Clinical trials: Iris Diseases
Iris Melanoma, Medium/Large Size Posterior Uveal Melanoma
Radiation Therapy in Preventing Liver Metastases in Patients With Uveal Melanoma Who HaveMonosomy 3 or DecisionDx Class 2 Disease and Are More Likely to Develop Liver Metastases
This clinical trial studies giving radiation therapy to the liver in patients with uveal (eye) melanoma who have a specific chromosome loss (monosomy 3) or are DecisionDx Class 2 and therefore more likely to have their disease…
- Conditions
- Iris Melanoma, Medium/Large Size Posterior Uveal Melanoma, Stage IIA Uveal Melanoma, Stage IIB Uveal Melanoma
- Trial name
- NCT02336763
- Testing
- External Beam Radiation Therapy, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Colorectal Cancer
c-CetuIRI Versus Ersecond-line Irinotecan s-IRI-CetuIRI
The primary endpoint is to evaluate the progression-free survival (PFS).
- Trial name
- NCT04833036
- Testing
- Irinotecan, cetuximab
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fudan University
Aniridia
Study of Ataluren in Participants With Nonsense Mutation Aniridia
This study is designed to evaluate the effect of ataluren on Maximum Reading Speed as measured using the Minnesota Low Vision Reading Test (MNREAD) Acuity Charts in participants with nonsense mutation aniridia.
- Trial name
- STAR (NCT02647359)
- Testing
- Ataluren
- Where
- 3 sites in United States, Canada
- Volunteers
- 39 people
- Sponsor
- PTC Therapeutics
Exfoliation Glaucoma, Cataract
Comparison Of iStent to Laser in Exfoliation Glaucoma Helsinki Study Group
The purpose of the study is to investigate the efficacy of an iStent trabecular microbypass stent compared to selective laser trabeculoplasty in combination with cataract surgery in eyes with exfoliation glaucoma (EXF)
- Trial name
- COILEH (NCT04635020)
- Testing
- iStent, SLT-laser, Cataract surgery
- Where
- Finland
- Volunteers
- 285 people
- Sponsor
- Helsinki University Central Hospital
Open Angle Glaucoma, Primary Open Angle Glaucoma
Topical Insulin for Glaucoma (TING2)
This study evaluates the safety and preliminary efficacy of topical sterile human insulin eye drops (EYED-002) in patients with open-angle glaucoma.
- Conditions
- Open Angle Glaucoma, Primary Open Angle Glaucoma, Low Tension Glaucoma, Pigmentary Glaucoma
- Trial name
- NCT07619482
- Testing
- EYED-002 Low Dose (721 U/mL topical insulin), EYED-002 High Dose (1442 U/mL topical insulin), EYED-002 (highest tolerated dose, 12-month)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Stanford University
Graft vs Host Disease, Congenital Aniridia
Safety and Performance Study of the ARGOS-IO System in Patients Undergoing Boston Keratoprosthesis Implantation
The ARGOS-IO pressure sensor is intended to be implanted in the human eye in combination with Boston Keratoprosthesis (BKPro) surgery and to remain in place indefinitely.
- Conditions
- Graft vs Host Disease, Congenital Aniridia, Chemical Burns, Stevens-Johnson Syndrome
- Trial name
- NCT02945176
- Testing
- ARGOS-IO system
- Where
- 2 sites in Germany
- Volunteers
- 13 people
- Sponsor
- Implandata Ophthalmic Products GmbH
Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma
Anti-inflammatory Therapy Following Selective Laser Trabeculoplasty
The type of anti-inflammatory medication used post selective laser trabeculoplasty (SLT) may have an impact on the intra-ocular pressure (IOP) lowering effect of SLT.
- Trial name
- NCT00485108
- Testing
- prednisolone 1%, ketorolac 0.5%, Artificial Tears (Methyl cellulose drops)
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Queen's University
IRIS, HIV
IMPAACT P1073: Study of IRIS for Infants and Children Initiating HAART at Int'l Sites
Your child is able to participate in this study, if your child's doctor is planning to start your child on HAART (which is a combination of at least 3 anti HIV drugs).
- Trial name
- NCT01240486
- Where
- 7 sites in India, South Africa and 3 more
- Volunteers
- 207 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Open Angle Glaucoma, Pseudoexfoliation Glaucoma
Trabeculopuncture as Predictive Test for the Success of Ab Interno Trabeculectomy
The purpose of this study is to perform trabeculopuncture a test to determine the distal outflow tract function to predict the success of ab interno trabeculectomy.
- Trial name
- NCT06523751
- Testing
- Trabeculopuncture
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- Wuerzburg University Hospital
Infertility
Predictors of Pregnancy Rate in Assisted Reproductive Technology According to Actual Guidelines
Goals: To explore the association of probability of pregnancy with certain prognostic factors in patients undergoing assisted reproductive technology in Russian population according to international and national guidelines.
- Trial name
- IRIS (NCT04249297)
- Testing
- Duphaston® (Dydrogesteron)
- Where
- 52 sites in Kazakhstan, Russia
- Volunteers
- 1,150 people
- Sponsor
- Abbott
Coronary Artery Disease
Evaluation of Effectiveness and Safety of PROMUS Element Stent (IRIS-ELEMENT )
This study is a non-randomized, prospective, open-label registry to compare the efficacy and safety of Promus Element stents versus first-generation drug-eluting stent (DES) in patients with coronary artery disease.
- Trial name
- NCT01350791
- Where
- South Korea
- Volunteers
- 3,001 people
- Sponsor
- Seung-Jung Park
Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus (RSV)
Infection With Respiratory Syncytial Virus in Infants
IRIS (Infection with RespIratory Syncytial Virus) is an observational, multi-center study enrolling infants with severe RSV infection and healthy controls.
- Conditions
- Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus (RSV), Respiratory Syncytial Virus-bronchiolitis
- Trial name
- IRIS (NCT04925310)
- Where
- 2 sites in Germany
- Volunteers
- 350 people
- Sponsor
- Hannover Medical School
Aniridia
Proteomic Study of Tears From Patients With a PAX6 Mutation
This is a single-center prospective pilot study involving the ophthalmology and medical genetics departments of the Montpellier University Hospital, and the proteomics platform of the Montpellier University Hospital.
- Trial name
- PLAPAX6 (NCT05562115)
- Testing
- Tear collection
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Montpellier
Angle Closure Glaucoma
Comparing Nd:YAG Laser and Sequential Double Frequency YAG-Nd:YAG Laser Iridotomy
No single type of laser or set of laser parameters is appropriate for all type of irides. Pure Nd:YAG laser iridotomy is very effective in the light color irides. It was considered as the gold standard for iridotomy.
- Trial name
- NCT02474238
- Testing
- The sequential technique, The pure Nd:YAG laser technique
- Where
- Thailand
- Volunteers
- 82 people
- Sponsor
- Prince of Songkla University
Coronary Artery Disease
IRIS Ultimaster Cohort in the IRIS-DES Registry
The purpose of this study is to evaluate the relative effectiveness and safety of Ultimaster stent compared to other drug eluting stents.
- Trial name
- IRISUltimaster (NCT02719106)
- Testing
- Ultimaster stent
- Where
- 15 sites in South Korea
- Volunteers
- 1,000 people
- Sponsor
- Duk-Woo Park, MD
Cataract, Floppy Iris Syndrome
Intraoperative Floppy Iris Syndrome
An assessment of the surgical performance of DisCoVisc compared to Healon5 during cataract surgery with intraocular lens implantation where miotic/small pupils or intraoperative Floppy Iris Syndrome exists.
- Trial name
- NCT00711347
- Testing
- DisCoVisc, Healon5
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Alcon Research
Aphakia Due to Trauma, Eye; Rupture, Traumatic, With Loss of Intraocular Tissue
Clinical Outcomes of Implantationof Black Diaphragm Intraocular Lens in Complete Aniridia and Aphakia Due to Posttraumatic Eye Rupture
Purpose: To assess long-term outcomes of implantation of black diaphragmintraocular lens (BD IOL) in postraumatic aniridia and aphakia due to eye rupture.
- Conditions
- Aphakia Due to Trauma, Eye; Rupture, Traumatic, With Loss of Intraocular Tissue, Aniridia
- Trial name
- NCT03581864
- Where
- Poland
- Volunteers
- 14 people
- Sponsor
- Medical University of Lublin
Meibomian Gland Dysfunction, Cataract
Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures
The development of optical coherence tomography (OCT) and its application for in vivo imaging has opened entirely new opportunities in ophthalmology.
- Conditions
- Meibomian Gland Dysfunction, Cataract, Glaucoma, Corneal Transplantation
- Trial name
- NCT03461978
- Testing
- Ultrahigh resolution Spectral Domain OCT
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Vienna
Immune Reconstitution Inflammatory Syndrome
Immune Reconstitution Syndrome in HIV-Infected Patients Taking Antiretroviral Therapy
This study will investigate what factors may lead to the development of immune reconstitution syndrome (IRIS) in HIV-infected patients and what the outcome is after IRIS.
- Trial name
- NCT00286767
- Where
- 3 sites in United States, Thailand
- Volunteers
- 525 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Psoriasis
Value Based Healthcare in Psoriasis
Rationale: Currently, the healthcare sector is under tremendous financial pressure, and many acknowledge that a dramatic shift is required as the current system is not sustainable.
- Trial name
- IRIS (NCT05480917)
- Testing
- Patients receiving PsoPlus care
- Where
- 2 sites in Belgium
- Volunteers
- 350 people
- Sponsor
- University Hospital, Ghent