Clinical trials: Irritable Bowel Disease
Irritable Bowel Syndrome
Pain Relief In Irritable Bowel Syndrome
The purpose of this study is to determine whether Proklama is effective in significative reduction of pain, other symptoms IBS's related, and improves quality of life concerning IBS disease.
- Trial name
- PRITON (NCT02573844)
- Testing
- Proklama
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Geophyt S.r.l.s.
Irritable Bowel Syndrome
Donor Versus Autologous Fecal Microbiota Transplantation for Irritable Bowel Syndrome
Many patients with irritable bowel syndrome (IBS) do not experience adequate symptom relief with current treatments. The pathophysiology of IBS is diverse, controversial and not completely understood.
- Trial name
- NCT04691544
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- Norway
- Volunteers
- 450 people
- Sponsor
- University Hospital of North Norway
Irritable Colon
Study to Assess the Effect Of Alosetron On Mucosal Blood Flow
This study will look at colonic mucosal blood flow in subjects who have taken alosetron vs placebo and healthy volunteers vs diarrhea-predominant Irritable Bowel Syndrome (d-IBS) patients.
- Trial name
- NCT00370032
- Testing
- alosetron
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Functional Gastrointestinal Disorders
The Association of Clinical Symptom Clusters With Underlying Mechanisms in Functional Gastrointestinal Disorders
Functional gastrointestinal disorders (FGID) are amongst the most common causes of abdominal pain and dysfunction seen in clinical practice, affecting between 10 to 15% of most populations (1).
- Trial name
- NCT04331223
- Testing
- Observation
- Where
- Switzerland
- Volunteers
- 5,000 people
- Sponsor
- Brain-Gut Research Group
Irritable Colon, Irritable Bowel Syndrome (IBS)
Study Of Women With Severe Diarrhea-Predominant Irritable Bowel Syndrome Having Failed Conventional Therapy
The purpose of this study is to compare the safety and effectiveness of different doses of an investigational medication in women with severe diarrhea-predominant Irritable Bowel Syndrome (IBS) who have failed conventional…
- Trial name
- NCT00067561
- Testing
- Alosetron
- Where
- 178 sites in United States, Australia
- Volunteers
- 702 people
- Sponsor
- GlaxoSmithKline
IBS - Irritable Bowel Syndrome
Effects of a Novel Machine Learning Mobile App on Diet Adherence in Individuals Following the Low Fodmap Diet
A high fermented, oligio-, di-, monosaccharide, and polyols (FODMAP) diet has been shown to exacerbate the symptoms of irritable bowel syndrome (IBS).
- Trial name
- NCT04256551
- Testing
- Heali mobile application + Registered Dietitian, Heali mobile application, Standard Dietary Education
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Arizona State University
Irritable Bowel Syndrome With Constipation
A Multistrain Probiotic in Patients With Irritable Bowel Syndrome With Predominant Constipation
Probiotics efficacy is mainly assessed by subjective endpoints such as the FDA responder rate or global relief, which partly explain contradictory results obtained in clinical trials with probiotic bacteria.
- Trial name
- EPORE (NCT04997057)
- Testing
- Probiotics mixture
- Where
- France
- Volunteers
- 80 people
- Sponsor
- CEN Biotech
IBS (Irritable Bowel Syndrome)
A Prospective Trial of a Variable Compression System for Moderate to Severe Irritable Bowel Syndrome
This prospective, interventional trial is intended to determine the safety and effectiveness of the Variable Compression System (VCS) device for Irritable Bowel Syndrome (IBS).
- Trial name
- NCT07540312
- Testing
- Variable Compression System
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- PGP Health
Irritable Bowel Syndrome
Efficacy and Safety of IBS Digital Behavioral Treatment
A Randomized, Double-Blind, Comparator-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Two Self-administered behavioral treatments for Adult Subjects with Symptomatic Irritable Bowel Syndrome (IBS).
- Trial name
- EASITx (NCT04133519)
- Testing
- Arm 1 - Active behavioral Treatment Arm (Regulora; Gut-Directed Hypnotherapy Software as a Medical Device - SaMD), Arm 2 - Active Comparator behavioral treatment arm (MR-1; Muscle Relaxation, Software as a Medical Device - SaMD)
- Where
- United States
- Volunteers
- 378 people
- Sponsor
- metaMe Health
Irritable Bowel Syndrome
Frequency of Sleep Abnormalities in Patients With Irritable Bowel Syndrome and Effect of Pharmacological Intervention
Irritable bowel syndrome (IBS), a common gastrointestinal (GI) disorder in India and in the rest of the World, is enigmatic in its pathogenesis.
- Trial name
- NCT04193501
- Testing
- Melatonin 3 mg
- Where
- 2 sites in India
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Irritable Bowel Syndrome
Evaluation of Treatment Effect of Low FODMAP Diet in Treatment of IBS Patients
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, affecting 15% of the population. IBS is characterized by recurrent abdominal pain/discomfort without identifiable organic lesions.
- Trial name
- NCT05144204
- Testing
- Low FODMAP diet
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Migraine, Irritable Bowel Syndrome
Effects of a Multispecies Probiotic on Migraine
The prevalence of migraine is higher in female patients with various intestinal diseases. An explanation could be that migraine is caused by a leaky gut, defined by increased intestinal permeability that permits particles to pass…
- Conditions
- Migraine, Irritable Bowel Syndrome, Headache, Migraine
- Trial name
- NCT04696458
- Testing
- Lactobacillus plantarum (CECT7484 and CECT7485)/ Pediococcus acidilactici (CECT7483)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Scripps Health
Irritable Bowel Syndrome, Microbial Colonization
Microbiota Profiling in IBS
This study investigates differences in microbiota profiles and metabolite levels between mild and severe IBS patients, compared to matched healthy controls. Two fecal samples, with one month in between, will be analyzed.
- Conditions
- Irritable Bowel Syndrome, Microbial Colonization, Dietary Habits
- Trial name
- IBSQUtrition (NCT03720314)
- Testing
- NA observational study
- Where
- Netherlands
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Constipation, Irritable Bowel Syndrome
Factors Affecting Dissatisfaction to Treatments in Patients With Chronic Constipation and IBS With Constipation
Chronic constipation (CC) and Irritable Bowel Syndrome with Constipation (IBS-C) are two conditions difficult to manage because factors affecting dissatisfaction to treatments are misleading.
- Trial name
- NCT02813616
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Ulcerative Colitis
Melatonin and Ulcerative Colitis: A Pilot Clinical Trial
Ulcerative colitis is an inflammatory bowel disease that afflicts up to one million people in the U.S. Symptoms include rectal urgency, bloody diarrhea, moderate to severe abdominal pain, fever, and fatigue.
- Trial name
- NCT00790478
- Testing
- Melatonin
- Where
- 2 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Emory University
Irritable Bowel Syndrome (IBS), Constipation - Functional
Effect of a Low FODMAP Diet in IBS and Functional Constipation with Bloating: a Randomized Double-Blind Trial
This clinical study aims to evaluate the effects of a low FODMAP diet compared to a high FODMAP diet in patients with Irritable Bowel Syndrome (IBS) and Functional Constipation (FC) with predominant bloating.
- Conditions
- Irritable Bowel Syndrome (IBS), Constipation - Functional, Bloating
- Trial name
- NCT06871748
- Testing
- Low FODMAP Diet, High FODMAP Diet
- Volunteers
- 34 people
- Sponsor
- Mahidol University
IBS - Irritable Bowel Syndrome
Irritable Bowel Syndrome and Control Volunteers: Diet Challenge
The purpose of this study is to study the relationship between the bile acids, short chain fatty acids and bacteria within the intestines.
- Trial name
- NCT03983434
- Testing
- Inulin
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Indiana University
IBS - Irritable Bowel Syndrome
A Trial to Evaluate the Effects of Bifidobacterium Longum NCC3001 on Intestinal and Psychological Symptoms in Subjects With Irritable Bowel Syndrome
This is a prospective, randomized, placebo-controlled, double-blind, multi-center parallel- design study to evaluate the effect of BL NCC3001 in subjects with Irritable Bowel Syndrome.
- Trial name
- Mood-01 (NCT05054309)
- Testing
- Bifidobacterium longum
- Where
- 11 sites in Canada
- Volunteers
- 146 people
- Sponsor
- Société des Produits Nestlé (SPN)
Irritable Bowel Syndrome
Efficacy of Hydrogen Breath Test in the Patients With Irritable Bowel Syndrome
Irritable bowel syndrome is characterized by abdominal discomfort and bowel habit change. It is increasing worldwide. But the pathophysiology of the irritable bowel syndrome is not proven.
- Trial name
- NCT02242175
- Testing
- Glucose breath test (hydrogen breath test)
- Where
- South Korea
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Irritable Bowel Syndrome
Effect of Menstrual Cycle on Central Nervous System (CNS) Processing of Gut Stimuli in Irritable Bowel Syndrome (IBS) and Control
The hypothesis of the study is that women perceive intestinal stimulation (rectal balloon distention) differently in different phases of the menstrual cycle, i.e there is an effect of hormones on the sensory pathway, and that…
- Trial name
- NCT00219531
- Testing
- perception of rectal balloon distention
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Penn State University