Clinical trials: Irritation; Vagina
Bacterial Vaginosis, Candidiasis
Vaginal Ecosystem and Network in the United States Study
The central premise of this study is that the intricate balance and diversity of the vaginal microbiome plays a pivotal role in the onset, progression, and severity of various gynecological conditions.
- Conditions
- Bacterial Vaginosis, Candidiasis, Urinary Tract Infections, Genitourinary Syndrome of Menopause
- Trial name
- VENUS (NCT06472765)
- Testing
- Vaginal Swab Collection
- Where
- 21 sites in United States, Canada
- Volunteers
- 3,250 people, healthy volunteers welcome
- Sponsor
- Vaginal Biome Science
Vaginitis Gardnerella
Treatment of Gardnerella Vaginalis Vaginal Colonization With Amoxicillin
This is a randomized, double-blind, placebo-controlled Phase 2 study designed to determine if amoxicillin will eradicate vaginal colonization/infection with Gardnerella vaginalis (GV) when administered to women who are…
- Trial name
- NCT03211156
- Testing
- Amoxicillin
- Where
- 2 sites in United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bacterial Vaginosis
Safety and Efficacy Study of Lactobacillus Administered Vaginally in Women With Bacterial Vaginosis
This is a phase IIa clinical trial in women with bacterial vaginosis. This study will determine whether treatment with vaginal lactobacillus in combination with antibiotic therapy (metronidazole) is effective in colonizing the…
- Trial name
- NCT00635622
- Testing
- LACTIN-V
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Osel, Inc.
Bacterial Vaginosis, HIV Infections
Effect of Bacterial Vaginosis on HIV Susceptibility and Female Genital Immunology
A non-randomized, interventional, longitudinal clinical study to quantify the impact of bacterial vaginosis treatment on HIV susceptibility and genital immunology in Kenyan women.
- Trial name
- NCT02527941
- Testing
- Metronidazole
- Where
- Kenya
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Menopause, Postmenopausal Vaginal Atrophy
Pharmacokinetic Assessment of the Absorption of Estradiol in Postmenopausal Women With Atrophic Vaginitis
This trial is conducted in Europe. The aim of this trial is to to evaluate the extent of systemic absorption of estradiol during treatment with two different doses of estradiol in postmenopausal women with atrophic vaginitis.
- Trial name
- NCT01486979
- Testing
- estradiol, 10 mcg, estradiol, 25 mcg
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- Novo Nordisk A/S
Vaginal Discharge, Dyspareunia
Evaluation of a Novel Female Hygiene Device for Postcoital Discomfort
Previous research has shown that semen deposition in the vagina after intercourse leads to dripping, discomfort, and vaginal odor.
- Conditions
- Vaginal Discharge, Dyspareunia, Female Sexual Dysfunction, Vaginitis
- Trial name
- NCT04885556
- Testing
- Tampon-like device for absorption of sexual fluids
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Female Urogenital Diseases, Vaginal Atrophy
Investigation of Microbiomes of Postmenopausal Women Looking for Outcomes and Response to Estrogen Therapy
In this proposed pilot study, 16S ribosomal RNA (rRNA) gene sequencing will be used in the analysis of bacterial communities (microbiomes) in postmenopausal women with vulvovaginal atrophy (VVA) before and after eight weeks of…
- Conditions
- Female Urogenital Diseases, Vaginal Atrophy, Postmenopausal Atrophic Vaginitis, Genitourinary Disease
- Trial name
- IMPLORE (NCT03996603)
- Testing
- Conjugated Estrogens Cream
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
Bacterial Vaginoses
Effects of Lactobacillus Pentosus KCA1 on the Gut and Vaginal Microbiome of Women With Bacterial Vaginosis
Bacterial vaginosis (BV) is under-reported, misdiagnosed and inappropriately treated in Nigeria. Treatment option rely on antibiotics that eliminates both good and pathogenic bacteria, with gross impact on the gut and vaginal…
- Trial name
- NCT04329338
- Testing
- Lactobacillus pentosus KCA1
- Where
- Nigeria
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Nnamdi Azikiwe University
HIV-1-infection, Bacterial Vaginoses
Estrogen, Probiotics and Vaginal Health to Prevent HIV Infection in ACB Women
This study will enrol African, Caribbean and Black (ACB) women who are known to have a more diverse vaginal microbiome, higher rates of bacterial vaginosis with lower numbers of protective lactobacilli, and are at increased risk…
- Trial name
- NCT03837015
- Testing
- Estring Vaginal Ring, RepHresh Pro-B
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McMaster University
Bacterial Vaginosis
Bacterial Vaginosis; A Randomized Trial to Reduce Recurrence
Randomized controlled trial (RCT) to evaluate the effectiveness of applying Purell® (62% ethyl alcohol in emollient gel) to the penis of male partners of women diagnosed with BV for preventing BV recurrence after treatment.
- Trial name
- NCT00542074
- Testing
- hygienic information plus 62% ethyl alcohol in emollient gel, hygienic information
- Where
- Kenya
- Volunteers
- 223 people
- Sponsor
- University of Washington
Vaginitis Bacterial, Cervicitis
Empiric Therapy of Mucopurulent Cervicitis (MPC)
Mucopurulent cervicitis (MPC) is a syndrome with associated symptoms including mucopurulent discharge (mucus and pus) from the cervix and other signs of inflammation such as easily induced cervical bleeding.
- Trial name
- NCT01072136
- Testing
- Azithromycin, Cefixime
- Where
- 4 sites in United States
- Volunteers
- 87 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Trichomonas Vaginalis
Accuracy and Acceptability of Self-Diagnostic Methods for Vaginitis in Adolescent Females
Symptoms of vaginitis are common among adolescent females, although studies have shown that neither experienced clinicians nor patients can accurately diagnose the cause of vaginitis based on symptoms alone.
- Trial name
- NCT00706368
- Testing
- Point of care tests
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Atrophic Vaginitis, Urinary Tract Infections
Hyaluronate for the Treatment and Prevention of Recurrent Urinary Tract Infection in Women Suffering Atrophic Vaginitis
In post-menopausal women, the condition atrophic vaginitis results from the loss of oestrogen and is characterised by dyspareunia (pain during intercourse), vaginal dryness, and vaginal irritation.
- Trial name
- HATPIN (NCT03981458)
- Testing
- Hyalofemme, Ialuril
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Vaginitis Atropic, Pelvic Organ Prolapse
Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients
To evaluate the difference of three vaginal estrogens creams comparative with placebo on improvement of hormonal cytology, local and systemic climacteric complaints, as well as its endometrial security.
- Conditions
- Vaginitis Atropic, Pelvic Organ Prolapse, Endometrial Hyperplasia
- Trial name
- NCT03032848
- Testing
- Conjugated Estrogen, Promestriene, Estriol
- Volunteers
- 69 people
- Sponsor
- Universidade Federal do Paraná
Bacterial Vaginosis
Photobiomodulation With Blue LED in Recurrent Bacterial Vaginosis
Introduction: Bacterial vaginosis (BV) is the most prevalent vaginal dysbiosis in women of reproductive age and is associated with adverse gynecological and obstetric outcomes; therefore, its diagnosis and appropriate treatment…
- Trial name
- NCT07835815
- Testing
- Metronidazole, Blue Light-Emitting Diode (LED)
- Volunteers
- 40 people
- Sponsor
- Patricia Lordelo
Vaginal Candidiasis, Vulvovaginal Candidiasis
Evaluation of VagiVitalAC for Treatment of Candida Vulvovaginitis
Candidiasis is an infection caused by a yeast (a type of fungus) called Candida. Candidiasis in the vagina is commonly called a "vaginal yeast infection." Another names for this infection is "vaginal candidiasis".
- Conditions
- Vaginal Candidiasis, Vulvovaginal Candidiasis, Candidal Vulvovaginitis
- Trial name
- NCT05012852
- Testing
- VagiVitalAC
- Where
- Sweden
- Volunteers
- 126 people
- Sponsor
- PepTonic Medical AB
Premature Birth, Bacterial Vaginosis
Effect of Probiotic Lactobacilli on Vaginal Flora of Pregnant Women at High Risk for Preterm Delivery
Purpose of the study is to determine the effect of probiotic lactobacilli on the vaginal flora and cytokine profile during pregnancy, and the incidence of preterm labour in women at high risk for preterm birth.
- Trial name
- NCT00217308
- Testing
- Lactobacilli GR-1 and RC-14
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Vulvovaginal Candidiasis, Genital
Effect of Ultra-gyn® on Vulvovaginal Candidiasis
The aim of this post-market clinical follow up study is to confirm the performance and the safety of Ultra-gyn® (when used in accordance with its approved labelling)
- Trial name
- NCT05273333
- Testing
- Ultra-gyn®
- Where
- Mauritius
- Volunteers
- 30 people
- Sponsor
- Biocodex
Healthy
Pubic Hair and the Urinary and Vaginal Microbiome
This research study seeks to find if there is a connection between the presence of pubic hair and the type of bacteria that live in the vagina and bladder.
- Trial name
- NCT03272204
- Testing
- No pubic hair, Pubic Hair
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Margaret Mueller
Vulvovaginal Candidiasis
DeVEnIR: Defining Vulvovaginal Candidiasis - Elements of Infection and Remedy
Female-specific health conditions are underrepresented in research. The taboo felt by women to talk about intimate wellbeing is fed by this gender gap in scientific knowledge.
- Trial name
- DeVEnIR (NCT06397248)
- Testing
- No intervention
- Where
- 3 sites in Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp