Clinical trials: Ischemia, Brain
Acute Ischemic Stroke
Study on Hibernation-like Therapy Based on Mechanical Thrombectomy
The goal of this clinical trial is to learn whether chlorpromazine and promethazine（C+P）is safe in Acute Ischemic Stroke（AIS) patients and determine the maximum dosage.
- Trial name
- CHILL-1 (NCT06663631)
- Testing
- chlorpromazine and promethazine, endovascular thrombectomy, rt-PA
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Capital Medical University
Surgical Complications From General Anesthesia, Hypertension
Monitoring Hypertensive Patients's Cerebral Oxygen Saturation
The purpose of this study is to determine whether there is a significant decrease in cerebral oxygen saturation in hypertensive patients undergoing major abdominal surgery and their correlation with standard monitoring parameters.
- Conditions
- Surgical Complications From General Anesthesia, Hypertension, Cerebral Ischemia, Cerebral Anoxia
- Trial name
- MHPCOS (NCT02147275)
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Huazhong University of Science and Technology
Acute Ischemic Stroke
Efficacy and Safety of Human Urinary Kallidinogenase Combined With Endovascular Therapy in Acute Ischemic Stroke With Large Vessel Occlusion
The purpose of this study is to evaluate the safety and efficacy of Human Urinary Kallidinogenase combined with endovascular therapy in acute ischemic stroke (AIS) patients with large vessel occlusion.
- Trial name
- HEAL (NCT06211712)
- Testing
- Experimental: Human Urinary Kallidinogenase
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huashan Hospital
Ischemic Stroke
A Study of Survival and Outcome After Stroke
The objective of this study is to determine the natural history of acute ischemic stroke from large vessel thromboembolism in the brain.
- Trial name
- SOS (NCT01193569)
- Where
- United Kingdom
- Volunteers
- 142 people
- Sponsor
- Penumbra Inc.
Stroke, Atrial Fibrillation
HEart and BRain Interfaces in Acute Ischemic Stroke
The primary aim of this prospective observational study is to investigate whether an enhanced diagnostic MRI work-up (including cardiac MRI, angiography of the aortic arch and the brain-supplying arteries) combined with an…
- Trial name
- HEBRAS (NCT02142413)
- Where
- Germany
- Volunteers
- 368 people
- Sponsor
- Charite University, Berlin, Germany
Stroke, Cardiovascular Diseases
MIDNOR-STROKE- a Long Term Follow-up Study of Patients With First Ever Ischemic Stroke in Central Norway
Annually 13000 Norwegians experience an ischemic stroke. The number of stroke is anticipated to increase with 50% within 2030 due to a growing number of elderly.
- Conditions
- Stroke, Cardiovascular Diseases, Cardiovascular Risk Factor, Brain Ischemia
- Trial name
- NCT03962127
- Testing
- no intervention
- Where
- 8 sites in Norway
- Volunteers
- 800 people
- Sponsor
- Norwegian University of Science and Technology
Aphasia, Broca
Effects of MTS-r on Speech Production in Non-fluent Aphasia Post-ischemic Stroke Patients
Aphasia is one of the most disabling complications in language production in patients with left hemisphere stroke. About 19% of patients who experience aphasia may have a spontaneously recovery after several weeks or months.
- Trial name
- Aphasia-ACV (NCT02241213)
- Testing
- Transcranial Magnetic Stimulation (TMS-r)
- Where
- Colombia
- Volunteers
- 100 people
- Sponsor
- Fundación Cardiovascular de Colombia
Stroke
Neuroprotection With Statin Therapy for Acute Recovery Trial (Neu-START)
The purpose of this dose escalation study is to evaluate the use of lovastatin for the treatment of acute ischemic stroke.
- Trial name
- Neu-START (NCT00243880)
- Testing
- lovastatin
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Columbia University
Stroke, Stroke, Ischemic
Individual Patient Expanded Access IND for the Treatment of Stroke
This protocol is part of an Individual Patient Expanded Access IND. The patient is an 84-year-old male with history of Ischemic Stroke of the Left Middle Cerebral Artery causing an acute posterior left frontal cortical infarct…
- Trial name
- NCT04907188
- Testing
- HB-adMSCs
- Where
- United States
- Sponsor
- Hope Biosciences Research Foundation
Acute Ischemic Stroke
Outcome in Patients Treated With Endovascular Thrombectomy - optIMAL Blood Pressure Control 2 (OPTIMAL-BP 2)
Though intravenous thrombolysis has been shown to improve symptoms in acute ischemic stroke patients, the recanalization rate remains low (22.6%) and only around 30% of patients benefit from the treatment.
- Trial name
- NCT06677970
- Testing
- BP lowering drugs (nicardipine, labetalol, urapidil), BP raising drug (phenylephrine) or BP lowering drugs (nicardipine, labetalol, urapidil)
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Yonsei University
Cryptogenic Stroke, Atrial Fibrillation
Early Detection of Atrial Fibrillation Using Mobile Technology in Cryptogenic Stroke Patients
The purpose of this study is to demonstrate the added value of mobile health (mHealth) to detect atrial fibrillation (AF) early in the care path of cryptogenic stroke and transient ischemic attack (TIA) patients.
- Trial name
- REMOTE (NCT05006105)
- Testing
- seven-day ECG Holter, 24-hour blood pressure monitor, Questionnaire: vision of mHealth
- Where
- 2 sites in Belgium
- Volunteers
- 225 people
- Sponsor
- Ziekenhuis Oost-Limburg
Ischemic Stroke
Effects of Intravascular Laser Irradiation of Blood for Mitochondral Dysfunction in Cerebral Ischemic Stroke
Background : This research is designed through randomization, control, and double-blind trial to explore the clinical effectiveness of intravenous laser irradiation of blood for ischemic stroke patient; The research will further…
- Trial name
- NCT06932627
- Testing
- ILIB
- Where
- Taiwan
- Volunteers
- 8 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Thrombosis, Atherothrombosis
In-vivo Thrombus Imaging With 18F-GP1, a Novel Platelet PET Radiotracer
To date, the investigators have successfully employed a radiotracer (18F-sodium fluoride) as a marker of necrotic inflammation in human atherosclerosis.
- Conditions
- Thrombosis, Atherothrombosis, Myocardial Infarction, STEMI
- Trial name
- iThrombus (NCT03943966)
- Testing
- 18F-GP1 PET CT
- Where
- United Kingdom
- Volunteers
- 73 people
- Sponsor
- University of Edinburgh
Myocardial Infarction, Cerebral Infarction
Acute Myocardial Infarction and Acute Cerebral Infarction (AMIAC) Registry and Follow-up
A registry of consecutive patients who were admitted and diagnosed with acute myocardial infarction or acute cerebral infarction were conducted at the Guangdong General Hospital or the First Affiliated Hospital of Guangzhou…
- Conditions
- Myocardial Infarction, Cerebral Infarction, Chronic Kidney Diseases, Mortality
- Trial name
- AMIAC (NCT03166696)
- Where
- 3 sites in China
- Volunteers
- 30,000 people
- Sponsor
- Guangdong Provincial People's Hospital
Ischemic Stroke
The Impact of Electroacupuncture Combined With NGF on Clinical Effect and Functional Changes on Ischemic Stroke
Ischemic stroke is a common clinical disease, often accompanied by motor dysfunction and cognitive impairment. At present, clinical treatment for patients with ischemic stroke recovery is limited and ineffective.
- Trial name
- NCT05231694
- Testing
- Nerver growth factor (NGF) injection, EA intervention
- Where
- China
- Volunteers
- 288 people
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Transient Ischemic Attack, Stroke
Fast Assessment of Stroke and Transient Ischemic Attack to Prevent Early Recurrence (FASTER)
Current management of patients with TIA (transient ischemic attack) or minor stroke includes the prompt investigation and treatment in the days and weeks after the event.
- Trial name
- NCT00109382
- Testing
- Aspirin, Clopidogrel, Simvastatin
- Where
- 18 sites in United States, Canada
- Volunteers
- 500 people
- Sponsor
- University of Calgary
Infarction, Middle Cerebral Artery, Middle Cerebral Artery Stroke
Multicenter Efficacy Study of Recombinant Human Erythropoietin in Acute Ischemic Stroke
The purpose of this randomized, double-blind, placebo-controlled multicenter study is to determine in a cohort of 506 patients with acute ischemic stroke in the middle cerebral artery territory, the effect of a three-day…
- Conditions
- Infarction, Middle Cerebral Artery, Middle Cerebral Artery Stroke, Stroke, Acute
- Trial name
- ESS (NCT00604630)
- Testing
- recombinant human erythropoietin alfa, 0.9% NaCl
- Where
- 9 sites in Germany
- Volunteers
- 522 people
- Sponsor
- Max-Planck-Institute of Experimental Medicine
Acute Ischemic Stroke
Albumin for Patients With Acute Large Vessel Occlusive Stroke Undergoing Endovascular Reperfusion Therapy
The objective of this study is to evaluate the effectiveness and safety of endovascular therapy combined with 25% human albumin in the treatment of acute large vessel occlusive stroke.
- Trial name
- NCT06538844
- Testing
- Intravenous infusion of human albumin, Saline
- Where
- 8 sites in China
- Volunteers
- 134 people
- Sponsor
- Capital Medical University
Hypertension, Coronary Disease
Analyzing How Genetics May Affect Response to High Blood Pressure Medications
High blood pressure is one of the most common health problems in the United States. There are many medications to treat high blood pressure, but there is a large variance in how people respond to these medications.
- Conditions
- Hypertension, Coronary Disease, Cerebrovascular Accident
- Trial name
- NCT00563901
- Where
- 2 sites in United States
- Volunteers
- 37,939 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Infarction
Space Flap for Cerebral Protection Following Decompressive Hemicraniectomy for Stroke
In this study the investigators want to investigate to what extent the application of an artificial bone flape (space flap) influences the success of a decompressive craniectomy.
- Trial name
- NCT04865757
- Testing
- Space Flap
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
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