Clinical trials: Irritation
Irritable Bowel Syndrome
Is There Any Correlation Between Plasmatic Zonulin and Expression of Intestinal Tight Junction Proteins in IBS Patients?
Increased intestinal permeability is one of the main pathophysiological mechanisms involved in irritable bowel syndrome. The expression of some intestinal tight junction proteins is decreased mostly in IBS-diarrhoea patients.
- Trial name
- BISII (NCT02877654)
- Testing
- colonoscopy with biopsies in the left colon to assess intestinal permeability
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Rouen
Irritable Bowel Syndrome
Efficacy, Safety and Tolerability of DNK333 (25 and 100 mg Bid) in Women With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)
This study will evaluate the tolerability, safety and efficacy of DNK333 against diarrhea caused by Irritable Bowel Syndrome in women.
- Trial name
- CDNK333B2201 (NCT00699166)
- Testing
- DNK333
- Where
- 29 sites in United States
- Volunteers
- 135 people
- Sponsor
- Novartis
Healthy
Dermacyd Tina Gel Sweet Flower - Photo Evaluation
The purpose of this study is to prove the absence of photo irritation and photo sensitivity potential of the product Dermacyd Tina Gel Sweet Flower.
- Trial name
- NCT00668629
- Testing
- Lactic acid (Dermacid)
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sanofi
Healthy Subjects, COVID-19 Pneumonia
Jing Si Herbal Tea for Long-Coronavirus Disease(COVID) Gut-brain Interaction
Dyspepsia refers to chronic or recurrent upper gastrointestinal symptoms. According to the Rome IV criteria, functional dyspepsia (FD) symptoms included meal related fullness, early satiation, epigastric pain or burning which are…
- Conditions
- Healthy Subjects, COVID-19 Pneumonia, Irritable Bowel Syndrome, Functional Gastrointestinal Disorders
- Trial name
- NCT05668104
- Testing
- Jing Si Herbal Tea Liquid Packet
- Where
- Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Buddhist Tzu Chi General Hospital
Irritable Bowel Syndrome, Cyclical Vomiting Syndrome
Multi Modal Imaging: An MRI Study to Investigate Differences in the Structure and the Function of the Brain at Rest.
The structural/RSN study involves Structural and Resting State Neuroimaging. The purpose of Structural Neuroimaging is to use MRI technology to identify cortical and white matter morphometric differences between patients with…
- Conditions
- Irritable Bowel Syndrome, Cyclical Vomiting Syndrome, Ulcerative Colitis, Vulvodynia
- Trial name
- MMI (NCT01517516)
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Irritable Colon
Safety and Efficacy Study of GR68755 (Alosetron Hydrochloride) to Treat Severe Diarrhea-Predominant Irritable Bowel Syndrome (IBS)
This study is an exploratory study aiming (i) to obtain clinical experience of GR68755 in Japanese subjects with severe d-IBS to explore the feasibility of the next phase study and (ii) to obtain reference data for endpoints and…
- Trial name
- NCT01855711
- Testing
- GR68755 (Alosetron hydrochloride) 1 mg tablet
- Volunteers
- 32 people
- Sponsor
- GlaxoSmithKline
Irritable Bowel Syndrome
Stress Management for Irritable Bowel Syndrome
The primary goal of this study is to test the efficacy of emotional awareness and expression training (EAET), a novel emotional processing intervention that the investigators have developed, for people with IBS.
- Trial name
- NCT01886027
- Testing
- Emotional Awareness and Expression Training, Relaxation Training
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Wayne State University
Irritable Bowel Syndrome
Efficacy of Acupuncture in Refractory Irritable Bowel Syndrome
The trial aims to examine the efficacy and safety of acupuncture in the treatment of refractory irritable bowel syndrome (IBS). The investigators will include 170 participants to receive acupuncture plus usual care or sham…
- Trial name
- NCT04276961
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Irritable Bowel Syndrome (IBS)
A Study To Investigate The Effect Of Solabegron (GW427353) On Gastrointestinal Transit In Healthy Volunteers
This study will test the hypothesis that GW427353, a beta-3 adrenergic agonist, retards the emptying of the colon and increases total colonic transit time.
- Trial name
- NCT00401479
- Testing
- Solabegron (GW427353)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Irritable Bowel Syndrome (IBS)
Efficacy of Pregabalin for Patients With Irritable Bowel Syndrome
To explore the efficacy of pregabalin for patients with irritable bowel syndrome (IBS).
- Trial name
- NCT07635394
- Testing
- The pregabalin group, Routine Treatment
- Where
- China
- Volunteers
- 258 people
- Sponsor
- Beijing Tiantan Hospital
Irritable Bowel Syndrome (IBS)
Collaborative Cognitive Behavioral Therapy / Hypnotherapy for Treatment of Pediatric Functional Gastrointestinal Disease
This program has been created to help patients with irritable bowel syndrome manage their symptoms and increase their functioning by using cognitive therapy skills and hypnosis.
- Trial name
- CAPP (NCT01966341)
- Testing
- CBT/ Hypnotherapy, Routine Management
- Where
- United States
- Sponsor
- Seton Healthcare Family
Breastfeeding Duration, Infant Feeding Practices
Effect of Teté Dance on Breastfeeding Duration in Irritable Infants
This study aims to evaluate the impact of a culturally adapted intervention, the Teté Dance, on the breastfeeding duration of irritable infants. Participants will be mothers of infants experiencing irritability during feeding.
- Trial name
- NCT06751186
- Testing
- Teté Dance Guided Support
- Where
- Peru
- Volunteers
- 150 people
- Sponsor
- Crianzamor
Irritable Bowel Syndrome, Constipation
Efficacy and Safety of Lubiprostone in Patients With Irritable Bowel Syndrome With Constipation
The primary purpose of this study is to evaluate the efficacy and safety of administration of lubiprostone in patients with irritable bowel syndrome with constipation.
- Trial name
- NCT00399542
- Testing
- Lubiprostone
- Volunteers
- 581 people
- Sponsor
- Sucampo Pharma Americas, LLC
Skin Irritability
Dermatological Evaluation of Topical Compatibility, Primary Skin Irritability, Accumulated Skin Irritability, and Dermal Sensitisation
Check the safety under normal conditions of use through the verification of emergence signs of irritability and sensitisation of the genital mucosa.
- Trial name
- DERM EV TOPIC (NCT02419248)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Kley Hertz S/A
Gastrointestinal Irritation, Nutrition, Healthy
Effects of Wheat Flour Milling Method on Glycemic Response and Gastrointestinal Symptoms
The goal of this clinical trial is to learn if the way wheat flour is ground - by stone milling (an older method) or roller milling (used for most flour today) - changes blood sugar levels after eating bread, in healthy adults…
- Trial name
- STONEMILL (NCT07858110)
- Testing
- Stone-milled wheat flour bread, Roller-milled wheat flour bread (sourdough)
- Where
- Norway
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Autism in Children, Autistic Disorder in Children and Adolescents
Clinical Trial Evaluating the Effects of Ganaxolone in Children With Autism
The goal of this study is to conduct a randomized, placebo-controlled trial (RCT) of ganaxolone, a neuroactive steroid (NAS), in autistic children and adolescents aged 5 to 17 years old.
- Conditions
- Autism in Children, Autistic Disorder in Children and Adolescents, Autism Spectrum Disorder
- Trial name
- NCT07635862
- Testing
- Ganaxolone (Ztalmy)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Stanford University
Hygiene
Dermacyd PH_DESILSTY_FL (Lactic Acid) - Photo Evaluation - Stay on Floral
Primary Objective: To demonstrate the absence of photoirritation and photosensitization potential of the product Dermacyd PHDESILSTYFL. Secondary Objective: None.
- Trial name
- NCT00933842
- Testing
- LACTIC ACID(ND)
- Where
- Brazil
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Sanofi
Irritable Bowel Syndrome
Effect of Functional Magnetic Therapy on Constipation Predominant- Irritable Bowel Syndrome (IBS-C)
The aim of this study is to evaluate the potential benefits of functional magnetic therapy on constipation improvement and related symptoms in patients with IBS-C, including abdominal pain, bloating, bowel habits, and quality of…
- Trial name
- NCT07256262
- Testing
- Functional magnetic stimulation (FMS), Conventional pharmacological therapy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Beni-Suef University
Gastrointestinal Diseases, Irritable Bowel Syndrome
A Practice Change for Patients With Severe Chronic, Clinically Unexplained Gastrointestinal Symptoms
This research project aims to test whether early interventions delivered remotely and prior to integrated care clinic appointments are effective.
- Trial name
- NCT05274854
- Testing
- a)standardised dietician supervised intervention, b) exercise intervention, c) internet delivered cognitive behavior therapy or d) nothing, a) consultant-led outpatient clinic or b) a integrated care clinic
- Where
- Australia
- Volunteers
- 200 people
- Sponsor
- The University of Queensland
Irritability, Anger
CBT for Anger and Aggression in Children: a Pilot Study of Irritability and Suicidality
This pilot study evaluated whether cognitive behavioral therapy for anger and aggression, added to treatment as usual, was associated with reductions in irritability and suicidal ideation in preteen children with externalizing…
- Conditions
- Irritability, Anger, Externalizing Behavior, Suicidal Ideation
- Trial name
- NCT07603986
- Testing
- Cognitive Behavioral Therapy for Anger and Aggression, Treatment as Usual (TAU)
- Where
- Israel
- Volunteers
- 46 people
- Sponsor
- Geha Mental Health Center
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