Clinical trials: Ischemia Preconditioning
Unruptured Cerebral Aneurysm
Remote Ischemic PreConditioning (RIPC)
The purpose of this study is to learn about protecting the brain from low blood flow (ischemia) with limb preconditioning. From human studies the investigators know that the brain can be protected from dangerous low blood flow by…
- Trial name
- NCT03814850
- Testing
- Standard Manual Aneroid Sphygmomanometer
- Where
- 2 sites in United States
- Sponsor
- Sebastian Koch
Spinal Cord Injuries
Ischaemic Preconditioning and Upper Body Exercise Performance in Persons With Spinal Cord Injury
Regular physical activity improves physical fitness, fatigue, quality of life, gait and reduces progression of the disability in persons with SCI. However, persons with SCI are less physically active than the general population.
- Trial name
- NCT05954715
- Testing
- Ischaemic Preconditioning
- Volunteers
- 40 people
- Sponsor
- Loughborough University
Raynaud Disease, Raynaud's Phenomenon
A Trial of Ischemic Preconditioning in Raynaud's Phenomenon (RP)
This trial will test the efficacy of brief periods of controlled limb ischemia (remote ischemic preconditioning, RIPC) as an effective treatment of patients with Raynaud's Phenomenon (RP).The hypothesis of this trial is that due…
- Trial name
- NCT02506062
- Testing
- Manual blood pressure cuff inflation over brachial artery
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Abdominal Aortic Aneurysm
Impact of Limb Remote Ischemic Preconditioning on Mortality and Quality of Life During Abdominal Aortic Aneurysm Repair
To investigate the influence of limb remote ischemic preconditioning (LRIP) on mortality, hospitalization costs and quality of life in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.
- Trial name
- NCT01910961
- Testing
- limb RIPC
- Volunteers
- 360 people
- Sponsor
- Cai Li
Pain
Remote Ischemic PreConditioning Effect on Postsurgical Pain
Remote Ischemic PreConditioning (RIPC) will improve the postoperative pain experience in patients undergoing abdominal surgery. Although abdominal surgery can be a lifesaving procedure many people have a significant amount of…
- Trial name
- RIPCEPP (NCT01383317)
- Testing
- Thigh Tourniquet (VBM Single Use Tourniquet Cuff Items 20-34-722SLZ-1)
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Wake Forest University Health Sciences
Sport Medicine, Sport
Ischemic Preconditioning - Perspectives of Use Vivio/in Vitro Studies
Both in sports and medicine, methods that can significantly contribute to improving the ability of tissues to perform their functions are constantly being searched.
- Conditions
- Sport Medicine, Sport, Physiological Adaptations, Sport Performance
- Trial name
- NCT07117643
- Testing
- Ischemic Preconditioning
- Where
- 2 sites in Poland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Remote Organ Ischemic Preconditioning
The Effects Of Remote Organ Ischemic Preconditioning On Systemic Inflammatory And Glycocalyx Integrity Parameters
Ischemia-reperfusion (IR) injury during liver transplantation is one of the major causes of mortality and morbidity associated with transplantation.
- Trial name
- NCT04216407
- Testing
- Remote ischemic preconditioning
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Acibadem University
Ischemia
Trial of the Effects of Remote Preconditioning on the Tissue Metabolism During Exercise and Ischemia
Previously, the preconditioning signaling pathways have been studied on molecular level or in animal model. By using MR spectroscopy and imaging in a dynamic human model of preconditioning, we will have a better understanding how…
- Trial name
- NCT00791206
- Testing
- Real preconditioning
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Myocardial Injury, Non-cardiac Surgery
The Effect of Remote Ischemic Preconditioning on Myocardial Injury After Noncardiac Surgery
This is a multicentre, parallel-group, randomised, sham-controlled, observer blinded trial, assessing the efficacy of remote ischemic preconditioning on preventing myocardial injury after noncardiac surgery.
- Conditions
- Myocardial Injury, Non-cardiac Surgery, Remote Ischemic Preconditioning
- Trial name
- NCT05733208
- Testing
- Remote ischemic preconditioning
- Where
- China
- Volunteers
- 766 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Contrast-induced Nephropathy
Efficacy of Remote Ischemic Preconditioning as Non Pharmacologic Strategy to Prevent Contrast Induced Nephropathy (PAIR)
This study evaluates remote ischemic preconditioning as an strategy to avoid contrast induced nephropathy. All of the patients will receive endovenous normal saline to prevent nephropathy, half of the patients will receive remote…
- Trial name
- PAIR (NCT03136458)
- Testing
- Ischemic preconditioning, Endovenous normal saline
- Where
- Colombia
- Sponsor
- Camilo Andrés Páez Angarita
Cardiotoxicity
Effect of Remote Ischaemic Conditioning in Oncology Patients
Cancer survival has improved steadily due to earlier detection and treatment. Despite the established efficacy of anthracycline chemotherapy, its damaging effects on the heart (cardiotoxicity) limits treatment and confers acute…
- Trial name
- ERIC-ONC (NCT02471885)
- Testing
- Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 128 people
- Sponsor
- University College, London
Myocardial Injury
Remote Ischemic Preconditioning in Coronary Artery Bypass Grafting With Cold Crystalloid Cardioplegic Arrest
Remote ischemic preconditioning (RIPC) with transient upper limb ischemia/reperfusion reduces myocardial injury in patients undergoing on-pump coronary artery bypass (CABG) surgery with cross-clamp fibrillation or blood…
- Trial name
- NCT01406678
- Testing
- RIPC, Control, isoflurane+sufentanil anesthesia
- Where
- Germany
- Volunteers
- 1,204 people
- Sponsor
- University Hospital, Essen
Multiple Sclerosis
RIPC on Activity, Fatigue and Gait in MS
This study evaluates whether Remote Ischaemic Preconditioning (RIPC) can improve activity, gait and fatigue in people with Multiple Sclerosis. Half the participants will receive RIPC, the other half will receive a sham treatment.
- Trial name
- MSIPC-2 (NCT03967106)
- Testing
- Ischaemic Preconditioning
- Where
- United Kingdom
- Volunteers
- 92 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Coronary Artery Disease
Remote Ischemic Preconditioning on the Prognosis of Patients With Elective PCI Using Drug-coated Balloon
Drug-coated balloon is being used more and more widely for the advantage of intervention without implantation. But the balloon needs to be released long enough to be effective.
- Trial name
- RIPC-DCB (NCT04766749)
- Testing
- RIPC
- Where
- China
- Volunteers
- 430 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Subcortical Vascular Dementia
Remote Ischemic Preconditioning for Subcortical Vascular Dementia
The purpose of this study is to determine whether the remote ischemic preconditioning are effective in the treatment of mild to moderate vascular dementia.
- Trial name
- RIPSVD (NCT03022149)
- Testing
- Doctormate® (200mmHg), Doctormate® (60mmHg)
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Tianjin Medical University General Hospital
Ischemic Reperfusion Injury
Single-cycle Remote Ischemic Preconditioning and Postconditioning (SCRIP) Trial
This trial is a 2 x 2 factorial design, double-blinded, randomized controlled trial to evaluate efficacy and safety of remote ischemic preconditioning and postconditioning in patient undergoing coronary angioplasty.
- Trial name
- SCRIP (NCT02649309)
- Testing
- RIPre, RIPost
- Where
- Thailand
- Volunteers
- 370 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Abdominal Aortic Aneurysm, Carotid Atherosclerosis
Preconditioning Shields Against Vascular Events in Surgery
Major vascular surgery involves operations to repair swollen blood vessels, clear debris from blocked arteries or bypass blocked blood vessels.
- Conditions
- Abdominal Aortic Aneurysm, Carotid Atherosclerosis, Critical Lower Limb Ischaemia
- Trial name
- SAVES (NCT01691911)
- Testing
- Remote preconditioning
- Where
- Ireland
- Volunteers
- 200 people
- Sponsor
- Mid Western Regional Hospital, Ireland
Type 2 Diabetes Mellitus
Ischemic Preconditioning and Type 2 Diabetes
The aim of this study is to determine the impact of 7 days of daily ischemic preconditioning (IPC) on vascular function and insulin sensitivity in Type 2 Diabetes Mellitus.
- Trial name
- NCT03598855
- Testing
- Ischemic Preconditioning
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Liverpool John Moores University
Cancer, Rectal
Safety & Efficacy of Ischemic Preconditioning by Embolization of the Inferior Mesenteric Artery in Surgery for Tumors of Lower and Middle Rectum
The present study will investigate the safety of inferior mesenteric artery embolization prior to rectal surgery, according to IDEAL recommendations (Lancet 2009).
- Trial name
- AMIREMBOL_2 (NCT06236633)
- Testing
- Ischemic preconditioning, Arteriogram
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute Kidney Injury
Ischemic Preconditioning to Prevent Acute Kidney Injury
The purpose of this study is to learn about the impact of ischemic preconditioning in reducing contrast induced kidney damage in people with pre-existing kidney problems who are undergoing cardiac catheterization procedures.
- Trial name
- NCT02167152
- Testing
- Ischemic preconditionin
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of Kansas Medical Center