Clinical trials: Ischemia Limb
Peripheral Artery Disease, Critical Limb Ischemia
Imaging-Guided Vessel Sizing in the Tibial Arteries
This study aims to investigate the utilization of intravascular imaging in treatment of tibial vessels in peripheral artery disease and critical limb ischemia (CLI).
- Trial name
- iVEST (NCT04748965)
- Testing
- Digital Subtraction Angiography
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Ischemic Heart Disease
Effect of Remote Preconditioning in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery
In recent several clinical trials, remote preconditioning showed very powerful myocardial protection. However, the myocardial protective effect by remote preconditioning was not evaluated on the patients undergoing off pump…
- Trial name
- NCT00889811
- Testing
- remote ischemic preconditioning
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Seoul National University Hospital
Peripheral Arterial Occlusive Disease, Chronic Limb-Threatening Ischemia
Safety of Antithrombotic Heparin Proteoglycan Mimetic APAC in Peripheral Arterial Occlusive Disease and Chronic Limb-threatening Ischemia
The goal of this study is to learn if a new medicine (called antiplatelet and anticoagulant [APAC]) can help the body to prevent blood clots and whether APAC is safe and well tolerated in patients with blocked or narrowed…
- Trial name
- HEALING (NCT07352800)
- Testing
- APAC - dose level 0.50 mg/kg,, Unfractionated heparin (UFH), APAC dose level 1: 0.25 mg/kg,
- Where
- 3 sites in Finland
- Volunteers
- 42 people
- Sponsor
- Aplagon Oy
Obstructive Coronary Artery Disease
Coronary Revascularization Versus Conservative Therapy in Patients With Treated Critical Limb Ischemia
The objective of the INCORPORATE trial is to evaluate whether an intentional invasive strategy with ischemia targeted, reasonably complete coronary revascularization and optimal medical therapy is superior as compared to a…
- Trial name
- INCORPORATE (NCT03712644)
- Testing
- FFR-guided coronary revascularization
- Where
- 2 sites in Austria, Hungary
- Volunteers
- 650 people
- Sponsor
- Medical University of Graz
Critical Limb Ischemia
Bone Marrow Aspirate Concentrate (BMAC) for Treatment of Critical Limb Ischemia (CLI)
Critical Limb Ischemia prevents the legs and feet from receiving oxygen and nutrients needed for proper function. This severe lack of blood flow can lead to painful legs while walking or at rest and can result in foot sores…
- Trial name
- NCT01245335
- Testing
- BMAC injection
- Where
- 34 sites in United States
- Volunteers
- 97 people
- Sponsor
- Harvest Technologies
Stroke Rehabilitation
Multimodal Correction of Post-stroke Motor and Cognitive Impairments
The aim of the study is the development and scientific substantiation of the effectiveness and safety of multimodal rehabilitation technology using innovative digital technologies, biofeedback (BFB), virtual reality (VR)…
- Trial name
- NCT05391919
- Testing
- Multimodal technology (MT), Conventional rehabilitation (CR)
- Where
- Russia
- Volunteers
- 90 people
- Sponsor
- Moscow Scientific and Practical Center of Medical Rehabilitation, Restorative and Sports Medicine
Diabetes Mellitus, Critical Limb Ischemia
N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes
In this pilot clinical study the investigators propose to conduct a prospective, randomized, double-blinded, placebo-controlled clinical trial for 30 days for participants with critical limb ischemia (CLI) who undergo a major…
- Conditions
- Diabetes Mellitus, Critical Limb Ischemia, Lower Limb Amputation Knee, Peripheral Arterial Disease
- Trial name
- NCT03253328
- Testing
- Active Arm N-acetyl cysteine (NAC)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Washington University School of Medicine
Ischemic Stroke, Upper Extremity Hemiparesis
Patient-tailored Transcranial Direct Current Stimulation to Improve Stroke Rehabilitation
In a double-blinded sham-controlled study the effect of patient-tailored transcranial direct current stimulation during rehabilitation training will be examined.
- Trial name
- PRACTISE (NCT05355831)
- Testing
- Active Transcranial Direct Current Stimulation
- Where
- 3 sites in Denmark
- Volunteers
- 22 people
- Sponsor
- Christina Kruuse
Angioplasty, Critical Lower Limb Ischemia
Outcomes of Straight-line Flow Versus Angiosome-targeted Angioplasty in Treatment of Critical Lower Limb Ischemia
Peripheral arterial disease (PAD) affects more than 200 million people worldwide. Although over 50% are asymptomatic, it accounts for 4% of all amputations.
- Trial name
- NCT06127134
- Testing
- peripheral angioplasty for tibial vessels
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Kafrelsheikh University
Stroke, Ischemic
Assessment of Functional Efficiency of the Upper Limb After Stroke
The aim of the study will be to: conduct the process of cultural and linguistic adaptation of questionnaires for assessing the functional efficiency of the upper limb to the Polish version and to assess psychometric properties…
- Trial name
- NCT06675487
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- University of Rzeszow
Critical Limb Ischemia
Comparison of Cilostazol-based Triple Antiplatelet Therapy Versus Dual Antiplatelet Therapy for Outcomes of below-the Knee Endovascular Intervention in Patients With Critical Limb Ischemia (TAP CLI Study)
Prospective, randomized, controlled, multi-center study A total of 390 subjects with critical limb ischemia will be included according to inclusion and exclusion criteria.
- Trial name
- NCT02829151
- Testing
- Triple antiplatelet therapy (aspirin (100 mg), clopidogrel (75 mg), and cilostazol (200 mg) ), Dual antiplatelet therapy (aspirin (100 mg) and clopidogrel (75 mg)) using aspirin and clopidogrel, Dual antiplatelet therapy (aspirin (100 mg) and cilostazol (200 mg)) using aspirin and cilostazol
- Where
- South Korea
- Volunteers
- 390 people
- Sponsor
- Yonsei University
Compresion Therapy, Post-operative Edema
Post-operative Complication, Impulsive Compression, in Situ Bypass
To investigate whether compression therapy with foot pump reduce post-operative edema, facilitate wound healing of operation wounds, promote healing of ischemic ulcers and shorten hospitalization, increase and improve the…
- Conditions
- Compresion Therapy, Post-operative Edema, Wound Complication, Ischemia Limb
- Trial name
- 50506 (NCT03192982)
- Testing
- A-V impulse 6000 Series, Standard treatment (compression)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Kolding Sygehus
Critical Limb Ischemia
Cost Analysis of Vascular Surgical Techniques
Whilst mortality rates and surgical limitations are widely known and understood for each intervention performed, the cost implications, in UHL, are not known.
- Trial name
- NCT06367803
- Where
- Ireland
- Volunteers
- 200 people
- Sponsor
- University Hospital of Limerick
Infrapopliteal Lesions, Critical Limb Ischemia
IBS Titan™ Sirolimus-eluting Iron Bioresorbable Peripheral Scaffold System Clinical Trial
The goal of this prospective, multicentre, single arm clinical trial is to assess the safety and effectiveness of Sirolimus-eluting Iron Bioresorbable Peripheral Scaffold System (IBS Titan™) in treating patients with…
- Trial name
- NCT05971394
- Testing
- Sirolimus-eluting Iron Bioresorbable Peripheral Scaffold System (IBS Titan™)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Biotyx Medical (Shenzhen) Co., Ltd.
Diabetes, Critical Limb Ischemia
Feasibility of Peripheral Angioplasty in Type D TASCII Lesions
This observational prospective study will evaluate, according o usual local clinical practice, feasibility of endoluminal revascularization in diabetic patients with type C and D lesions, according to TASC II Criteria.
- Trial name
- NCT01297387
- Testing
- PTA BPG procedure,
- Where
- Italy
- Volunteers
- 344 people
- Sponsor
- IRCCS Multimedica
Chronic Limb Threatening Ischemia
Clinical Outcomes Following Surgical Debridement of Diabetic Foot Infection with Borderline Vascularity
Observe Timing to complete healing of wounds \& Limb salvage in both cohorts those who are undergoing Debridement only and those who are undergoing Debridement plus PTA
- Trial name
- NCT05553509
- Testing
- PER CUTANEOUS TRANSLUMINAL ANGIOPLASTY
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Peripheral Arterial Disease, Critical Limb Ischemia
Tibiopedal Access for Crossing of Infrainguinal Artery Occlusions
The objective of this prospective, non-randomized, multicenter, post-market, observational study is to compile clinical data on percutaneous techniques used to obtain tibiopedal access and to cross infrainguinal arterial…
- Trial name
- NCT01609621
- Testing
- Retrograde tibiopedal arterial access
- Where
- 11 sites in United States, Germany and 1 more
- Volunteers
- 199 people
- Sponsor
- Cook Group Incorporated
Peripheral Arterial Disease
Use of Ixmyelocel-T (Formerly Vascular Repair Cells [VRC]) in Patients With Peripheral Arterial Disease to Treat Critical Limb Ischemia
This study is designed to evaluate the safety and efficacy of autologous Vascular Repair Cells (VRC) for patients with peripheral arterial disease as a treatment for critical limb ischemia.
- Trial name
- RESTORE-CLI (NCT00468000)
- Testing
- Ixmyelocel-T
- Where
- 20 sites in United States
- Volunteers
- 86 people
- Sponsor
- Vericel Corporation
Chronic Stroke, Ischemic Stroke
Proof-of-concept for Use of Transcutaneous Spinal Stimulation (TSS) With the ExaStim® Stimulation System in Adults With Chronic Ischemic Stroke
The goal of this clinical trial is to learn about the safety, tolerability, and feasibility of ExaStim transcutaneous electrical stimulation combined with task-specific rehabilitation, and to characterize changes in arm function…
- Conditions
- Chronic Stroke, Ischemic Stroke, CVA (Cerebrovascular Accident)
- Trial name
- EXA2611 (NCT07917221)
- Testing
- Transcutaneous Spinal Stimulation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Arterial Occlusive Disease, Peripheral Vascular Disease
Study of HGF Via Plasmid Vector to Improve Perfusion in Critical Limb Ischemia
The primary purpose of this study was to assess the overall safety of different dose regimens of AMG0001 (HGF transferred via plasmid vector) as well as evaluate the improvement of blood perfusion in subjects with critical limb…
- Conditions
- Arterial Occlusive Disease, Peripheral Vascular Disease, Ischemia
- Trial name
- NCT00060892
- Testing
- HGF plasmid
- Where
- 24 sites in United States
- Volunteers
- 104 people
- Sponsor
- AnGes USA, Inc.