Clinical trials: Irritation
Irritable Bowel Syndrome
Chronic Gastrointestinal Sequelae of an Acute Outbreak of Bacterial Gastroenteritis in Walkerton Ontario
Acute Bacterial dysentery leads to chronic symptoms of disturbed bowel habit in a minority of individuals. This condition known as post infectious irritable bowel syndrome (PI-IBS) remains poorly understood.
- Trial name
- NCT00235326
- Where
- Canada
- Volunteers
- 4,561 people, healthy volunteers welcome
- Sponsor
- McMaster University
Atopic Dermatitis (AD)
Tolerance Evaluation of a Nighttime Moisturizing Balm on Babies and Adults With Eczema
The purpose of this 14-day, two phase clinical study is to test the tolerance of a new over-the-counter moisturizing balm on subjects with eczema.
- Trial name
- NCT02357940
- Testing
- Experimental Product
- Where
- 2 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Autism in Children, Autistic Disorder in Children and Adolescents
Clinical Trial Evaluating the Effects of Ganaxolone in Children With Autism
The goal of this study is to conduct a randomized, placebo-controlled trial (RCT) of ganaxolone, a neuroactive steroid (NAS), in autistic children and adolescents aged 5 to 17 years old.
- Conditions
- Autism in Children, Autistic Disorder in Children and Adolescents, Autism Spectrum Disorder
- Trial name
- NCT07635862
- Testing
- Ganaxolone (Ztalmy)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Stanford University
Irritable Bowel Syndrome
A Study Evaluating Oral Eluxadoline Administered to Pediatric Participants With Irritable Bowel Syndrome With Diarrhea (IBS-D)
This study will assess the long-term safety of oral Eluxadoline administered to pediatric participants with IBS-D who have completed study intervention in the Phase 2 study 3030-202-002 or the Phase 3 study 3030-303-002.
- Trial name
- NCT04880876
- Testing
- 25mg Eluxadoline, 100mg Eluxadoline
- Where
- 6 sites in United States
- Volunteers
- 124 people
- Sponsor
- AbbVie
Gastrointestinal Disorder, Functional
PHAGE Study: Bacteriophages as Novel Prebiotics
The PHAGE study is designed to determine if a commercial prebiotic product can change the composition of bacteria in the gut for improved intestinal health.
- Trial name
- NCT03269617
- Testing
- Bacteriophage mixture
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Functional Bowel Disorder, Irritable Bowel Syndrome
The 5Ad Diet for Functional Bowel Disorders
The goal of this randomised controlled trial (RCT) is to compare the efficacy of the newly developed 5Ad diet against the widely researched low fermentable oligo-, di-, monosaccharide and polyols (FODMAP) diet in reducing…
- Conditions
- Functional Bowel Disorder, Irritable Bowel Syndrome, Food Intolerance, Food Intolerance Syndromes
- Trial name
- NCT06338189
- Testing
- The 5Ad Diet, The Low FODMAP Diet
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Suffolk
Irritable Bowel Syndrome, Traditional Chinese Medicine
Trial of Chinese Prescription Shugan Decoction on Irritable Bowel Syndrome（Diarrhea Type）
The purpose of this study is to evaluate the efficacy and safety of the Chinese prescription Shugan decoction on irritable bowel syndrome（diarrhea type）.
- Trial name
- NCT00948870
- Testing
- Shugan decoction
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Irritable Bowel Syndrome, Vitamin D Deficiency
Vitamin D Supplementation in IBS
Irritable bowel syndrome (IBS) is a very common functional gastrointestinal disorder affecting nearly 20% of the North American population.
- Conditions
- Irritable Bowel Syndrome, Vitamin D Deficiency, Abdominal Pain
- Trial name
- NCT03148288
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Beth Israel Deaconess Medical Center
Irritable Bowel Syndrome
SMART Program in Irritable Bowel Syndrome (IBS)
This is a pilot study to determine the efficacy of the Stress Management and Resilience Training (SMART) program in improving gastrointestinal and psychological symptoms, health-related quality of life, and satisfaction of care…
- Trial name
- NCT03454386
- Testing
- Stress Management and Resilience Training Program, Self-Management Stress Reduction Program
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of California, Los Angeles
IBS - Irritable Bowel Syndrome
The Prevalence of Irritable Bowel Syndrome Using Rome IV Criteria in Medical Student and The Related Factors
A cross-sectional study of 350 medical student Universitas Indonesia from first grade until fifth grade was done during November-December 2016. This study used stratified randomized sampling.
- Trial name
- IBS (NCT03178877)
- Testing
- No intervention
- Where
- Indonesia
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Skin Irritation, Healthy Volunteers
Safety of Topical Exosome-Containing Liquid in Healthy Volunteers
This Phase 1 split-site pilot study will evaluate the safety and dermal tolerability of a topical exosome-containing liquid in 10 healthy adult volunteers.
- Trial name
- EV-SAFE-1 (NCT07703969)
- Testing
- Exosome-Containing Liquid, Vehicle Liquid
- Where
- Kazakhstan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- West Kazakhstan Marat Ospanov Medical University
Pain
A Safety Study to Investigate the Skin Irritancy Potential of Diclofenac-Menthol Gel
This research study is being conducted to investigate the skin irritancy potential of a new medication which contains two active ingredients (diclofenac and menthol) together in a gel formulation and is being developed to treat…
- Trial name
- NCT02169154
- Testing
- 1% Diclofenac Sodium, 3% Menthol, 0.09% Menthol
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Irritable Bowel Syndrome Variant of Childhood
Clinical Study of Selective Fecal Microbiota Transplantation in the Treatment of Irritable Bowel Syndrome.
In order to seek a more precise and convenient treatment, we made a self-made precise transplant capsule that is effective against diarrhea.
- Trial name
- NCT04890405
- Testing
- Standardized FMT, Precision Flora Transplantation
- Volunteers
- 70 people
- Sponsor
- Yanling Wei
Constipation Predominant Irritable Bowel Syndrome
A Long-Term Safety Study of Tenapanor for the Treatment of IBS-C
This phase 3, open label study will evaluate the safety of tenapanor 50 mg BID in subjects with constipation-predominant irritable bowel syndrome (IBS-C) defined by the ROME III criteria.
- Trial name
- T3MPO-3 (NCT02727751)
- Testing
- Tenapanor
- Where
- United States
- Volunteers
- 312 people
- Sponsor
- Ardelyx
Best Comfort and Lowest Skin Irritation
Safety and Tolerability of Transcranial Direct Current Stimulation (tDCS)
Testing safety and tolerability of transcranial direct current stimulation (2 mA, 20 minutes) in four different protocols: saline-soaked sponges electrode with electrode gel tap-water-soaked sponges tap-water-soaked-sponges +…
- Trial name
- NCT01148212
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Irritable Bowel Syndrome
Mindfulness-Based Stress Reduction for Bowel Symptoms: Collection of Pilot Survey Data
Irritable bowel syndrome (IBS) is a very common, chronic disorder that significantly affects quality of life, and results in enormous expenditures each year in the United States.
- Trial name
- NCT00880256
- Testing
- mindfulness-based stress reduction
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Skin Irritation, Skin Sensitization
HRIPT Study to Evaluate the Irritation and Allergenic Potential of Medical-grade Norway Spruce (Picea Abies) Resin Salve (Abilar)
The goal of this clinical trial is to assess whether a medical-grade Norway spruce resin-based topical product (Abilar) causes skin irritation or allergic sensitization in healthy adult volunteers.
- Trial name
- HRIPT-REPRIP2M (NCT06810856)
- Testing
- Abilar® Resin Salve
- Where
- United Kingdom
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Repolar Pharmaceuticals Oy
IBS - Irritable Bowel Syndrome
Sex Differences in Effectiveness of CBT on IBS Project 3
Cognitive Behavioral Therapy (CBT) is the most well researched and most effective treatment for IBS targeting the brain-gut-microbiome (BGM) axis, and preliminary data show that this therapeutic effect is associated with a…
- Trial name
- U54_P3_CBT (NCT05155631)
- Testing
- COGNITIVE BEHAVIORAL THERAPY
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of California, Los Angeles
Functional Constipation, Irritable Bowel Syndrome Characterized by Constipation
Mode of Action of Moviprep
The University of Nottingham have been developing new, non-invasive magnetic resonance imaging (MRI) techniques to image the bowel.
- Trial name
- NCT01622972
- Testing
- Polyethyleneglycol
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Constipation-predominant Irritable Bowel Syndrome
Effect of Lubiprostone on Small Bowel Contractions in Female Patients With Constipation Irritable Bowel Syndrome (C-IBS)
Irritable Bowel Syndrome (IBS) is a common disorder, defined by symptom-based diagnostic criteria. The pathogenesis is multifactorial and gut motor dysfunction is considered to be a contributing factor.
- Trial name
- NCT01085643
- Testing
- Lubiprostone
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Cedars-Sinai Medical Center
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