Clinical trials: Ischemia, Myocardial
Coronary Artery Disease
Impact of Coronary Images Used During Patient Education on Coronary Artery Disease and Subsequent Lifestyle Modifications. Is a Picture Really Worth a Thousand Words?
Subjects in this research study have Coronary Artery Disease (CAD). This occurs when there is a build-up of fatty material in the wall of the heart arteries that causes narrowing of the arteries.
- Trial name
- NCT01275716
- Testing
- Impact of Coronary Images Used During Patient Education on Coronary Artery Disease and Subsequent Lifestyle Modifications
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Chicago
Myocardial Infarction
COlchicine for Left VEntricular Remodeling Treatment in Acute Myocardial Infarction
Inflammatory processes have been identified as key mediators of ischemia/ reperfusion injury in ST-segment elevation myocardial infarction.
- Trial name
- COVERT-MI (NCT03156816)
- Testing
- Colchicine group (experimental arm)
- Where
- 8 sites in France
- Volunteers
- 194 people
- Sponsor
- Hospices Civils de Lyon
Coronary Disease
Randomized Comparison of ExoSeal® and Angio-Seal Vascular Closure Devices: The CLOSE-UP II Trial
Is the ExoSeal VSD non-inferior to Angio-Seal vascular closure device (VSD) in the incidence of adverse access site related events at 30 days.
- Trial name
- CLOSE-UP II (NCT02234830)
- Testing
- Exoseal closure device, Angioseal closure device
- Where
- 2 sites in Denmark
- Volunteers
- 818 people
- Sponsor
- Aarhus University Hospital Skejby
Cardiac Disease, Heart Failure
Interactive Guided Ultrasound Examinations Done by Non-experts of Ultrasound Imaging
This prospective study is a pilot study for evaluating a guidance system that aims to facilitate high-quality echocardiographic acquisitions.
- Conditions
- Cardiac Disease, Heart Failure, Cardiac Ischemia
- Trial name
- EPISODE (NCT03642730)
- Testing
- TransThoracic Echocardiography imaging
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Philips Healthcare
Coronary Disease, Mitral Valve Insufficiency
Should we Repair Ischemic Mitral Regurgitation?
The purpose of this study is to assess whether adding mitral valve repair to coronary artery bypass grafting improves outcome in patients with ischemic mitral regurgitation.
- Trial name
- NCT00443365
- Testing
- Mitral valve repair
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Silesia
Left Ventricular Systolic Dysfunction, Myocardial Infarction
Adherence to Cied Implantation Guidelines and Cardiac Rehabilitation
There are limited data on how the guideline indications for ICD implantation are applied in clinical practice across Europe. Moreover, the impact of "time-dependence" of some indications to implantation on the guidelines…
- Trial name
- ANGELICA (NCT05764109)
- Where
- Italy
- Volunteers
- 488 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Counterpulsation, Angina Pectoris
Effectiveness of ECP Therapy in Stable Angina Pectoris Patients
External Counterpulsation (ECP) is a non-invasive therapy using pressured cuff that is performed on patients with refractory stable angina pectoris to relieve symptoms and increase quality of life.
- Trial name
- NCT04873687
- Testing
- External Counter Pulsation (ECP) therapy
- Where
- Indonesia
- Volunteers
- 84 people
- Sponsor
- Universitas Padjadjaran
Acute Coronary Syndrome, Angina Pectoris
DUrable Polymer-based STent CHallenge of Promus Element Versus ReSolute Integrity in an All Comers Population
The introduction of drug-eluting stents (DES) in the treatment of coronary artery disease has led to a significant reduction in morbidity but there are further demands on DES performance.
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, Angina, Unstable, Myocardial Infarction
- Trial name
- DUTCH PEERS (NCT01331707)
- Testing
- Resolute Integrity (Zotarolimus-eluting stent), Promus Element (Everolimus-eluting stent)
- Where
- 4 sites in Netherlands
- Volunteers
- 1,811 people
- Sponsor
- Foundation of Cardiovascular Research and Education Enschede
Coronary Heart Disease, Atherosclerosis
Fluvastatin AmelIorates aTHerosclerosis Study
The study is designed to assess the effect of statin on atherosclesrosis progression as well as to explore its potential mechanism besides lipid modifying , such as effect on inflammation and vascular calcification.
- Trial name
- FAITH (NCT01681199)
- Testing
- Fluvastatin extended release tablet
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Beijing Anzhen Hospital
Cardiovascular Diseases, Heart Diseases
University of North Carolina Alumni Heart Study
To continue surveillance of the participants in the University of North Carolina Alumni Heart Study, which tests the hypothesis that hostility and related psychosocial factors are involved in the pathogenesis of coronary heart…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Depression
- Trial name
- NCT00005398
- Testing
- There is no intervention
- Where
- United States
- Volunteers
- 6,340 people
- Sponsor
- Duke University
Coronary Disease
Bile Acids and Gut Microbiota as Potent Coronary Atheroma Risk Factors: a Prospective Study in Human
The purpose of this study is to describe the composition of bile acids and the gut microbiota comparing two populations: patients with coronary atheroma and the healthy subjects.
- Trial name
- MABAC (NCT02375893)
- Testing
- No intervention, Healthy subject
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myocardial Infarction
Warning Model of Myocardial Remodeling After Acute Myocardial Infarction Using Multimodal Feature Structure Technology
Acute myocardial infarction (AMI) is one of the most important diseases threatening human life. The existing MI prognosis prediction scales mostly predict the incidence of death, recurrent MI and heart failure through 6-8…
- Trial name
- NCT06062316
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Psoriasis, Vascular Inflammation
Trial on the Effect of Adalimumab on Vascular Inflammation in Patients With Psoriasis
This study is a double-blinded randomized multicenter placebo controlled trial to determine the effect of adalimumab on vascular inflammation (ascending aorta and carotides) in patients with moderate to severe psoriasis.
- Conditions
- Psoriasis, Vascular Inflammation, Coronary Atherosclerosis
- Trial name
- NCT01722214
- Testing
- Adalimumab
- Where
- 5 sites in Canada
- Volunteers
- 107 people
- Sponsor
- Innovaderm Research Inc.
Cardiovascular Disease
Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine
SEARCH is a randomised, double-blind, multi-centre United Kingdom (UK) trial of 12,064 patients with myocardial infarction (MI) prior to study entry which aims to demonstrate whether a more intensive cholesterol lowering regimen…
- Trial name
- SEARCH (NCT00124072)
- Testing
- Simvastatin 20 mg daily, Folic acid 2 mg + vitamin B12 1 mg daily, Simvastatin 80 mg daily
- Where
- United Kingdom
- Volunteers
- 12,064 people
- Sponsor
- University of Oxford
Coronary Heart Disease
Optical Coherence Tomography Assessment of Intimal Tissue and Malapposition
The purpose of this study is to use a high-resolution intracoronary imaging modality, called optical coherence tomography (OCT) to examine two different types of coronary artery stents used to treat patients with coronary artery…
- Trial name
- OPTIMA (NCT01137019)
- Testing
- Biolimus-eluting stent, Everolimus-eluting coronary stent
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- Dr Peter Barlis
Ischemia, Angina
PrEssure wiRe Compared to Microcatheter-based Sensing Technology For the Evaluation of FFR Measurements
The model by which physicians measure the lack of blood flow in the vessels that supply blood to the heart muscle is called Fractional Flow Reserve (FFR).
- Trial name
- PERFORM (NCT02648230)
- Testing
- St. Jude Medical Pressure Wire, ACIST Navvus Microcatheter
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Columbia University
Acute Coronary Syndrome
Multi-dimensional Prevention Program After Acute Coronary Syndrome (ELIPS) (SPUM-ACS- SP1)
To demonstrate the effectiveness of the ELIPS programme (Multi-dimEnsionaL preventIon Program after Acute coronary Syndrome), which aims at improving quality of care of patients admitted to hospital with Acute Coronary Syndrome…
- Trial name
- NCT01075867
- Where
- 4 sites in Switzerland
- Volunteers
- 2,498 people
- Sponsor
- University Hospital, Geneva
Atherosclerosis, Coronary Artery Disease
The OMEGA Clinical Trial
The purpose of this study is to evaluate the safety and effectiveness of the OMEGA Coronary Stent System for the treatment of subjects with a de novo atherosclerotic coronary artery lesion.
- Trial name
- NCT01419171
- Testing
- OMEGA™ Monorail Coronary Stent System
- Where
- 37 sites in United States, Belgium and 5 more
- Volunteers
- 328 people
- Sponsor
- Boston Scientific Corporation
Clinical Study
Chronoprognosis of Myocardial Infarction in Patients With Type 2 Diabetes Mellitus
Purpose: To develop a mathematical model for the occurrence of MI in patients with T2D by studying the relationship between the internal personalized biorhythms of the patients and the external transit rhythms of space objects…
- Trial name
- NCT05645419
- Testing
- personalized chronoprevention
- Where
- Kazakhstan
- Volunteers
- 60 people
- Sponsor
- University Medical Center, Kazakhstan
Percutaneous Coronary Artery Intervention, Coronary Artery Bypass Graft
Effect of Chinese Traditional Medicine for Post Revascularization Treatment of Coronary Artery Disease
The purpose of this study is to built the standard of Chinese Traditional Medicine test for Post percutaneous coronary artery intervention and coronary artery bypass graft，also for acute coronary syndrome，according to the…
- Conditions
- Percutaneous Coronary Artery Intervention, Coronary Artery Bypass Graft, Acute Coronary Syndrome
- Trial name
- NCT00965471
- Testing
- cipher prescription 1, cipher prescription 2
- Volunteers
- 940 people
- Sponsor
- Guangzhou University of Chinese Medicine
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