Clinical trials: Ischemia, Myocardial
Coronary Artery Disease
Prognostic Assessment of Contrast Echocardiography (PACE Study)
This study will demonstrate whether patients with prognostically-significant myocardial abnormalities detected with AI-700 contrast ECHO have a rate of cardiac death or MI that is higher than that of patients with normal AI-700…
- Trial name
- PACE (NCT00670332)
- Where
- United States
- Volunteers
- 773 people
- Sponsor
- Acusphere
Myocardial Infarction, Myocardial Injury
Distribution of Highly Sensitive Troponin in the Critically Unwell & Associated Mortality
The current diagnostic criteria for a heart attack require evaluation of a patient's symptoms and ECG but importantly a blood test called troponin.
- Trial name
- DIGNITY (NCT03630237)
- Where
- United Kingdom
- Volunteers
- 1,500 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Coronary Artery Disease
Role of CYP2C19 Polymorphism in the Drug Interaction Between Clopidogrel and Omeprazole
Clopidogrel, an inhibitor of ADP induced platelet aggregation and activation, is one of the most commonly used drugs in patients with cardiovascular disease.
- Trial name
- NCT01094275
- Testing
- Clopidogrel 75mg, Omeprazole 20mg
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Neil Kleiman, MD
Acute Myocardial Infarction (AMI), Acute Myocardial Infarction of Anterior Wall
Recombinant Human Thymosin Beta 4 for Injection(NL005) for Acute Myocardial Infarction
The goal of this phase IIc clinical trial is to learn if recombinant human thymosin beta 4 injection (NL005) works to treat heart damage in people who have had a serious type of heart attack called ST-segment elevation myocardial…
- Conditions
- Acute Myocardial Infarction (AMI), Acute Myocardial Infarction of Anterior Wall, Acute Myocardial Infarction With ST Elevation, Acute Myocardial Infarction of Left Ventricle
- Trial name
- NCT07586865
- Testing
- Recombinant Human Thymosin Beta 4 Injection (NL005)
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Beijing Northland Biotech. Co., Ltd.
Coronary Artery Disease
Objective Confirmation of thе Anti-ischemic Effectiveness of Trimetazidine 80mg Once Daily in Patients With Stable Angina Who Had a History of Myocardial Infarction (METHOD)
METHOD is a prospective observational program that will be conducted in 1centre of the Russian Federation. Prospective follow-up will be for about 6 months.
- Trial name
- METHOD (NCT05210465)
- Testing
- speckle tracking mode of the stress ECHO test with dobutamine
- Where
- 2 sites in Russia
- Volunteers
- 36 people
- Sponsor
- Servier Russia
Heart Transplant Failure and Rejection, Coronary Artery Disease
Percutaneous Coronary Intervention in Patients witH OrthotoPic hEart Transplantation: the PCI-HOPE a Multicenter Study.
This is a retrospective, multicenter, study including patients undergone to one or more percutaneous revascularization after OHT.
- Trial name
- PCI-HOPE (NCT03538509)
- Testing
- PCI and implantation drug eluting stent or bare metal stent
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fabrizio D'Ascenzo
Coronary Artery Disease, Atrial Fibrillation
TEmporary Spinal CoRd StiMulatIon to PrevenNt Atrial FibrillaTION AFter Cardiac Surgery
To compare of atrial arrhythmia incidence in patients with coronary artery disease and atrial fibrillation history, undergoing either coronary artery bypass grafting plus temporary spinal cord stimulation or coronary artery…
- Trial name
- TerminationAF (NCT03539354)
- Testing
- Temporary spinal cord stimulation, Coronary artery bypass grafting, B-blockers
- Where
- 2 sites in Russia
- Volunteers
- 60 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Myocardial Infarction
Early Versus Late Loading of Ticagrelol in Patients With STEMI
Current guidelines recommend percutaneous coronary intervention (PCI) for most patients with ST segment elevation acute myocardial infarction (STEMI) or with non ST segment elevation acute coronary syndrome (NSTEACS) .
- Trial name
- NCT04267224
- Testing
- Ticagrelor 90mg
- Volunteers
- 800 people
- Sponsor
- Assiut University
Acute Myocardial Infarction, Stable Angina
Development and Efficacy Evaluation of Integrated Chronic Care and Health Promotion Model for Patients With Coronary Artery Disease in Taiwan
The hypothesis of this project is to examine whether the integrated health care program as the intervention group can reduce the recurrence and mortality of coronary artery-related diseases than the traditional one as the…
- Trial name
- NCT01357096
- Testing
- Integrated health care team, Traditional group
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Coronary Artery Disease, Optical Coherence Tomography
Korea University Anam Hospital Optical Coherence Tomography Registry
All comer registry who had undergone intravascular optical coherence tomography during and/or after coronary intervention.
- Trial name
- NCT02966262
- Testing
- Optical coherence tomography
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Korea University Anam Hospital
Acute Coronary Syndrome, Angina Pectoris
Diagnostic Performance of Artificial Intelligence Algorithms in Prediction of Acute Coronary Syndrome Based on White Blood Cell Properties
The goal of this observational study is to evaluate whether artificial intelligence (AI) algorithms can predict or exclude acute coronary syndrome (ACS) in adults using data generated by routine hematology testing.
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, NSTEMI - Non-ST Segment Elevation MI, STEMI - ST Elevation Myocardial Infarction
- Trial name
- NCT06384846
- Where
- Austria
- Volunteers
- 3,350 people, healthy volunteers welcome
- Sponsor
- RobotDreams GmbH
Acute Coronary Syndrome, Culprit Plaque
OCT-Features in Culprit and Not Culprit Coronary Plaque in ACS Patients
The OCT-FORMIDABLE register will include with a retrospective fashion all consecutive patients that perform OCT on culprit and not culprit plaque in any subset in patients with ACS.
- Conditions
- Acute Coronary Syndrome, Culprit Plaque, Non Culprit Plaque
- Trial name
- OCT-FORMIDABLE (NCT02486861)
- Testing
- optical coherence tomography
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques
Ticin Pilot Study: Sirolimus-Eluting Balloon for Stabilization and Regression of Non-Obstructive Coronary Plaques.
The goal of this pilot clinical trial is to evaluate the use of the Selution SLR sirolimus-eluting balloon, in addition to guideline-directed medical therapy (GDMT), for the preventive treatment of non-flow-limiting vulnerable…
- Conditions
- Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques, Multivessel Coronary Artery Disease, Coronary Vessel
- Trial name
- NCT06928883
- Testing
- Sirolimus drug eluting ballooon therapy, Optimal guidelines-directed medical therapies (GDMT)
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Cardiocentro Ticino
Ischemic Heart Disease
Improving Wellbeing in Ischemic Heart Disease
The purpose of this research is to see if Heart Health Yoga (HHY) Program when added on to standard cardiac rehabilitation (CR) will improve overall wellbeing and quality of life for patients experiencing ischemic heart disease…
- Trial name
- NCT04974541
- Testing
- Heart Health Yoga, Psychosocial education
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Mayo Clinic
Cardiac Valve Disease, Coronary Artery Disease
Telehealth Interventions for Cardiac Surgery
The goal of this clinical trial is to compare telehealth monitoring at home against usual care in patients undergoing planned heart surgery. The main questions it aims to answer are: 1.
- Conditions
- Cardiac Valve Disease, Coronary Artery Disease, Surgical Complication
- Trial name
- TICS (NCT05621954)
- Testing
- Telehealth Monitoring
- Where
- United Kingdom
- Volunteers
- 318 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
ST Elevated Myocardial Infarction
Neutrophil/Lymphocyte (N/L) Ratio and Long Term Follow-up in ST-elevation Myocardial Infarction
Although the pre-procedural neutrophil to lymphocyte ratio (N/L) has been associated with adverse outcomes among patients with coronary artery disease, its role during the acute phase of ST-segment elevation myocardial infarction…
- Trial name
- NCT01663194
- Testing
- primary percutaneous coronary intervention, each groups
- Where
- Turkey (Türkiye)
- Volunteers
- 1,034 people
- Sponsor
- TC Erciyes University
Coronary Arteriosclerosis, Myocardial Infarction
Culturally-Tailored Approach to Improve Medication Use in Patients With Heart Attacks
Our research aims to improve the use of medicines known to prevent recurrent heart attacks. In particular, we know that statin treatment is useful after heart attacks, but many patients do not use it.
- Trial name
- NCT00426231
- Testing
- Navigation by a health worker, Information control
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Johns Hopkins University
Acute Coronary Syndrome, Cardiac Rehabilitation
Outpatient Cardiac Tele-Rehabilitation in a Public Sports Center
The aim of this study is to establish an innovative Cardiac Tele-Rehabilitation (CTR) model. It could expands assistance resources through coordination with public administrations, developing a physical exercise program (PEP)…
- Conditions
- Acute Coronary Syndrome, Cardiac Rehabilitation, Telerehabilitation, Secondary Prevention
- Trial name
- NCT04121702
- Testing
- Cardiac Rehabilitation
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Juan Izquierdo García
Platelet Reactivity
High (100mg) Versus Standard (60mg) Loading Dose of Prasugrel in Patients With ST-elevation Myocardial Infarction (STEMI), Undergoing Primary Percutaneous Coronary Intervention (PCI)
This is a prospective, multi-center, non-randomized, controlled study in 2 sequential groups of P2Y12 inhibitor-naive consecutive STEMI patients undergoing primary PCI.
- Trial name
- NCT01835353
- Testing
- Prasugrel 100mg loading dose, Prasugrel 60mg loading dose
- Where
- Greece
- Volunteers
- 82 people
- Sponsor
- University of Patras
Coronary Heart Disease, Myocardial Infarction
Prospective Coronary Heart Disease Cohort
To evaluate the biomarkers for the prognosis of coronary heart disease, patients with coronary heart disease will be recruited and followed up for at least 2 years.
- Trial name
- NCT05699629
- Where
- China
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Shandong First Medical University
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