Clinical trials: Ischemia Preconditioning
Transplant Dysfunction
Remote Ischaemic Preconditioning in Transplantation (RIPTRANS)
Remote ischemic preconditioning (RIPC) is a concept where remotely induced ischemia produces protection against ischemia-reperfusion injury in a remote organ.
- Trial name
- NCT03855722
- Testing
- RIPC
- Where
- Finland
- Volunteers
- 496 people
- Sponsor
- Helsinki University Central Hospital
Cardiac Complication, Myocardial Infarction
Cellular precOnditioning for Post-Surgical Myocardial Ischemic Complications - Observational Study
The goal of this observational study is to collect health data on people who are at high risk of having heart complications and are having a surgery that is not on the heart.
- Conditions
- Cardiac Complication, Myocardial Infarction, Myocardial Ischemia, Myocardial Injury
- Trial name
- COSMIC (NCT05762601)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Ottawa Hospital Research Institute
Peripheral Arterial Diseases
Effects of Remote Ischemic Preconditioning on Moderate PVD Patients A Pilot Randomized Control Trial
Remote ischemic Preconditioning (RIPC) is a phenomena first observed in cardio-thoracic patients in which exposing the limbs for periods of short intermittent ischemia produces protective effect on heart muscle.
- Trial name
- RIPC-PVD (NCT02273232)
- Testing
- Remote Ischemic Preconditioning, Supervised Exercise, Standard Care
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- National University of Ireland, Galway, Ireland
Lung Neoplasms
Effect of Remote Ischemic Preconditioning on Lung Injury After Pulmonary Resection
The purpose of this study is to determine whether ischemic preconditioning reduces lung injury in patients undergoing pulmonary resection.
- Trial name
- NCT01307085
- Testing
- remote ischemic preconditioning
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Cai Li
Effectivity of RIPC in Outcomes of TAVI Procedure
Cardioprotective Effect of RIPC in Patients Undergoing TAVI
We aim to investigate whether RIPC (remote ischemic preconditioning) is effective in the TAVI setting to reduce post-procedural myocardial damage and improve patient outcome.
- Trial name
- CARE-TAVI (NCT02283398)
- Testing
- without RIPC, RIPC
- Where
- 3 sites in Germany
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Pressure; Brachial Plexus
The Effect of Remote Ischemic Preconditioning (RIPC) on Blood Pressure and Its Vascular Protection Effect
The purpose of this study is to determine the effect of remote ischemic preconditioning (RIPC) on blood pressure and its vascular protection effect among Chinese young healthy adults and primary hypertensive patients stage I.
- Trial name
- NCT02414997
- Testing
- RIPC
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Brain Ischemia
The Neuroprotection of Sevoflurane Preconditioning on Intracranial Aneurysm Surgery
The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery.
- Trial name
- NCT01204268
- Testing
- Sev-I group, Sevo continuous inhalation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xijing Hospital
Liver Surgery, Remote Ischaemic Preconditioning
Lactate Clearance After RIPC in Liver Resection
The primary aim of the study is the evaluation of the efficacy of remote ischemic preconditioning (RIPC) in terms of increase of the clearance of lactates 4 hours after the end of the hepatic resection.
- Trial name
- ARAGON (NCT05594641)
- Testing
- Remote ischaemic preconditioning, Control
- Where
- Italy
- Volunteers
- 74 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Exercise
Ischemic Preconditioning in Endurance Athletes
The aim of this study is to investigate the effect of remote ischemic preconditioning on biochemical and functional indices of cardiac function induced by a 30 km run in healthy trained long distance runners.
- Trial name
- NCT01774461
- Testing
- Remote ischemic preconditioning
- Where
- Netherlands
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Acute Mountain Sickness
Optimization Strategy for the Prevention of AMS by RIPC Combined With Acetazolamide
The primary objective of the study will be to determine whether rapid remote limb ischemic preconditioning (RIPC) combined with acetazolamide can further reduce the incidence of acute mountain sickness (AMS) during the 6-hour…
- Trial name
- NCT05023941
- Testing
- Acetazolamide, Doctormate® (twice daily for 6 days), Doctormate® (forth daily for 3 days)
- Where
- China
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Ji Xunming,MD,PhD
Ischemic Preconditioning, Acute Kidney Injury
Remote Ischemic Preconditioning During Lower Limb Revascularization
The aim of this study is to evaluate the role of remote ischemic preconditioning (RIPC) in preventing acute kidney injury after lower limb revascularization.
- Conditions
- Ischemic Preconditioning, Acute Kidney Injury, Limb Ischemia
- Trial name
- NCT04016857
- Testing
- RIPC, Control
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Messina
Ischaemic Reperfusion Injury
Remote Ischaemic Preconditioning in Children Undergoing Cardiac Surgery
Surgical correction of congenital heart defects in children requires the utilization of cardiopulmonary bypass, a technique that temporarily substitutes heart and lung functions during surgery.
- Trial name
- NCT01680601
- Testing
- Remote ischaemic preconditioning (RIPC)
- Where
- United Kingdom
- Volunteers
- 51 people
- Sponsor
- NHS Greater Glasgow and Clyde
Acute Cholecystitis, Endothelial Dysfunction
Remote Ischemic Preconditioning in Patients Undergoing Acute Minor Abdominal Surgery
This study examines if remote ischemic preconditioning in patients undergoing minor acute abdominal surgery (laparoscopic cholecystitis due to acute cholecystitis) is associated with a modulation of endothelial dysfunction.
- Trial name
- PUMAS (NCT04156711)
- Testing
- Remote Ischemic Preconditioning (RIPC)
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Zealand University Hospital
Aortic Valve Disease, Myocardial Ischemia
Remote Ischemic Preconditioning in Patients Undergoing Isolated Aortic Valve Replacement Surgery
The goal is to investigate the efficacy, safety and possible neuro- and cardioprotective effects of remote ischemic preconditioning (RIPC) in adult cardiac patients undergoing isolated aortic valve replacement surgery with a…
- Trial name
- NCT02694016
- Testing
- Remote ischemic preconditioning
- Where
- Finland
- Volunteers
- 4 people
- Sponsor
- Oulu University Hospital
Myocardial Injury, Cardiac Surgery
Effect of Cyclosporine and Remote Ischemic Preconditioning in Reperfusion Ischemia Injury on Tetralogy Fallot Patients With Correction Surgery
The study aimed to evaluate the combined effects of cyclosporine and remote ischemic preconditioning on MDA, calcium cytosol concentration, and mitochondrial edema in tetralogy Fallot patients undergoing corrective surgery.
- Trial name
- NCT05691764
- Testing
- Cyclosporin, remote ischemic preconditioning
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Indonesia
Ischemic Preconditioning
A Trial Comparing the Ischemic Preconditioning Effects of Ticagrelor and Clopidogrel in Humans
Antiplatelet therapy remains a cornerstone in the treatment of acute and chronic coronary artery disease. Aspirin was the first such therapy to prove its benefits in acute myocardial infarction.
- Trial name
- ETCH (NCT01743937)
- Testing
- Coronary occlusion with balloon inflation
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- University of Texas Southwestern Medical Center
Myocardial Reperfusion Injury, Hypoxia
Effects of Hypoxic-hyperoxic Preconditioning in Cardio-surgical Patients
Coronary artery bypass grafting (CABG) with cardiopulmonary bypass is a common surgical therapy for patients suffering from coronary artery diseases.
- Conditions
- Myocardial Reperfusion Injury, Hypoxia, Hyperoxia, Coronary Artery Disease
- Trial name
- NCT05354648
- Testing
- Hypoxic-hyperoxic preconditioning
- Volunteers
- 120 people
- Sponsor
- Alexander Averyanov
Hypertension, Vascular Diseases
The Effect of Chronic Remote Ischaemic Preconditioning on Blood Pressure in Older Adults
The purpose of this study is to assess whether remote ischaemic conditioning, applied chronically, improves vascular health in older adults
- Trial name
- RIPCo (NCT05971407)
- Testing
- Remote Ischaemic Preconditioning
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Ischaemic Heart Diseases
The Effect of Ischaemic-Reperfusion and Remote Ischaemic Preconditioning in Man - A Bradykinin Dependent Pathway
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed at relieving this blockage as quickly as possible to minimize damage to the heart muscle.
- Trial name
- NCT00965393
- Testing
- Forearm vascular study, bradykinin receptor antagonist (HOE-140)
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Chronic Kidney Diseases
The Renal Protective Effects of Remote Ischemic Preconditioning in Patients With Chronic Kidney Disease
The incidence of Chronic kidney disease (CKD) is showing an upward trend, but the therapeutic effect of treatment is limited. Remote ischemic conditioning (RIC) has the potential to safeguard remote organs via the repeated…
- Trial name
- NCT06501222
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Yuanjun Yang