Clinical trials: Irritable Bowel Syndrome - Diarrhoea
Diarrhea-predominant Irritable Boewl Syndrome
Efficacy and Safety of Modified Gegen Qinlian Decoction for Diarrhea-predominant Irritable Boewl Syndrome
Diarrhea-predominant irritable boewl syndrome(IBS-D) seriously affect the quality of life in patients. Clinically, it is effective to apply therapeutic method of clearing heat and promoting diuresis to the common syndrome of…
- Trial name
- NCT04312477
- Testing
- Modified Gegen Qinlian Decoction
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Irritable Bowel Syndrome
Effect of Lactobacillus Plantarum 299v on Symptoms of Irritable Bowel Syndrome
In patients with IBS, will supplementation with a probiotic demonstrate symptomatic efficacy and will the probiotic influence gut microflora and thus improve clinical outcomes, as compared to no intervention.
- Trial name
- NCT01886781
- Testing
- Lactobacillus plantarum 299v, Run in period, Wash - out period
- Where
- South Africa
- Volunteers
- 81 people
- Sponsor
- University of Stellenbosch
Irritable Bowel Syndrome With Diarrhea (IBS-D)
G-PUR® for Symptomatic Treatment in Irritable Bowel Syndrome With Diarrhea
A randomized, double-blind, placebo-controlled pilot study in patients with IBS-D according to Rome IV criteria evaluating the clinical efficacy and safety of oral administration of 2g G-PUR® tid compared to placebo in a cohort…
- Trial name
- NCT04138186
- Testing
- 2.0g G-PUR®, oral administration
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Glock Health, Science and Research GmbH
Irritable Bowel Syndrome
Efficacy, Safety and Tolerability of DNK333 (25 and 100 mg Bid) in Women With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)
This study will evaluate the tolerability, safety and efficacy of DNK333 against diarrhea caused by Irritable Bowel Syndrome in women.
- Trial name
- CDNK333B2201 (NCT00699166)
- Testing
- DNK333
- Where
- 29 sites in United States
- Volunteers
- 135 people
- Sponsor
- Novartis
Irritable Colon
Safety and Efficacy Study of GR68755 (Alosetron Hydrochloride) to Treat Severe Diarrhea-Predominant Irritable Bowel Syndrome (IBS)
This study is an exploratory study aiming (i) to obtain clinical experience of GR68755 in Japanese subjects with severe d-IBS to explore the feasibility of the next phase study and (ii) to obtain reference data for endpoints and…
- Trial name
- NCT01855711
- Testing
- GR68755 (Alosetron hydrochloride) 1 mg tablet
- Volunteers
- 32 people
- Sponsor
- GlaxoSmithKline
Food Intolerance Syndromes, Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Combined Lactulose H2-breath Test With Abdominal Imaging
Hydrogen (H₂) breath tests serve several purposes. (i) detect malabsorption of carbohydrates such as lactose and fructose, (ii) measurement of oro-caecal transit time (iii) associate hydrogen production with the onset of…
- Conditions
- Food Intolerance Syndromes, Small Intestinal Bacterial Overgrowth Syndrome (SIBO), Breath Tests
- Trial name
- NCT07145580
- Where
- Switzerland
- Volunteers
- 510 people
- Sponsor
- Klinik Arlesheim
Irritable Bowel Syndrome
Effect of Herbal Extract Granules Combined With Probiotics on Irritable Bowel Syndrome With Diarrhea
The aims of this study are to investigate the effect of famous herbal formula extract and probiotics on irritable bowel syndrome with diarrhea, and to determine whether these two experimental items affect intestinal permeability…
- Trial name
- NCT01342718
- Testing
- Herbal extract granule and probiotics
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Kyunghee University Medical Center
Irritable Bowel Syndrome
Study to Determine Efficacy of Probiotics in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is the most common functional GI disorder in which abdominal pain and/or discomfort is associated with changes in bowel habit, and with features of disordered defecation.
- Trial name
- NCT02545413
- Testing
- Probiotic VSL#3
- Where
- India
- Sponsor
- Next Gen Pharma India Pvt. Ltd.
Irritable Bowel Syndrome
A Randomized, Double-blind, and Placebo-controlled Study on the Treatments of Irritable Bowel Syndrome
The purpose of this study is to test the efficacy and safety of pinaverium and an herbal medication for irritable bowel syndrome (IBS).
- Trial name
- NCT01641224
- Testing
- Pinaverium, Atractylodes, Paeonia Lactiflora
- Where
- 4 sites in China
- Volunteers
- 800 people
- Sponsor
- University of Minnesota
Irritable Bowel Syndrome
Clinical Trials of N-acetyl Glucosamine Capsule for IBS-D Treatment
This study is a randomized double-blind placebo-controlled clinical trail to evaluate the clinical efficacy and safety of 1.1 chemical drugs N-acetyl-D-glucosamine on Chinese IBS-D patients coming from thirty- six centers in…
- Trial name
- NCT02504060
- Testing
- N-acetyl-D-glucosamine
- Where
- China
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Third Military Medical University
Irritable Bowel Syndrome With Diarrhea
A Mediterranean Approach to Low FODMAP Diet (MED-LFD) for Managing IBS Symptoms
Irritable Bowel Syndrome (IBS) is a common functional bowel disorder characterized by absence of any organic cause. The vast majority of patients associate their symptoms with specific food consumption, creating the need for…
- Trial name
- NCT03997708
- Testing
- Med-LFD, Nutritional Guidelines of the British National Institute for Health and Care Excellence (NICE) Managing IBS
- Where
- Greece
- Volunteers
- 108 people
- Sponsor
- Attikon Hospital
Diarrhea Predominant Irritable Bowel Syndrome
Study of Asimadoline to Treat Diarrhea-Predominant Irritable Bowel Syndrome (D-IBS)
The purpose of this study is to determine whether asimadoline is safe and effective at treating D-IBS.
- Trial name
- NCT01100684
- Testing
- Asimadoline
- Where
- 142 sites in United States
- Volunteers
- 611 people
- Sponsor
- Tioga Pharmaceuticals
Irritable Bowel Syndrome
A Preliminary Study to Explore Clinical Endpoints in Patients (Male) With Diarrhea-predominant Irritable Bowel Syndrome
The purpose of this study is to explore and examine endpoints that allow evaluation of the "clinically significant improvements, focusing on the patient's chief complaint and the severity of major IBS symptoms" by this drug in…
- Trial name
- NCT00918411
- Testing
- Ramosetron
- Where
- 4 sites in Japan
- Volunteers
- 98 people
- Sponsor
- Astellas Pharma Inc
Irritable Bowel Syndrome
8 Weeks Treatment With DDP225 in Patients With Diarrhea Predominant IBS
In this study, female patients with IBS-d will be treated for 8 weeks to assess the safety and effectiveness of DDP225 on GI transit and in reducing IBS symptoms.
- Trial name
- NCT00230581
- Testing
- DDP225
- Where
- 16 sites in United States, Canada
- Volunteers
- 88 people
- Sponsor
- Dynogen Pharmaceuticals
Diarrhea-predominant Irritable Bowel Syndrome
Tong-Xie-Yao-Fang Granules for Diarrhea-predominant Irritable Bowel Syndrome
The purpose of this study is to test the efficacy and safety of a traditional Chinese medication Tong-Xie-Yao-Fang for patients with diarrhea-predominant irritable bowel Syndrome (IBS-D).
- Trial name
- NCT02538692
- Testing
- Tong-Xie-Yao-Fang
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Irritable Bowel Syndrome
Mediterranean Diet and the Gut Microbiome
This study will evaluate the impact of a Mediterranean-style diet on microbiome diversity compared to a typical American diet. The study will observe the microbiome composition comparisons in healthy volunteers as well as in…
- Trial name
- NCT03269032
- Testing
- American Diet, Mediterranean-style Diet
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Irritable Bowel Syndrome - Diarrhoea, Traditional Chinese Medicine (TCM)
Fengliao Changweikang for Diarrhea-predominant Irritable Bowel Syndrome: N-of-1 Trial
Irritable bowel syndrome with diarrhea (IBS-D) is a functional gastrointestinal disorder, with characteristics of defecation related abdominal pain and diarrhea.
- Conditions
- Irritable Bowel Syndrome - Diarrhoea, Traditional Chinese Medicine (TCM), N of 1 Study Design, Efficacy and Safety
- Trial name
- NCT07061184
- Testing
- FLCWK
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Irritable Colon
Study to Assess the Effect Of Alosetron On Mucosal Blood Flow
This study will look at colonic mucosal blood flow in subjects who have taken alosetron vs placebo and healthy volunteers vs diarrhea-predominant Irritable Bowel Syndrome (d-IBS) patients.
- Trial name
- NCT00370032
- Testing
- alosetron
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Irritable Bowel Syndrome With Diarrhoea
Mesalazine for the Treatment of Diarrhoea-predominant Irritable Bowel Syndrome (IBS-D)
The purpose of the trial is to define the clinical benefit and possible mediators of the benefit of mesalazine in Irritable Bowel Syndrome (IBS) with diarrhoea.
- Trial name
- MIBS (NCT01316718)
- Testing
- Mesalazine
- Where
- United Kingdom
- Volunteers
- 108 people
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome With Diarrhea
Comparing the Efficacy of Nitazoxanide Versus Rifaximin in Adult Patients With Irritable Bowel Syndrome Without Constipation
This study aim to compare the efficacy of nitazoxanide in 2-week course of treatment with rifaximin in treating diarrhea associated with IBS.
- Trial name
- NCT05453916
- Testing
- Nitazoxanide 500Mg Oral Tablet, Rifaximin 550Mg Tab
- Where
- Egypt
- Sponsor
- Sadat City University