Clinical trials: Ischemia, Brain
Acute Ischemic Stroke
Implant for Augmentation of Cerebral Blood Flow Trial, Effectiveness and Safety in a 24 Hour Window (ImpACT-24A)
The primary objective of the study is to assess the safety and effectiveness of SPG stimulation with the ISS in patients with an acute ischemic stroke in the anterior circulation initiated within 24 hours from stroke onset.
- Trial name
- ImpACT-24A (NCT03767192)
- Testing
- Active Stimulation
- Where
- 8 sites in United States, Germany and 1 more
- Volunteers
- 327 people
- Sponsor
- BrainsGate
Acute Ischemic Stroke
A Study to Evaluate the Safety and Potential Efficacy of LT3001 Drug Product in Subjects With AIS
This is a multicenter, double-blind, single-dose, randomized, and placebo-controlled prospective Phase IIa clinical study, designed to evaluate LT3001 drug product versus placebo/control in subjects with AIS.
- Trial name
- NCT04091945
- Testing
- LT3001 Drug Product
- Where
- 10 sites in United States, Taiwan
- Volunteers
- 24 people
- Sponsor
- Lumosa Therapeutics Co., Ltd.
Stroke, Ischemic
An Exploratory Study of Ganglioside GM1 in Acute Ischemic Stroke
The purpose of this study was to evaluate the efficacy and safety of higher doses of monosialoganglioside GM1 injection in the treatment of patients with acute ischemic stroke.
- Trial name
- NCT04952064
- Testing
- Monosialoganglioside GM1
- Where
- China
- Volunteers
- 300 people
- Sponsor
- General Hospital of Shenyang Military Region
Amyotrophic Lateral Sclerosis, Brainstem Stroke
Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit
This project adds to non-invasive BCIs for communication for adults with severe speech and physical impairments due to neurodegenerative diseases.
- Conditions
- Amyotrophic Lateral Sclerosis, Brainstem Stroke, Muscular Dystrophies, Parkinson's Disease and Parkinsonism
- Trial name
- BCI-FIT (NCT04468919)
- Testing
- BCI-FIT multi-modal access, BCI-FIT adaptive signal modeling, BCI-FIT active querying
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Acute Ischemic Stroke, Basilar Artery Occlusion
Efficacy and Safety of Endovascular Recanalization for Acute Basilar Artery Occlusion With Extended Time Window (ANGEL-BAO)
The aim of this study is to assess the efficacy and safety of endovascular treatment versus medical management in patients with acute basilar artery occlusion with extended time window of 24-72 hours from onset.
- Trial name
- ANGEL-BAO (NCT06101667)
- Testing
- Best medical management, Endovascular treatment
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, Thrombolytic (t-PA) Treatment
Long-Term Survival After Ischaemic Stroke: Ebrictus Study
A number of large trials have confirmed the benefits of thrombolysis in acute stroke, but there are gender differences. The authors sought to examine the relationship between sex and outcome after thrombolysis.
- Conditions
- Ischemic Stroke, Thrombolytic (t-PA) Treatment, Gender Bias, Long Term Adverse Effects
- Trial name
- EBRICTUS (NCT03247036)
- Testing
- IV thrombolytic (t-PA) treatment vs not
- Where
- Spain
- Volunteers
- 21,000 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Atherosclerosis, Cardiovascular Disease
A Study of VERVE-102 (LY4636581) in Adults With or at High Risk for Cardiovascular Disease
The purpose of this study is to measure the change in bad cholesterol (LDL-C) with VERVE-102 compared to placebo in adults who have plaque buildup in their arteries or are at high risk of developing it.
- Conditions
- Atherosclerosis, Cardiovascular Disease, Hypercholesterolemia
- Trial name
- HEART-3 (NCT07839936)
- Testing
- VERVE-102
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Verve Therapeutics, Inc.
Acute Ischemic Stroke
Evaluation of the Safety and Efficacy of Hemacord HPC, Cord Blood in Subjects With Acute Ischemic Stroke
This is a phase one study investigating the safety and efficacy profile of allogeneic cord blood hematopoietic progenitor cells (HPC, Cord Blood), when administered by intravenous infusion and intrathecal injection, in subjects…
- Trial name
- NCT03735277
- Testing
- HPC, Cord Blood
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- BHI Therapeutic Sciences
Acute Ischemic Stroke, Cerebral Stroke
Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke
Extensive research is being conducted in search of neuroprotective agents for possible use in the acute phase of stroke and agents that can be used for neurorepair in later stages of stroke.
- Trial name
- RESPECT-ETB (NCT05691244)
- Testing
- Drug: Normal Saline, Sovateltide
- Where
- 54 sites in United States, Germany and 2 more
- Volunteers
- 514 people
- Sponsor
- Pharmazz, Inc.
Acute Ischemic Stroke, Transient Ischemic Attack
The Extended CTA for the Successful Screening of Cardioaortic Thrombus in Acute Ischemic Stroke and TIA (DAYLIGHT) Trial
Embolic strokes of undetermined source (ESUS) represent a subset of cryptogenic strokes that are suspected to have an occult embolic source.
- Conditions
- Acute Ischemic Stroke, Transient Ischemic Attack, Intracardiac Thrombus
- Trial name
- DAYLIGHT (NCT05522244)
- Testing
- extended CTA
- Where
- Canada
- Volunteers
- 830 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Acute Ischemic Stroke
Evaluation of Functional Recovery of Patients With Acute Ischemic Stroke Treated by Thrombectomy
The management of cerebral infarctions (CI) is a real public health issue. The French National Authority for Health recommends Mechanical Thrombectomy (MT) either in combination with Intravenous Thrombolysis (IVT), or alone…
- Trial name
- EPIC (NCT04916782)
- Testing
- Quality of life Questionnaire
- Where
- France
- Volunteers
- 540 people
- Sponsor
- University Hospital, Montpellier
Stroke, Ischemic
DELTA (Detecting and Predicting Atrial Fibrillation in Post-Stroke Patients)
Atrial Fibrillation (AF) is an abnormal heart rhythm. Because AF is often asymptomatic, it often remains undiagnosed in the early stages. Anticoagulant therapy greatly reduces the risks of stroke in patients diagnosed with AF.
- Trial name
- NCT05795842
- Testing
- wearable wristband model, Samsung Galaxy Watch 6, Standard of care extended ECG monitoring
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Emory University
Intracerebral Hemorrhage, Ischemic Stroke
Regulating Blood Pressure During Recovery From Intracerebral Hemorrhage and Ischemic Stroke
The purpose of this research study is to determine whether blood pressure treatment regimens with spironolactone are better than blood pressure treatment regimens without spironolactone at lowering blood pressure in stroke…
- Conditions
- Intracerebral Hemorrhage, Ischemic Stroke, Spironolactone
- Trial name
- REDUCE (NCT04760717)
- Testing
- Spironolactone Pill
- Where
- 5 sites in United States
- Volunteers
- 160 people
- Sponsor
- Yale University
Stroke, Ischemic, Inflammation
MR Evidence of Cardiac Inflammation Post-Stroke
The present study is an investigator initiated, single-centre, prospective, proof-of-concept cohort study aiming to enroll 44 patients with acute middle cerebral artery (MCA) ischemic stroke, involving the right (n=22) and left…
- Conditions
- Stroke, Ischemic, Inflammation, Myocardial Injury
- Trial name
- MIRACLE (NCT05714618)
- Testing
- Gadolinium-enhanced cardiac MRI, B Natriuretic Peptide, Systemic inflammatory markers
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Luciano A. Sposato
Cadasil
CERebrolysin In CADASIL
The objective of this trial is the global risk-benefit assessment of Cerebrolysin as compared to Placebo in patients with genetically proven CADASIL.
- Trial name
- CERICA (NCT05755997)
- Testing
- Cerebrolysin, 0.9 % NaCl
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- Ever Neuro Pharma GmbH
Acute Ischemic Stroke
SY007 in Patients With Acute Ischemic Stroke
This Phase 1b multiple center, randomized, double-blind, placebo-controlled study is a dose escalation trial evaluating the safety, tolerability, PK characteristics and efficacy of SY-007 after injection in acute ischemicstroke…
- Trial name
- NCT04891913
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Suzhou Yabao Pharmaceutical R&D Co., Ltd.
Acute Ischemic Stroke
Efficacy and Safety of Home-based Structured Physical Exercise in Patients With Acute Ischemic Stroke
This study is a randomized controlled, open-label, blinded endpoint trial. The investigators aim to assess the efficacy and safety of home-based structured physical exercise in participants with acute ischemic stroke.
- Trial name
- HOPE-STROKE 2 (NCT07271082)
- Testing
- Exercise intervention
- Where
- 6 sites in China
- Volunteers
- 208 people
- Sponsor
- Capital Medical University
Stroke, Ischemic
Microcirculation and Plasticity After Stroke
Reperfusion is the main goal of early medical interventions after stroke, such as thrombolysis and thrombectomy. Recanalization works only if applied early - the earlier the better, but with a statistical cutoff of 4.5 hours…
- Trial name
- IMPreST (NCT04035746)
- Testing
- Observation of microcirculation and plasticity of the brain
- Where
- Switzerland
- Volunteers
- 49 people
- Sponsor
- University of Zurich
Ischemic Stroke
Clopidogrel Response in Acute Ischemic Stroke. The Bochumer CRISP Study
The aim of this study was to determine the prevalence rate and risk factors for chemical laboratory clopidogrel low-response (CLR) in the acute phase after an ischemic stroke.
- Trial name
- Bo-CRISP (NCT01843361)
- Where
- Germany
- Volunteers
- 159 people
- Sponsor
- Ruhr University of Bochum
Ischemic Stroke
iTBS for Acute Ischemic Stroke After Thrombectomy
The goal of this randomized, single-blind, parallel-controlled clinical trial is to evaluate the efficacy and safety of intermittent theta burst stimulation (iTBS) as an adjunctive therapy for acute anterior circulation ischemic…
- Trial name
- NCT06941961
- Testing
- intermittent theta burst stimulation
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Yi Yang
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