Clinical trials: Iron
Heart Aneurysm
A Novel Ferumoxytol-enhanced Cardiac Magnetic Resonance Imaging for the Detection of Intracardiac Thrombus
The incidence of thrombosis in ventricular aneurysm was reported to be 35%-40%, which may lead to systemic thromboembolism. Patients with ventricular aneurysm without detectable thrombus are not routinely treated with…
- Trial name
- NCT06146751
- Testing
- Superparamagnetic Iron Oxide Nanoparticles
- Where
- China
- Volunteers
- 320 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
CKD, Sleep Disorder
Sucrosomial Iron on Insomnia in Non-dialysis Chronic Kidney Disease Patients With Iron Deficiency Anemia
Insomnia or sleep disturbance is a common disorder in patients with chronic kidney disease (CKD), but is often unrecognized and undertreated.
- Trial name
- NCT06279429
- Testing
- Sideral® Sucrosomial Iron, Iron chewable tablet
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Kuang Tien General Hospital
Iron Overload
Safety Study of Crushed Deferasirox Film Coated Tablets in Pediatric Patients With Transfusional Hemosiderosis
This study employed a prospective, single-arm, global multi-center interventional open-label, non-randomized design to identify and assess safety profile of the crushed deferasirox FCT when administered up to 24 weeks in…
- Trial name
- MIMAS (NCT03372083)
- Testing
- Deferasirox
- Where
- 10 sites in Egypt, Italy and 5 more
- Volunteers
- 44 people
- Sponsor
- Novartis Pharmaceuticals
Non-transfusion Dependent Thalassemia
Efficacy and Safety of Deferasirox in Non-transfusion Dependent Thalassemia Patients With Iron Overload and a One Year Open-label Extension Study
CICL670A2209: This study will evaluate the safety and efficacy of deferasirox in non-transfusion dependent thalassemia patients with iron overload.
- Trial name
- THALASSA (NCT00873041)
- Testing
- deferasirox
- Where
- 21 sites in United States, Greece and 7 more
- Volunteers
- 166 people
- Sponsor
- Novartis Pharmaceuticals
Iron Deficiency (Without Anemia)
Effect of Ferrous iROn and cUrcumin sTatus on Inflammatory and Neurotrophic markErs
INTRODUCTION: Iron is a vital nutrient for many physiological processes including DNA production, oxygen transport and neuronal processes.
- Trial name
- Fe-ROUTINE (NCT04465851)
- Testing
- Ferrous Sulphate 65 mg, Curcumin, Ferrous Sulphate 18mg
- Where
- United Kingdom
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Westminster
Neurodevelopmental Disorders, Lactation
Iron Supplement Effect on Child Development
Objective: To evaluate the effect of Iron supplement with two different amounts (one in the higher limit and another in the lower limit of the suggested amount) according to the presence of mutations in the HFE gene in the…
- Trial name
- NCT02690675
- Testing
- Iron fortified formula milk
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Breast Cancer, Sentinel Lymph Node
Sentinel Lymph Node Localisation With an Ultra-low Dose of Magtrace in Breast Cancer Patients
The overall aim is to demonstrate that the use of superparamagnetic iron oxide nanoparticles (SPIO) as a tracer in an ultra-low dose (0.1 ml) is non-inferior for sentinel lymph node (SLN) detection in patients with breast cancer…
- Trial name
- MagSnow2 (NCT06169072)
- Testing
- Superparamagnetic Iron Oxide, Technetium99
- Where
- Sweden
- Volunteers
- 220 people
- Sponsor
- Vastra Gotaland Region
Hereditary Hemochromatosis C282Y Homozygous
HEPFER-Evaluation of a New Phenotypic Biological Marker in Genetic Type 1 Hemochromatosis
HFE(High iron FE)-related hereditary hemochromatosis has a highly variable penetrance. No phenotypic or genetic markers can predict the disease.
- Trial name
- HEPFER (NCT01784939)
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Rennes University Hospital
HNSCC, Soft Tissue Cancer
Nano-Carbon Iron Suspension Injection Combined With Radiotherapy for Solid Tumors Phase II Clinical Trial
Study Primary Objective: To evaluate the efficacy of CNSI-Fe intra-tumoral injection combined with radiotherapy in patients with solid tumors. Study Secondary Objectives: 1.
- Trial name
- NCT07491783
- Testing
- Carbon Nanoparticle Iron Suspension for Injection
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Sichuan Enray Pharmaceutical Sciences Company
Iron Deficiency Anemia
IRON DEFICIENCY ANEMIA IN RELATION TO PINCH STRENGTH AND HAND DEXTERITY IN PRESCHOOL CHILDREN
Anemia is a major public health problem among preschool-aged children. The evidence demonstrated that early childhood anemia is a strong predictor of adulthood anemia (Gessner, 2009).
- Trial name
- IDA (NCT05959122)
- Testing
- CBC serum iron serum ferritin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
IDA - Iron Deficiency Anemia, Anemia
Iron Deficiency Anemia (IDA) and the Brain
This is a trial with an observational and an interventional arm, in patients with moderate to severe anemia and control subjects.
- Conditions
- IDA - Iron Deficiency Anemia, Anemia, Iron Deficiency Anemia, Anemia, Iron Deficiency
- Trial name
- IDA (NCT05929729)
- Testing
- Ferric derisomaltose, NovaFerrum
- Where
- 4 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Iron Deficiency Anemia
Maintenance of Multivitamin Supplements After Sleeve Gastrectomy
A prospective randomized study of patients undergoing a laparoscopic sleeve gastrectomy was performed. Patients were randomized into 2 groups: those patients receiving the multivitamin supplement during 3 months (Group 1), and…
- Trial name
- NCT02620137
- Testing
- Multicentrum® (Pfizer, Spain) 3 months, Multicentrum® (Pfizer, Spain) 12 months
- Volunteers
- 80 people
- Sponsor
- Hospital General Universitario Elche
Thalassemia Major, Hemosiderosis
Efficacy Study in Removing Excess Iron From the Heart
The purpose of this study is to determine whether deferiprone has superior efficacy in removing excess iron from the heart when compared with deferoxamine.
- Trial name
- NCT00105495
- Testing
- Ferriprox (deferiprone), Desferal (deferoxamine)
- Where
- 4 sites in Greece, Italy
- Volunteers
- 60 people
- Sponsor
- ApoPharma
Iron Deficiency Anemia
Impact of Intravenous Iron on Musculoskeletal Function in Older Adults
Anaemia is a risk factor for functional decline and frailty in older adults including decreased physical performance and muscle strength, increased hospitalisation risk and mortality, falls, and poorer recovery from activities of…
- Trial name
- FERIDA (NCT05708170)
- Testing
- Ferinject, Ferrous Sulfate 200 MG
- Volunteers
- 100 people
- Sponsor
- Liverpool Hope University
Iron Deficiency, Anemia
The Effects of Iron and Omega-3 Fatty Acid Supplementation on Cognition and Immune Function in Iron Deficient Children
The aim of this study is to determine if providing iron and a mixture of DHA and EPA, alone and in combination, to children with iron deficiency and poor n-3 fatty acid intake will improve their cognitive performance, activity…
- Trial name
- FeFA (NCT01092377)
- Testing
- DHA and EPA Fish Oil capsule, Iron tablet
- Where
- South Africa
- Volunteers
- 320 people
- Sponsor
- North-West University, South Africa
MDS, CMML
Non Interventional Study on Iron Toxicity After First Allo-transplant in MDS/CMML
Stem cell transplantation and blood product transfusions are standard of care for Myelodysplastic Syndromes (MDS). Several studies have shown changes in serum ferritin and non-transferrin-bound iron (NTBI) in patients undergoing…
- Trial name
- NCT06267898
- Where
- 6 sites in Belgium, Czechia and 1 more
- Volunteers
- 222 people
- Sponsor
- European Society for Blood and Marrow Transplantation
Iron Deficiency Anemia in Childbirth
Iron Administration Via Colonic TET Combined With WMT for ID
The colon can absorb iron.We propose an integrated approach utilizing colonic transendoscopic enteral tubing to deliver iron in different valence states, coupled with washed microbiota transplantation .
- Trial name
- NCT06487299
- Testing
- Ferrous Lactate, Iron sucrose, 0.9% NaCl solution
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Iron-refractory, Iron-deficiency Anemia (IRIDA)
Pharmacokinetics and Absolute Bioavailability of Fer-In-Sol and Triferic Administered Orally With Shohl's Solution in Healthy Volunteers
The main purpose is to determine the pharmacokinetics (PK) of Triferic iron administered orally in healthy adult volunteers. It is a randomized multiple treatments, single dose study.
- Trial name
- NCT02767128
- Testing
- Triferic, Fer-In-Sol, Shohl's solution
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Rockwell Medical Technologies, Inc.
Obesity
Evaluation of the Effect of Body Weight and Composition on Iron Absorption and Blood Volume
A total of 75 subjects will be recruited for this study (25 normal weight, 25 overweight, 25 obese). In each subject blood volume will be determined using the minimally invasive carbon monoxide-rebreathing method (substudy 1) and…
- Trial name
- NCT01884506
- Testing
- labeled iron solution, labeled iron solution and ascorbic acid
- Where
- Switzerland
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Iron Deficiency Anaemia in Childbirth
Ferric Derisomaltose (Iron Isomaltoside) Versus Iron Sucrose for Treatment of Iron Deficiency in Pregnancy
Ion deficiency anemia (IDA) is associated with poor neonatal outcomes and maternal morbidity. Iron replacement may be done with oral iron or intravenous iron, with intravenous iron being utilized later in pregnancy or if there is…
- Trial name
- NCT05251493
- Testing
- Iron Isomaltoside 1000, ferric derisomaltose, Iron sucrose
- Where
- Canada
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area