Clinical trials: Iodine
Neuroblastoma, Pheochromocytoma
Iodine I 131 Metaiodobenzylguanidine in Treating Patients With Recurrent, Progressive, or Refractory Neuroblastoma or Malignant Pheochromocytoma or Paraganglioma
The purpose of this research study is to find how active and safe 131 I-MIBG is in patients with resistant neuroblastoma, malignant pheochromocytoma and malignant paraganglioma.
- Trial name
- NCT00107289
- Testing
- iobenguane I 131
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Iodine Deficiency
Study of the Effect of Iodized Oil Supplementation During Infancy
In iodine-deficient countries or regions that have inadequate iodized salt distribution, the World Health Organization (WHO) recommends choosing one of two methods to improve iodine intakes in breastfeeding infants: 1) iodine…
- Trial name
- INSIGHT (NCT01126125)
- Testing
- Iodized oil
- Where
- Morocco
- Volunteers
- 241 people
- Sponsor
- Swiss Federal Institute of Technology
Chronic Rhinosinusitis (Diagnosis)
Betadine Rinses for Chronic Rhinosinusitis Prospective Cohort Study
Povidone Iodine solution is a nasal antiseptic. Its application has been shown to be clinically safe, tolerable and effective against bacteria and fungi associated with chronic rhinosinusitis.
- Trial name
- Betadine (NCT04097613)
- Testing
- Povidone-Iodine, Budesonide
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- St. Paul's Hospital, Canada
Wound Infections
Povidone Iodine and Cesarean Section Wound Infections
The aim of this randomized clinical trial is to compare the efficiency of hand scrubbing by Povidone-Iodine solution 10% over 7.5% concentration in decreasing post-cesarean section wound infections \& compare side effects of both…
- Trial name
- NCT01700803
- Testing
- Povidone Iodine 10% vand cesarean section wound infections, Povidone Iodine 7.5% vand cesarean section wound infections
- Where
- Egypt
- Volunteers
- 3,231 people
- Sponsor
- Assiut University
Thyroid
Metformin to Mitigate Sequelae of Radioactive Iodine Treatment for Thyroid Cancers
This pilot clinical trial studies how will metformin hydrochloride works in mitigating the side effects of radioactive iodine treatment in patients with differentiated thyroid cancer.
- Trial name
- NCT03109847
- Testing
- Metformin Hydrochloride, Radioactive Iodine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Cognitive Developmental Delay, Birth Weight
Iodine Status in Pregnancy and Associated Health Outcomes
Iodine is a key micronutrient in the diet, essential for healthy growth, and is particularly important during pregnancy and breastfeeding when demands are increased to support the developing baby.
- Trial name
- Hiba (NCT03552341)
- Testing
- Maternal iodine status
- Volunteers
- 246 people
- Sponsor
- University of Leeds
Surgical Site Infection
Subcutaneous Tissue Irrigation With Povidone Iodine in Decreasing the Rate of Surgical Site Infection Following Cesarean Section
This study aims to assess the efficacy of Povidone Iodine (Betadine®) irrigation of subcutaneous tissue prior to skin closure in reducing the incidence of surgical site infection after elective caesarean section and post…
- Trial name
- NCT03549702
- Testing
- Povidone iodine 1% solution
- Where
- Egypt
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Nutrition, Healthy, Elderly
Study on the Relationship Between Iodine Nutrition and Thyroid Diseases in the Elderly
The aging trend of China's population is intensifying. More than 50% of the elderly in China suffer from thyroid disease. Thyroid dysfunction in the elderly increases the risk of cardiovascular and metabolic diseases.
- Trial name
- NCT05716191
- Testing
- Naturally different iodine levels exposure
- Where
- 3 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Thyroid Cancer
Trail Evaluating Apatinib With IMRT for Inoperable or Iodine Refractory Thyroid Cancer
To determine the efficacy and safety of intensity modulated radiation therapy combined with apatinib for inoperable or iodine refractory thyroid cancer.
- Trial name
- NCT03300765
- Testing
- Apatinib, Intensity modulated radiation therapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xiayun He, MD
Dietary Iodine Deficiency, Thyroid; Functional Disturbance
Serum Thyroglobulin as a Marker of Iodine Status During Pregnancy
The purpose of the investigation is to assess iodine status of pregnant women at week 16 of gestation targeting serum thyroglobulin as a biomarker of iodine deficiency.
- Trial name
- NCT02927119
- Testing
- iodine
- Volunteers
- 189 people
- Sponsor
- University of Debrecen
Differentiated Thyroid Cancer
Investigating National Solutions for Personalised Iodine-131 Radiation Exposure
This is a single-arm non-interventional prospective observational study to perform quantitative I-131 imaging and patient-specific dosimetry for patients undergoing radioiodine treatment.
- Trial name
- INSPIRE (NCT04391244)
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Royal Marsden NHS Foundation Trust
COVID-19
Gargling and Nasal Rinses to Reduce Oro- and Nasopharyngeal Viral Load in Patients With COVID-19
For this study, 48 patients who have been diagnosed with COVID-19 will be randomly assigned to four study groups: control, saline, chlorhexidine gluconate, and povidone-iodine.
- Trial name
- NCT04344236
- Testing
- Saline oral/nasal rinse, 0.5% Povidone/Iodine oral/nasal rinse, 0.12% Chlorhexidine oral/nasal rinse
- Where
- United States
- Sponsor
- NYU Langone Health
Breast Cancer, Metastatic Breast Cancer
Radioactive Iodide (131I) Treatment of 124I PET/CT Detected Breast Cancers
This is a treatment protocol designed to accompany the ongoing institutional 124I PET/CT pilot imaging study for patients with invasive breast cancer.
- Trial name
- NCT01360177
- Testing
- 124 PET/CT imaging, Na134I, Tri-iodothyronine
- Where
- United States
- Sponsor
- Stanford University
Thyroid Cancer
Iodine Nutrition Status and Clinical Characteristics of Thyroid Cancer
The effect of iodine nutritional status on thyroid cancer has been controversial for many years. We designed a prospective cohort study that recruiting patients in different iodine areas who underwent thyroid cancer surgery in…
- Trial name
- NCT06623500
- Testing
- Iodine excess, Iodine suitable
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Shandong Provincial Hospital
Covid19, Povidone Iodine Adverse Reaction
Phase I/II Trial of Povidone-iodine (PVP-I) Nasal Swab For Preventing COVID-19 Spread in Healthy Subjects
Title: Phase I/II Trial (Safety and Dosing) of Povidone-iodine (PVP-I) Nasal Swab For Preventing COVID-19 Spread in Healthy Subjects: Summary: This study will evaluate in a PH I/II trial in healthy volunteers the safety and…
- Trial name
- NCT04510402
- Testing
- Povidine iodine nasal swabs
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Osteoarthritis
Vancomycin Powder and Dilute Povidone Iodine Lavage for Infection Prophylaxis in High Risk Total Joint Arthroplasty
This is a prospective, randomized, controlled, open label, parallel four-arm design, multi-center study to compare different intraoperative interventions in the prevention of acute PJI development.
- Trial name
- NCT04075526
- Testing
- Povidone iodine, Vancomycin powder, Conventional
- Where
- 14 sites in United States
- Volunteers
- 2,129 people
- Sponsor
- NYU Langone Health
Refractory Hurthle Cell Thyroid Cancer
Sorafenib Tosylate With or Without Everolimus in Treating Patients With Advanced, Radioactive Iodine Refractory Hurthle Cell Thyroid Cancer
This randomized phase II trial studies the effects, good and bad, of using everolimus along with sorafenib tosylate versus sorafenib tosylate alone in treating patients with advanced radioactive iodine refractory thyroid cancer.
- Trial name
- NCT02143726
- Testing
- sorafenib, everolimus
- Where
- 21 sites in United States
- Volunteers
- 35 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Graves Disease
Evaluation of Optimal Time of Methimazole Discontinuation Before Radio-iodine Therapy in Hyperthyroid Grave's Patients
Iodine therapy is the best treatment for graves disease.Most patients receive methimozale prior to radio-iodine treatment. This may decrease treatment response to iodine therapy.
- Trial name
- NCT01560299
- Testing
- Methimazole
- Where
- Iran
- Volunteers
- 150 people
- Sponsor
- Mashhad University of Medical Sciences
Recurrent B-Cell Non-Hodgkin Lymphoma, Recurrent Hodgkin Lymphoma
Iodine I 131 Monoclonal Antibody BC8 Before Autologous Stem Cell Transplant in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma
This phase I trial studies the side effects and best dose of iodine I 131 monoclonal antibody BC8 when given before autologous stem cell transplant in treating patients with Hodgkin lymphoma or non-Hodgkin lymphoma that has…
- Conditions
- Recurrent B-Cell Non-Hodgkin Lymphoma, Recurrent Hodgkin Lymphoma, Recurrent T-Cell Non-Hodgkin Lymphoma, Refractory B-Cell Non-Hodgkin Lymphoma
- Trial name
- NCT00860171
- Testing
- Autologous Hematopoietic Stem Cell Transplantation, Iodine I 131 Monoclonal Antibody BC8, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Fred Hutchinson Cancer Center
Non-Hodgkin's Lymphoma
Safety and Efficacy Study of Iodine-131 Anti-B1 Antibody for the Retreatment of Patients With Non-Hodgkin's Lymphoma
The purpose of this study is to enable retreatment with Iodine-131 Anti-B1 Antibody therapy for patients with non-Hodgkin's lymphoma (NHL) who previously responded (PR, CCR, or CR) for at least 3 months to Iodine-131 Anti-B1…
- Trial name
- NCT00022893
- Testing
- Iodine-131 Anti-B1 Antibody
- Where
- 5 sites in United States, United Kingdom
- Sponsor
- Corixa Corporation