Clinical trials: Ischaemic Reperfusion Injury
Ischemic Heart Disease, Coronary Artery Disease
Assessment of Myocardial Ischemic-Reperfusion Injury During Off- and On- Pump CABG
Assessment of myocardial ischemic-reperfusion injury during off- and on- pump CABG.
- Conditions
- Ischemic Heart Disease, Coronary Artery Disease, Ischemic Reperfusion Injury, CABG
- Trial name
- NCT03050489
- Testing
- On-Pump CABG., Off-Pump CABG., BH-CABG MSC.
- Where
- Russia
- Volunteers
- 336 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Liver Cancer, Hepatobiliary Tract Adenomas and Carcinomas
Observational Study of Biomarker During Liver Surgery
The investigators would like to study whether Sirtuin 1 (SIRT1) plays a cytoprotective role in liver ischemia/reperfusion, and ultimately to develop therapeutic strategies to improve hepatic function of patients with liver…
- Trial name
- NCT02102971
- Testing
- Hepatocellular carcinoma
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Florida
Endothelial Dysfunction
To Compare the Ischemic Pre-conditioning and Post-conditioning on Reperfusion Injury in Humans.
Reperfusion Injury occurs by the sudden blood flow to the injured and ischemic myocardium during restoration of blood flow either by Mechanical revascularization or thrombolysis.
- Trial name
- NCT00385151
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Emory University
Graft Failure, Ischemia-reperfusion Injury
Induction of HO-1; a Therapeutic Approach to Reduce Ischaemia Reperfusion Injury (IRI) Following Deceased Donor Renal Transplantation
This is a blinded, placebo-controlled, randomised controlled trial looking at the effects of Heme arginate (HA) on cadaveric renal transplantation.
- Trial name
- HOT (NCT01430156)
- Testing
- Heme arginate (Normosang), 0.9% sodium chloride
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Edinburgh
End Stage Chronic Renal Failure, Chronic Kidney Disease (Stages 4 and 5)
Deceased Donor Kidney Storage at 10 Celsius Versus Conventional Storage
The goal of this clinical trial is to test how storage temperature of deceased donor kidneys affects kidney function after transplant in adult patients receiving a kidney transplant.
- Conditions
- End Stage Chronic Renal Failure, Chronic Kidney Disease (Stages 4 and 5), Kidney Transplantation Recipients
- Trial name
- NCT07385651
- Testing
- 10˚C deceased donor kidney storage using Traferox XPort
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University Medical Center
Myocardial Reperfusion Injury
Concomitant Milrinone and Esmolol Treatment in Patients with Acute Myocardial Infarction
Heart attack is the leading cause of death in the developed world. Following heart attack, re-establishing blood flow in a clogged heart vessel using percutaneous coronary intervention (PCI) is the standard of care.
- Trial name
- COMET-AMI (NCT02098629)
- Testing
- Milrinone, Esmolol, Saline Infusion
- Where
- Singapore
- Volunteers
- 25 people
- Sponsor
- Shantou University Medical College
Myocardial Ischemia, Coronary Disease
Efficacy of FX06 in the Prevention of Myocardial Reperfusion Injury
The purpose of the study is to evaluate whether FX06 is capable of limiting infarct size following balloon catheterization for acute myocardial infarction.
- Conditions
- Myocardial Ischemia, Coronary Disease, Myocardial Infarction
- Trial name
- NCT00326976
- Testing
- FX06, Percutaneous coronary intervention
- Where
- 32 sites in Austria, Belgium and 9 more
- Volunteers
- 234 people
- Sponsor
- Fibrex Medical Research & Development GmbH
Cardiovascular Disease, Ischemic Heart Disease
The Metformin in Coronary Artery Bypass Graft (CABG) (MetCAB) Trial
Rationale: In patients with a myocardial infarction, occlusion of a coronary artery induces myocardial ischemia and cell death. If untreated, the area of myocardium exposed to this interruption in blood supply, will largely…
- Trial name
- MetCAB (NCT01438723)
- Testing
- Metformin
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Liver Transplantation, Ischemia-reperfusion Injury
Effects of Ursodeoxycholic Acid on Graft Recovery Early After Adult Liver Transplantation
This study is designed to investigate the possible beneficial effects of UDCA on liver graft recovery early after adult liver transplantation.
- Conditions
- Liver Transplantation, Ischemia-reperfusion Injury, Cholestasis
- Trial name
- NCT01073202
- Testing
- ursodeoxycholic acid
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Acute Myocardial Infarction
Stellate Ganglion Morphine Infiltration on Myocardial Ischemia-Reperfusion Injury
The goal of this clinical trial is to investigate whether morphine modulates the functions of the stellate ganglion to reduce myocardial ischemia/reperfusion injury in AMI patients.
- Trial name
- tSGM-AMI (NCT06947135)
- Testing
- Morphine
- Where
- 3 sites in China
- Volunteers
- 166 people
- Sponsor
- The Second Hospital of Anhui Medical University
Ischemic Preconditioning
The Study of Potency of Cross-preconditioning to Prevent Ischemic-reperfusion Injury for Heart Transplantation Recipient
In recent years, a large number of studies confirmed the protective effect of ischemic preconditioning on myocardium against ischemia/reperfusion injury, but the clinical data of the effectiveness of ischemic preconditioning in…
- Trial name
- NCT03900390
- Testing
- cross-preconditioning
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Mengya Liang
Ischemic Reperfusion Injury, Other Reconstructive Surgery
RIPC During Free Flap With Preoperative Radiotherapy
Remote ischemic preconditioning (RIPC) has shown organ-protective effects in many clinical settings including patients with ischemic heart disease.
- Conditions
- Ischemic Reperfusion Injury, Other Reconstructive Surgery, Radiotherapy
- Trial name
- NCT03535623
- Testing
- remote ischemic preconditioning (RIPC)
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Reperfusion Injury
Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)
The purpose of this study is to establish the effectiveness of the combined drug approach (anti-thrombin III, infliximab, apotransferrin, human recombinant erythropoietin beta, C1-inhibitor, glutathione, alfa-tocopherol…
- Trial name
- CAPITL (NCT02251041)
- Testing
- Antithrombin-III, Infliximab, Apotransferrin
- Where
- Belgium
- Volunteers
- 143 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Acute Myocardial Infarction
Sodium Nitrite in Acute Myocardial Infarction
The purpose of this study is to determine whether the intravenous infusion of sodium nitrite safely prevents ischemia-reperfusion injury in subjects with acute myocardial infarction resulting in improved left ventricular function.
- Trial name
- NCT00924118
- Testing
- Sodium Nitrite
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
C.Surgical Procedure; Cardiac
Acute Normovolemic Hemodilution in High Risk Cardiac Surgery Patients.
Transfusions are one of the most overused treatments in modern medicine, and saving blood is one important issue all around the world.
- Trial name
- ANH (NCT03913481)
- Testing
- Acute normovolemic hemodilution, Standard care
- Where
- 32 sites in United States, Bahrain and 9 more
- Volunteers
- 2,000 people
- Sponsor
- Università Vita-Salute San Raffaele
Heart Valve Diseases, Aortic Diseases
Effective Myocardial Protection Time of Del Nido Cardioplegia in Adult Cardiac Surgery
This single-center, prospective, observational cohort study quantifies the effective myocardial protection window of Del Nido cardioplegia during adult open-heart surgery performed under cardiopulmonary bypass (CPB) and aortic…
- Conditions
- Heart Valve Diseases, Aortic Diseases, Myocardial Ischemia, Reperfusion Injury, Myocardial
- Trial name
- DN-TIME-2025 (NCT07249424)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Muhammet Talha Ceran, MD
Ischemia Reperfusion Injury
Feasibility and Safety of Allogeneic Adipose Mesenchymal Stem Cells (aMSCs) Delivery Into Kidney Allografts Procured From Deceased Donors With High Kidney Donor Profile Index (KDPI)
The purpose of this research is to test an investigational drug called Adipose Mesenchymal Stem Cells (aMSCs) for the treatment of ischemia re-perfusion injury (IRI) in patients that have had a kidney transplant.
- Trial name
- NCT04388761
- Testing
- Allogeneic adipose derived mesenchymal stem cells
- Sponsor
- Tambi Jarmi
End Stage Liver Failure
N-acetylcysteine in Liver Transplantation
N-acetylcysteine (NAC) is used to treat Tylenol toxicity. NAC is a rich source of the sulfhydryl group (SH) which is important for replenishing the body's glutathione stores.
- Trial name
- NAC (NCT00736541)
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ibtesam Hilmi
Ischaemic Heart Diseases
Loop Isolation-based Uploading Pre-conditioning
Myocardial protection is of crucial importance for surgical coronary revascularization in patients with ischaemic heart diseases.
- Trial name
- NCT03766529
- Testing
- loop isolation-based uploading preconditioning (LiuPhD)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanjing Medical University
Heart Failure, Ischemia Reperfusion Injury
Functional and Metabolic Effects of Ketone Bodies on Human Atrial Tissue in Patients With and Without Heart Failure
This proof of concept study aims to evaluate the effects of applying ketone bodies to human atrial tissue biopsies using an atrial strips model and high resolution respirometry.
- Conditions
- Heart Failure, Ischemia Reperfusion Injury, Mitochondrial Pathology
- Trial name
- NCT04379934
- Testing
- 3-hydroxybuturate
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- University of Aarhus