Clinical trials: Ischaemic Myocardial Dysfunction
Ischemic Cardiomyopathy
Study of Efficacy and Safety of Percutaneous Coronary Intervention to Improve Survival in Heart Failure
This study will assess whether percutaneous coronary intervention (angioplasty of the heart arteries) can improve survival and reduce hospitalization in patients with heart failure due to coronary disease, who have been treated…
- Trial name
- REVIVED-BCIS2 (NCT01920048)
- Testing
- Percutaneous Coronary Intervention, Drug Therapy for Heart Failure, Device Therapy for Heart Failure
- Where
- 40 sites in United Kingdom
- Volunteers
- 700 people
- Sponsor
- King's College London
Myocardial Infarction with Nonobstructive Coronary Arteries
Stockholm Myocardial Infarction with Nonobstructive Coronaries Study 3
The present pilot study will investigate the prevalence of CMD in an unselected cohort of patients with the working diagnosis MINOCA and to study if the diagnostic yield can be improved by adding adenosine to the CMR…
- Trial name
- SMINC-3 (NCT05426408)
- Testing
- Cardiac magnetic resonance imaging to study coronary microvascular dysfunction
- Where
- Sweden
- Volunteers
- 85 people
- Sponsor
- Karolinska Institutet
Heart Failure, Myocardial Infarction
High-intensity Exercise Training in Patients With Post-infarction Heart Failure
Introduction: Moderate-intensity endurance-training is known to reduce symptoms, increase exercise tolerance, and improve quality of life in patients with chronic heart failure.
- Trial name
- NCT00218933
- Testing
- Moderate intensity exercise training, High intensity exercise training
- Where
- Norway
- Volunteers
- 27 people
- Sponsor
- Norwegian University of Science and Technology
Coronary Artery Disease, Left Ventricular Systolic Dysfunction
Preoperative Gastric Ultrasound and Left Ventricular Function in Coronary Artery Bypass Surgery
This study aims to investigate whether reduced heart function is associated with differences in stomach contents before elective coronary artery bypass graft (CABG) surgery.
- Conditions
- Coronary Artery Disease, Left Ventricular Systolic Dysfunction, Gastric Contents
- Trial name
- NCT07898215
- Testing
- Gastric Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Adiyaman University
Coronary Artery Disease, Cognitive Impairment
Cerebral Oxygenation and Neurological Functioning After Cardiac Surgery
The overall goal of this research program is to determine quantitative predictors of quantitative long-term neurological functioning following different cardiac surgery procedures.
- Conditions
- Coronary Artery Disease, Cognitive Impairment, Delirium
- Trial name
- CONFUSE (NCT04081649)
- Where
- Canada
- Volunteers
- 95 people
- Sponsor
- Dr. Gordon Boyd
Microvascular Angina
Effect of ACE-Inhibition on Microvascular Function in Women With Assessed Microvascular Dysfunction
The aim of this study is to explore effects of long term treatment with ACE-inhibitor on the small vessel function assessed by coronary flow reserve (CFR) by transthoracic echocardiography and flow mediated dilation in…
- Trial name
- NCT02525081
- Testing
- Ramipril (ACE-inhibitor)
- Where
- Denmark
- Volunteers
- 63 people
- Sponsor
- Bispebjerg Hospital
Coronary Heart Disease, Congestive Heart Failure
Standard Drug Therapy vs. Implanted Defibrillator for Primary Prevention of Sudden Cardiac Death
Recent ACC/AHA/ESC guidelines recommend prophylactic ICD implantation in most patients with coronary heart disease and LVEF < 40%.
- Conditions
- Coronary Heart Disease, Congestive Heart Failure, Ventricular Dysfunction, Low Cardiac Output
- Trial name
- SMART-ICD (NCT00524862)
- Testing
- Optimized medical therapy, Implantable Cardioverter Defibrillator
- Where
- 10 sites in Canada
- Volunteers
- 5,000 people
- Sponsor
- Unity Health Toronto
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Cardiac Structure and Function in Patients with Cystic Fibrosis
In a prospective observational cohort study (n = 100), the investigators aim to assess the correlation between cardiac biomarkers, advanced echocardiography and cystic fibrosis genotype and severity and determine whether these…
- Conditions
- Cystic Fibrosis, Cystic Fibrosis-related Diabetes, Cystic Fibrosis, Pulmonary, Cystic Fibrosis of Pancreas
- Trial name
- NCT06084468
- Where
- 2 sites in Denmark
- Volunteers
- 104 people
- Sponsor
- Herlev and Gentofte Hospital
Coronary Microvascular Dysfunction, Coronary Artery Vasospasm
Belgian Registry on Coronary Function Testing
The goal of this prospective, multicenter registy is to describe the 'real-world' use of coronary function tests, which may consist of bolus thermodilution measurements of coronary microvascular function and/or invasive…
- Trial name
- BELmicro (NCT06089031)
- Testing
- Coronary Function Test
- Where
- 13 sites in Belgium
- Volunteers
- 650 people
- Sponsor
- University Hospital, Antwerp
Myocardial Infarction, Inflammation
Simvastatin Effect on Inflammation and Endothelial Function After Myocardial Infarction
During myocardial infarction, inflammatory response may negatively influence ventricle wall remodeling as well as endothelium-dependent vasomotor function in the coronary and systemic arterial systems.
- Conditions
- Myocardial Infarction, Inflammation, Endothelial Dysfunction
- Trial name
- NCT00906451
- Testing
- Simvastatin
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- Brasilia Heart Study Group
Coronary Artery Disease, Ischaemic Heart Disease
Coronary Artery Endothelial Dysfunction With Drug Coated Balloons
Use of intracoronary acetylcholine to investigate endothelial function in coronary arteries treated with either drug coated balloon angioplasty of drug eluting stents.
- Conditions
- Coronary Artery Disease, Ischaemic Heart Disease, Endothelial Dysfunction
- Trial name
- SPARTAN-VM (NCT04901767)
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Coronary Microvascular Dysfunction, Myocardial Ischemia
Diagnostic and Prognostic Value of Angiography-derived IMR
The importance of the microvasculature in determining clinical outcomes has been highlighted in patients with coronary artery disease (CAD).
- Trial name
- CHART-MiCro (NCT04825028)
- Testing
- Angiography-drived Index of Microcirculatory Resistance
- Where
- China
- Volunteers
- 271 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Disease, Heart Failure Systolic
The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)
The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy (STICH3C) trial is a prospective, unblinded, international multi-center randomized trial of 754 subjects enrolled in approximately 45 centers comparing…
- Trial name
- NCT05427370
- Testing
- Revascularization by PCI, Revascularization by CABG
- Where
- 46 sites in United States, Austria and 14 more
- Volunteers
- 754 people
- Sponsor
- Sunnybrook Health Sciences Centre
Non-ST Segment Elevation Myocardial Infarction, ST Segment Elevation Myocardial Infarction
Comparison of Clopidogrel and Ticagrelor on Microvascular Dysfunction in ST-Segment Elevation Myocardial Infarction
Ticagrelor is a non-thienophyridine, direct P2Y12 blocker that is more potent than clopidogrel and is associated with less interindividual variability.
- Trial name
- NCT02026219
- Testing
- Clopidogrel, Ticagrelor
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Inha University Hospital
Coronary Artery Disease, Clopidogrel, Poor Metabolism of
PTRG-DES Consortium
The PTRG-DES consortium is a coalition composed of multi-center, real-world registries including CAD patients treated with DES in South Korea.
- Conditions
- Coronary Artery Disease, Clopidogrel, Poor Metabolism of, Platelet Dysfunction, Stent Thrombosis
- Trial name
- PTRG (NCT04734028)
- Testing
- Clopidogrel Tablets
- Where
- South Korea
- Volunteers
- 13,160 people
- Sponsor
- Gyeongsang National University Hospital
Microvascular Angina, Angina, Stable
iCorMicA - Stratified Medicine in Angina
The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry.
- Conditions
- Microvascular Angina, Angina, Stable, Ischemia With No Obstructive Coronary Arteries (INOCA), Coronary Microvascular Dysfunction (CMD)
- Trial name
- iCorMicA (NCT04674449)
- Testing
- Disclosure of IDP results, IDP performed but results not disclosed
- Where
- 39 sites in Ireland, Netherlands and 2 more
- Volunteers
- 1,500 people
- Sponsor
- NHS Greater Glasgow and Clyde
Coronary Arterioscleroses, Platelet Dysfunction Due to Drugs
The IDEAL-PCI Extended Registry
The purpose of this study is to determine the efficacy and safety of a routine individualized antiplatelet therapy after coronary stent implantation by evaluating "on-treatment" platelet reactivity with Multiple Electrode…
- Trial name
- IDEAL-PCI ext (NCT02974777)
- Testing
- DAPT reduction, DAPT on-target, DAPT intensification
- Where
- Austria
- Sponsor
- Kaiser Franz Josef Hospital
Coronary Heart Disease, Heart Valve Diseases
Does Coronary Angiography Cause Cognitive Dysfunction?
The purpose of the study is to study if coronary angiography cause cognitive dysfunction.
- Trial name
- NCT01428947
- Testing
- Arterial approach
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Ventricular Tachycardia, Coronary Artery Disease
Coronary Flow During Rapid Heart Rates
The goal of this observational study is to learn about the factors which determine how well ventricular tachycardia (VT) is tolerated. The main questions it aims to answer are: 1.
- Conditions
- Ventricular Tachycardia, Coronary Artery Disease, Heart Failure, Coronary Microvascular Dysfunction
- Trial name
- VT flow (NCT05841199)
- Testing
- Pressure and flow measurement during simulated VT
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Imperial College London
Coronary Microvascular Dysfunction (CMD), Angina Pectoris With Normal Coronary Arteriogram
Endothelin Role In COronary Microcirculation
Coronary microvascular dysfunction is an important cause of angina in patients who do not have significant blockages in the major coronary arteries.
- Conditions
- Coronary Microvascular Dysfunction (CMD), Angina Pectoris With Normal Coronary Arteriogram, Microvascular Angina
- Trial name
- ERICOM (NCT07670091)
- Testing
- Cardiac MRI, Invasive Coronary Angiogram, Endothelin Receptor Antagonist
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust