Clinical trials: Ischaemic Reperfusion Injury
Myocardial Infarction
Myocardial Protection of Exenatide in AMI
Experimental evidence suggests exenatide, a glucagon-like peptide 1 receptor analogue, has significant cardiovascular protective effects in various conditions.
- Trial name
- EMPIRE (NCT01580514)
- Testing
- exenatide BYETTA® (Amylin-Lilly), Saline
- Where
- South Korea
- Volunteers
- 127 people
- Sponsor
- Kyunghee University Medical Center
Renal Cell Carcinoma
Effect of Ketorolac and Remote Ischemic Preconditioning on Renal Ischemia-reperfusion Injury in Patients Undergoing Partial Nephrectomy
Partial nephrectomy is a widely accepted alternative to radical nephrectomy in patients with clinically localized, unilateral renal cell carcinoma and a normal contralateral kidney.
- Trial name
- NCT01836406
- Testing
- Ketorolac tromethamine and remote ischemic preconditioning
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Yonsei University
Liver Transplantation, Post-Reperfusion Syndrome
HOPE With Cytokine Filtration in Liver Transplantation (Cyto-HOPE)
Ischemia-reperfusion injury (IRI) is unavoidably typical of solid organ transplantation. Post-reperfusion syndrome (PRS), characterized by hemodynamic instability at reperfusion of the implanted graft, is a possible complication…
- Conditions
- Liver Transplantation, Post-Reperfusion Syndrome, Ischaemia-Reperfusion Injury, Early Allograft Dysfunction
- Trial name
- Cyto-HOPE (NCT04203004)
- Testing
- HOPE with cytokine filtration by CytoSorb
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Papa Giovanni XXIII Hospital
Hepatic Ischemic and Reperfusion Injury
Liver Protection of RIPC in Pediatric Living Donor Liver Transplantation
Remote ischemic preconditioning(RIPC) is emerging as an promising therapeutic paradigm to combat the detrimental impact of ischemic and reperfusion injury.
- Trial name
- RIPC-PLDT (NCT02830841)
- Testing
- remote ischemic preconditioning(RIPC)
- Where
- China
- Volunteers
- 208 people
- Sponsor
- RenJi Hospital
Acute Ischemic Stroke, Acute Renal Injury
Recombinant Human C1 Esterase Inhibitor (Conestat Alfa) in the Prevention of Acute Ischemic Cerebral and Renal Events After Transcatheter Aortic Valve Implantation
The aim of this trial is to assess the safety and efficacy of conestat alfa (Ruconest®, Pharming Technologies B.V.) on renal and cerebral ischemic events in patients undergoing TAVI for severe symptomatic aortic stenosis (AS)…
- Trial name
- PAIR-TAVI (NCT05145283)
- Testing
- Conestat alfa (Ruconest®), NaCl 0.9%)
- Where
- 2 sites in Switzerland
- Volunteers
- 141 people
- Sponsor
- University Hospital, Basel, Switzerland
Aortic Dissection Type A
Remote Ischemic Preconditioning for Aute Type A Aortic Dissection Surgery
The goal of this clinical trial is to learn if a technique called remote ischemic preconditioning (RIPC) helps protect organs during emergency surgery for acute type A aortic dissection (ATAAD).
- Trial name
- NCT07383909
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- 16 sites in China
- Volunteers
- 1,312 people
- Sponsor
- Fujian Medical University
Myocardial Infarction, Inflammation
Effects of Oxygen Treatment on Mechanisms Involved in Ischemia-reperfusion Injury: A Pilot Study in Healthy Volunteers
Oxygen treatment is widely used in acutely ill patients. In particular, oxygen treatment is routinely used in acute coronary syndrome (ACS) patients with suspected acute myocardial infarction and variably recommended in…
- Conditions
- Myocardial Infarction, Inflammation, Acute Coronary Syndrome (ACS), Reperfusion Injury
- Trial name
- NCT02286544
- Testing
- Salmonella typhi vaccine (Typhim Vi®), Oxygen (Oxymask®), Atorvastatin
- Where
- Sweden
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Kidney Transplantation, Ischemic Reperfusion Injury
A Study of Retrograde Reperfusion of Renal Graft to Reduce Ischemic-reperfusion Injury
To evaluate whether retrograde venous reperfusion of a renal graft before antegrade arterial reperfusion can reduce ischemic-reperfusion injury.
- Conditions
- Kidney Transplantation, Ischemic Reperfusion Injury, Reperfusion
- Trial name
- NCT05179434
- Testing
- Retrograde renal graft reperfusion, Conventional antegrade renal graft reperfusion (without retrograde reperfusion)
- Where
- Kazakhstan
- Volunteers
- 30 people
- Sponsor
- West Kazakhstan Medical University
Myocardial Infarction, Myocardial Reperfusion Injury
Efficacy of Endovascular Catheter Cooling Combined With Cold Saline for the Treatment of Acute Myocardial Infarction
The purpose of this study is to determine whether treatment of patients suffering from ST-elevation myocardial infarction (STEMI) with 1-2 liters of cold saline and central venous catheter cooling with Philips InnerCool RTx…
- Conditions
- Myocardial Infarction, Myocardial Reperfusion Injury, Anterior Wall Myocardial Infarction, Inferior Wall Myocardial Infarction
- Trial name
- CHILL-MI (NCT01379261)
- Testing
- Cooling
- Where
- 10 sites in Austria, Denmark and 2 more
- Volunteers
- 120 people
- Sponsor
- Region Skane
Acute Myocardial Infarction (AMI), ST Elevation (STEMI) Myocardial Infarction
Combined Antioxidant Therapy for Acute Myocardial Infarction
The goal of this clinical trial is to learn if a combined antioxidant therapy (CAT) can reduce heart damage caused by the return of blood flow after blocked arteries are reopened in adults with ST-elevation myocardial infarction…
- Conditions
- Acute Myocardial Infarction (AMI), ST Elevation (STEMI) Myocardial Infarction, Reperfusion Injuries, Myocardial
- Trial name
- CAT-AMI (NCT07776288)
- Testing
- Combined antioxidant therapy
- Where
- Chile
- Volunteers
- 46 people
- Sponsor
- University of Chile
Renal Artery Stenosis
Ciclosporin A Preconditioning for Renal Artery Stenosis
Renal artery stenosis is one the leading cause of secondary hypertension. Previous randomized controlled trials in humans have failed to demonstrate an improvement of renal function after stenosis dilation, probably because of a…
- Trial name
- CicloSAAR (NCT03382301)
- Testing
- Ciclosporin A preconditioning before renal artery stenosis dilation, NaCl preconditioning before renal artery stenosis dilation
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Hospices Civils de Lyon
Ischemia-Reperfusion Injury, Free Flap
Non-invasive Remote Ischemic PreConditioning (RIPC) in Free Flaps for Breast Reconstruction
This prospective randomized clinical study investigates the effects of Remote Ischemic Conditioning (RIC) on tissue perfusion and ischemia-reperfusion injury in patients undergoing free flap reconstruction in reconstructive…
- Conditions
- Ischemia-Reperfusion Injury, Free Flap, Conditioning Therapy
- Trial name
- RIPC (NCT07487220)
- Testing
- Remote ischemic preconditiong
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- Ruhr University of Bochum
Ischemia Reperfusion Injury
Remote Ischemic Preconditioning in Cardiac Surgery
Aim of the work : Evaluation of the role of Remote Ischemic Preconditioning (RIP) on liver function in patients undergoing on-pump cardiac surgery.
- Trial name
- NCT04647370
- Testing
- remote ischemic preconditioning
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Cardiogenic Shock, Postresuscitation Disease
Role of Candidate Proteins in Capillary Leakage During Acute Circulatory Failure
Testing the association between circulating candidate proteins and the level of vascular leakage for three distinct forms of circulatory failure: cardiogenic shock, septic shock, and post-resuscitation syndrome.
- Conditions
- Cardiogenic Shock, Postresuscitation Disease, Septic Shock
- Trial name
- NCT05586282
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rheumatic Disease of Heart Valve, Ischemic Reperfusion Injury
Effect of Remote Ischemic Perconditioning on Acute Kidney Injury in Adult Valve Replace
The purpose of this study is to determine whether Remote Ischemic Perconditioning is effective on Acute kidney injury in adult valve replacement.
- Trial name
- NCT01476969
- Testing
- Remote ischemic postconditioning
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Central South University
Ischemia-Reperfusion Injury, Atherosclerosis
Does a Seven Day Treatment With Dipyridamole Induce Protection Against Ischemia-Reperfusion Injury?
This study is performed to determine whether a seven day treatment with dipyridamole (slow release, 200mg twice daily) can induce a protective effect against ischemia-reperfusion injury, after ischemic exercise of the…
- Trial name
- NCT00457405
- Testing
- dipyridamole
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Organ Preservation Solutions
Peri-operative rATG-perfusion of Solid Transplants
The increasing demand for organ transplantation and the shortage of available organs limit the success of organ transplantation programs.
- Trial name
- ATG-perfusion (NCT03377283)
- Testing
- organ perfusion with rabbit anti-thymocyte globulin (rATG), organ perfusion with saline
- Volunteers
- 80 people
- Sponsor
- Medical University Innsbruck
Urologic Injuries, Urology
The Clinical Research of Traditional Chinese Medicine Compound Formulas
To observe the efficacy and safety of Shenkangling, a traditional Chinese medicine decoction, for renal ischemia-reperfusion injury, and to provide evidence-based medical evidence and ideas for clinical therapeutic use.
- Trial name
- NCT07153731
- Testing
- Shenkangling
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Transplanted Kidney Ischemia Reperfusion Injury
Limitation of Ischemic Injury of a Kidney Stored in Machine Perfusion in Hypothermia - Evaluation of the Impact on Kidney Allograft Function
The aims of this study are: 1. assessment of ischemia injury of kidney retrieved from standard and expanded criteria deceased donor before transplantation 2. assessment of efficacy of kidney ischemia injury decreasing 3.
- Trial name
- NCT01731457
- Testing
- etanercept
- Where
- Poland
- Volunteers
- 94 people
- Sponsor
- Medical University of Warsaw
Carotid Stenosis, Ischemia Reperfusion Injury
Perioperative Time Course of MMP-9 and Its Inhibitor During Carotid Artery Stenting and Carotid Endarterectomy
The aim was the comparison of the perioperative time courses of matrix metalloproteinase-9 (MMP-9) and its inhibitor (TIMP-1) during elective carotid artery stenting (CAS).
- Trial name
- NCT03410576
- Testing
- Carotid artery stenting, Carotid endarterectomy
- Where
- Hungary
- Volunteers
- 25 people
- Sponsor
- University of Pecs