Clinical trials: Irritable Bowel
IBS
Probiotic in Irritable Bowel Syndrome (IBS) Patients With Diarrhea
We present the study design of a clinical trial designed to assess the clinical effects of the multispecies probiotic combination "BIO-25" in IBS-D patients.
- Trial name
- IBS-D (NCT01667627)
- Testing
- Bio-25
- Where
- Israel
- Volunteers
- 107 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Gut Microbiome, Gut Microbiota
Effect of Probiotics on Endurance Athletes' Microbiome at Rest and Post-race
This study is intended to investigate the use of probiotics (LAB4 probiotics, Cultech, Port Talbot, Wales, UK) and the effect this has on gastrointestinal symptoms experienced during elite long-distance triathlon (ironman)…
- Conditions
- Gut Microbiome, Gut Microbiota, Aerobic Exercise, Gastrointestinal Tract Irritation
- Trial name
- NCT05615961
- Testing
- Probiotics (Lab4 probiotics, Cultech, Port Talbot, Wales, UK)
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Non-erosive Reflux Disease/Diarrheal Irritable Bowel Syndrome
Study on the Rule and Mechanism of Treating Functional Gastrointestinal Diseases From the Perspective of Liver and Spleen
To clarify the changes of intestinal flora - gut - brain axis in FGIDs patients represented by NERD disharmony of liver and stomach and IBS-D disharmony of liver and spleen, and confirm that the imbalance between intestinal flora…
- Trial name
- NCT04454996
- Testing
- tong-jiang granules, Chang 'an II Recipe
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Irritable Bowel Disease
Relaxation Exercise and Education in Patients With Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by chronic recurrent abdominal pain, bloating, changes in bowel habits or bowel movements (1-3).
- Trial name
- NCT06690762
- Testing
- Education
- Volunteers
- 100 people
- Sponsor
- Muş Alparslan University
Irritable Bowel Syndrome
Study to Evaluate the Efficacy and Safety of Vibegron Administered Orally for 12 Weeks to Women With Irritable Bowel Syndrome
This study will evaluate the efficacy and safety of vibegron, a beta-3 adrenergic receptor (β3-AR) agonist, in the treatment of pain associated with irritable bowel syndrome (IBS) due to IBS with predominant diarrhea (IBS-D) or…
- Trial name
- NCT03806127
- Testing
- Vibegron
- Where
- 41 sites in United States
- Volunteers
- 222 people
- Sponsor
- Urovant Sciences GmbH
Irritable Bowel Syndrome
Comparative Efficacy and Safety of Fenoverine
It is a randomized double-blind parallel phase IV study to compare Fenoverine and Trimebutine maleate in the efficacy and safety. Study Hypothesis: Fenoverine is non-inferior to Trimebutine maleate in its efficacy and safety.
- Trial name
- FEN-401 (NCT01507922)
- Testing
- Fenoverine, Timebutine
- Where
- 7 sites in South Korea
- Volunteers
- 186 people
- Sponsor
- Bukwang Pharmaceutical
Irritable Bowel Syndrome
Subsensory Sacral Nerve Stimulation for Irritable Bowel Syndrome
Sacral nerve stimulation (SNS) has become a well-established treatment for patients with fecal incontinence since 1995. The mechanism of action of SNS is still not fully understood but recent studies have shown changes in both…
- Trial name
- NCT01948973
- Testing
- Subsensory, OFF, Suprasensory
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- University of Aarhus
Irritable Bowel Syndrome
Ayurvedic Herbs in Diarrhea Predominant Irritable Bowel Syndrome
In the present study the investigators are trying to evaluate the effect of Murraya koenigii leaves, Punica granatum and Curcuma which is administered to the patients in a combined form as tea.
- Trial name
- AHIB (NCT01418066)
- Testing
- Ayurvedic Herbs
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Universität Duisburg-Essen
Irritable Bowel Syndrome, Diarrhea
A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Diarrhea (IBS-D)
The purpose of this study is to evaluate how well brenipatide (LY3537031) is tolerated, what side effects may occur, and the safety and efficacy in participants with Irritable Bowel Syndrome-Diarrhea (IBS-D).
- Trial name
- RENEW-IBS-D (NCT07545759)
- Testing
- LY3537031
- Where
- 89 sites in United States, Belgium and 8 more
- Volunteers
- 531 people
- Sponsor
- Eli Lilly and Company
Acupuncture-like Transcutaneous Electrical Nerve Stimulation, Irritable Bowel Syndrome
Acupuncture-like Transcutaneous Electrical Nerve Stimulation on Bowel Symptom and Quality of Life in Patients With Irritable Bowel Syndrome
To discuss the effects of improving the irritable bowel syndrome patients' quality of life and defecation after implementing acupuncture-like Transcutaneous Electrical nerve stimulation.
- Trial name
- NCT05042661
- Testing
- acupuncture-like transcutaneous electrical nerve stimulation
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Persistent Physical Symptoms (PPS)
CBT Plus SMC Compared to SMC for Persistent Physical Symptoms in Secondary Care (PRINCE)
Brief Summary: Persistent Physical Symptoms (PPS), also known as medically unexplained symptoms (MUS) is a term used to describe a range of persistent bodily symptoms for which the exact cause is unclear.
- Trial name
- PRINCE (NCT02426788)
- Testing
- Cognitive behavioural therapy (CBT)
- Where
- 7 sites in United Kingdom
- Volunteers
- 324 people
- Sponsor
- King's College London
Irritable Bowel Syndrome
Assessing Associations Between IBS Symptoms, Nutrition and QoL in IBS Patients Using a Questionnaire
This study is a cross-sectional observational study design that aimed to include 2000 IBS patients. We used several validated questionnaires, to assess IBS characteristics (such as subtype, severity), psychological features (QoL…
- Trial name
- IBSQUtrition (NCT03824821)
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 2,076 people
- Sponsor
- Wageningen University
Irritable Bowel Syndrome
Online Low-FODMAP Diet in Irritable Bowel Syndrome
This study aimed to assess the impact of implementing the low Fermentable Oligo-, Di- and Monosaccharides, And Polyols (FODMAP) diet, through an online educational service platform, on the quality of life of patients living with…
- Trial name
- NCT07172581
- Testing
- Online low-FODMAP diet
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Irritable Bowel Syndrome (IBS)
New Microbiota-endocrine Axis in Fructose Malabsorption-caused Visceral Hypersensitivity in Irritable Bowel Syndrome.
Irritable bowel syndrome (IBS) affects around 4% of the general population and remains the most common functional bowel disorder.
- Trial name
- ENDOLORII (NCT07337707)
- Testing
- urine intestinal permeability test or lactulose/mannitol test, Blood test, food diary
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Rouen
Constipation-predominant Irritable Bowel Syndrome, Abdominal Pain
Effect of taVNS on Abdominal Pain and Other Symptoms in Constipation-predominant Irritable Bowel Syndrome
This study aims to investigate the effects and possible mechanisms of transcutaneous auricular vagal nerve stimulation (taVNS) on abdominal pain and other symptoms in patients with IBS-C.
- Trial name
- NCT05392439
- Testing
- taVNS
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Tongji University
Inflammatory Bowel Disease
A Trial of Multi-convergent Therapy for Functional Symptoms and Stress in Patients With Inflammatory Bowel Disease
The purpose of this study is to determine whether multi-convergent therapy is helpful to patients with inflammatory bowel disease who have functional abdominal symptoms or high perceived levels of psychological stress.
- Trial name
- NCT01426568
- Testing
- Multi-Convergent Therapy
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- Cardiff and Vale University Health Board
Irritable Bowel Syndrome With Constipation (IBS-C)
A Phase 3, International, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Efficacy and Safety Trial of Linaclotide Administered Orally for 12 Weeks to Patients With Irritable Bowel Syndrome With Constipation (IBS-C)
This clinical trial is an international, multicenter, randomized, double-blind, placebo-controlled, parallel-group trial comparing one dose of linaclotide to placebo.
- Trial name
- D5630C00001 (NCT01880424)
- Testing
- Linaclotide
- Where
- 82 sites in United States, Australia and 3 more
- Volunteers
- 1,722 people
- Sponsor
- AstraZeneca
Repetitive Transcranial Magnetic Stimulation, Chronic Visceral Pain
Lf-rTMS Attenuates Visceral Pain in Irritable Bowel Syndrome With Diarrhea
Objectives: To identify a central hub of visceral pain in IBS-D and elucidate the mechanism by which repetitive transcranial magnetic stimulation (rTMS) confers analgesic effects.
- Conditions
- Repetitive Transcranial Magnetic Stimulation, Chronic Visceral Pain, Functional Magnetic Resonance Imaging, IBS (Irritable Bowel Syndrome)
- Trial name
- NCT06757491
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 42 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Irritable Bowel Syndrome
Pathophysiological Effects of Persistently Colonized Microbiome on Irritable Bowel Syndrome
The goal of this clinical trial is to explore the pathophysiological effects of the persistently colonized microbiome in irritable bowel syndrome (IBS) patients.
- Trial name
- IBS (NCT06013410)
- Testing
- colonoscopy
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Irritable Bowel Syndrome (IBS), Constipation - Functional
Effect of a Low FODMAP Diet in IBS and Functional Constipation with Bloating: a Randomized Double-Blind Trial
This clinical study aims to evaluate the effects of a low FODMAP diet compared to a high FODMAP diet in patients with Irritable Bowel Syndrome (IBS) and Functional Constipation (FC) with predominant bloating.
- Conditions
- Irritable Bowel Syndrome (IBS), Constipation - Functional, Bloating
- Trial name
- NCT06871748
- Testing
- Low FODMAP Diet, High FODMAP Diet
- Volunteers
- 34 people
- Sponsor
- Mahidol University