Clinical trials: Ischaemic Myocardial Dysfunction
Acute Respiratory Distress Syndrome, Cardiogenic Shock
Study of Immunity Dysfunction Induced by Extracorporeal Assistance (ECMO / ECLS)
Study of immunosuppression biomarkers in patients with ARDS or cardiogenic shock with ECMO / ECLS, compared to patients with ARDS or cardiogenic shock without ECMO / ECLS
- Trial name
- IMPEC (NCT03262155)
- Testing
- Blood test
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Rennes University Hospital
Angina, Microvascular, Coronary Microvascular Dysfunction
Southeastern Europe Microcirculation Registry
SATURATION is a prospective multicenter registry of consecutive patients who undergo coronary physiology testing using Pressure Wire X and Coroflow Coroventis Cardiovascular System software (Abbott Vascular, Abbott Park, IL, USA)…
- Conditions
- Angina, Microvascular, Coronary Microvascular Dysfunction, Coronary Artery Disease
- Trial name
- SATURATION (NCT06393478)
- Where
- 10 sites in Croatia, Greece and 3 more
- Volunteers
- 900 people
- Sponsor
- Institute for Cardiovascular Diseases Dedinje
Coronary Artery Disease, Microvascular Dysfunction
Mainz Intracoronary Database. The Coronary Slow-flow and Microvascular Diseases Registry
Primary goal of the registry is to collect prospective data on patients undergoing coronary angiography in Mainz. Following amendment of the procol, this study will also include patients who received an Aborb bioresorbable…
- Trial name
- MICAT (NCT02180178)
- Testing
- observational only- no intervention
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Johannes Gutenberg University Mainz
Acute Coronary Syndrome
Index of Microcirculatory Resistance After Drug-Eluting Stent Implantation With High Dose Atorvastatin Loading
Pre-treatment with statins decreased the incidence of cardiac enzyme increase after percutaneous coronary intervention (PCI) and distal embolization suspected to cause post-PCI myocardial damage.
- Trial name
- RESIST-ACS (NCT01491256)
- Testing
- Pre-procedural High dose atorvastatin loading, No pre-procedural high-dose atorvastatin loading
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- The Korean Society of Circulation
Cardiovascular Diseases, Heart Diseases
Subclinical Thyroid Dysfunction and Risk of Myocardial Infarction and Stroke
To examine the association of subclinical hypothyroidism and risk of myocardial infarction and stroke in a large prospective cohort of post-menopausal women.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypothyroidism, Myocardial Infarction
- Trial name
- NCT00094237
- Volunteers
- 3,200 people
- Sponsor
- University of North Carolina, Chapel Hill
Coronary Artery Disease, Endothelial Dysfunction
Functional Change in Endothelium After Cardiac cAtheterization, With and Without Music Therapy
The purpose of this study is to determine the effect of music therapy before, during, and after cardiac catheterization is associated on (a) change in reactive hyperemia index measured before and after catheterization using…
- Trial name
- FEAT (NCT01632670)
- Testing
- Music therapy
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Emmanouil Brilakis
Recent Myocardial Infarction, Ventricular Dysfunction
CArdiosphere-Derived aUtologous Stem CElls to Reverse ventricUlar dySfunction
The purpose of this study is to determine whether giving cardiosphere-derived stem cells (CDCs) to patients with decreased heart function and/or a large amount of damaged muscle after a heart attack is safe.
- Trial name
- CADUCEUS (NCT00893360)
- Testing
- Autologous stem cell infusion
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Cedars-Sinai Medical Center
Ischemic Heart Disease
Exploration of Cerebral Pathophysiology During and After CABG Using CPB
Purpose: The purpose of this study is to examine cerebral oxidative and inflammatory stress and cerebral hemodynamics during and after coronary artery bypass grafting and correlate with postoperative cognitive function.
- Trial name
- NCT02941380
- Volunteers
- 24 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Angina Pectoris, Variant
Efficacy Study of Atorvastatin to Treat Variant Angina
The objective of this study is to evaluate effect of statin treatment for vasospastic angina.
- Trial name
- ESAVA (NCT00620204)
- Testing
- atorvastatin
- Where
- South Korea
- Volunteers
- 136 people
- Sponsor
- Samsung Medical Center
Ischaemic Heart Disease, Aortic Stenosis
Remifentanil/Sufentanil for CABG+/-AVR Evaluated by Recovery, Cognitive Function, Haemodynamics and Biochemical Markers.
To evaluate the effect on cognitive function, recovery, cardioprotection and haemodynamics of standard Remifentanil anaesthesia to standard Sufentanil anaesthesia in patients undergoing coronary artery bypass with or without…
- Trial name
- PRECON2 (NCT02053818)
- Testing
- Remifentanil, Sufentanil
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital
Coronary Artery Disease of Significant Bypass Graft, Metabolic Dysfunction-associated Fatty Liver Disease
Positive Association of US-FLI With the Severity of CAD
As a multisystem disease, metabolic dysfunction-associated fatty liver disease (MAFLD) is closely linked to the onset and progression of coronary heart disease (CHD).
- Conditions
- Coronary Artery Disease of Significant Bypass Graft, Metabolic Dysfunction-associated Fatty Liver Disease, SYNTAX Score, Ultrasonography
- Trial name
- NCT06541132
- Testing
- Observational study without human intervention
- Where
- China
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Chongqing Medical University
ST Segment Elevation Myocardial Infarction
Early Intracoronary Administration of Fasudil in the Primary PCI of ST-segment-Elevation Myocardial Infarction
The study aims to evaluate whether an early intracoronary administration of Fasudil Hydrochloride during primary PCI of STEMI can improve epicardial and myocardial perfusion as well as clinical outcomes.
- Trial name
- NCT03753269
- Testing
- Fasudil Hydrochloride
- Volunteers
- 600 people
- Sponsor
- RenJi Hospital
Myocardial Infarction
Allogeneic Heart Stem Cells to Achieve Myocardial Regeneration
The purpose of this study is to determine whether Allogeneic Cardiosphere-Derived Cells (CAP-1002) is safe and effective in decreasing infarct size in patients with a myocardial infarction.
- Trial name
- ALLSTAR (NCT01458405)
- Testing
- CAP-1002 Allogeneic Cardiosphere-Derived Cells
- Where
- 32 sites in United States
- Volunteers
- 135 people
- Sponsor
- Capricor Inc.
Coronary Heart Disease, Cardiac Dysfunction
Efficacy and Safety Trials of Yangxinshi Tablets in the Treatment of Patients With Coronary Heart Disease Complicated by Cardiac Dysfunction
A randomized controlled trial was conducted to evaluate the efficacy and safety of Yangxinshi tablets in improving the condition of patients with coronary heart disease complicated by cardiac dysfunction.
- Trial name
- HEARTPOWER (NCT07110415)
- Testing
- Yangxinshi tablet, Blank control
- Where
- 96 sites in China
- Volunteers
- 2,708 people
- Sponsor
- SPH Qingdao Growful Pharmacetical Co.,Ltd
Sleep Apnea Syndrome, Coronary Artery Disease
Evolution of Oxidative Stress in Coronary Patients With Moderate Sleep Apnea Syndrome After Treatment With Continuous Positive Airway Pressure
Published data indicate that obstructive sleep apnea syndrome (OSAS) worse the prognosis of coronary artery disease (CAD) and that oxidative stress can link this 2 diseases.
- Trial name
- CardioX SAS (NCT02893865)
- Testing
- Continuous positive airway pressure
- Where
- France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Montpellier
Coronary Artery Disease (CAD)
Epicardial Delivery of XC001 Gene Therapy to Promote Angiogenesis in CAD Patients Undergoing Treatment With CABG
This is a 26-week (with a 26-week extension) multicenter, randomized, double-blind, placebo-controlled Phase 2 study of XC001 versus placebo.
- Trial name
- EXACT-CABG (NCT07118449)
- Testing
- XC001
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- XyloCor Therapeutics, Inc.
Takotsubo Cardiomyopathy, Acute Coronary Syndrome
Effectiveness of a Resilience-Based Rehabilitation Program for Patients With Coronary Heart Disease
To handle daily life challenges, one needs to be psychologically resilient. It plays a crucial role in disease development, prognosis, as well as social, occupational, and community participation.
- Conditions
- Takotsubo Cardiomyopathy, Acute Coronary Syndrome, Psychological Resilience
- Trial name
- NCT06332859
- Testing
- Resilience training
- Where
- Austria
- Volunteers
- 130 people
- Sponsor
- Pensionsversicherungsanstalt
Cardiovascular Diseases, Coronary Disease
Studies of Left Ventricular Dysfunction (SOLVD)
To determine if enalapril treatment of left ventricular dysfunction (LVD) due to ischemic or hypertensive heart disease led to reduced mortality and morbidity in symptomatic and asymptomatic patients.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Heart Failure
- Trial name
- NCT00000516
- Testing
- enalapril
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Myocardial Ischemia, Critical Illness
Bright Light Exposure in Surgical Patients
1. Elucidate the influence of intense light therapy pretreatment in patients undergoing cardiac surgery. We hypothesize that intense light exposure is associated with the peripheral stabilization of Per2 in human buccal swabs and…
- Conditions
- Myocardial Ischemia, Critical Illness, Endothelial Dysfunction
- Trial name
- NCT03822949
- Testing
- Day Light, ICU Intense Light
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Colorado, Denver
Refractory Angina, Microvascular Angina
Coronary Sinus Reducer Implantation in Patients With Ischaemia and Non-obstructed Coronary Arteries and Coronary Microvascular Dysfunction.
To demonstrate the feasibility and efficacy of the CS Reducer for the treatment of patients with ischaemia and non-obstructed coronary arteries (INOCA) and coronary microvascular dysfunction (CMD) and through a nested mechanistic…
- Conditions
- Refractory Angina, Microvascular Angina, Microvascular Coronary Artery Disease, Coronary Disease
- Trial name
- REMEDY-PILOT (NCT05492110)
- Testing
- Coronary sinus reducer, Invasive coronary physiology
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Imperial College London