Clinical trials: Ischemia, Myocardial
Coronary Artery Disease, Coronary Artery Bypass Grafting
TOP-CABG Trial: Follow-up Extension (TOP-CABG FE)
To further evaluate the long-term effects of the two antiplatelet strategies on saphenous vein graft patency, long-term adverse cardiovascular events, and bleeding events after coronary artery bypass grafting (CABG), we plan to…
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Grafting, Dual Antiplatelet Therapy, Bleeding
- Trial name
- NCT07871591
- Volunteers
- 2,290 people
- Sponsor
- China National Center for Cardiovascular Diseases
Chest Pain, Acute Coronary Syndrome
Improving the Accuracy of Referrals of Patients With Chest Pain
This is a multicenter, prospective, investigator-initiated, randomized controlled trial aiming to reduce the percentage of non-cardiac chest pain (NCCP) patients admitted to the cardiac emergency department (ED) by performing the…
- Conditions
- Chest Pain, Acute Coronary Syndrome, Myocardial Infarction, Myocardial Ischemia
- Trial name
- URGENT2 (NCT04904107)
- Testing
- modified HEART score (including POC hs cTnI analysis), Standard care and triage according to the local (EMT)protocol.
- Where
- 2 sites in Netherlands
- Volunteers
- 852 people
- Sponsor
- VieCuri Medical Centre
Myocardial Infarction, Myocardial Ischemia
Does OCT Optimise Results of Stenting on the Left Main Stem
The DOCTORS-LM study will investigate the impact of using optical coherence tomography (OCT) to guide the procedure in angioplasty of lesions of the left main stem responsible for myocardial ischemia.
- Conditions
- Myocardial Infarction, Myocardial Ischemia, Non ST Segment Elevation Myocardial Infarction
- Trial name
- DOCTORS-LM (NCT04391413)
- Testing
- Use of OCT to guide the angioplasty procedure
- Where
- 12 sites in France
- Volunteers
- 197 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Coronary Artery Disease, Ischemic Heart Disease (IHD)
Gangwon PCI Prospective Registry
This prospective, multicenter registry will consecutively enroll patients of all ages undergoing percutaneous coronary intervention (PCI) at four university hospitals in Gangwon Province, Republic of Korea.
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease (IHD), Unstable Angina (UA), Non-ST Elevated Myocardial Infarction
- Trial name
- GWPCI (NCT02038127)
- Testing
- Percutaneous Coronary Intervention (PCI)
- Where
- 4 sites in South Korea
- Volunteers
- 10,000 people
- Sponsor
- Yonsei University
Ischemic Heart Disease, Ischemic Heart Disease Chronic
DAN-RELEASE - Reconsidering Long-Term Aspirin in the Elderly Patients With Stable Ischemic Heart Disease
DAN-RELEASE is a national, randomized, registry-based trial including 7,000 participants in Denmark. The trial aims to determine whether discontinuation of long-term aspirin therapy is non-inferior to continued aspirin therapy in…
- Conditions
- Ischemic Heart Disease, Ischemic Heart Disease Chronic, Chronic Coronary Syndrome, Myocardial Infarction
- Trial name
- DAN-RELEASE (NCT07795398)
- Testing
- Continuation of daily low-dose Aspirin, Discontinuation of daily low-dose Aspirin
- Where
- 2 sites in Denmark
- Volunteers
- 7,000 people
- Sponsor
- Odense University Hospital
Myocardial Infarction, Myocardial Ischemia
Time for a Diagnostic Paradigm Shift From STEMI/NSTEMI to OMI/NOMI
The investigators hypothesize that occlusion myocardial infarction(MI)/non-occlusion MI approach to MI treatment will better predict acute coronary occlusion on coronary angiography, better limit infarct size, better preserve…
- Conditions
- Myocardial Infarction, Myocardial Ischemia, Acute Coronary Syndrome, Diagnosis
- Trial name
- DIFOCCULT-3 (NCT06570759)
- Testing
- Early intervention for OMI, Standard early intervention for STEMI, Standard delayed intervention for NSTEMI
- Where
- 18 sites in Turkey (Türkiye)
- Volunteers
- 6,000 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Perioperative Myocardial Injury
Incidence and Outcome of Perioperative Myocardial Injury After Non-cardiac Surgery
This observational study includes patients undergoing major non-cardiac surgery, and screens them for the occurrence of perioperative myocardial injuries (PMI).
- Trial name
- BASEL-PMI (NCT02573532)
- Where
- Switzerland
- Volunteers
- 19,645 people
- Sponsor
- University Hospital, Basel, Switzerland
Myocardial Ischemia, Heart Defects, Congenital
Spectroscopic Assessment of Myocardial Oxygenation Changes in Pediatric Heart Surgery
The goal of this observational study is to investigate the ability of the SpectroCor Tissue Oxygenation Monitor and its accessory SpectroCor Sensor to observe and monitor changes in cardiac oxygen availability in pediatric…
- Conditions
- Myocardial Ischemia, Heart Defects, Congenital, Reperfusion Injury, Myocardial
- Trial name
- NCT07785141
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Spectrocor
Hypertension, Stroke
A Cluster-Randomized Controlled Trial
The goal of this study is to learn if an AI-generated personalized health report combined with face-to-face guidance from cardiologists can help rural adults with high blood pressure control their blood pressure better and reduce…
- Conditions
- Hypertension, Stroke, Cardiovascular, Coronary Heart Disease
- Trial name
- NCT07845448
- Testing
- AI-powered personalized health report with cardiologist consultation and prescription optimization, Integrated management (follow-up, education, quality control) without AI report and cardiologist consultation
- Volunteers
- 14,400 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Angina Pectoris, Myocardial Ischemia
Self Expanding Coronary Sinus Reducer for Treatment of Symptomatic Coronary Microvascular Dysfunction (CMD)
VahatiCor's Coronary Sinus Reducer (A-FLUX) has been designed to improve angina or angina-like symptoms in patients with CMD. SERRA-I is an early feasibility study that evaluates the safety and clinical performance of the A-FLUX…
- Conditions
- Angina Pectoris, Myocardial Ischemia, Heart Diseases, Cardiovascular Diseases
- Trial name
- SERRA-I US (NCT07449325)
- Testing
- A-FLUX Reducer System
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- VahatiCor, Inc.
Ischemic Heart Diseases
AI-enhanced Heart MRI for Evaluating Blood Flow
This study will compare the standard MRI protocol with an advanced MRI protocol for the assessment of ischemic heart disease. The goal is to evaluate whether the advanced protocol provides comparable or improved diagnostic…
- Trial name
- NCT07833774
- Testing
- Accelerated advanced MRI sequences protocol
- Volunteers
- 300 people
- Sponsor
- IRCCS San Raffaele
ST Elevation Myocardial Infarction
Study of Efficacy and Safety of GNR-060 vs Metalyse in Patients With ST Elevation Myocardial Infarction
GNR-060(JSC "GENERIUM", Russia) is a proposed biosimilar to the referent product Metalyse. This study is to compare the clinical efficacy and safety of GNR-060 vs Metalyse as a thrombolitic agent in patients with with ST…
- Trial name
- NCT05601999
- Testing
- GNR-060, Metalyse
- Where
- 11 sites in Russia
- Volunteers
- 244 people
- Sponsor
- AO GENERIUM
Computed Tomography Angiography, Coronary Artery Disease
Randomized Prospective Trial on the Cost-Effectiveness of Photon-Counting CT Versus Energy-Integrating Detector CT in Suspected Chronic Coronary Syndrome
Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Coronary computed tomography angiography (CCTA) is recommended as a first-line imaging test in patients with suspected obstructive CAD.
- Trial name
- COST-PCCT-CCS (NCT07831304)
- Testing
- Radomization to undergo CCTA with EID-CT, Randomization to undergo CCTA with PCD-CT
- Where
- Italy
- Volunteers
- 630 people
- Sponsor
- IRCCS San Raffaele
Coronary Artery Disease, Ischemic Heart Disease (IHD)
Prognostic Value of Hyperpolarized 13C MRI for Clinical Myocardial Viability
Heart failure due to coronary artery disease represents a significant cause of mortality. The detection of patients eligible for bypass surgery is a pivotal concern.
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease (IHD), Myocardial Viability
- Trial name
- NCT06047028
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Coronary Artery Disease, Ischemic Heart Disease
LONG NAGOMI™ PMCF STUDY
The study is designed as a prospective, multi-center, observational PMCF (post-market clinical follow-up) study of the Ultimaster Nagomi™ _stent (lengths of 38, 44 and 50 mm) in the treatment of coronary artery disease according…
- Trial name
- LONG NAGOMI (NCT07399002)
- Testing
- LONG NAGOMI
- Where
- 10 sites in Spain
- Volunteers
- 1,039 people
- Sponsor
- Fundación EPIC
4-electrode Tablet-based Electrocardiogram (ECG) System, Electrical Activity of the Heart
4-electrode ECG (DigitalCardio®) vs Standard 10-electrode ECG: Evaluating Ease of Use and Recording Quality
The goal of this clinical trial is to compare the time required to record a complete Electrocardiogram (ECG) trace using the DigitalCardio (CardioSecur®) tablet device versus a standard 12-lead ECG device in eligible patients.
- Conditions
- 4-electrode Tablet-based Electrocardiogram (ECG) System, Electrical Activity of the Heart, Atrial or Ventricular Arrhythmias, Intracardiac Conduction Abnormalities
- Trial name
- FAST-ECG (NCT07732283)
- Testing
- standard 10-electrode ECG acquisition, 4-electrode DigitalCardio acquisition
- Where
- 2 sites in France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Clinique Bizet
Ischemic Heart Disease, Coronary Artery Disease
Controlled Trial of High-risk Coronary Intervention With Percutaneous Left Ventricular Unloading
Over 100,000 coronary stent procedures, where small balloons are used to stretch open a narrowed blood vessel, are performed every year in the United Kingdom to treat people who have conditions such as angina or have suffered a…
- Trial name
- CHIP-BCIS3 (NCT05003817)
- Testing
- Percutaneous left ventricular unloading
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Ischemic Heart Disease, Coronary Artery Disease
Electronic Letters to Improve Patient Activation in IHD: The NUDGE-IHD Trial
The goal of this clinical trial is to learn whether simple electronic information letters can increase patient activation and improve risk-factor monitoring in adults in Denmark with ischemic heart disease (IHD) who have LDL…
- Conditions
- Ischemic Heart Disease, Coronary Artery Disease, Hypercholesterolemia, Lipoprotein(a)
- Trial name
- NUDGE-IHD (NCT07382414)
- Testing
- LDL-C information letter, Lp(a) information letter
- Where
- Denmark
- Volunteers
- 123,000 people
- Sponsor
- Tor Biering-Sørensen
Ventricular Tachycardia (VT)
Safety and Performance Assessment of the Sphere-9™ Catheter and Affera™ Ablation System for the Treatment of Ventricular Tachycardia (Sphere-9 VT EFS)
Sphere-9 VT EFS is a prospective, multi-center, non-randomized, unblinded feasibility study. Adult subjects with recurrent, sustained, scar-related monomorphic ventricular tachycardia will be enrolled and treated with the…
- Trial name
- NCT06703489
- Testing
- Sphere-9 Catheter with the Affera Mapping and Ablation System
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Ventricular Tachycardia, Ischemic Heart Disease
Pulsed Field Ablation for Post-Infarction Ventricular Tachycardia
ASCEND is a randomized controlled open-label pilot study evaluating the safety and effectiveness of pulsed field ablation (PFA) with the novel FARAPOINT catheter compared to the standard radiofrequency (RFA) ablation with…
- Conditions
- Ventricular Tachycardia, Ischemic Heart Disease, Sustained VT
- Trial name
- ASCEND-VT (NCT06891456)
- Testing
- RFA Ablation, PFA Ablation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Pasquale Santangeli