Clinical trials: Ischemia, Myocardial
Coronary Artery Disease
Intravascular ULTrasound Guided Versus Conventional Angiography Guided Strategy to Deploy Zotarolimus and Everolimus Eluting Third Generation Stents in the Long Coronary Artery Lesions: ULTRA-ZET Trial
Although first generation DES reduced instent restenosis, still remained the unsolved problems such as stent thrombosis and restenosis in the era of DES.
- Trial name
- NCT01979744
- Testing
- IVUS guided percutaneous coronary angioplasty with Resolute integrity stent insertion, Angiography guided percutaneous coronary angioplasty with Resolute integrity stent insertion, Angiography guided percutaneous coronary angioplasty with Promus element stent implantation
- Where
- South Korea
- Volunteers
- 568 people
- Sponsor
- Yonsei University
Acute Coronary Syndrome
Diagnostic Value of Heart-Fatty Acid Binding Protein and Ischemia Modified Albumin as Biochemical Markers on Non ST Segment Elevation Acute Coronary Syndrome at the Emergency Room.
Early diagnostic of non ST elevation coronary syndrome in patients admitted to the emergency room is difficult. Two news biochemical markers have been assessed and studies have suggested that heart fatty binding protein and…
- Trial name
- NCT00714298
- Testing
- Measure of Initial heart fatty acid binding protein and ischemia modified albumin
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Toulouse
Cardiac Disease
Attenuation Corrected Cardiac SPECT Using the GE Hawkeye Camera System
The accuracy of stress single photon emission computed tomography (SPECT) is limited by imaging artifacts, many of which are caused by soft tissue attenuation.
- Trial name
- Hawkeye (NCT00587730)
- Testing
- GE Attenuation Corrected Hawkeye Camera
- Where
- United States
- Volunteers
- 608 people
- Sponsor
- Mayo Clinic
Heterozygous Familial Hypercholesterolemia, Premature Coronary Heart Disease
A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease
VT-10201 is an Open-label, Phase 1b, Single-ascending Dose Study That Will Evaluate the Safety of VERVE-102 Administered to Patients With Heterozygous Familial Hypercholesterolemia (HeFH) or Premature Coronary Artery Disease…
- Trial name
- NCT06164730
- Testing
- VERVE-102
- Where
- 27 sites in United States, Australia and 4 more
- Volunteers
- 85 people
- Sponsor
- Verve Therapeutics, Inc.
Coronary Artery Disease, Stable Angina
MR INFORM - MR Perfusion Imaging to Guide Management of Patients With Stable Coronary Artery Disease
The purpose of this study is to determine if MR Perfusion Imaging is non-inferior to coronary angiography with measurement of Fractional Flow Reserve (FFR) in guiding management of patients with stable chest pain.
- Conditions
- Coronary Artery Disease, Stable Angina, Myocardial Ischaemia
- Trial name
- NCT01236807
- Testing
- MR perfusion guidance, FFR guidance
- Where
- United Kingdom
- Volunteers
- 915 people
- Sponsor
- King's College London
Vasospastic Angina
A Therapeutic Confirmatory Study to Evaluate the Efficacy and Safety of Cilostazol in Subjects With Vasospastic Angina
This study will be conducted in accordance with the local regulation of New Drug Application. Overall duration of this trial will be 3 years after approval of KFDA.
- Trial name
- STELLA (NCT02087007)
- Testing
- Cilostazol
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Saphenous Vein Graft Disease, Myocardial Ischemia
Use of the GARDEX™ Embolic Protection Device During Percutaneous Coronary Interventions of Saphenous Vein Graft
This is a multi center, prospective study designed to demonstrate the safety and performance of the GARDEX Embolic Protection System when used as an adjunctive device during saphenous vein graft (SVG) interventions.
- Conditions
- Saphenous Vein Graft Disease, Myocardial Ischemia, Embolism
- Trial name
- NCT01042444
- Testing
- GARDEX™
- Where
- 3 sites in Israel
- Volunteers
- 6 people
- Sponsor
- Gardia Medical
Coronary Artery Disease
"Pharmacodynamic Comparison of Omeprazole Versus Pantoprazole on Platelet Reactivity in Patients With Acute Coronary Syndromes on Dual Antiplatelet Therapy With New P2Y12 Inhibitors" -Trial dOPPLER-
Clopidogrel and Prasugrel are pro-drug necessitating conversion in active metabolites through CYP 450 system (CYP), particularly CYP3A and CYP2C19 isoforms.
- Trial name
- dOPPLER (NCT02028234)
- Testing
- Pantoprazole,, Omeprazole
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Roma La Sapienza
Coronary Artery Disease
RADIQAL Study (Radiation Dose and Image Quality Trial)
The Azurion R4.0 is developed by Philips Medical Systems Nederland B.V., a Philips Healthcare company. The Azurion is an interventional X-ray system which is used for live X-ray imaging during invasive cardiac procedures.
- Trial name
- RADIQAL (NCT06944509)
- Testing
- treatment with the Azurion system with Xres5, Azurion with Clairy IQ
- Where
- 6 sites in United States, Czechia and 2 more
- Volunteers
- 824 people
- Sponsor
- Philips Clinical & Medical Affairs Global
ST-elevation Myocardial Infarction (STEMI)
Effect of Digitally Supported Medical Nutrition Therapy on Left Ventricular Ejection Fraction in Patients With ST-Elevation Myocardial Infarction
This study is designed to investigate the effect of a nutrition program supported by digital content on heart function in patients who have experienced a heart attack with ST-elevation.
- Trial name
- NCT07427199
- Testing
- Digital Content-Supported Medical Nutrition Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Saglik Bilimleri Universitesi
ST Elevation Myocardial Infarction
The Effect of Low-Level Tragus Stimulation on Echocardiographic Parameters in Patients With ST-Segment Elevation Myocardial Infarction - A Single-Centre Randomized Control Trial
The goal of this clinical trial is to learn the effect of low level tragus stimulation (LLTS) on echocardiographic parameter in patient with ST-segment Elevation Myocardial Infarction (STEMI) who undergo primart percutaneous…
- Trial name
- ELITE-STEMI (NCT07058857)
- Testing
- Parasym Neuromodulation Device (Treatment Group)
- Where
- Indonesia
- Volunteers
- 100 people
- Sponsor
- Universitas Diponegoro
Atherosclerosis, Atheroscleroses, Coronary
SIALIDASE INHIBITION AS ANTIATHEROSCLEROTIC THERAPY
The aim of this double-blind, randomized, placebo-controlled, multicenter study is to evaluate the pathogenetic effects of the dietary supplement "Tertinat" on a fundamental mechanism of atherosclerosis development: its ability…
- Conditions
- Atherosclerosis, Atheroscleroses, Coronary, Carotid Atherosclerosis
- Trial name
- SIAT (NCT06590012)
- Testing
- Tertinat
- Where
- 10 sites in Russia
- Volunteers
- 1,228 people
- Sponsor
- Institute for Atherosclerosis Research, Russia
De Novo Stenosis, Coronary Artery Disease
Paclitaxel-Coated Balloon Versus Zotarolimus-Eluting Stent for Treatment of De Novo Coronary Artery Lesions
Coronary restenosis has been one of the main reasons affecting the prognosis of patients with coronary artery disease (CAD) after percutaneous coronary intervention (PCI).
- Conditions
- De Novo Stenosis, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- CAGE-FREEIII (NCT05209412)
- Testing
- Lepu Paclitaxel coated balloon, Resolute Integrity Zotarolimus eluting stents, Aspirin
- Where
- China
- Volunteers
- 370 people
- Sponsor
- Xijing Hospital
Coronary Artery Disease, Aortic Valve Disease
Deploying Novel Imaging Modalities Towards a Three-dimensional (3D) CARDIOvascular PATHology
The goal of the 3D-CARDIOPATH study is to investigate the potential added value of emerging 3D imaging modalities by imaging ex vivo cardiac specimens (diseased coronary arteries, calcific aortic valves, and thrombotic materials)…
- Conditions
- Coronary Artery Disease, Aortic Valve Disease, Aortic Valve Calcification, STEMI
- Trial name
- 3D-CARDIOPATH (NCT05975567)
- Testing
- Three-dimensional imaging of the collected cardiac specimens
- Volunteers
- 70 people
- Sponsor
- Aristotle University Of Thessaloniki
Stroke, Stroke, Cardiovascular
EMG Control Assistance Virtual Reality Interface Coupled With Cerebellar-iTBS for Arm Recovery After Stroke (ERICA)
The investigators hypothesize that a myoelectric (EMG) controlled virtual reality (VR) interface allows for effective upper limb motor recovery of stroke patients.
- Trial name
- ERICA (NCT06911671)
- Testing
- Virtual Reality Interface + Cerebellar iTBS (c-iTBS), Physical Therapy
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Ischemic Heart Disease
Evaluation of Integrated Cardiac Imaging in Ischemic Heart Disease
Main purpose of the study: To comparatively assess the diagnostic performance of non invasive anatomical and functional imaging modalities to detect significant obstructive coronary artery disease as demonstrated at invasive…
- Trial name
- EVINCI (NCT00979199)
- Testing
- Non invasive cardiac imaging
- Where
- 16 sites in Finland, France and 7 more
- Volunteers
- 697 people
- Sponsor
- Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy
Myocardial Infarction
Stem Cell Mobilization by G-CSF Post Myocardial Infarction to Promote Myocyte Repair
Eighty-six patients with heart attacks will be identified at our hospital. Post heart attack we will assess heart function, blood flow to the heart, and heart cell function.
- Trial name
- NCT00394498
- Testing
- Granulocyte Colony Stimulating Factor
- Where
- Canada
- Volunteers
- 86 people
- Sponsor
- University of Ottawa
Stable Angina, Acute Coronary Syndrome
Novasight Hybrid Intravascular Ultrasound and Optical Coherence Tomography System (IVUS OCT)
Collection of coronary images with a hybrid IVUS OCT system.
- Trial name
- NCT03484975
- Testing
- Observation group
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Conavi
Coronary Artery Disease, Type 2 Diabetes
Can Insulin Glargine Improve Myocardial Function in Patients With T2D and Coronary Artery Disease (CAD)
The field of secondary prevention remains an extremely important goal for diagnostic and therapeutic approaches keeping in mind that 40% of all patients with acute myocardial infarction have prediabetes, commonly as impaired…
- Trial name
- NCT01035528
- Testing
- insulin glargine, metformin
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Munich Municipal Hospital
Myocardial Infarction, Cerebrovascular Accident
Analyzing Gene Regions That May Interact With the Effectiveness of High Blood Pressure Drugs
High blood pressure is one of the most common health problems in the United States. There are many drug treatment options for high blood pressure, but these medications are not always effective.
- Conditions
- Myocardial Infarction, Cerebrovascular Accident, Death, Sudden, Cardiac
- Trial name
- NCT00573092
- Where
- United States
- Sponsor
- University of Washington
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