Clinical trials: Irritation
Female Dry Genital Mucosa
Dermal and Gynecological Acceptability (Irritability and Sensitization in the Genital Mucosa) of an Investigational Product and Evaluation of Moisture Efficacy by TEWL and Perceived Efficacy.
To evaluate the safety of an investigational product through the verification of signs of irritability and sensitization of the genital mucosa, as well as the instrumental moisturizing efficacy by TEWL and barrier integrity…
- Trial name
- DERM GYN ACCEP (NCT03007615)
- Testing
- Intimate Lubricant Gel
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Kley Hertz S/A
Functional Gastrointestinal Disorders Such as Irritable Bowel Syndrome and Functional Dyspepsia, Irritable Bowel Syndrome
A Pharmacy-based Observational Study to Learn More About Iberogast Advance in the Real-world Setting
This is an observational study in which data from people with functional gastrointestinal disorders who decide on their own or by recommendation of their doctors or pharmacists to take Iberogast Advance are collected and studied.
- Conditions
- Functional Gastrointestinal Disorders Such as Irritable Bowel Syndrome and Functional Dyspepsia, Irritable Bowel Syndrome, Functional Dyspepsia
- Trial name
- NCT05389709
- Testing
- Iberogast (STW5-II, BAY98-7410)
- Where
- Germany
- Volunteers
- 184 people
- Sponsor
- Bayer
Healthy
Phase I Study to Assess Irritation, Sensitization and Adhesion of a Novel Ibuprofen 200 mg TEPI Medicated Plaster
This trial will be conducted with the aim to investigate the dermal response (skin irritation, sensitization) and the adhesion of Ibuprofen 200 mg TEPI Medicated Plaster as compared to a Placebo TEPI Plaster in two phases…
- Trial name
- NCT03639571
- Testing
- Ibuprofen 200 mg TEPI Medicated Plaster
- Where
- Bulgaria
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Medherant Ltd
Irritable Bowel Syndrome
The Efficacy of Single-strain Probiotics in Patients With Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is one of the most common, yet still not fully understood, gastrointestinal disorders in adults. One suspected etiology involves intestinal dysbiosis, i.e.
- Trial name
- NCT05064930
- Testing
- Probiotic Bifidobacterium lactis, Probiotic Bacillus coagulans
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Nordic Biotic Sp. z o.o.
Psoriasis Vulgaris
Skin Irritation of LEO 90100 Foam (Calcipotriol Hydrate Plus Betamethasone Dipropionate) in Healthy Japanese Subjects
This trial is looking at whether the LEO 90100 foam causes irritation of the skin in healthy Japanese male adults without psoriasis.
- Trial name
- NCT03442244
- Testing
- LEO 90100 foam, Vehicle of LEO 90100 foam
- Where
- Japan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- LEO Pharma
Irritable Bowel Syndrome
The Effect of Zespri Green Kiwifruit on Digestive and Gut Health Functions
The proposed study will primarily demonstrate the efficacy of kiwifruit as a food intervention for the relief of constipation and associated symptoms in functionally constipated adults, and those with IBS-C.
- Trial name
- NCT02888392
- Testing
- Kiwifruit, Psyllium
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zespri International Limited
Crohn's Disease
Long-term Safety Study of Brodalumab in Adults With Crohn's Disease
The purpose of this study is to evaluate the safety and efficacy of long-term treatment with brodalumab in adults with Crohn's disease.
- Trial name
- NCT01199302
- Testing
- Brodalumab
- Where
- 34 sites in United States, Australia and 6 more
- Volunteers
- 67 people
- Sponsor
- Amgen
Myopia
A Study to Evaluate a Modified Contact Lens
This study is being conducted to evaluate the product performance of SofLens daily disposable contact lenses packaged in an investigational Test solution versus SofLens daily disposable contact lenses packaged in the currently…
- Trial name
- NCT01391364
- Testing
- SofLens in investigational solution, SofLens in currently marketed solution
- Where
- United States
- Volunteers
- 438 people
- Sponsor
- Bausch & Lomb Incorporated
Sunscreening Agents
Evaluation of the Irritation Potential of Sunscreen Products in Human Eyes
Evaluation of the human eye irritation potential of a test sunscreen formulation.
- Trial name
- NCT02854137
- Testing
- BAY987521, Control
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Bayer
Diaper Dermatitis
BM Collection From NICU Infants for Composition
The primary objective of this study is to collect feces from premature infants over a five weeks period to characterize its composition.
- Trial name
- NCT02570698
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Kimberly-Clark Corporation
Neuralgia, Shingles
Dose-Finding Study of REN-1654 in Patients With Post-Herpetic Neuralgia
The purpose of this study is to gain initial safety and efficacy data on the experimental agent REN-1654 in patients with painful post-herpetic neuralgia (PHN).
- Conditions
- Neuralgia, Shingles, Peripheral Nervous System Disease
- Trial name
- NCT00099528
- Testing
- REN-1654
- Where
- 16 sites in United States
- Volunteers
- 90 people
- Sponsor
- Renovis
Skin Care
A Photoxicity and Photoallergy Study of a Developmental Face Cream, Serum and Lotion
The purpose of this study is to demonstrate the absence of sensitisation and irritation potential of a product when applied to the skin and exposed to ultraviolet (UV) radiation.
- Trial name
- NCT04006795
- Testing
- Serum, Lotion, Cream
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Major Depressive Disorder (MDD)
A Study to Assess the Skin Irritation and Sensitization of Selegiline TDS in Healthy Subjects
The two products used in this study are transdermal patches that contain selegiline. The test drug is the Selegiline Transdermal Delivery System (TDS). The comparator drug is the EMSAM® TDS.
- Trial name
- NCT07452692
- Testing
- Selegiline Transdermal Delivery System
- Where
- 3 sites in Bulgaria
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Corium Innovations, Inc.
Irritable Bowel Syndrome
Safety and Efficacy of Oral AGN 203818 for the Relief of Irritable Bowel Syndrome Pain
This study will explore the safety and effectiveness of different doses of AGN 203818 in relieving Irritable Bowel Syndrome pain. The study is being conducted in 2 parts.
- Trial name
- NCT00441766
- Testing
- AGN 203818
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Allergan
Acne Vulgaris
A Study of Different Use Regimens Using Two Acne Treatments
A study to determine if using 2 acne products in the morning is as safe and efficacious as using one product in the morning and one product in the evening.
- Trial name
- NCT00907257
- Testing
- benzoyl peroxide wash, Tretinoin gel
- Where
- 12 sites in United States
- Volunteers
- 247 people
- Sponsor
- Bausch Health Americas, Inc.
Healthy
Evaluation of Adhesion Quality and Irritation of an Alternate Second Generation Estradiol Transdermal System
The primary objective of this study was to compare the adhesive quality of the current Mylan estradiol placebo transdermal system, with that of an alternate second generation Mylan estradiol placebo transdermal system following a…
- Trial name
- NCT00650442
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Hygiene
Dermacyd Breeze Pocket BR (Lactic Acid) - Acceptability
The purpose of this study is to prove the safety of the gynaecological formulation in normal conditions of use.
- Trial name
- NCT00793026
- Testing
- Dermacyd Breeze Pocket BR (Lactic Acid)
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sanofi
Oral Manifestations
Oral Irritation Study of Two Experimental Mouthrinses
This study is 25 days long. People participating in this study will be asked to brush their teeth two times a day. People will be assigned to a mouthwash and will rinse four times a day at the site for five days.
- Trial name
- NCT01156376
- Testing
- Potassium Oxalate without Fluoride, Potassium Oxalate with Fluoride, Active Comparator PO-116-A
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Healthy
Dermacyd Tina Gel Tangerina Mix - Photo Evaluation
The purpose of this study is to prove the absence of photo irritation and photo sensitivity potential of the product Dermacyd Tina Gel Tangerina Mix.
- Trial name
- NCT00668889
- Testing
- Lactic acid (Dermacid)
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sanofi
Healthy
Cumulative Irritation Test of PAC-14028 in Healthy Volunteers
The purpose of this study is to determine the cumulative irritation potential of the products listed by the Sponsor.
- Trial name
- NCT01638117
- Testing
- PAC14028-Vehicle, PAC14028-0.1, PAC14028-0.3
- Where
- South Korea
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Amorepacific Corporation