Clinical trials: Ischemia Preconditioning
Lactic Acidosis
Remote Ischemic Preconditioning During Cardiopulmonary Bypass
The objective of study is to detect effect of remote ischemic preconditioning on serum lactate levels during and after cardiac surgery with cardiopulmonary bypass in addition to its effect on cardiac and renal clinical outcomes.
- Trial name
- RIPC (NCT03723993)
- Testing
- Inflated cuff, Non inflated cuff
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fayoum University
Acute Kidney Injury, Heart Failure
Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial
This is a prospective, double-blind, sham-controlled, multicenter, randomized clinical trial is to study the effects of remote ischemic preconditioning on contrast-associated acute kidney injury, functional capacity, and major…
- Conditions
- Acute Kidney Injury, Heart Failure, Contrast Induced Nephropathy, Coronary Angiography
- Trial name
- RICH (NCT04982419)
- Testing
- Remote ischemic preconditioning
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
Heart Failure, Left Ventricular Dysfunction
Pilot Study of Remote Ischemic Preconditioning in Heart Failure
The purpose of this study is to determine the effect of remote ischemic preconditioning on exercise capacity in patients with heart failure.
- Trial name
- NCT01128790
- Testing
- Remote ischemic preconditioning
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University Health Network, Toronto
Ischemic Preconditioning
The Study of Potency of Cross-preconditioning to Prevent Ischemic-reperfusion Injury for Heart Transplantation Recipient
In recent years, a large number of studies confirmed the protective effect of ischemic preconditioning on myocardium against ischemia/reperfusion injury, but the clinical data of the effectiveness of ischemic preconditioning in…
- Trial name
- NCT03900390
- Testing
- cross-preconditioning
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Mengya Liang
Ischemia-Reperfusion Injury, Free Flap
Non-invasive Remote Ischemic PreConditioning (RIPC) in Free Flaps for Breast Reconstruction
This prospective randomized clinical study investigates the effects of Remote Ischemic Conditioning (RIC) on tissue perfusion and ischemia-reperfusion injury in patients undergoing free flap reconstruction in reconstructive…
- Conditions
- Ischemia-Reperfusion Injury, Free Flap, Conditioning Therapy
- Trial name
- RIPC (NCT07487220)
- Testing
- Remote ischemic preconditiong
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- Ruhr University of Bochum
Myocardial Ischemia
Ticagrelor And PrEconditioning in Patients With coronaRy Artery diSease
The aim of this study is to assess the pleiotropic effects of ticagrelor that could represent possible mechanisms for its beneficial effects on cardiovascular mortality. We will test three different hypotheses: 1.
- Trial name
- TAPER-S (NCT02701140)
- Testing
- Coronary stenting, intracoronary ECG recording, Coronary Flow reserve
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- Italo Porto
Stroke Rehabilitation, Ischemic Preconditioning
Ischemic Preconditioning as an Intervention to Improve Stroke Rehabilitation - Froedtert
This study will be the first study to use ischemic preconditioning (IPC) as an intervention to improve stroke rehabilitation. IPC is a well studied, well tolerated intervention which has been shown to improve regional blood flow…
- Conditions
- Stroke Rehabilitation, Ischemic Preconditioning, Physical and Rehabilitation Medicine
- Trial name
- NCT03023150
- Testing
- Ischemic Preconditioning
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Hypoxic Preconditioning, Carotid Artery Stenosis
Hypoxic Preconditioning on Patients
The purpose of this study is to study the effects of intermittent whole-body hypoxic preconditioning on patients with carotid artery stenosis.
- Conditions
- Hypoxic Preconditioning, Carotid Artery Stenosis, Ischemic Cerebrovascular Disease
- Trial name
- NCT02966418
- Testing
- Mild Hypoxia Preconditioning
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Hua Yan
Acute Lung Injury
Limb RIPC in Patients Undergoing Lung Lobectomy. Study of Oxidative Lung Damage
Background: In patients undergoing lung lobectomy, lung collapse and re-expansion after resection is associated to severe oxidative lung injury.
- Trial name
- NCT02734654
- Testing
- remote ischemic preconditioning (RIPC)
- Volunteers
- 53 people
- Sponsor
- Instituto de Salud Carlos III
Myocardial Ischemia
Preconditioning With Sevoflurane and Propofol in Patients Undergoing Minimally Invasive Mitral Valve Surgery
The main aim of this study is to compare markers of cardiac injury (Troponin I), inflammatory response and platelets function during minimally invasive mitral valve repair or replacement (MIMV) via right mini-thoracotomy in two…
- Trial name
- MINI-SEVO (NCT02551328)
- Testing
- sevofluorane
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Fondazione Toscana Gabriele Monasterio
Ischemia
Inspired Helium for Ischemic Protection During Knee Replacement Surgery
The purpose of this study is to determine whether breathing in helium reduces indications of injury to the skeletal muscle seen in blood tests after knee replacement surgery.
- Trial name
- NCT02012361
- Testing
- Control Group, Single-Dose Heliox Group, Muscle Biopsy
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cyanosis
Effect of Remote Ischemic Preconditioning on Children Undergoing Cardiac Surgery
This study is conducted in order to evaluate the effect of remote ischemic preconditioning on children undergoing cardiac surgery, especially focusing on possible differences according to preoperative cyanosis.
- Trial name
- NCT01311310
- Testing
- RIPC (remote ischemic preconditioning)
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Ischemia Reperfusion Injury
The Effect of Remote Ischemic Preconditioning in Patients Undergoing Major Liver Surgery
The project has been designed to determine whether a brief period of leg ischemia will reduce the I/R injury sustained by the liver during liver surgery and liver transplantation.
- Trial name
- NCT00796588
- Testing
- remote preconditioning
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Royal Free Hampstead NHS Trust
Ischemic Preconditioning
Conditioning Based Intervention Strategies
The overall objective of this study is to uncover and utilize the mechanisms behind the activation of endogenous organ protection by remote ischemic conditioning (RIC), high intensity traditional resistance training (TRT) and low…
- Trial name
- ConBIS (NCT03380663)
- Testing
- Remote Ischemic Conditioning (RIC)
- Where
- Denmark
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Laparoscopic Colorectal Surgery
Limb Remote Ischemic Preconditioning for Heart and Intestinal Protection During Laparoscopic Colorectal Surgery
Remote ischaemic preconditioning may confer the cytoprotection in critical organs. The investigators hypothesized that limb remote ischemic preconditioning (RIPC) would reduce heart and gastrointestinal function injury in…
- Trial name
- NCT01832337
- Testing
- Limb remote ischemic preconditioning (LRIP)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fei Li
Renal Cell Carcinoma
Effect of Ketorolac and Remote Ischemic Preconditioning on Renal Ischemia-reperfusion Injury in Patients Undergoing Partial Nephrectomy
Partial nephrectomy is a widely accepted alternative to radical nephrectomy in patients with clinically localized, unilateral renal cell carcinoma and a normal contralateral kidney.
- Trial name
- NCT01836406
- Testing
- Ketorolac tromethamine and remote ischemic preconditioning
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Yonsei University
Exercise
Ischemic Preconditioning in Endurance Athletes
The aim of this study is to investigate the effect of remote ischemic preconditioning on biochemical and functional indices of cardiac function induced by a 30 km run in healthy trained long distance runners.
- Trial name
- NCT01774461
- Testing
- Remote ischemic preconditioning
- Where
- Netherlands
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Perioperative/Postoperative Complications
Remote Ischemic Preconditioning Before Abdominal Surgery
Major abdominal surgeries are associated with perioperative cardiac morbidity of up to 10%. Ischemic preconditioning may have a protective effect.
- Trial name
- NCT01340742
- Testing
- Remote Ischemic Pre-conditioning, Control
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Myocardial Injury
Effect of Delayed Remote Ischemic Preconditioning on Myocardial Injury
The purpose of this study is to evaluate delayed myocardial protective effect of RIPC in patients undergoing cardiac valve replacement surgery.
- Trial name
- RIPC (NCT01903161)
- Testing
- delayed remote ischemic preconditioning, control
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Hospital
Duchenne Muscular Dystrophy (DMD)
The Safety, Efficacy and Tolerability of Remote Ischemic Preconditioning as a Therapy to DMD
Background: Duchenne muscular dystrophy (DMD) is an X chromosome recessive hereditary disease and mainly characterized by progressive muscle weakness and atrophy.
- Trial name
- NCT02614820
- Testing
- Remote Ischemic Preconditioning Training Apparatus
- Where
- China
- Volunteers
- 100 people
- Sponsor
- General Hospital of Chinese Armed Police Forces