Clinical trials: Irritation
Clavicle Fracture, Non Union/Malunion
Plating Clavicle Fractures
The anterior-inferior clavicle plate position will have a lower rate of soft tissue irritation that limits activity and/or requires hardware removal compared to superior plate position.
- Trial name
- NCT00871468
- Testing
- superior plate, anterior-inferior plate
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- United States Army Institute of Surgical Research
Edema, Depression
Safety and Efficacy Study of Gamaline+Hipericin in PMS
GAMALINE is already register for PMS and HIPERICIN as antidepressive drug. Both plant extracts. The investigators will try the mixture and see if the vasomotor symptoms will disappear.
- Conditions
- Edema, Depression, Hot Flashes, Anxiety
- Trial name
- GH (NCT01283568)
- Where
- Brazil
- Volunteers
- 240 people
- Sponsor
- Phytopharm Consulting Brazil
Irritable Bowel Syndrome, Diarrhea
Assessment of Gastric Emptying Speed in Patients Who Experience Diarrhea Following a Trigger Meal
The rapid diarrhea that patients experience who have diarrhea occurring after eating specific foods may be causing a "physiologic gastric dumping syndrome".
- Trial name
- NCT01114113
- Testing
- SmartPill capsule
- Sponsor
- Money, Mary E., M.D.
Irritable Bowel Syndrome
Brain-derived Neurotrophic Factor Participates in Visceral Hyperalgesia in Irritable Bowel Syndrome (IBS) Patients
Brain-derived neurotrophic factor (BDNF), originally known to be a member of the nerve growth factor family, has aroused attention as a modulator in visceral hyperalgesia recently.
- Trial name
- NCT00925223
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shandong University
Constipation - Functional, Constipation-predominant Irritable Bowel Syndrome
MOWOOT Device Treatment for Adults With Chronic Constipation
The primary objective is to compare the effectiveness of the experimental Intermittent Colonic Exoperistalsis (ICE) treatment with MOWOOT, with the active control of trans-anal irrigation (TAI) as standard-of-care.
- Conditions
- Constipation - Functional, Constipation-predominant Irritable Bowel Syndrome, Constipation Chronic Idiopathic, Constipation; Neurogenic
- Trial name
- MOTACC (NCT04666155)
- Testing
- Intermittent Colonic Exoperistalsis with MOWOOT device, Standard of care with Trans-Anal Irrigation
- Where
- 3 sites in United Kingdom
- Volunteers
- 86 people
- Sponsor
- usMIMA S.L.
Abdominal Pain, Inflammatory Bowel Diseases
Understanding Abdominal Pain in IBD and IBS
Abdominal pain is a central symptom of Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS). IBD is an autoimmune disease characterized by inflammation of the gastrointestinal tract.
- Conditions
- Abdominal Pain, Inflammatory Bowel Diseases, Irritable Bowel Syndrome
- Trial name
- NCT04020835
- Where
- 3 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Healthy
Study to Evaluate the Safety, Local and Systemic Tolerability, and Pharmacokinetics of Multiple-Dose Topical Administration of PF-07038124 in Japanese Healthy Participants
The purpose of this study is to evaluate the safety, tolerability, skin irritation potential, and PK of PF-07038124 in Japanese healthy adult participants.
- Trial name
- NCT04863417
- Testing
- PF-07038124 or vehicle
- Where
- Japan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Skin Irritation
A 21-Day Topical Safety Study of Diltiazem Hydrochloride Using a Cumulative Irritant Patch Test Design
The purpose of the study is to determine whether Diltiazem Hydrochloride 2% Cream will cause irritation to skin on the back of healthy volunteers after repeated application over 21-days.
- Trial name
- NCT01821274
- Testing
- Diltiazem Hydrochloride 2% Cream, Vehicle Cream, 0.1% solution o sodium lauryl sulfate (SLS)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ventrus Biosciences, Inc
Irritable Bowel Syndrome (IBS), Pediatrics
Pentabiocel in Pediatric IBS
Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder characterized by chronic abdominal pain and altered bowel habits, including diarrhea, constipation, or a combination of both.
- Trial name
- NCT06720805
- Testing
- Pentabiocel
- Where
- 4 sites in Italy
- Volunteers
- 56 people
- Sponsor
- University of Roma La Sapienza
Irritable Bowel Syndrome
Irritable Bowel Syndrome and Low FODMAP Diet
The patients having a syndrome SII would be more intolerant in the fructose than the healthy subjects and would benefit from a fructose diet but also from the fructans which contain some fructose.
- Trial name
- FructIBS (NCT02188680)
- Testing
- Low FODMAPS diet
- Where
- France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Rouen
Irritable Bowel Syndrome (IBS), Intestinal Diseases
Exclude or Expose in Irritable Bowel Syndrome: What Works for Whom and How?
This research project will assess how two treatments for irritable bowel syndrome (one dietary and one behavioral) work and for whom.
- Conditions
- Irritable Bowel Syndrome (IBS), Intestinal Diseases, Gastrointestinal Disease
- Trial name
- NCT06940596
- Testing
- FODMAP Diet, Exposure-based Cognitive Behavioral Therapy
- Where
- Australia
- Volunteers
- 235 people
- Sponsor
- University of Melbourne
Irritable Bowel Syndrome (IBS)
Effectiveness of Thyme in the Management of Clinical Symptoms in Patients with Irritable Bowel Syndrome
The goal of this clinical trial is to learn if thyme supplement enhances the effects of a low FODAMP diet on reducing clinical symptoms and improving the quality of life of patients with irritable bowel syndrome or not.
- Trial name
- NCT06609746
- Testing
- Thyme extract
- Volunteers
- 52 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Irritable Bowel Syndrome
Acupuncture for Irritable Bowel Syndrome (IBS)
The purpose of this study is to determine whether acupuncture is effective in reducing the symptoms of irritable bowel syndrome (IBS).
- Trial name
- NCT00093327
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 287 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Irritable Colon
Sb-705498 Rectal Pain Study
SB-705498 has demonstrated efficacy in several preclinical and human experimental pain models. This study will investigate the efficacy of SB-705498 in patients with rectal pain.
- Trial name
- NCT00461682
- Testing
- SB-705498
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Irritable Bowel Syndrome, Fibromyalgia
Clinical Trial Examining Effects of Monosodium Glutamate (MSG) on Irritable Bowel Syndrome (IBS) and Fibromyalgia (FM)
Objective: Randomized, double blind, placebo-controlled, crossover, clinical trial to examine the effects of the food additive glutamate (in the form of MSG) on IBS and fibromyalgia.
- Trial name
- NCT00829218
- Testing
- Glutamate additive-free diet
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon Health and Science University
Irritable Bowel Syndrome, Dyspepsia
Treatment of Abdominal Distension by Biofeedback - a Randomized Controlled Trial
Background: Abdominal bloating is a frequent and bothersome complaint in patients with functional gut disorders without satisfactory treatment to date.
- Trial name
- NCT01205100
- Testing
- Bio-feedback
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Irritable Bowel Syndrome
Efficacy of the DOMINO Diet App in IBS
The aim of this study is to evaluate whether the DOMINO diet application is an effective tool in the treatment of Irritable bowel syndrome in tertiary care.
- Trial name
- EDDI (NCT05808036)
- Testing
- Dietary intervention: DOMINO app, Dietary intervention: low FODMAP diet
- Where
- Belgium
- Volunteers
- 110 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hygiene
Dermacyd PH_DESILSTY_FR (Lactic Acid) - Compatibility - Stay on Frutal
Primary Objective: To demonstrate the absence of irritation potential (primary dermic irritability and cumulated dermic irritability) and allergy (sensibilization) of the product Dermacyd PHDESILSTYFR.
- Trial name
- NCT00933907
- Testing
- LACTIC ACID(ND)
- Where
- Brazil
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Sanofi
Gastroduodenal Erosions
Pilot Study of OXP001(2) and Brufen in Healthy Subjects
The study will compare the study drug to an already marketed formulation of prescription strength ibuprofen (Brufen® the reference product) by looking at how the drug is taken up by the body and also by performing a specialist…
- Trial name
- NCT02521207
- Testing
- Ibuprofen
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Oxford Pharmascience Ltd
Irritable Bowel Syndrome, Irritable Bowel Syndrome With Diarrhea
Hydrogen Breath Test an Instrument to Predict Rifaximin-Response in Irritable Bowel Syndrome Predominant Diarrhea
The purpose of this study is to learn more about how to improve treatment of patients with diarrhea predominant Irritable Bowel Syndrome (IBS-D) symptoms.Included patients will be requested to answer online surveys and will…
- Trial name
- NCT03729271
- Testing
- Rifaximin, Glucose and lactulose hydrogen breath testing
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- University of Michigan
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