Arthritis Knee, Age Related Osteoporosis, Pain, Knee Joint Contracture
- Trial name
- NCT06562374
- Testing
- Low Frequency Ultrasound Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Osteoporosis Postmenopausal
Efficacy and Safety of Odanacatib (MK-0822) in Participants With Involutional Osteoporosis (MK-0822-022)
The purpose of this study is to assess the dose-response on the percent change from baseline in lumbar spine bone mineral density (BMD) at lumbar vertebrae 1 to 4 (L1- L4) when odanacatib (MK-0822) 10 mg, 25 mg, 50 mg or placebo…
- Trial name
- NCT00620113
- Testing
- Odanacatib, Vitamin D3, Calcium carbonate
- Volunteers
- 287 people
- Sponsor
- Merck Sharp & Dohme LLC
Involutional Osteoporosis
A Phase II/III, Double-blind, Parallel Group Comparative Study of Oral Administration of NE-58095 Tablets
The present phase II/III, multicenter, randomized, double-blind, parallel group comparative study is designed to evaluate the efficacy and safety of once-monthly oral administration of NE-58095 delayed release (DR) tablets for 12…
- Trial name
- NCT02063854
- Testing
- NE-58095 IR, NE-58095 DR
- Where
- 25 sites in Japan
- Volunteers
- 871 people
- Sponsor
- Takeda
Osteoporosis, Osteopenia
Models of Primary Osteoporosis Screening in Male Veterans
Models of Osteoporosis Screening in Male Veterans aims to test 1 distinct care model of primary osteoporosis screening in men within the VA healthcare setting.
- Conditions
- Osteoporosis, Osteopenia, Osteoporotic Fracture
- Trial name
- MOPS (NCT04079868)
- Testing
- Bone Health Service Model
- Where
- 3 sites in United States
- Volunteers
- 3,512 people
- Sponsor
- VA Office of Research and Development