Clinical trials: Ischemia, Brain
Stroke, Ischemic Stroke
Myosuit Chronic Stroke Protocol
A stroke is a vascular condition that can suddenly cause the loss of neurological functions. The disability derived from a stroke can imply reduced communication and limited activities of daily living in the long term.
- Conditions
- Stroke, Ischemic Stroke, Haemorrhagic Stroke
- Trial name
- MyoSCSP (NCT05579197)
- Testing
- Lower-limb robotic intervention
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Acute Stroke, Ischemic Stroke
Rescue Intracranial Stenting in Acute Ischemic Stroke
In acute ischemic stroke caused by intracranial large vessel occlusion, rescue intracranial stenting has been recently a treatment option to achieve recanalization in patients with the failure of mechanical thrombectomy.
- Conditions
- Acute Stroke, Ischemic Stroke, Intracranial Atherosclerosis, Stent Stenosis
- Trial name
- RISIS (NCT04986774)
- Testing
- Rescue intracranial stenting
- Where
- Vietnam
- Volunteers
- 85 people
- Sponsor
- Can Tho Stroke International Services Hospital
Ischemic Stroke, Diabete Mellitus
DPP4 Inhibitor Intervention on Post-stroke Cognitive Impairment in Ischemic Stroke Patients With Type 2 Diabetes
Post-stroke cognitive impairment (PSCI) increases the risk of disability and mortality in stroke patients, thereby exacerbating the disease burden of stroke.
- Trial name
- NCT07241897
- Testing
- Sentagliptin Phosphate - single dose
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Hypoxic Ischemic Encephalopathy of Newborn, Neonatal Encephalopathy
Investigating Cerebral Oxygenation in the Newborn
The goal of this single centre observational study is to use near-infrared spectroscopy (NIRS) monitoring to investigate cerebral oxygenation in two groups of newborn infants who are at high risk of brain injury.
- Conditions
- Hypoxic Ischemic Encephalopathy of Newborn, Neonatal Encephalopathy, Premature Infant Disease
- Trial name
- ICON (NCT05588960)
- Testing
- Near-infrared spectroscopy monitoring (Masimo O3 Regional Oximeter with Neonatal Sensor)
- Where
- United Kingdom
- Volunteers
- 99 people
- Sponsor
- University of Edinburgh
Anoxic Brain Injury
Safety and Efficacy Assessment of Autologous Bone-marrow Derived Adult Mesenchymal Stem Cell Therapy in Patients With Anoxic(or Hypoxic) Brain Injury Pilot Trial
The purpose of study is to evaluate the safety and efficacy of autologous bone marrow-derived stem cells therapy in patients with anaerobic (hypoxic) brain injury.
- Trial name
- NCT02210624
- Testing
- HYNR-CS inj.
- Where
- South Korea
- Volunteers
- 4 people
- Sponsor
- Hyun Young Kim
Ischemic Stroke
Stent Retriever's(TonbridgeMT) Endovascular Therapy for Acute Ischemic Stroke(AIS)
The study is a prospective, multi-center, stratified randomized, single-blind, parallel assignment, active control, non-inferiority trial.
- Trial name
- NCT03210623
- Testing
- stent retriever(TonbridgeMT), Solitaire™
- Where
- 17 sites in China
- Volunteers
- 220 people
- Sponsor
- Ton-Bridge Medical Tech. Co., Ltd
Acute Ischemic Stroke
Intra-arterial Methylprednisolone After Successful Endovascular Thrombectomy Anterior Circulation Large Vessel Occlusion
The purpose of IMPACT-LVO trial is to investigate the efficacy and safety of early adjunctive intra-arterial combined with intravenous administration methylprednisolone sodium succinate after successful endovascular thrombectomy…
- Trial name
- IMPACT-LVO (NCT07141303)
- Testing
- The methylprednisolone sodium succinate
- Where
- China
- Volunteers
- 1,060 people
- Sponsor
- Tang-Du Hospital
Acute Stroke, Acute Ischemic Stroke
Cytokine Registry Database of Stroke Patients
Various molecules (cytokines: interleukins, interferons and neural proteins) found in human and animal blood are reported to be elevated in acute stroke (Ischemic and hemorrhagic).
- Conditions
- Acute Stroke, Acute Ischemic Stroke, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- CRISP (NCT03297827)
- Testing
- Serum and Urine measurement of cytokines.
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of New Mexico
Cardioembolic Stroke, Atrial Fibrillation
Hirudin Plus Aspirin in the Secondary Prevention of Cardioembolic Stroke Due to Nonvalvular Atrial Fibrillation
To investigate the efficacy and safety of hirudin plus aspirin therapy compared with warfarin in the secondary prevention of cardioembolic stroke due to nonvalvular atrial fibrillation.
- Trial name
- NCT02181361
- Testing
- hirudin plus aspirin, Warfarin
- Where
- China
- Volunteers
- 239 people
- Sponsor
- Xijing Hospital
Ischemic Stroke
Gut Microbiota and Serum Markers for Cognitive Impairment and Poor Prognosis After Ischemic Stroke
Post-stroke cognitive impairment(PSCI) is one of the most important factors causing disabilities after stroke. Recent study found that gut microbiota plays a key role in neurological diseases.
- Trial name
- NCT04688138
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Stroke
Mechanical Thrombectomy Of Acute Occlusion In Ischemic Stroke
Assessment of Therapeutic benefits and hazards of Mechanical Thrombectomy in Ischemic stroke patients with proximal occlusion within 4.5 hours from stroke onset.
- Trial name
- NCT03144960
- Testing
- Mechanical Thrombectomy
- Volunteers
- 20 people
- Sponsor
- Assiut University
Cerebrovascular Accident
Safety and Efficacy of NeuroFlo Technology in Ischemic Stroke (SENTIS)
The purpose of this study is to assess the safety and efficacy of the NeuroFlo™ catheter for use in patients with ischemic stroke.
- Trial name
- SENTIS (NCT00119717)
- Testing
- NeuroFlo™ catheter, Control
- Where
- 72 sites in United States, Austria and 8 more
- Volunteers
- 515 people
- Sponsor
- CoAxia
Coronary Artery Disease, Depression
The Recovery of Cardiovascular Patients With Depression
Cardiovascular disease increases the risk of depression and vice versa. Many cardiovascular patients are subjected to percutaneous coronary intervention (PCI).
- Conditions
- Coronary Artery Disease, Depression, Cardiovascular Diseases
- Trial name
- NCT03841474
- Testing
- Psychiatric treatment with sertraline, Psychiatric treatment with escitalopram
- Where
- Croatia
- Volunteers
- 150 people
- Sponsor
- Klinički Bolnički Centar Zagreb
Stroke, Acute, Stroke, Ischemic
Effects of Atalante Exoskeleton on Gait Recovery in Non- or Poorly Ambulatory Patients With Hemiparesis in the Acute/Subacute Phase (Month 1 to 4)
The present clinical investigation - EarlyExo, is an interventional, international, multicentric, prospective, single-blinded randomized controlled trial.
- Conditions
- Stroke, Acute, Stroke, Ischemic, Stroke, Subacute, Stroke Hemorrhagic
- Trial name
- EarlyExo (NCT06107010)
- Testing
- Use of the Atalante exoskeleton
- Where
- 5 sites in France, Germany and 1 more
- Volunteers
- 66 people
- Sponsor
- Wandercraft
Ischemic Stroke
The Safety and Efficacy of NouvSoma001 in Ischemic Stroke
This is a single-center, randomized, open-label, placebo-controlled, dose-escalation trial. The objective of this research is to evaluate the safety, tolerability, and preliminary efficacy of intravenous administration of…
- Trial name
- NCT06612710
- Testing
- extracellular vesicles derived from human induced neural stem cell for intravenous injection
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Wei Wang
Cardiovascular Diseases, Heart Diseases
Postmenopausal Progestins, MI and Stroke
To evaluate the cardiovascular effects of postmenopausal hormone replacement therapy and the suspected beneficial effects on myocardial infarction and stroke.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Cerebrovascular Accident
- Trial name
- NCT00005220
- Sponsor
- University of Washington
Stroke, Acute Ischemic
Mechanical Thrombectomy of Medium Sized Vessels "M2 of MCA".
Mechanical thrombectomy recently has revolutionized the treatment of stroke. Trials have demonstrated the superiority of mechanical thrombectomy in large vessel occlusions, such as in the intracranialinternal carotid artery and…
- Trial name
- NCT05091320
- Testing
- Mechanical thrombectomy, medical treatment
- Volunteers
- 60 people
- Sponsor
- Assiut University
Ischemic Stroke, Remote Ischaemic Preconditioning
Effect of Remote Ischemic Preconditioning on Early Neurological Deterioration in Acute Perforating Artery Infarction
This study aims to conduct a prospective, randomized, double-blind, multicenter, parallel-controlled, group-sequential trialto scientifically evaluate the safety and efficacy of remote ischemic preconditioning (RIC) in preventing…
- Trial name
- RIC-END (NCT07237542)
- Testing
- remote ischemic preconditioning
- Where
- China
- Volunteers
- 910 people
- Sponsor
- Jinling Hospital, China
Ischemic Stroke, Spasticity
Dry Needling and Bobath Treatment Clinical Effects Focused on Stroke Patients
The investigators aim to determine if dry needling technique in a non myofascial trigger point area generate the same changes in spasticity, function and pain responses as with dry needling in a myofascial trigger point area.
- Trial name
- NCT03906305
- Testing
- Dry needling in a myofascial trigger points area plus physical therapy based on Bobath concept, Dry needling in a non myofascial trigger points area plus physical therapy based on Bobath concept
- Where
- Spain
- Volunteers
- 18 people
- Sponsor
- Universidad Rey Juan Carlos
Ischemic Stroke
Phase 2 Study of TXA127 in Post-ischemic Stroke Patients
This is a 50-patient, Phase 2, double-blind, randomized, placebo-controlled, hybrid decentralized study to evaluate the safety and efficacy of daily subcutaneous (SC) injection of TXA127 in post-ischemic stroke patients.
- Trial name
- NCT06135103
- Testing
- talfirastide
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Constant Therapeutics LLC
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