Clinical trials: Ischemia, Myocardial
Myocardial Infarction
Pattern of Repeat Cardiovascular Events During Follow-up After First Diagnosed Event-MI
Recurrent myocardial infarctions (reinfarctions) can be due to recurrence at the original treatment site, the presence of untreated lesions elsewhere, or in progressive lesions.
- Trial name
- PRECLUDE-MI (NCT03099395)
- Volunteers
- 100,000 people
- Sponsor
- Uppsala University
Atherosclerotic Vascular Disease
Colchicine in Vascular Inflammation Assessed With PET Imaging
The purpose of this trial is to assess the effects of colchicine on vascular inflammation measured by (FDG)-PET imaging in patients with atherosclerotic vascular disease.
- Trial name
- COLPET (NCT02162303)
- Testing
- Colchicine
- Where
- Canada
- Volunteers
- 106 people
- Sponsor
- Montreal Heart Institute
Myocardial Infarction
Remote Ischemic Preconditioning Combined to Local Ischemic Postconditioning in Acute Myocardial Infarction
RIRE-1 is a randomized, open-label with blinded end-point study that will test the hypothesis that remote ischemic preconditioning initiated at the time of the admission in the cathlab reduces infarct size in ST-segment elevation…
- Trial name
- RIRE-1 (NCT01390142)
- Testing
- Control, RIPer, RIPer + IPost
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Angers
Chronic Heart Failure, Coronary Disease
Role of Endothelial Function, Muscular Fitness and Metabolism in Functional Activity in Patients With Chronic Heart Failure (CHF)
Shortness of breath, fatigue, and exercise intolerance are clinical symptoms of chronic heart failure (CHF). Recent studies suggested that peripheral impairment was the major cause of clinical symptoms, and mechanism may be…
- Conditions
- Chronic Heart Failure, Coronary Disease, Dilated Cardiomyopathy
- Trial name
- NCT01139086
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Coronary Artery Disease
Intravascular Optical Coherence Tomography Imaging - Length of Anti-Platelet Therapy After Drug Eluting Stent Placement
Patients who receive drug-coated stents (as opposed to the less frequently used bare metal stents) are currently recommended aspirin plus a thienopyridine such as Plavix, Effient, or Ticlid for one year.
- Trial name
- FDI-DAPT-ZES (NCT01219894)
- Sponsor
- Emory University
Spinal Cord Injury
Cardiovascular Disease Study
Coronary heart disease (CHD) is a leading cause of death in the spinal cord injured (SCI) population, occurring at younger ages than in the able-bodied population.
- Trial name
- NCT00857194
- Testing
- 2 hour Oral Glucose Tolerance Test, Fat Meal Test
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- VA Office of Research and Development
STEMI, Cardiovascular Disease
Vascular Healing After Implantation of FANTOM Bioresorbable Scaffold in STEMI: A FANTOM STEMI Study
The study will assess the safety and performance of the Fantom sirolimus eluting bioresorbable vascular scaffold (BVS) in the acute setting of myocardial infarction with unstable lesions and thrombogenic milieu.This is a…
- Conditions
- STEMI, Cardiovascular Disease, Bioresorbable Scaffold
- Trial name
- FANTOM STEMI (NCT03785431)
- Testing
- PCI with Phantom Bioresorbable Scaffold
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Medical University of Warsaw
Chronic Ischemic Cardiomyopathy, Coronary Artery Bypass Surgery
Human Umbilical Cord Stroma MSC in Myocardial Infarction
The purpose of this phase 1/2 clinical trial is to evaluate the efficacy and safety of allogeneic human umbilical cordstroma derived multipotent stem cells (hUCS-MSCs) in myocardial infarction (MI).
- Trial name
- HUC-HEART (NCT02323477)
- Testing
- stem cell transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Ankara University
Ischemic Heart Disease, Stenotic Coronary Lesion
RESOLUTE ONYX China RCT Study
It is a randomized controlled trial to evaluate the safety and efficacy of the Medtronic Resolute Onyx™ Zotarolimus-Eluting Coronary Stent System in comparison with the Medtronic Resolute Integrity™ Zotarolimus-Eluting coronary…
- Conditions
- Ischemic Heart Disease, Stenotic Coronary Lesion, Cardiovascular Diseases, Arteriosclerosis
- Trial name
- NCT03466151
- Testing
- Resolute Onyx™ Zotarolimus-Eluting Coronary Stent System, Resolute Integrity™ Zotarolimus-Eluting Coronary Stent System
- Where
- 2 sites in China
- Volunteers
- 550 people
- Sponsor
- Medtronic Vascular
Unstable Angina
Ischemia Driven Enoxaparin Therapy in ACS Presenting as Low Risk (IDEAL)
The purpose of this study is to determine whether enoxaparin (an anticoagulant) is effective in the treatment of patients presenting to the emergency room with chest pain and no electrocardiogram or bloodwork evidence of a heart…
- Trial name
- IDEAL (NCT00518245)
- Testing
- enoxaparin
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- Canadian Heart Research Centre
Coronary Artery Disease (CAD)
Comparison of Orbital Versus Rotational Atherectomy Effects On Coronary Microcirculation in PCI
The investigators hypothesize that the orbital atherectomy system (OAS), a newer generation atherectomy device, reduces the incidence of microcirculatory compromise as compared to older generation rotational atherectomy (RA) due…
- Trial name
- ORACLE (NCT03021577)
- Testing
- Orbital Atherectomy System (OAS), Rotablator Rotational Atherectomy System, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Columbia University
Coronary Artery Disease (CAD)
Prognostic Value of High Dose Dobutamine Stress Magnetic Resonance Imaging
High-dose dobutamine/atropine stress cardiac magnetic resonance imaging (DS-MRI) has been incorporated in daily clinical practice for the detection of ischemic heart disease.
- Trial name
- DS-Prognosis (NCT00837005)
- Where
- Germany
- Volunteers
- 2,500 people
- Sponsor
- Heidelberg University
Stem Cell Transplantation, Ventricular Dysfunction, Left
The Transendocardial Autologous Cells (hMSC or hBMC) in Ischemic Heart Failure Trial (TAC-HFT)
The technique of transplanting progenitor cells into a region of damaged myocardium, termed cellular cardiomyoplasty, is a potentially new therapeutic modality designed to replace or repair necrotic, scarred, or dysfunctional…
- Trial name
- TAC-HFT (NCT00768066)
- Testing
- Autologous human mesenchymal cells (hMSCs), Autologous human bone marrow cells (hBMCs)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Miami
Cardiovascular Disease, Coronary Artery Disease
Italian Registry on Unprotected Left Main
The RITMO (Registro Italiano sul trattamento del Tronco coMune non protettO) observational study will appraise the prevalence, management strategy, and prognosis of unprotected left main coronary artery disease in Italy.
- Trial name
- RITMO (NCT00612053)
- Where
- Italy
- Volunteers
- 1,200 people
- Sponsor
- University of Turin, Italy
Type 2 Diabetes Mellitus, Coronary Artery Disease
DARE: Diabetes in cArdiac REhabilitation
The aim of the DARE study is to see whether strict glycemic control during cardiac rehabilitation may ameliorate the improvement of exercise capacities (VO2 peak, peak workload, ventilatory threshold)in patients with type 2…
- Trial name
- NCT00354237
- Testing
- Conventional antidiabetic treatment, Intensive insulin treatment
- Where
- 12 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Coronary Artery Disease
Global Pretest Probability Study of Coronary Artery Disease
The use of pre-test probability (PTP) and coronary artery calcium (CAC) scores is guideline-recommended in the evaluation of coronary artery disease (CAD) and stable chest pain.
- Trial name
- GPS-CAD (NCT05722145)
- Where
- Singapore
- Volunteers
- 100,000 people
- Sponsor
- National Heart Centre Singapore
Cerebrovascular Accident, Chronic Obstructive Pulmonary Disease
Tocilizumab for the Treatment of Cytokine Release Syndrome in Patients With COVID-19 (SARS-CoV-2 Infection)
This phase III trial compares the effect of adding tocilizumab to standard of care versus standard of care alone in treating cytokine release syndrome (CRS) in patients with SARS-CoV-2 infection.
- Conditions
- Cerebrovascular Accident, Chronic Obstructive Pulmonary Disease, Chronic Renal Failure, Coronary Artery Disease
- Trial name
- NCT04361552
- Testing
- Best Practice, Tocilizumab
- Where
- United States
- Sponsor
- Emory University
Cardiogenic Shock Acute, Bypass, Cardiopulmonary
Prognosis of Patients With Mixed Cardiogenic-Vasoplegic Shock
Mixed cardiogenic-vasoplegic shock (M-CS) represents a distinct and severe phenotype of cardiogenic shock characterized by concomitant myocardial dysfunction and inappropriate systemic vasodilation.
- Conditions
- Cardiogenic Shock Acute, Bypass, Cardiopulmonary, Septic Shock, Mechanical Circulatory Support
- Trial name
- PROMIX (NCT07354568)
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Normal and Abnormal Cardiovascular Physiology
Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging
Background: Magnetic resonance imaging (MRI) is an important non-invasive tool to study and diagnose cardiovascular disease. MRI scanners use strong magnetic fields and radio waves to create pictures of body organs.
- Trial name
- NCT03581318
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute STEMI, Primary Percutaneous Coronary Arterial Intervention
Dose Reducing Door-to-balloon Time in ST-elevation Myocardial Infarction Cause Less Cost?
The investigators tried to determined whether the less D2B time led to costs savings benefited insurance payer and better outcomes to patients.
- Trial name
- NCT01545206
- Where
- Taiwan
- Volunteers
- 215 people
- Sponsor
- Far Eastern Memorial Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.