Clinical trials: Ischaemic Reperfusion Injury
Cardiac Arrest
Reoxygenation After Cardiac Arrest II (REOX II Study)
The broad objective of this study is to test the association between hyperoxia exposure after resuscitation from cardiac arrest and outcome.
- Trial name
- REOX II (NCT02698826)
- Testing
- Protocol for rapid FiO2 optimization
- Where
- 5 sites in United States
- Volunteers
- 16 people
- Sponsor
- The Cooper Health System
Healthy
Sitagliptin and Endothelial Dysfunction
Over the years, numbers of cardioprotective drugs have been evaluated to attenuate lethal ischemia-reperfusion (IR) injuries. There is little study whether sitagliptin protects against endothelial dysfunction induced by IR injury…
- Trial name
- NCT02406950
- Testing
- Sitagliptin
- Where
- South Korea
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Kyunghee University Medical Center
Acute Myocardial Infarction, Ischemia-reperfusion Injury
The Effect of Melatonin on Ischemia-reperfusion Injury Following Acute Myocardial Infarction
In Denmark, 12.000 people a year, is struck by acute myocardial infarction. A third of these cannot be saved before treatment is possible.
- Trial name
- NCT01172171
- Testing
- Melatonin, N-acetyl-5-methoxytryptamine, Isotonic saline, Natrium chloride
- Where
- 2 sites in Denmark
- Volunteers
- 41 people
- Sponsor
- Herlev Hospital
Liver Transplant
Serum Markers of Ischemia Reperfusion Injury in Liver Transplant Patients
This is an observational study examining serum markers in patients who are undergoing either a cadaveric liver transplant or a living related liver transplant.
- Trial name
- NCT00698399
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Hepatic and Hepatobiliary Disorders
Indocyanine Green Clearance Test in Liver Transplantation (LivInG)
The gap between patients awaiting and those undergoing liver transplantation (LT) continues to grow. Marginal organs carry higher risk of failure after LT however they are increasingly used to fill such gap.
- Trial name
- LivInG (NCT05228587)
- Testing
- Indocyanine green
- Where
- Italy
- Volunteers
- 162 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ischemia Reperfusion Injury, Heart Transplantation
Role of Intraoperative Thymoglobulin in Decreasing Ischemia-Reperfusion Injury in Pediatric Heart Transplant Recipients
The restoration of normal blood flow following a period of ischemia may result in ischemia / reperfusion injury (I/RI), which is characterized by inflammation and oxidative damage to tissues.
- Trial name
- NCT00709293
- Testing
- Anti-Thymocyte Globulin, Normal Saline
- Where
- United States
- Sponsor
- University of California, Los Angeles
Myocardial Infarction
ShenFu Injection for Myocardial Protection in Patients With Acute ST Segment Elevation Myocardial Infarction
The purpose of this study is to evaluate whether perioperative use of Shenfu Injection could reduce myocardial injury (enzymatic infarct size and infarct volume according to cardiac magnetic resonance imaging) in patients with…
- Trial name
- SF-STEMI (NCT02709798)
- Testing
- Shenfu Injection, 5% Glucose Injection
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Anzhen Hospital
Acute Myocardial Infarction With ST Elevation
Dextran Use for Primary Angioplasty Protection in Acute Myocardial Infarction
Reperfusion therapy in acute myocardial infarction saves viable myocardium, but paradoxically reestablishment of coronary artery flow also induces damage and cell death, decreasing the full benefit of reperfusion in terms of…
- Trial name
- DUPAP (NCT03148834)
- Testing
- Controlled Reperfusion
- Volunteers
- 100 people
- Sponsor
- Centro Cardiovascular Salta
Arthroplasty, Replacement
Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Lower Extremity Operations
Ischemia reperfusion injury causes the release of free oxygen radicals. The selective alpha2-receptor agonist, dexmedetomidine, has an inhibitory effect on inflammatory responses during ischemic injury.
- Trial name
- NCT02648958
- Testing
- Dexmedetomidine, normal saline
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Yonsei University
Acute Ischemic Stroke, Reperfusion Injury
Ischemic Post-conditioning in Acute Ischemic Stroke Thrombectomy (PROTECT-1b)
Ischemic post-conditioning is a neuroprotective strategy attenuating reperfusion injury in animal stroke models. The investigators have conducted a 3 + 3 dose-escalation trial to demonstrate the safety and tolerability of…
- Trial name
- PROTECT (NCT05909982)
- Testing
- Mechanical thrombectomy combined with ischemic post-conditioning
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Capital Medical University
Liver Failure, Liver Failure, Acute
Use of N-Acetylcysteine During Liver Procurement
Randomized prospective study on the impact on the post-LT outcome by the infusion of N-acetylcysteine (NAC) during the liver procurement procedure, as an anti-oxidant agent to reduce the ischemia-reperfusion damage of organs for…
- Conditions
- Liver Failure, Liver Failure, Acute, Liver Diseases, Carcinoma, Hepatocellular
- Trial name
- NCT01394497
- Testing
- N-acetylcystein
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Azienda Ospedaliera di Padova
Reperfusion Injury
Remote Ischaemic PreConditioning (RIPC) in Partial Nephrectomy for the Prevention of Ischemia/Reperfusion Injury
"Remote Ischaemic PreConditioning" (RIPC) is performed prior to partial nephrectomy. Postoperative calprotectin dynamics and Blood Oxygen-Level-Dependent (BOLD) MRI are used to to demonstrate the potential renoprotective effect…
- Trial name
- NCT03068689
- Testing
- RIPC
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Stroke Patients
Prevention and Treatment of Reperfusion Injury After Mechanical Thrombectomy in Acute Ischemic Stroke
Ischemic stroke accounts for 80% of all strokes and there is a lack of effective treatment options.Mechanical thrombectomy can significantly improve the vascular recanalization rate and reduce the disability rate of stroke, but…
- Trial name
- NCT05282290
- Testing
- Antihypertensive drugs (no restriction on the type of drugs)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Ischemia-reperfusion Injury
Heme Arginate in Functional Magnetic Resonance Imaging (fMRI)
Ischemia reperfusion injury may be attenuated by HO-1 induction. Heme arginate showed protective effects during prolonged ischemia in animal studies.
- Trial name
- NCT01461512
- Testing
- heme arginate administration
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- MWolzt
ST-elevation Myocardial Infarction (STEMI), Acute Myocardial Infarction (AMI)
Timing of Empagliflozin in Primary PCI: Pre-Reperfusion Versus Post-Reperfusion Versus Placebo in South Asian STEMI Patients
The goal of this clinical trial is to learn if giving the drug empagliflozin before versus after a heart procedure called primary PCI (percutaneous coronary intervention) affects how much heart muscle is damaged during a heart…
- Conditions
- ST-elevation Myocardial Infarction (STEMI), Acute Myocardial Infarction (AMI), Coronary Artery Disease
- Trial name
- TEMPO-STEMI (NCT07749014)
- Testing
- empagliflozin
- Where
- Pakistan
- Volunteers
- 480 people
- Sponsor
- Rehman Medical Institute - RMI
Liver Transplant; Complications, Ischemia Reperfusion Injury
Abdominal Regional Perfusion in Donation After Cardiac Death for Multi-Organ Transplantation
The main purpose of this study is to increase the pool of organs available for donation by performing ARP to recondition donation after cardiac death (DCD) organs prior to transplantation.
- Conditions
- Liver Transplant; Complications, Ischemia Reperfusion Injury, Cirrhosis, Liver Cancer
- Trial name
- NCT03946852
- Testing
- Abdominal Regional Perfusion
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre
Ischemia-Reperfusion Injury
Adenosine Receptors Influence Ischemia-Reperfusion Injury
Ischemic preconditioning is defined as the development of tolerance to ischemia-reperfusion injury by a previous short bout of ischemia resulting in a marked reduction in infarct size.
- Trial name
- NCT00184847
- Testing
- acetylcholine, twenty minutes of forearm ischemia, three 5-minute periods of forearm ischemia
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Disorder; Heart, Functional, Postoperative, Cardiac Surgery, Cardiac Insufficiency Following Cardiac Surgery
Statin Therapy In Atrial Refractoriness and Reperfusion Injury
Patients with coronary artery disease are often prescribed drugs called statins because research has shown that, by lowering cholesterol, they reduce the risk of having a heart attack or other complications in the long-term.
- Conditions
- Disorder; Heart, Functional, Postoperative, Cardiac Surgery, Cardiac Insufficiency Following Cardiac Surgery, Atrial Fibrillation, Ischaemia-reperfusion Injury
- Trial name
- STARR (NCT01780740)
- Testing
- Atorvastatin
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Oxford
Platelet Aggregation Inhibitors, Anti-inflammatory Agent
ACCEL-LOADING-ACS Study
The purpose of this study is to determine whether adjunctive cilostazol loading/maintenance to standard treatment (aspirin, clopidogrel, and statin) is effective in reduction of major adverse cardiovascular events, platelet…
- Conditions
- Platelet Aggregation Inhibitors, Anti-inflammatory Agent, Myocardial Reperfusion Injury
- Trial name
- NCT01354808
- Testing
- Dual Anti-Platelet Therapy (DAPT), Triple Anti-Platelet Therapy (TAPT)
- Where
- South Korea
- Volunteers
- 220 people
- Sponsor
- Gyeongsang National University Hospital
Ischemia Reperfusion Injury
Intravenous Estrogen in Kidney Transplant Study
Ischemia perfusion injury (IRI) is a major cause of organ injury during kidney transplantation. Currently there are no treatments for IRI other than dialysis.
- Trial name
- PERT (NCT03663543)
- Testing
- Conjugated Estrogen, Normal saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania