Clinical trials: Ischemic Brain
Acute Ischemic Stroke
Effects of Cerebrospinal Fluid Drainage on Cerebral Hemodynamics
This pilot interventional study investigates whether continuous cerebrospinal fluid (CSF) drainage via lumbar drain can improve cerebrovascular reactivity (CVR) in patients with acute ischemic stroke and hemodynamic failure, as…
- Trial name
- NCT07056907
- Testing
- Lumbar drain placement
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Atherosclerotic Cardiovascular Disease
In Silico Study Assessing the Impact of Inclisiran on Major Adverse Cardiovascular Events in Patients With Established Cardiovascular Disease
Study CKJX839B1FR01 in an In silico trial to predict the efficacy of Inclisiran therapy on major adverse cardiovascular events (MACE) and cardiovascular (CV) death in virtual patients with atherosclerotic cardiovascular disease…
- Trial name
- SIRIUS (NCT05974345)
- Testing
- Inclisiran sodium, Ezetimibe, Evolocumab
- Where
- France
- Volunteers
- 204,691 people
- Sponsor
- Novartis Pharmaceuticals
Subcortical Aphasia, Ischemic Stroke
The Effect of Venlafaxine on Language Function in Patients With Subcortical Aphasia: A fMRI Study
Previous studies have demonstrated that venlafaxine significantly improves the language function of healthy subjects and increase of fMRI activation in cortical language area.
- Trial name
- NCT03588572
- Testing
- Venlafaxine hydrochloride capsules
- Where
- 2 sites in China
- Volunteers
- 43 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Brain Ischemia Hypoxia, Muscle; Ischemic
Multisite Tissue Oxygenation Guided Perioperative Care in Cardiac Surgery
The BOTTOMLINE-CS trial is an international, open, single-center, pragmatic, randomised controlled trial to investigate whether multisite tissue oxygen saturation monitoring-guided perioperative care reduces composite…
- Conditions
- Brain Ischemia Hypoxia, Muscle; Ischemic, Muscle Hypoxia
- Trial name
- BOTTOMLINECS (NCT04896736)
- Testing
- Multisite tissue oxygenation-guided care, Usual care
- Where
- China
- Volunteers
- 1,960 people
- Sponsor
- Yale University
Chronic Kidney Diseases, Dementia
BRINK (BRain In Kidney Disease) Memory Study 2.0
In this study, the investigators will be looking at results of tests of memory and thinking and daily activities in a group of people without known chronic kidney disease (CKD) , and a group of CKD patients, and follow the…
- Conditions
- Chronic Kidney Diseases, Dementia, Dementia, Vascular, Stroke
- Trial name
- BRINK (NCT04975464)
- Where
- 2 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Anne Murray
Ischemic Stroke
Effect of Different Feeding Modes on Psychological Condition and Experience in Stroke Patients
The goal of this clinical trial is to compare the differences on Psychological Condition and Experience in ischemic stroke patients using Intermittent Oro-esophageal Tube and Nasogastric Tube.
- Trial name
- NCT06328894
- Testing
- Nasogastric Tube Feeding, Intermittent Oro-esophageal Tube Feeding, comprehensive rehabilitation therapy
- Where
- 2 sites in China
- Volunteers
- 156 people
- Sponsor
- Zeng Xi
Stroke, Ischemic
The Effect of The Five-Session Dual-tDCS On Lower-Limb Performance in Sub-Acute Stroke
The aim of the present study is to determine the effect of the five-session dual-tDCS combine with physical therapy on gait performance, balance and lower limbs muscle strength in patients with subacute stroke.
- Trial name
- NCT04287231
- Testing
- Transcranial direct current stimulation
- Where
- Thailand
- Volunteers
- 24 people
- Sponsor
- Mahidol University
Cerebral Infarction
Evaluation of Ambulatory ECG Telemetry for the Early Detection of Atrial Fibrillation During Hospital Assessment of Cerebral Infarction
The aim of the study is to show that an ambulatory ECG telemetry monitoring of some patients hospitalized for cerebral infarction increases the frequency of the diagnosis of atrial fibrillation, cause of their stroke, and…
- Trial name
- TELEMETRIE (NCT03992157)
- Testing
- ECG telemetry
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Hopital Foch
Depression, Pain
Efficacy of Pain Treatment on Depression in Patients With Dementia
The purpose of this study is to determine whether pain treatment can reduce symptoms of depression in patients suffering from dementia and depression. Depression is commonly diagnosed in patients with dementia.
- Conditions
- Depression, Pain, Dementia
- Trial name
- DEP-PAIN-DEM (NCT02267057)
- Testing
- Paracetamol, Buprenorphine
- Where
- Norway
- Volunteers
- 163 people
- Sponsor
- University of Bergen
Acute Ischemic Stroke
Study to Assess the Safety and Efficacy of THR-18 When Administered to Patients Suffering Acute Ischemic Stroke and Treated With Tissue Plasminogen Activator (tPA)
This will be a randomized, double-blind, placebo-controlled, multi-center, multi-national, escalating dose, pilot study comparing two doses of THR-18 to placebo when administered to patients suffering acute ischemic stroke and…
- Trial name
- NCT01253512
- Testing
- THR-18
- Where
- Israel
- Volunteers
- 22 people
- Sponsor
- Thrombotech Ltd.
Stroke
The SMARTChip Stroke Study
Stroke is one of the leading causes of death and disability in the UK and currently costs the country £7bn per year. There is an overwhelming need to accurately and rapidly triage patients to allow best use of finite NHS…
- Trial name
- NCT02795481
- Where
- United Kingdom
- Volunteers
- 399 people, healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Cerebral Infarction
Physical Activity After Stroke: How Does it Effect Chronical Inflammation and Insulin Sensitivity
Decreased insulin sensitivity is and independent risk factor for stroke despite glycemic control. It is known that physical exercise increases insulin sensitivity in healthy subjects.
- Trial name
- NCT00376207
- Testing
- Physical exercise
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Bispebjerg Hospital
Anarthria, Dysarthria
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia
The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with…
- Conditions
- Anarthria, Dysarthria, Tetraplegia, Spinal Cord Injuries
- Trial name
- BG-Speech-01 (NCT05724173)
- Testing
- BrainGate Neural Interface System
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Leigh R. Hochberg, MD, PhD.
Carotid Artery Plaque, Ischemic Stroke
18F FDG and 68Ga FAPI PET/MR Imaging of Carotid Artery Plaque Vulnerability: A Clinical Study in Carotid Artery Plaque Patients
Carotid atherosclerotic plaque rupture is the main cause of ischemic stroke attacks, and early and precise assessment of plaque vulnerability can prevent ischemic stroke.
- Conditions
- Carotid Artery Plaque, Ischemic Stroke, PET / MR
- Trial name
- NCT07004673
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Acute Ischaemic Stroke, Transient Ischaemic Attack
THALES - Acute STroke or Transient IscHaemic Attack Treated With TicAgreLor and ASA for PrEvention of Stroke and Death
Study to investigate if the study drug ticagrelor and ASA is more effective than Placebo (inactive tablet) and ASA in preventing new stroke events
- Trial name
- THALES (NCT03354429)
- Testing
- Ticagrelor
- Where
- 387 sites in Argentina, Australia and 26 more
- Volunteers
- 11,016 people
- Sponsor
- AstraZeneca
Patent Foramen Ovale, Cryptogenic Stroke
Encore PFO Closure Device - The PerFOrm Trial
The objective of this study is to establish reasonable assurance of safety, effectiveness, and noninferiority of the Encore PFO closure device when compared to any investigator chosen FDA-approved PFO closure device.
- Trial name
- NCT05537753
- Testing
- Encore PFO closure device, FDA-approved PFO closure device
- Where
- 8 sites in United States
- Volunteers
- 500 people
- Sponsor
- Encore Medical Inc.
Coronary Stenosis, Cerebral Stenosis
Combined Coronary and Cerebral Angiography and Intervention for Coronary and Cerebrovascular Atherosclerosis
Intracranial atherosclerosis is common vascular lesion in Asian acute stroke patients and intracranial atherosclerosis patients have high rate of coronary artery disease (CAD).
- Trial name
- NCT02315924
- Testing
- simultaneous coronary and cerebral intervention, staged coronary and cerebral intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Gender Heterogeneity in the Influencing Factors for Cerebral Microbleeds in Acute Ischemic Stroke Patients
The investigators continuously collected data from 482 AIS inpatients at the Neurology Department of Hebei General Hospital. Both demographic and clinical data were collected from the study subjects.
- Trial name
- NCT05882123
- Testing
- cerebral microbleeds
- Volunteers
- 482 people
- Sponsor
- Xin Guo
Apnea Syndrome, Stroke
Relationship Between Sleep Apnea Syndrome and Patent Foramen Ovale Among Victims of Cryptogenic Ischemic Stroke
Obstructive sleep apnea syndrome (OSAS) and patent foramen ovale (FOP) are considered as risk factors for stroke. OSAS generates a pressure increase in the right cavity during inspiratory efforts, which increases the number of…
- Trial name
- NCT04846205
- Testing
- systematic etiological
- Where
- France
- Volunteers
- 159 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Atrial Fibrillation, Stroke
Occult Paroxysmal Atrial Fibrillation in Patients With Non-cardioembolic Ischemic Stroke of Determined Mechanism
The aim of this study is to determine the yield of 3 weeks outpatient mobile cardiac monitoring for detection of atrial fibrillation in patients with history of stroke of known cause.
- Trial name
- NCT01410396
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Northwestern University
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