Clinical trials: Ischemic Bowel
Ischemia
Biomagnetic Signals of Intestinal Ischemia
The lack of blood flow to the small intestine causes mesenteric ischemia. Using a Superconducting QUantum Interference Device (SQUID) which measures the magnetic field of the small intestine, we are hoping to identify…
- Trial name
- NCT00285545
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of South Alabama
Acute Mesenteric Ischemia, Short Bowel Syndrome
Antithrombotic Management of Acute Mesenteric Ischaemia
Guidelines on the acute and long-term pharmacological treatment of acute mesenteric ischaemia (AMI) recommend the use of thrombolytic, antiplatelet or anticoagulant therapy depending on the aetiology of AMI and the use of…
- Trial name
- NCT05706012
- Testing
- Survey
- Where
- Belgium
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Colorectal Cancer, Inflammatory Bowel Diseases
Optimizing Postoperative Nutrition in Colorectal Surgery
Major surgical operations of the gastrointestinal tract, such as colorectal resections due to several diseases, lead to significant burden on the human body, which is expressed during the first postoperative hours with an intense…
- Conditions
- Colorectal Cancer, Inflammatory Bowel Diseases, Bowel Ischemia, Malnutrition
- Trial name
- OPTI-NUTRICS (NCT06737211)
- Testing
- Peripheral Parenteral Nutrition
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- National and Kapodistrian University of Athens
Mesenteric Ischemia, Bowel; Ischemic
Copenhagen Mesenteric Stent Study - A Randomized Trial of Stent Versus Covered Stent Treatment for Chronic Mesenteric Ischemia
Chronic mesenteric ischemia (CMI) is often caused by narrowings in the arteries providing blood to the intestines. Endovascular stent placement is considered the preferred treatment for this condition.
- Conditions
- Mesenteric Ischemia, Bowel; Ischemic, Superior Mesenteric Atherosclerosis, Mesenteric Artery Stenosis
- Trial name
- COMESS (NCT05244629)
- Testing
- BMS vs. CS
- Where
- Denmark
- Volunteers
- 98 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Mesenteric Ischemia
Investigation of Chronic Intestinal Ischemia
Patients suspected of chronic mesenteric ischemia caused by atherosclerosis or median arcuate ligament syndrome shall be investigated with trans mucosal and transserosal laser Doppler flowmeter and visible light spectroscopy.
- Trial name
- NCT02914912
- Where
- 2 sites in Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Chronic Limb-Threatening Ischemia, Colorectal Carcinoma
Comparison of Outcomes of Patients With Stage IV Chronic Limb-threatening Ischemia and Colorectal Cancer
Colorectal cancer (CRC) and chronic limb-threatening ischemia (CLTI) are relatively frequent and potentially fatal diseases. However, studies that are comparing clinical outcomes between CRC and CLTI patients in more advanced…
- Conditions
- Chronic Limb-Threatening Ischemia, Colorectal Carcinoma, Colorectal Carcinoma Metastatic in the Liver
- Trial name
- NCT05116696
- Testing
- For chronic limb-threatening ischemia (CLTI) patients revascularisation surgery; for colorectal liver metastasis (CRLM) patients metastatic liver surgery
- Where
- Serbia
- Volunteers
- 836 people
- Sponsor
- Clinical Centre of Serbia
Necrotizing Enterocolitis of Newborn, Bowel Ischemic
CEUS Evaluation of Bowel Perfusion in Necrotizing Enterocolitis
There is no bedside imaging technique that can quantify dynamic bowel perfusion with high soft tissue contrast and sensitivity in necrotizing enterocolitis (NEC).
- Trial name
- NCT03549507
- Testing
- Sulfur hexafluoride lipid-type A microspheres
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Hospital of Philadelphia
Chronic Arthritis, Ischemic Heart Disease
Misoprostol for Small Bowel Ulcers and Obscure Bleeding Due to Aspirin or Nonsteroidal Antiinflammatory Drugs
Anti-inflammatory tablets (non-steroidal anti-inflammatory drugs) continue to be used commonly worldwide to relieve pain caused by arthritis. Likewise, aspirin is used by many patients in order to prevent blood clots.
- Conditions
- Chronic Arthritis, Ischemic Heart Disease, Atrial Fibrillation, Anemia
- Trial name
- MASTERS (NCT02202967)
- Testing
- Misoprostol
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- NHS Greater Glasgow and Clyde
Mesenteric Vascular Disease
Mesenteric Ischemia Markers Study
Vascular bowel disease remains a socially significant and potentially fatal condition (if it develops into AMI), primarily due to delayed diagnosis.
- Trial name
- MESMARK (NCT07460700)
- Testing
- Blood samples
- Where
- Belarus
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Belarusian State Medical University
IHD, Gastro-Intestinal Disorder
Clinical Study Evaluating the Gastroprotective Effect of Carvedilol in Patients With Ischemic Heart Disease on Aspirin Therapy
The aim of this study is to investigate the possible efficacy of Carvedilol as gastroprotective agent against aspirin-induced upper gastro-intestinal complications in patients with ischemic heart disease (IHD).
- Conditions
- IHD, Gastro-Intestinal Disorder, Aspirin Induced Esophageal Ulcer
- Trial name
- NCT05553717
- Testing
- Carvedilol
- Volunteers
- 66 people
- Sponsor
- Tanta University
Acute Mesenteric Ischemia
Acute Intestinal Necrosis- the Preoperative Diagnostic Approach
To investigate a number of blood based parameters in patients with intestinal ischaemia compared to patients with other acute abdominal diseases.
- Trial name
- AIN (NCT05665946)
- Testing
- Blood sample analysis
- Volunteers
- 2,958 people
- Sponsor
- Aalborg University Hospital
Mesenteric Artery Ischemia
Incidence, Treatment and Outcome After Acute Mesenteric Ischemia in the Region of Västra Götaland, 2000-2023.
The goal of this retrospective observational study is to describe the incidence and outcome of patients diagnosed with acute mesenteric ischemia (AMI) in the Västra Götaland region of Sweden between 2000-2023.
- Trial name
- AMIGO (NCT07274306)
- Where
- 2 sites in Sweden
- Volunteers
- 2,446 people
- Sponsor
- Sahlgrenska University Hospital
Colon Cancer, Fragility
Prehabilitation of Frail Surgical Cancer Patients Using Remote Ischemic Preconditioning
This project will examine the efficacy of a simple, cost-effective, non-invasive intervention, called remote ischemic preconditioning (RIPC), to reduce frailty in pre-surgical, frail, elderly patients with colon cancer.
- Conditions
- Colon Cancer, Fragility, Prehabilitation, Surgery
- Trial name
- Prehab (NCT03853473)
- Testing
- Remote Ischemic Preconditioning
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Medical College of Wisconsin
Critical Limb Ischemia, Peripheral Arterial Disease
Pilot Safety Study of Injectable SIS for Critical Limb Ischemia
This study is intended to collect safety and effectiveness data on the Cook Injectable Small Intestinal Submucosa (SIS)
- Conditions
- Critical Limb Ischemia, Peripheral Arterial Disease, Peripheral Vascular Disease
- Trial name
- CLIC (NCT02145845)
- Testing
- Injectable SIS
- Where
- Czechia
- Volunteers
- 13 people
- Sponsor
- Cook Group Incorporated
Rectal Neoplasms, Colitis, Ischemic
Anterior Perineal Plane for Ultra Low Anterior Resection of the Rectum
Anal sphincter preserving operations are now commonplace for both cancer and non-cancerous rectal diseases. However, this has not always been the case and this development has been facilitated by the invention of circular…
- Conditions
- Rectal Neoplasms, Colitis, Ischemic, Colitis, Ulcerative
- Trial name
- APPEAR (NCT00534131)
- Testing
- Standard abdominal approach for rectal excision, APPEAR Procedure, Proctectomy
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- Queen Mary University of London
Cardiac Surgery With Cardiopulmonary Bypass, Acute Mesenteric Ischemia
Perioperatively Assessed Biomarker I-FABP Level for Prediction of Acute Mesenteric Ischemia and Its Correlation With Acute Kidney Injury, Followed by Extracorporeal Circulation (aMIKI)
Acute mesenteric ischemia (AMI) is a severe condition that might occur after cardiovascular surgery. Several risk factors for AMI, such as multimorbidity, the use of vasopressors, and an increase in inflammatory markers have been…
- Conditions
- Cardiac Surgery With Cardiopulmonary Bypass, Acute Mesenteric Ischemia, Acute Kidney Injury, Non-Occlusive Mesenteric Ischaemia
- Trial name
- aMIKI (NCT06365827)
- Testing
- observational study
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Giessen
Coronary Artery Disease, Atrial Fibrillation
The Genomic Medicine at VA Study
This trial will determine the clinical effectiveness of polygenic risk score testing among patients at high genetic risk for at least one of six diseases (coronary artery disease, atrial fibrillation, type 2 diabetes mellitus…
- Conditions
- Coronary Artery Disease, Atrial Fibrillation, Type 2 Diabetes, Colorectal Cancer
- Trial name
- GenoVA (NCT04331535)
- Testing
- Polygenic risk score (PRS)
- Where
- United States
- Volunteers
- 1,071 people
- Sponsor
- Boston VA Research Institute, Inc.
Anastomotic Leak, Bowel Resection
Intra-Operative Infrared Thermography for Bowel Resection
This prospective randomized control pilot study evaluates the use of intra-operative infrared thermography compared to conventional visual assessment for preventing anastomotic leaks in bowel resection surgeries.
- Conditions
- Anastomotic Leak, Bowel Resection, Intestinal Ischemia
- Trial name
- NCT07906704
- Testing
- Intra-operative Infrared Thermography, Conventional visual assessment
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Sir Ganga Ram Hospital
Open/ Laparoscopic/ Robotic Resection of the Colon
Collection of Electrophysiological Data During Colon Resection
The study is conducted to record continuous electrophysiological signals from intact and ischemic bowel tissue during colonic resection surgery, in order to train the Exero Medical Leak Detection System classification algorithm…
- Trial name
- NCT04854473
- Testing
- Exero Medical Leak Detection System
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Exero Medical Ltd.
Pelvic Cancer, Rectal Cancer
Perineal Flap Reconstruction Following Surgery for Advanced Pelvic Malignancy
Flap reconstruction is utilised increasingly for repair of skin and soft tissue defects following pelvic exenteration. Many methods have been proposed but the outcomes associated with each remain largely unknown and the choice…
- Conditions
- Pelvic Cancer, Rectal Cancer, Flap Disorder, Flap Ischemia
- Trial name
- NCT05074082
- Testing
- Flap reconstruction
- Where
- Ireland
- Volunteers
- 883 people
- Sponsor
- St Vincent's University Hospital, Ireland