Clinical trials: Irritation
Inflammatory Bowel Disease, Irritable Bowel Syndrome
BÜHLMANN fCAL™ ELISA - Aid in Differentiation of IBD From IBS
The purpose of this study is to confirm the sensitivity and specificity of the BÜHLMANN fCAL™ ELISA as an aid in diagnosis to differentiate between Inflammatory Bowel Disease (IBD; Crohn's Disease (CD), Ulcerative Colitis (UC)…
- Trial name
- NCT02351635
- Testing
- fecal calprotectin level
- Where
- 7 sites in United States
- Volunteers
- 478 people, healthy volunteers welcome
- Sponsor
- Bühlmann Laboratories AG
Irritable Bowel Syndrome With Constipation
Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)
The objectives of this study are to evaluate the safety, efficacy, and dose response of two delayed release formulations of linaclotide (DR; DR formulation 1 is DR1; DR formulation 2 is DR2) administered orally to patients with…
- Trial name
- NCT02559206
- Testing
- Linaclotide
- Where
- 71 sites in United States
- Volunteers
- 759 people
- Sponsor
- Ironwood Pharmaceuticals, Inc.
Irritable Bowel Syndrome, Gastrointestinal Diseases
Evaluation of Efficacy of Skål Pro Powder on Symptoms of Irritable Bowel Syndrome
The objective of this randomized, double-blind, placebo-controlled study is to evaluate the effectiveness of Skal Pro in alleviating symptoms, enhancing stool consistency, improving quality of life, and addressing psychological…
- Conditions
- Irritable Bowel Syndrome, Gastrointestinal Diseases, Colonic Diseases, Functional, Intestinal Disease
- Trial name
- NCT06271538
- Testing
- Skal Pro
- Where
- Malaysia
- Volunteers
- 57 people
- Sponsor
- EP Plus Group Sdn Bhd
NSAID Related Gastric Irritation
Pilot Study of OXP001 and Brufen in Healthy Subjects
Oxford Pharmascience (the sponsor) is developing a new formulation of Ibuprofen (OXP001 - the study drug) which it is proposed will have less of the side effects than are currently reported with standard prescription strength…
- Trial name
- NCT02050958
- Testing
- OXP001, Ibuprofen
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Oxford Pharmascience Ltd
Irritable Bowel Syndrome With Diarrhea
Irritable Bowel Syndrome With Diarrhea (IBS-D) Rifaximin Re-Treatment Study
This study will evaluate the effectiveness and safety of repeat treatment with rifaximin 550 mg three times a day in patients with IBS with diarrhea who respond to initial treatment of rifaximin 550 mg three times a day.
- Trial name
- TARGET3 (NCT01543178)
- Testing
- open-label rifaximin, double-blind rifaximin
- Where
- 296 sites in United States, Germany and 1 more
- Volunteers
- 2,583 people
- Sponsor
- Bausch Health Americas, Inc.
Tissue Adhesives
Quantifying Adhesive Residue on Skin Following Removal of Maxillofacial Prosthetic Adhesives: An In Vivo Study
This pilot interventional in vivo study aims to quantitatively evaluate and compare the amount of adhesive residue left on the skin following removal of extraoral maxillofacial prosthetic adhesives.
- Trial name
- ARMS (NCT07647458)
- Testing
- Secure Adhesive Regular,, Secure Adhesive Extra Strength, Daro Adhesive Regular
- Where
- India
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Amrita Vishwa Vidyapeetham
Irritable Bowel Syndrome, Traditional Chinese Medicine
Trial of Chinese Prescription Shugan Decoction on Irritable Bowel Syndrome（Diarrhea Type）
The purpose of this study is to evaluate the efficacy and safety of the Chinese prescription Shugan decoction on irritable bowel syndrome（diarrhea type）.
- Trial name
- NCT00948870
- Testing
- Shugan decoction
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Constipation - Functional, Irritable Bowel Syndrome Characterized by Constipation
Reclassifying Constipation Using Imaging and Manometry
Constipation is a common condition in which an individual suffers with hard stools which are infrequent and difficult to pass. It is poorly understood and treatment is often unsatisfactory.
- Trial name
- RECLAIM (NCT03226145)
- Testing
- MRI Motility, High Resolution Manometry, Bisacodyl
- Where
- 3 sites in United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Constipation-predominant Irritable Bowel Syndrome
Effect of Saccharomyces Cerevisiae on the Improvement of Gastro-intestinal Disorders Associated to IBS With C Phenotype
The main objective is to assess the effect of an 8-week daily supplementation with IbSium® (probiotic yeast Saccharomyces cerevisiae CNCM I-3856) on the improvement gastro-intestinal disorders associated to the type C IBS…
- Trial name
- IBS-GO (NCT03150212)
- Testing
- Saccharomyces cerevisiae CNCM I-3856
- Where
- 5 sites in France
- Volunteers
- 456 people, healthy volunteers welcome
- Sponsor
- Lesaffre International
Irritable Bowel Syndrome
Developing Novel Microbiota-Targeted Therapies for Irritable Bowel Syndrome
This longitudinal study is being done to understand mechanisms underlying development of irritable bowel syndrome (IBS) and the role of the gut bacteria in development of symptoms.
- Trial name
- NCT02249169
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
IBS
The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome (IBS)
This study objective is to assess the short and long term effects of partially hydrolyzed guar gum (PHGG) administration on clinical symptoms of IBS and quality of life of these patients.
- Trial name
- NCT01779765
- Testing
- PHGG, Maltodextrin
- Where
- Israel
- Volunteers
- 130 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Irritation/Irritant, ICD - Irritant Contact Dermatitis
The Effects of Repeated Exposure to Antiseptics During COVID-19 Pandemic on Skin Parameters
The global coronavirus disease pandemic (COVID-19) has led to an increased need to wear protective equipment such as wearing face masks and practicing hygiene measures such as more frequent use of antiseptics.
- Conditions
- Irritation/Irritant, ICD - Irritant Contact Dermatitis, Antiseptic
- Trial name
- NCT05276102
- Testing
- Emollient cream
- Where
- Croatia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Irritable Bowel Syndrome, Abdominal Pain
Percutaneous Electrical Nerve Field Stimulation for Adults With Irritable Bowel Syndrome
This is a prospective, double-blind, randomized, sham-controlled pilot study evaluating the efficacy of percutaneous electrical nerve field stimulation for the treatment of adult patients with irritable bowel syndrome (IBS).
- Conditions
- Irritable Bowel Syndrome, Abdominal Pain, Autonomic Nervous System Imbalance
- Trial name
- NCT04428619
- Testing
- Peripheral Electrical Nerve Field Stimulation (PENFS) Device
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, Los Angeles
Irritable Bowel Syndrome
Safety Study of Probiotics in Adults With Irritable Bowel Syndrome
Determine the safety and preliminary effectiveness of VSL#3 in adults with IBS.
- Trial name
- NCT00971711
- Testing
- Probiotic
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Baylor College of Medicine
IBS - Irritable Bowel Syndrome
Efficacy and Safety of a Probiotic Formulation in Adults With Irritable Bowel Syndrome With Diarrhea (IBS-D)
The purpose of the study is to monitor safety and to evaluate the efficacy of a probiotic formulation on abdominal pain, abnormal defecation, comorbid mood disorders (anxiety and depression) as well as general quality of life in…
- Trial name
- NCT05509725
- Testing
- Probiotic formulation
- Where
- Turkey (Türkiye)
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Lallemand Health Solutions
Metabolic Dysfunction-Associated Steatotic Liver Disease, Non Celiac Wheat Sensitivity
Liver Steatosis and Fibrosis in Non-Celiac Wheat Sensitivity Patients: a Prospective Study
Hypothesizing an intestinal barrier impairment as a common pathophysiological substrate of both Non Celiac Wheat Sensitivity (NCWS) and Metabolic Dysfunction-Associated Steatotic Liver Disease (MAFLD), in a retrospective cohort…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Non Celiac Wheat Sensitivity, Irritable Bowel Syndrome, Functional Dyspepsia
- Trial name
- NCT07750535
- Testing
- Prevalence and severity of liver steatosis and fibrosis,
- Where
- 2 sites in Italy
- Volunteers
- 250 people
- Sponsor
- University of Palermo
Irritable Bowel Syndrome
Multi-strain Probiotic in the Management of IBS-D
1. To assess the effect of multistrain probiotics on abdominal pain using a validated symptom severity score in IBS patients. 2.
- Trial name
- NCT03251625
- Testing
- Probiotic Formula Capsule
- Volunteers
- 400 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Cumulative Irritation and Sensitization
Irritation and Sensitization Study of d-Amphetamine Transdermal System
The study will assess skin irritation as well as sensitization for d-ATS patch in healthy subjects.
- Trial name
- dATS (NCT04094025)
- Testing
- dATS
- Where
- United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Noven Therapeutics
Skin and Connective Tissue Diseases
Skin Irritation Test of LEO 80185 Gel in Healthy Japanese Subjects
The purpose of the study is to investigate skin irritation of LEO 80185 gel, gel vehicle and Liquid Paraffin in healthy Japanese male subjects.
- Trial name
- NCT02379793
- Testing
- LEO 80185 gel, vehicle, liquid paraffin
- Where
- Japan
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- LEO Pharma
Attention Deficit and Disruptive Behavior Disorders, Marijuana Abuse
Divalproex Sodium (Depakote) for Explosive Tempers in Adolescents and Adults
The purpose of this study is to compare the effectiveness of divalproex sodium (Depakote) versus placebo in treating disruptive behavior disorder and explosive tempers in adolescents and adults.
- Trial name
- NCT00218114
- Testing
- Divalproex Sodium
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- New York State Psychiatric Institute
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