Clinical trials: Irritation
BACTERIAL VAGINOSIS, Signs and Symptoms to be Evaluated and Recorded Include
A Multi-center, Double-blind, Randomized Study, Comparing Clindamycin Phosphate Vaginal Cream 2% (Watson Laboratories, Inc.) to Clindesse® (Ther-Rx™, Clindamyin Phosphate Vaginal Cream 2%) and Both Active Treatments to a Placebo Control in the Treatment of Bacterial Vaginosis in Non-pregnant Women
A multi-center, double-blind, randomized, placebo controlled, parallel-group study, comparing Clindamycin phosphate vaginal cream 2% (Watson Laboratories, Inc.) to Clindesse® (Ther-Rx™, Clindamyin Phosphate Vaginal Cream 2%) and…
- Conditions
- BACTERIAL VAGINOSIS, Signs and Symptoms to be Evaluated and Recorded Include, Vaginal Discharge Color, Odor, and Consistency, Vulvovaginal Itching and Irritation (Subjective) Absent, Mild, Moderate, or Severe
- Trial name
- NCT02210689
- Testing
- clindamycin phosphate vaginal cream 2%
- Where
- 18 sites in United States, Dominican Republic and 1 more
- Volunteers
- 604 people
- Sponsor
- Actavis Inc.
Non-Coeliac Wheat Sensitivity (NCWS), Irritable Bowel Syndrome
In Vivo Effects of Amylase Trypsin Inhibitors
Wheat is the most important staple food consumed in the Western world and provides beneficial health effects and functional properties.
- Trial name
- ATI (NCT05157867)
- Testing
- Amylase trypsin inhibitors
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Irritability, Neurodevelopmental Disorders
A Scalable Trans Diagnostic Intervention Targeting Adolescent Agency Supported by Conversational AI (AGENCIA)
The aim of this clinical trial is to evaluate whether AGENCIA, a brief psychological program supported by digital technology and artificial intelligence, can help reduce emotional and behavioral difficulties in adolescents aged…
- Conditions
- Irritability, Neurodevelopmental Disorders, Impulsivity, Emotional Dysregulation
- Trial name
- AGENCIA (NCT07560072)
- Testing
- AGENCIA Digital Self-Guided, AGENCIA In-person With Digital Assistant
- Where
- Spain
- Volunteers
- 465 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Actinic Keratoses
Treatment of Actinic Keratoses (AK) on the Face
Actinic keratoses (AK) are common cutaneous lesions associate with chronic ultraviolet radiation exposure. While most authorities consider AK as a pre-malignant lesion, some consider it as an incipient squamous cell carcinoma…
- Trial name
- NCT02411851
- Testing
- ingenol mebutate 0.015%, dermasil lotion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Constipation-predominant Irritable Bowel Syndrome, Abdominal Pain
Effect of taVNS on Abdominal Pain and Other Symptoms in Constipation-predominant Irritable Bowel Syndrome
This study aims to investigate the effects and possible mechanisms of transcutaneous auricular vagal nerve stimulation (taVNS) on abdominal pain and other symptoms in patients with IBS-C.
- Trial name
- NCT05392439
- Testing
- taVNS
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Tongji University
Diarrhea Predominant Irritable Bowel Syndrome
A Phase 2 Pilot Study to Assess ASP7147 in Patients With Diarrhea Predominant Irritable Bowel Syndrome (IBS-D)
This trial will evaluate the effect of ASP7147 on daily abdominal pain due to IBS-D during 4 weeks of treatment. It will also evaluate safety and tolerability in patients with IBS-D over the 4-week treatment period.
- Trial name
- NCT01896583
- Testing
- ASP7147
- Where
- 13 sites in United States
- Volunteers
- 64 people
- Sponsor
- Seldar Pharma, Inc.
Irritable Bowel Syndrome With Constipation, Irritable Bowel Syndrome
A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of DDP733 for IBS-c
This study will evaluate the safety, tolerability and pharmacodynamics of the investigational drug DDP733 in treating subjects with IBS-c. A placebo control will be utilized.
- Trial name
- NCT00215566
- Testing
- DDP733
- Where
- 15 sites in Canada
- Volunteers
- 90 people
- Sponsor
- Dynogen Pharmaceuticals
Lower Abdominal Pain, Diarrhea
Efficacy and Safety of Encapsulated Bifidobacterium Longum BBH016 in Subjects With Lower Gastrointestinal Symptoms
Functional lower gastrointestinal (GI) symptoms such as abdominal pain, diarrhea, loose stools, and bloating are common in adults without identifiable organic disease and are associated with impaired quality of life and increased…
- Conditions
- Lower Abdominal Pain, Diarrhea, Irritable Bowel Syndrome
- Trial name
- NCT07484412
- Testing
- Bifidobacterium longum BBH016
- Where
- South Korea
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Pouchitis, Irritable Pouch Syndrome
Efficacy of Liraglutide Therapy in Patients With IPAA
Patients with an ileal pouch-anal anastomosis(IPAA; pouch) due to refractory inflammatory bowel disease and increased bowel frequency in the absence of significant pouch inflammation will be randomized to liraglutide or placebo…
- Trial name
- NCT04763564
- Testing
- Liraglutide Pen Injector
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of North Carolina, Chapel Hill
Irritable Bowel Syndrome, Ulcerative Colitis
Osteopathy on IBS Symptoms in Patients With Ulcerative Colitis in Remission
Type : interventional, randomized single blind study Aim : to evaluate 3 sessions of osteopathy on IBS-like symptoms associated with ulcerative colitis in remission Number of patients : 50 (randomization 1:1) Duration of the…
- Trial name
- OSTEOMIC (NCT04159311)
- Testing
- Osteopathy
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Clinique Paris-Bercy
Irritable Bowel Syndrome
Fecal Amino Acids，Gut Taste Receptors and Irritable Bowel Syndromes
Clinical data, fresh feces and intestinal mucosal tissues of patients with diarrheal IBS were collected. High performance liquid chromatography, immunohistochemistry and immunofluorescence were used to study the amino acid levels…
- Trial name
- NCT06489444
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Constipation
Constipation Associated With Irritable Bowel Syndrome (IBS-C)
Multi-centre, double-blind, randomised, placebo-controlled, parallel group study.
- Trial name
- NCT00796354
- Testing
- MOVICOL, Sugar Pill
- Where
- 21 sites in Czechia, France and 5 more
- Volunteers
- 210 people
- Sponsor
- Norgine
Irritable Bowel Syndrome
A Randomized, Double-blind, and Placebo-controlled Study on the Treatments of Irritable Bowel Syndrome
The purpose of this study is to test the efficacy and safety of pinaverium and an herbal medication for irritable bowel syndrome (IBS).
- Trial name
- NCT01641224
- Testing
- Pinaverium, Atractylodes, Paeonia Lactiflora
- Where
- 4 sites in China
- Volunteers
- 800 people
- Sponsor
- University of Minnesota
Irritable Bowel Syndrome With Diarrhea
Study on the Molecular Mechanism of Diarrhea-predominant Irritable Bowel Syndrome With Anxiety and Depression Based on Multi-omics Correlation Analysis
The research group intends to carry out a case-control study to recruit IBS-D patients with anxiety and depression symptoms, by collecting intestinal mucosa for single-cell transcriptome sequencing, collecting peripheral blood…
- Trial name
- NCT05311293
- Testing
- Endoscopy
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Irritation/Irritant
21 Day Cumulative Skin Irritation of RUT058-60
The purpose of this study is to determine the skin irritation potential of RUT058-60 after repetitive patch application to abraded and non-abraded skin of human subjects.
- Trial name
- NCT02198963
- Testing
- Hypochlorous acid solution 106 mg/L, 0.1% (w/v) Sodium Lauryl Sulfate, 0.9% Physiological Saline, USP
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Pulmatrix Inc.
Irritable Bowel Syndrome (IBS)
Effectiveness of Thyme in the Management of Clinical Symptoms in Patients with Irritable Bowel Syndrome
The goal of this clinical trial is to learn if thyme supplement enhances the effects of a low FODAMP diet on reducing clinical symptoms and improving the quality of life of patients with irritable bowel syndrome or not.
- Trial name
- NCT06609746
- Testing
- Thyme extract
- Volunteers
- 52 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Irritable Bowel Syndrome
Diets in Symptom Relief and the Influence of Quality of Life in People With Irritable Bowel Syndrome
Subjects with confirmed diagnosis of Irritable Bowel Syndrome will be blinded and randomly assigned to one of two groups, the low FODMAP diet or the conventional IBS diet group.
- Trial name
- NCT02450370
- Testing
- Low FODMAP diet, Conventional IBS diet group
- Where
- Hong Kong
- Volunteers
- 103 people
- Sponsor
- Hong Kong Sanatorium & Hospital
Best Comfort and Lowest Skin Irritation
Safety and Tolerability of Transcranial Direct Current Stimulation (tDCS)
Testing safety and tolerability of transcranial direct current stimulation (2 mA, 20 minutes) in four different protocols: saline-soaked sponges electrode with electrode gel tap-water-soaked sponges tap-water-soaked-sponges +…
- Trial name
- NCT01148212
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Irritable Bowel Syndrome
Management of Irritable Bowel Syndrome in Primary Care (MIBS Trial)
Aims: 1. To pilot an randomized, controlled trial (RCT) to assess the effectiveness of the commonly prescribed medications in UK general practice for IBS: mebeverine (anti-spasmodic) and methylcellulose (bulking-agent) and of the…
- Trial name
- MIBS (NCT00934973)
- Testing
- mebeverine, methylcellulose, CBT website with support
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Hazel Everitt
Irritable Bowel Syndrome
Efficacy of Physiotherapy Techniques on Irritable Bowel Syndrome (IBS). Pilot Study.
Introduction and State of Question Irritable Bowel Syndrome can be classified as a functional digestive disorder characterized by abdominal pain, bloating, and changes in the frequency and consistency of bowel movements.
- Trial name
- IBS (NCT04486469)
- Testing
- Physical Therapy Group
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- IBS Group, Alcalde
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