Clinical trials: Ischemic Brain
Ischemic Stroke
One Pass Tirofiban In Management of Ischemic Stroke Thrombectomy In China
In recent years, the positive results of trials for mechanical thrombectomy (MT) have brought a new era for large artery occlusion patients, especially those beyond the time window of intravenous thrombolysis.
- Trial name
- OPTIMISTIC (NCT04851457)
- Testing
- Intravenous tirofiban combination therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai East Hospital
Ischemic Stroke, Atrial Fibrillation
Atrial Fibrillation and Carotid Atherosclerosis in Ischemic Stroke Patients-(AFCAS)
The main aim of the study is to investigate the prevalence and characteristics of ischemic stroke patients with atrial fibrillation and concurrent carotid atherosclerosis.
- Conditions
- Ischemic Stroke, Atrial Fibrillation, Carotid Stenosis
- Trial name
- AFCAS (NCT04821700)
- Testing
- Carotid Stenosis
- Where
- Greece
- Volunteers
- 3,000 people
- Sponsor
- University of Thessaly
Stroke, Ischemic, Genetic Disease
CUHK Stroke Biobank
The purpose of the study are: 1. To make quality, characterized samples and related data available for future studies, including Genome Wide Association Studies (GWAS), genomics, and biomarker research; 2.
- Conditions
- Stroke, Ischemic, Genetic Disease, Atherosclerosis, Cerebral
- Trial name
- NCT03291392
- Testing
- Gene expression or biomarkers exploration
- Where
- Hong Kong
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Hypoxic Ischemic Encephalopathy, Perinatal Asphyxia
Ascorbic Acid and Ibuprofen in Infants With Hypoxic Ischemic Encephalopathy
Oxygen radicals and inflammation are important causes for brain injury in neonates following perinatal asphyxia. Animal studies demonstrated potential benefits to the brain when using both of vitamin C and ibuprofen.
- Trial name
- NCT00624871
- Testing
- Ascorbic acid (vitamin C), Ibuprofen
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Al-Azhar University
Stroke, Ischemic
Triage of Patients Presenting Beyond 24 Hours With Ischemic Stroke Due to Vertebrobasilar Artery Occlusion
Endovascular thrombectomy (EVT) for posterior circulation occlusion is generally performed within a window of less than 24 hours from the time the patient was last known well (LKW).
- Trial name
- VBAO-LATE (NCT06510634)
- Testing
- Endovascular Therapy
- Where
- China
- Volunteers
- 236 people
- Sponsor
- Tianjin Huanhu Hospital
Subarachnoid Hemorrhage
Preconditioning for Aneurismal Subarachnoid Hemorrhage
In remote preconditioning, ischemia in one organ protects distant organs from ischemic insults. e.g. brief induced limb ischemia protects the brain from an otherwise more severe stroke.
- Trial name
- NCT01110239
- Testing
- remote limb preconditioning
- Volunteers
- 34 people
- Sponsor
- University of Miami
Acute Ischemic Stroke
A Safety and Dose Finding Study of Plasmin (Human) Administered Into the Middle Cerebral Artery of Stroke Patients
This study tests the drug, Plasmin (Human), in patients with a stroke due to a clot in the middle cerebral artery (MCA). Plasmin is an enzyme that causes clot lysis by cleaving a clot component, fibrin.
- Trial name
- NCT01014975
- Testing
- Plasmin (Human)
- Where
- 23 sites in Australia, Austria and 4 more
- Volunteers
- 40 people
- Sponsor
- Grifols Therapeutics LLC
Intracranial Aneurysm, Intracranial Aneurysm, Wide Neck Aneurysm, Large Neck Aneurysm Lesion
Microvention AnEurysm & STroke Real-life Data cOllection
The MAESTRO registry is a post-market, single-arm, non-interventional, multicenter registry
- Conditions
- Intracranial Aneurysm, Intracranial Aneurysm, Wide Neck Aneurysm, Large Neck Aneurysm Lesion, Aneurysmal Subarachnoid Hemorrhage, Ischemic Stroke
- Trial name
- MAESTRO (NCT06494436)
- Testing
- All Microvention Class III implantable device CE marked, All Microvention Mechanical Thrombectomy Class III device CE marked
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Microvention-Terumo, Inc.
Chronic Subdural Hematoma, Anticoagulant-induced Bleeding
Management of Anticoagulants and Antithrombotics in Patients With CSDH
Primary objective of the study will be to compare, up to 6 months after surgery, number of relapses (post operative re-bleeding) or intracerebral hemorrhage (others than subdural hematomas) and thromboembolic or cardiovascular…
- Conditions
- Chronic Subdural Hematoma, Anticoagulant-induced Bleeding, Thromboembolic Stroke, Cardiovascular Stroke
- Trial name
- THERCA (NCT05079295)
- Testing
- CSDH evacuation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University Hospital of Ferrara
Acute Ischemic Stroke, Cerebral Autoregulation
Ultra-early Identification of Futile Recanalization After Reperfusion Therapy in Acute Ischemic Stroke Based on Cerebral Autoregulation Monitoring
This multicenter, prospective, and interventional diagnostic accuracy study enrolls patients undergoing thrombectomy with intraoperative cerebral autoregulation monitoring and follows them up at predefined time points up to 90…
- Trial name
- FACTOR (NCT07747701)
- Testing
- NIRS-based cerebral oxygenation and blood pressure monitoring, Carotid compression test
- Where
- 4 sites in China
- Volunteers
- 227 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Ischemic Stroke, Intracranial Hematoma
Investigation of Clot in Ischemic Stroke and Hematoma Evacuation
The aim of the study is to collect and analyze specimen from ischemic stroke patients undergoing thrombectomy procedures and from patients undergoing minimally invasive surgery for intracranial hematoma evacuation.
- Trial name
- INSIGHT (NCT04693767)
- Testing
- Mechanical thrombectomy, Minimally invasive surgery
- Where
- 27 sites in United States
- Volunteers
- 400 people
- Sponsor
- Penumbra Inc.
Cerebral Stroke
Conjunctival and Retinal Vascularization and Small Vessel Disease
The purpose of the study is to use a simple photography of conjunctival vessels to search for an association between conjunctival vessels abnormalities and the load of small vessel disease as quantified by MRI in patients with…
- Trial name
- EVACORMA (NCT04447599)
- Testing
- photography of conjunctival vessels
- Where
- France
- Volunteers
- 850 people
- Sponsor
- University Hospital, Toulouse
Stroke
Triple Antiplatelets for Reducing Dependency After Ischaemic Stroke
The risk of recurrence is greatest immediately after stroke or Transient Ischaemic Attack (TIA). Existing prevention strategies (antithrombotic, lipid/blood pressure lowering, endarterectomy) reduce, not abolish, further events.
- Trial name
- TARDIS (NCT01661322)
- Testing
- Aspirin, Dipyradimole, Clopidogrel
- Where
- United Kingdom
- Volunteers
- 3,096 people
- Sponsor
- University of Nottingham
Acute Ischemic Stroke
Mild Acute Ischemic Stroke With Large Vessel Occlusion (MISTWAVE)
Stroke remains the leading cause of disability in the United States. An estimated 40-50% of all ischemic strokes are caused by large-vessel occlusion of a major cerebral artery (LVO).
- Trial name
- MISTWAVE (NCT03731351)
- Testing
- Mechanical Thrombectomy
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- The Cleveland Clinic
Acute Coronary Syndrome, Venous Thrombosis
Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)
This prospective cohort study will provide information about: Characteristics of Rivaroxaban use in patients who are prescribed Rivaroxaban for the first time compared to patients who are prescribed standard of care for the first…
- Conditions
- Acute Coronary Syndrome, Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation
- Trial name
- NCT02468102
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Standard of care drugs
- Where
- Sweden
- Volunteers
- 99,999 people
- Sponsor
- Bayer
Collateral Circulation, Large-artery Occlusion
Study of Collateral Circulation in Patients With Symptomatic Intracranial Anterior Circulation Occlusion
Intracranial artery stenosis is the leading cause of stroke onset or recurrence in Asian. Multiple studies have shown that anterior circulation is most common in intracranial artery stenosis, especially the middle cerebral artery…
- Conditions
- Collateral Circulation, Large-artery Occlusion, Cerebral Infarction
- Trial name
- NCT04091412
- Testing
- Butylphthalide Soft Capsules
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Hebei Medical University
Chronic Gastritis, Gastric Cancer (GC)
Validating a Medical AI Fine-Tuning Platform for Major Diseases
The goal of this observational study is to leverage the abundant patient resources and standardized medical records from Beijing Friendship Hospital, Xuanwu Hospital, and Beijing Anzhen Hospital, combined with the existing data…
- Conditions
- Chronic Gastritis, Gastric Cancer (GC), Coronary Artery Disease, Stroke
- Trial name
- NCT07795645
- Testing
- Smart Medical Big Data Dataset Construction, Large-Scale Medical Knowledge Graph Construction, Multi-Disease Medical Large Model Fine-Tuning Platform Construction and Fine-Tuning
- Where
- China
- Volunteers
- 96,000 people
- Sponsor
- Beijing Friendship Hospital
Back Pain, Coronary Artery Disease
Detecting and Addressing Preclinical Disability
The Physical Functioning Inventory (PFI) is a standardized patient reported outcome measure that assesses preclinical disability.
- Conditions
- Back Pain, Coronary Artery Disease, Chronic Obstructive Pulmonary Disease, Diabetes
- Trial name
- NCT01979081
- Testing
- Tailored advice from a physiotherapist and/or an occupational therapist through the myOSCAR patient portal
- Where
- Canada
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- McMaster University
Stroke, Stroke, Ischemic
Understanding the Need and Feasibility of Transitional Care Training Program Among Family Caregivers of Geriatric Stroke Survivors in Pakistan
The main intention of the study is to understand the need and feasibility of transitional care training program among family caregivers of geriatric stroke survivors in Pakistan
- Conditions
- Stroke, Stroke, Ischemic, Stroke Hemorrhagic
- Trial name
- NCT06341881
- Testing
- Transitional Care Training Program
- Where
- 3 sites in Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Stroke, Acute Ischemic Stroke
Extended Time Window Intravenous Tenecteplase Thrombolysis Registry for Acute Ischemic Stroke
The EXTEND-TNK Registry is a prospective, multicenter, observational cohort study designed to evaluate the effectiveness and safety of intravenous tenecteplase administered beyond 4.5 hours after last known well in patients with…
- Trial name
- EXTEND-TNK (NCT07536165)
- Testing
- Tenecteplase
- Where
- 2 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
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