Clinical trials: Ischemia, Brain
Stroke, Transient Ischemic Attack
Smoking Cessation Intervention After Stroke or Transient Ischaemic Attack.
Patients with stroke or transient ischemic attach should receive advise on smoking cessation. It is however unknown if an intensive smoking cessation program is better than ordinary advise on smoking cessation during…
- Trial name
- NCT00228098
- Testing
- Smoking cessation
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Odense University Hospital
Chronic Stroke, Ischemic Stroke
Proof-of-concept for Use of Transcutaneous Spinal Stimulation (TSS) With the ExaStim® Stimulation System in Adults With Chronic Ischemic Stroke
The goal of this clinical trial is to learn about the safety, tolerability, and feasibility of ExaStim transcutaneous electrical stimulation combined with task-specific rehabilitation, and to characterize changes in arm function…
- Conditions
- Chronic Stroke, Ischemic Stroke, CVA (Cerebrovascular Accident)
- Trial name
- EXA2611 (NCT07917221)
- Testing
- Transcutaneous Spinal Stimulation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Hypoxic-Ischemic Encephalopathy, Perinatal Asphyxia
EEG-Based Decision-Support Algorithm for Hypoxic-Ischemic Encephalopathy in Term Newborns
This retrospective, multicenter, observational study evaluates how well a decision-support algorithm can tell apart mild forms of hypoxic-ischemic encephalopathy (HIE) from moderate or severe forms in full-term newborns born…
- Conditions
- Hypoxic-Ischemic Encephalopathy, Perinatal Asphyxia, Neonatal Brain Injury
- Trial name
- COOLDECIDE (NCT07764315)
- Volunteers
- 310 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ischemic Stroke
Pilot Study of Aspirin Versus Warfarin for Cervicocephalic Arterial Dissection
Pilot Study of Aspirin Versus Warfarin for Cervicocephalic Arterial Dissection.
- Trial name
- NCT00265408
- Testing
- aspirin, warfarin
- Where
- United States
- Sponsor
- University of California, San Diego
Stroke, Acute
Treatment Evaluation of Acute Stroke for Using in Regenerative Cell Elements
The primary objectives of this study is to evaluate the efficacy of HLCM051 on functional outcome in subjects with acute ischemic stroke and to evaluate the safety of HLCM051 in subjects with acute ischemic stroke.
- Trial name
- TREASURE (NCT02961504)
- Testing
- HLCM051
- Where
- Japan
- Volunteers
- 206 people
- Sponsor
- Healios K.K.
Ischemic Stroke
HEMS for Mechanical Thrombectomy
Elapsed time from the onset of stroke symptoms to the point of revascularization is the key determinant of the optimal outcome of acute ischemic stroke.
- Trial name
- NCT04834284
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Tampere University Hospital
Ischemic Stroke, Intracranial Arteriosclerosis
Pair Antiplatelet THerapy in Ischemic Stroke With Intracranial Artery Stenosis
The goal of this clinical trial is to learn about efficacy and safety of dual antiplatelet therapy in ischemic stroke with intracranial artery stenosis.
- Conditions
- Ischemic Stroke, Intracranial Arteriosclerosis, Secondary Prevention, Antiplatelet Drug
- Trial name
- PATH-ICAS (NCT06243133)
- Testing
- clopidogrel for 90 days combined with aspirin for 90 days, clopidogrel for 30 days combined with aspirin for 90 days
- Where
- China
- Volunteers
- 1,100 people
- Sponsor
- Sichuan Provincial People's Hospital
Ischemic Stroke
Ticagrelor Versus Cilostazol in Minor Ischemic Stroke or TIA
Along with the current clinical trial, the efficacy and safety of ticagrelor and aspirin administered within the first 24 hours of first-ever ischemic stroke compared to cilostazol and aspirin were assessed through NIHSS, mRS…
- Trial name
- NCT06196047
- Testing
- Ticagrelor 90 MG, Cilostazol 100 MG
- Where
- Egypt
- Volunteers
- 900 people
- Sponsor
- Kafrelsheikh University
Acute Ischemic Stroke
Safety, Tolerability, and Preliminary Efficacy of HRS-7450 Injection in the Treatment of Acute Ischemic Stroke: a Multi-center, Randomized, Double-blind, Double-dummy, Placebo-controlled Clinical Trial
This study is a multi-center, randomized, double-blind, double-dummy, placebo-controlled, single dose escalation study aimed at evaluating the overall safety, tolerability, and preliminary efficacy of HRS-7450 in patients with…
- Trial name
- NCT06447415
- Testing
- HRS-7450, 0.9% sodium chloride injection
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Cardiovascular Diseases, Coronary Disease
Dietary Patterns and Risk of Cardiovascular Disease
To study, prospectively, the association between dietary patterns and risk of coronary heart disease (CHD), ischemic stroke, and hemorrhagic stroke in cohort studies of 121,700 women age 30 to 55 years at baseline in 1976 (the…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Cerebrovascular Disorders, Heart Diseases
- Trial name
- NCT00005514
- Volunteers
- 120,000 people
- Sponsor
- Harvard School of Public Health (HSPH)
Neurologic Manifestations, Premature Birth
The Neu-Prem Trial: Neuromonitoring of Preterm Newborn Brain During Birth Resuscitation
The purpose of this study is to characterize the normal brain function of premature infants (23 to 31+6 weeks GA) during birth transition and through the first 72 hours of life.
- Conditions
- Neurologic Manifestations, Premature Birth, Hypoxia-Ischemia, Brain
- Trial name
- Neu-Prem (NCT02605733)
- Testing
- EEG, NIRS
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Sharp HealthCare
Nervous System Diseases, Stroke
Safety and Long-term Effectiveness of High Frequency Repetitive Transcranial Magnetic Stimulation of Stroke (RAICup)
The aim of the study is to determine if 2-week repetitive transcranial magnetic stimulation at the subacute phase of stroke (between day 7 and day 14) improves significantly arm motility at 3 months with remaining effect at one…
- Conditions
- Nervous System Diseases, Stroke, Cerebrovascular Disorders, Brain Infarction
- Trial name
- RAICup (NCT01059149)
- Testing
- repetitive transcranial magnetic stimulation
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neurologic Disorder, Disorder of Consciousness
Prognostic Factors to Regain Consciousness
The study aims to identify factors that predict the medium and long-term outcome of patients with disorders of consciousness (DOC) undergoing early neurological rehabilitation.
- Conditions
- Neurologic Disorder, Disorder of Consciousness, Traumatic Brain Injury, Stroke
- Trial name
- NCT04445649
- Testing
- Coma-Recovery-Scale-Revised (CRS-R)
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
s100b, Hypoxia-Ischemia, Brain
Cord Blood S100B Protein Concentration in Neonates With Fetal Growth Restriction
S100B protein is a biomarker that increases following central nervous system (CNS) damage. Measuring this protein's levels may allow for the early identification of infants at high risk for developmental abnormalities, such as…
- Conditions
- s100b, Hypoxia-Ischemia, Brain, Fetal Growth Restriction (FGR)
- Trial name
- NCT06893926
- Testing
- Prenatal ultrasound examination with blood flow analysis, Umbilical cord blood gas analysis, Umbilical cord blood S100B protein level
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Institute of Mother and Child, Warsaw, Poland
Vertebrobasilar Artery Occlusion, Endovascular Treatment
Randomized Clinical Trial of Endovascular Treatment for Progressive Stroke With Vertebrobasilar Artery Occlusion
This multicenter, prospective, open-label randomized controlled trial with blinded assessment was designed to assess the efficacy and safety of endovascular treatment for progressive stroke due to vertebrobasilar artery occlusion.
- Trial name
- NCT07557485
- Testing
- Endovascular Recanalization, Medical Therapy Alone
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Feng Gao
Acute Ischemic Stroke
Study of the Effects of the Non-invasive Trigeminal Nerve Stimulation on Ischemic Stroke Patients
In patients with ischemic stroke, the primary focus revolves around enhancing the neuroprotective and rehabilitative effects of external trigeminal nerve stimulation (eTNS) and elucidating its underlying central mechanisms.
- Trial name
- NCT06540417
- Testing
- External trigeminal nerve stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xidian University
Ischemic Stroke
Superselective Citicoline and Verapamil for Ischemic Neuroprotection and Greater Effective Response
This is a phase 1, blinded-outcome, randomized, placebo controlled study to investigate the safety and feasibility of super-selective intra-arterial administration of verapamil and citicoline immediately following successful…
- Trial name
- SCAVINGER (NCT02823106)
- Testing
- Verapamil and Citicoline
- Where
- United States
- Sponsor
- Justin Fraser
Stroke, Cerebral Infarction
For Patients With Ischemic Stroke, Clinically Study the Effectiveness and Safety of Butylphthalide.
This is a prospective, open, single-arm, the real world of clinical trials. The researchers plan to recruit 300 eligible patients.
- Conditions
- Stroke, Cerebral Infarction, Brain Infarction, Brain Ischemia
- Trial name
- NCT05068349
- Testing
- Butylphthalide
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Qianfoshan Hospital
Stroke, Ischemic, Atrial Fibrillation
Atrial CMR in Patients With CVA of Unknown Source and no Known AF
This research study will investigate a new method for identifying which patients should be offered blood thinners or therapies to reverse the underlying causes after stroke.
- Trial name
- CARM-AF (NCT04555538)
- Testing
- Cardiac MRI
- Where
- 3 sites in United Kingdom
- Volunteers
- 92 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Stroke, Acute, Progressing Stroke
Safety and Efficacy of Therapeutic INduced HYPERTENSION in Acute Non-cardioembolic Ischemic Stroke (SETIN-HYPERTENSION)
The purpose of this study is to evaluate the safety and efficacy of the induced hypertension using phenylephrine in patients with noncardioembolic ischemic stroke.
- Trial name
- NCT01600235
- Testing
- Phenylephrine
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- Samsung Medical Center
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