Clinical trials: Ischemic Brain
Ischemic Stroke
Antithrombotic Drug Use in Patients With Ischemic Stroke and Microbleeds
To observe the effect of different antithrombotic drugs on the prognosis of ischemic stroke patients with cerebral microbleeds. And further combined with proteomic methods to explore serological markers that can be used to…
- Trial name
- AIM-2 (NCT05032053)
- Testing
- Antithrombotic drugs
- Where
- 16 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Xijing Hospital
Acute Ischemic Stroke
Post-registration Trial of the Non-immunogenic Staphylokinase in Acute Ischemic Stroke (FORPI Registry)
The aim of FORPI Registry is to study the safety and efficacy of the non-immunogenic staphylokinase in patients with acute ischemic stroke in routine clinical practice.
- Trial name
- NCT06707987
- Testing
- Non-immunogenic staphylokinase
- Where
- Russia
- Volunteers
- 23,250 people
- Sponsor
- Supergene, LLC
Post-Stroke Cognitive Impairment (PSCI), Ischemic Stroke
Evaluation of Clinical Efficacy and Mechanism of Hand Jing-Well Acupoint Transcutaneous Electrical Stimulation in Improving Post-Stroke Cognitive Impairment
This study evaluates a non-invasive electrical stimulation therapy applied to specific acupoints on the fingers (called Jing-Well points) to improve thinking and memory problems after stroke.
- Conditions
- Post-Stroke Cognitive Impairment (PSCI), Ischemic Stroke, Cognitive Dysfunction, Cognitive Disorder, Hemorrhagic Strokes
- Trial name
- NCT07736885
- Testing
- Transcutaneous Electrical Stimulation at Jing-Well Acupoints
- Where
- China
- Volunteers
- 70 people
- Sponsor
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Acute Cerebral Ischemia
Study to Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke
This is a prospective, multicenter, randomized, double-blind, parallel, phase IV study designed to evaluate the safety and efficacy of sovateltide (PMZ-1620, IRL-1620) as a potential treatment for cerebral ischemic stroke.
- Trial name
- NCT05955326
- Testing
- Sovateltide, Normal Saline
- Where
- 6 sites in India
- Volunteers
- 160 people
- Sponsor
- Pharmazz, Inc.
Atrial Fibrillation, Ischemic Stroke
Precision Medicine in Ischemic Stroke and Atrial Fibrillation
The overall goal of this study is to minimize morbidity due to Atrial Fibrillation (AF). The specific objective is to develop and implement a rational and personalized approach to AF risk estimation that can inform management…
- Trial name
- PreMISe-AF (NCT04637087)
- Testing
- Atrial fibrillation risk electronic health record alert
- Where
- United States
- Volunteers
- 805 people
- Sponsor
- Massachusetts General Hospital
Ischemic Stroke, Systemic Embolism
Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial
This trial is a prospective, randomized, multicenter, multinational, blinded, superiority trial. The objective of this trial is to evaluate the effectiveness of left atrial appendage exclusion (LAAE) for the prevention of…
- Trial name
- LeAAPS (NCT05478304)
- Testing
- AtriClip LAA Exclusion System
- Where
- 138 sites in United States, Australia and 8 more
- Volunteers
- 6,573 people
- Sponsor
- AtriCure, Inc.
Ischemic Stroke
Boosting REcanalization of Thrombectomy for Ischemic Stroke by Intra-arterial TNK (BRETIS-TNK)
Thrombolysis and endovascular thrombectomy are the most efficient treatments for acute ischemic stroke patients in time window. However, sufficient recanalization (mTICI2b-3) can 't be acquired in all patients under thrombectomy.
- Trial name
- NCT04202458
- Testing
- intra-arterial tenecteplase administration
- Where
- China
- Volunteers
- 30 people
- Sponsor
- General Hospital of Shenyang Military Region
Spinal Cord Injury, Amyotrophic Lateral Sclerosis
iBCI Optimization for Veterans With Paralysis
VA research has been advancing a high-performance brain-computer interface (BCI) to improve independence for Veterans and others living with tetraplegia or the inability to speak resulting from amyotrophic lateral sclerosis…
- Conditions
- Spinal Cord Injury, Amyotrophic Lateral Sclerosis, Brain Stem Infarctions, Locked-in Syndrome
- Trial name
- NCT05470478
- Testing
- Mobile neural decoding platform (mobile iBCI)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- VA Office of Research and Development
Stroke, Acute Cerebral Infarction
Perfusion Imaging Evaluation for Ischemic Stroke on 6-24 Hours Undergoing Endovascular Thrombectomy
This study aims to evaluate the hypothesis that thrombectomy devices plus medical management leads to superior clinical outcomes in acute ischemic stroke patients at 90 days as compared to medical management alone in…
- Trial name
- PESET (NCT03502408)
- Testing
- Endovascular Thrombectomy
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Aneurysmal Subarachnoid Hemorrhage
Hypercapnia to Prevent Secondary Ischemia in SAH
Delayed cerebral vasospasm and secondary ischemic infarction are feared complications after aneurysmal subarachnoid hemorrhage (aSAH). To date, there is no effective therapy to prevent these ischemic complications.
- Trial name
- SAHCO2 (NCT01799525)
- Testing
- Hypercapnia by reduction of respiratory volume
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Wuerzburg University Hospital
Intracranial Artery Stenosis
Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis
Intracranial atherosclerotic disease (ICAD) is the most common cause of ischemical cerebrovascular events. The risk of stroke recurrence or death of ICAD patients remains very high.
- Trial name
- BASIS (NCT03703635)
- Testing
- intracranial balloon angioplasty, aggressive medical management
- Where
- 31 sites in China
- Volunteers
- 512 people
- Sponsor
- Ministry of Science and Technology of the People´s Republic of China
Stroke, Acute, Progressing Stroke
Safety and Efficacy of Therapeutic INduced HYPERTENSION in Acute Non-cardioembolic Ischemic Stroke (SETIN-HYPERTENSION)
The purpose of this study is to evaluate the safety and efficacy of the induced hypertension using phenylephrine in patients with noncardioembolic ischemic stroke.
- Trial name
- NCT01600235
- Testing
- Phenylephrine
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- Samsung Medical Center
Hypoxic Ischemic Encephalopathy (HIE)
Caffeine for Hypoxic Ischemic Encephalopathy
CHIME is a randomized, parallel-arm, double-blind, placebo-controlled trial focused on infants with hypoxic ischemic encephalopathy (HIE).
- Trial name
- CHIME (NCT06855108)
- Testing
- Caffeine citrate oral solution
- Where
- 7 sites in Bangladesh, Democratic Republic of the Congo and 4 more
- Volunteers
- 830 people
- Sponsor
- NICHD Global Network for Women's and Children's Health
Stroke, Ischemic
BEACON-AA: Apixaban With or Without Clopidogrel in Stroke Patients With Atrial Fibrillation and Cerebral Atherosclerosis
This trial aims to compare the safety and efficacy of apixaban alone versus apixaban combined with clopidogrel in patients with acute ischemic stroke associated with non-valvular atrial fibrillation and concomitant symptomatic…
- Conditions
- Stroke, Ischemic, Atrial Fibrillation, Intracrnaial Arterioscelrosis
- Trial name
- NCT07237308
- Testing
- Apixaban, Clopidogrel
- Where
- South Korea
- Volunteers
- 586 people
- Sponsor
- Yonsei University
Stroke, Ischemic, Upper Limb Injury
MOdularity for SEnsory Motor Control
For this project the investigators ask, how the activation and organization of muscle synergies may be disrupted by brain lesions, and whether it is possible to modify synergy activations by means of specific therapies.
- Conditions
- Stroke, Ischemic, Upper Limb Injury, Rehabilitation
- Trial name
- MOSE (NCT03530358)
- Testing
- Technology-aided rehabilitation, Conventional rehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 132 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Ischemia Stroke, Electro-acupuncture
Electroacupuncture-Induced Changes in Tongue Features in Early Stroke Patients Using ZMT-1A Imaging System
This prospective clinical study aims to evaluate changes in tongue characteristics before and after a four-week course of electroacupuncture in patients undergoing early rehabilitation following ischemic stroke.
- Trial name
- ZMT-StrokeEA (NCT07107958)
- Testing
- Electroacupuncture
- Where
- 3 sites in Vietnam
- Volunteers
- 200 people
- Sponsor
- Dr Nguyen Ngo Le Minh Anh MD, PhD
Acute Ischemic Stroke
CERebrolysine Effect on Blood-brain Barrier in acUte Ischemic Stroke
The study investigates whether Cerebrolysin stabilizes blood-brain barrier integrity in a manner that can be monitored using serum levels of the principal tight junction proteins, e.g., occludin (OCL), claudin-5 (CLN), and zonula…
- Trial name
- CERBERUS (NCT06078215)
- Testing
- Cerebrolysin
- Where
- Poland
- Volunteers
- 350 people
- Sponsor
- Poznan University of Medical Sciences
Congenital Heart Defects, Brain Ischemia
Hypothermia Therapy in Pediatric Cardiac Intensive Care Unit for Suspected for Brain Injury
Cardiac pathology is a major risk for brain injury and neurodevelopmental deficit. The most common cause of cardiac pathology is congenital heart defects (CHD) about 4-8/1000 live births a year.
- Conditions
- Congenital Heart Defects, Brain Ischemia, Hypoxia Brain, Child
- Trial name
- Coolheart (NCT02395276)
- Testing
- Whole body hypothermia
- Volunteers
- 75 people
- Sponsor
- Sheba Medical Center
Cerebrovascular Accident, Stroke
Determining Optimal Post-Stroke Exercise (DOSE)
The investigators will conduct a proof-of-concept study to provide preliminary evidence of efficacy of physical exercise dose on ambulatory function in adults undergoing sub-acute stroke rehabilitation.
- Conditions
- Cerebrovascular Accident, Stroke, Cerebral Infarction, Brain Infarction
- Trial name
- NCT01915368
- Testing
- Stroke Management Program (SMP), Stroke Monitoring Program (SMonP), Stroke Supplementary Program (SSP)
- Where
- 8 sites in Canada
- Volunteers
- 75 people
- Sponsor
- University of British Columbia
Hemorrhagic Stroke, Intracerebral, Acute Ischemic Stroke
Feasibility of a Digital Goals-of-Care Decision Aid for Clinicians and Families of Patients With SABI
The goal is to pilot test a highly accessible, web-based, pragmatic, scalable intervention to overcome ongoing problems with high stakes decision-making by surrogate decision-makers of patients in ICUs with severe acute brain…
- Conditions
- Hemorrhagic Stroke, Intracerebral, Acute Ischemic Stroke, Traumatic Brain Injury
- Trial name
- NCT05671874
- Testing
- Web/mobile/tablet-based digital decision aid + communication (DA+C) tool
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
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