Clinical trials: Ischemia Limb
Critical Limb Ischemia
Percutaneous Deep Vein Arterialization Post-Market Study
The objective of this post-market study is to evaluate the safety and effectiveness of the LimFlow System in creating a below-the-knee arterio-venous fistula for venous arterialization in subjects with critical limb ischemia.
- Trial name
- PROMISE UK (NCT03807661)
- Testing
- Percutaneous deep vein arterialization, LimFlow System
- Where
- 6 sites in United Kingdom
- Volunteers
- 28 people
- Sponsor
- LimFlow SA
Peripheral Arterial Disease, Coronary Artery Disease
Selective Coronary Revascularization in Peripheral Artery Disease Patients (SCOREPAD Trial)
The primary objective of this study is to determine whether among symptomatic Peripheral Arterial Disease (PAD) patients with no known Coronary Artery Disease (CAD) who had undergone lower-extremity revascularization, a strategy…
- Trial name
- NCT06250790
- Testing
- Coronary CT angiography and FFRct analysis
- Where
- Latvia
- Volunteers
- 600 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Chronic Limb Ischemia
Lower-Limb Adventitial Infusion of DexaMethasone Via Bullfrog to Reduce Occurrence of Restenosis After Atherectomy (ATX)-Based Revascularization
This is a prospective, multi-center, randomized pilot study to document the effects of adventitial delivery of dexamethasone after atherectomy-based revascularizations of lesions below the knee in symptomatic patients with…
- Trial name
- LIMBO-ATX (NCT02479620)
- Testing
- Dexamethasone Sodium Phosphate Injection, USP, 4 mg/mL
- Where
- 10 sites in United States
- Volunteers
- 120 people
- Sponsor
- Mercator MedSystems, Inc.
Microcirculation, Orthostatic Intolerance
Influence of RIC on the Orthostatic Competence of the Microcirculation
The goal of this clinical trial (pilot study) is to learn about the microcirculatory regulation of the lower extremity under orthostatic stress with and without RIC - Remote Ischemic Preconditioning in healthy participants.
- Conditions
- Microcirculation, Orthostatic Intolerance, Remote Ischemic Preconditioning, Hemodynamics
- Trial name
- NCT05990907
- Testing
- Remote ischemic preconditioning
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ISAR Klinikum
Ischemic Preconditioning, Acute Kidney Injury
Remote Ischemic Preconditioning During Lower Limb Revascularization
The aim of this study is to evaluate the role of remote ischemic preconditioning (RIPC) in preventing acute kidney injury after lower limb revascularization.
- Conditions
- Ischemic Preconditioning, Acute Kidney Injury, Limb Ischemia
- Trial name
- NCT04016857
- Testing
- RIPC, Control
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Messina
OPCABG
Study on the Myocardial Protective Effect of Upper Limb Ischemic Preconditioning in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
The purpose of the study was to verify the myocardial protective effect of RIPC in patients undergoing OPCABG.
- Trial name
- NCT03340181
- Testing
- RIPC
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Shanghai Zhongshan Hospital
Stroke, Cardiovascular
Cortical Excitability Sequential Changes in Response to Transcranial Magnetic Stimulation Post Stroke
This study was conducted to investigate the cortical excitability changes per session in response to the application of low frequency repetitive transcranial magnetic stimulation *LF-rTMS* on the contralesional hemisphere and its…
- Trial name
- NCT03845595
- Testing
- (LF-rTMS) group, Control group
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Limb Injury, Limb Ischemia
The Effect of Emotional Freedom Technique on Patients Receiving Preventive Foot Care
It is planned to examine the effect of the emotional liberation technique on the anxiety level in patients who receive preventive foot wound care and treatment in the postoperative period.
- Conditions
- Limb Injury, Limb Ischemia, Complication Diabetic, Complication,Postoperative
- Trial name
- NCT07066371
- Testing
- Emotional freedom technique
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bitlis Eren University
Critical Limb Ischemia, Tibialis Vessels Occlusion
Single Versus Multiple Vessels Endovascular Tibial Arteries Revascularization for Critical Limb Ischemia
This study aims to Compare the outcomes of angioplasty for single tibial vessel occlusion versus multiple tibial vessel occlusions in patients with critical limb ischemia.
- Trial name
- NCT07383064
- Testing
- Endovascular Revascularization
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Aswan University
Hemiplegia Following Ischemic Stroke
The Effectiveness of Rehabilitation Training Based on Brain-computer Interface Technology to Improve the Upper Limb Motor Function of Ischemic Stroke.
To evaluate the effectiveness and safety of rehabilitation training based on brain-computer interface in improving the upper motor function, self-care ability in daily life and quality of life in patients with ischemic stroke.
- Trial name
- REBUILT (NCT04387474)
- Testing
- Brain-computer interface, Traditional rehabilitation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Tiantan Hospital
Peripheral Vascular Diseases
Safety Study of Using Stem Cells to Stimulate Development of New Blood Vessels in Peripheral Vascular Disease
The purpose of this study is to determine if bone marrow derived adult stem cells are safe and effective in inducing development of new blood vessels (angiogenesis) in the legs of patients with severe peripheral vascular disease.
- Trial name
- NCT00113243
- Testing
- adult stem cells
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Murphy, Michael P., MD
Brain Diseases, Ischemic Stroke
Stroke Cerebral Reorganization Pathways (SPECTRE)
SPECTRE is a prospective longitudinal study in order to identify whether patients with different degrees of motor recovery are distinguished by distinct brain post-stroke plasticity patterns in the acute and sub-acute phases.
- Conditions
- Brain Diseases, Ischemic Stroke, Stroke, Brain Infarction
- Trial name
- SPECTRE (NCT06784518)
- Testing
- Clinical scores and functional MRI
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Rennes University Hospital
Stroke, TIA
The Effect Of Remote Limb Ischemic Preconditioning For Carotid Artery Stenting
Remote limb ischemic preconditioning is neuro-protective and anti-inflammatory for ischemia- reperfusion injury. As the extent of its effect is unknown, the investigators will use clinical outcome, serum biochemical markers and…
- Conditions
- Stroke, TIA, Coronary Stenosis
- Trial name
- NCT01175876
- Testing
- remote limb ischemic preconditioning, Carotid Artery Stenting
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Critical Limb Ischemia
Aspirin and Clopidogrel Reactivity in Patients With Critical Limb Ischemia (CLI)
Critical Limb Ischemia (CLI) is defined as limb pain that occurs at rest, or impending limb loss that is caused by severe compromise of blood flow to the affected extremity.
- Trial name
- NCT02094755
- Testing
- Blood draw only
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Myocardial Reperfusion Injury, Myocardial Ischemia
Remote Postconditioning in Patients With Acute Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention (PCI)
Background: Experimental studies suggest that remote limb ischaemic postconditioning (RemPostCon) can reduce infarct size in pigs.
- Conditions
- Myocardial Reperfusion Injury, Myocardial Ischemia, Myocardial Infarction
- Trial name
- RemPostCon (NCT00865722)
- Testing
- Remote Postconditioning
- Where
- 2 sites in Italy
- Volunteers
- 96 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Peripheral Artery Disease, Critical Limb Ischemia
Platelet Reactivity in PAD Undergoing Percutaneous Angioplasty
Dual antiplatelet therapy has a key role in a prevention of thrombosis of treated artery in patients undergoing percutaneous transluminal angioplasty (PTA).
- Conditions
- Peripheral Artery Disease, Critical Limb Ischemia, Claudication, Intermittent
- Trial name
- PAD (NCT04165629)
- Testing
- Aspirin 300mg and Clopidogrel 300mg
- Where
- Serbia
- Volunteers
- 450 people
- Sponsor
- Clinical Centre of Serbia
Stroke, Acute, Stroke, Ischemic
Prognosis and Diagnosis of Spasticity in Acute-post Stroke Patients
Spasticity, or greater muscle resistance, is a major disabling condition following stroke. Recovery of lost motor function in patients with stroke may be affected by spasticity, which most commonly develops in elbow and ankle…
- Conditions
- Stroke, Acute, Stroke, Ischemic, Stroke Hemorrhagic, Spasticity as Sequela of Stroke
- Trial name
- NCT05179473
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- McGill University
Peripheral Arterial Disease, Peripheral Vascular Diseases
Cysteinyl Leukotriene Antagonist in Atherosclerosis Inhibition in Patients After Endovascular Treatment Due to Peripheral Arterial Disease
Atherosclerosis is a civilization disease, which pathophysiology is based on chronic inflammatory response in the wall of vessels that is caused by increase of pro-inflammatory substances.
- Conditions
- Peripheral Arterial Disease, Peripheral Vascular Diseases, Lower Limb Ischemia, Atherosclerosis of Artery
- Trial name
- CADET-PAD (NCT04277702)
- Testing
- Montelukast 10mg, Endovascular treatment, Standard anti-platelet treatment
- Volunteers
- 200 people
- Sponsor
- Jagiellonian University
Arteriosclerosis, Peripheral Artery Disease
Durg Coated Balloon Angioplasty in Infrapopliteal Lesions
This study is a multicenter observational study designed to evaluate the the effectiveness and safety of drug-coated balloon (DCB) angioplasty for below the knee arterial lesions in patients critical with Limb Threatening…
- Conditions
- Arteriosclerosis, Peripheral Artery Disease, Chronic Limb Threatening Ischemia
- Trial name
- Act (NCT05620095)
- Testing
- drug-coated balloon
- Where
- 10 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology
Chronic Total Occlusion of Artery of the Extremities
FastWire REvascularisation of Extremities, (For LOWer Limbs) - FREEFLOW
This study is to assess the safety and efficacy of the FastWire System. It is intended to assess that the FastWire System can facilitate the intra-luminal placement of conventional guidewires or treatment devices beyond…
- Trial name
- NCT06492733
- Testing
- FastWire System - Peripheral
- Where
- 6 sites in United States
- Volunteers
- 65 people
- Sponsor
- Versono Medical Ltd