Clinical trials: Ischemic Brain
Stroke Ischemic, Medium Vessel Occlusions
Advancing Reperfusion Therapy for Ischemic Stroke: Perfusion-guided Endovascular Intervention for Medium Vessel Occlusion Therapy
The investigators initiated a multicenter, prospective, randomized, open label, blinded-endpoint (PROBE) controlled trial to evaluate the efficacy and safety of perfusion-guided endovascular treatment (EVT) compared to standard…
- Trial name
- ARTS-PIVOT (NCT07323368)
- Testing
- Endovascular treatment, Best medical treatment (BMT)
- Where
- 6 sites in China
- Volunteers
- 568 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Atrial Fibrillation
Smartphone Electrocardiogram for Recording Atrial Fibrillation After a Cerebral Ischemic Event
To determine the diagnostic yield of a 30-day smartphone electrocardiogram recording compared to 24-hour Holter monitor for detecting occult paroxysmal atrial fibrillation in patients with a recent ischemic stroke or transient…
- Trial name
- SMART-AF (NCT04332718)
- Testing
- Smartphone ECG
- Where
- Malaysia
- Volunteers
- 236 people
- Sponsor
- Sarawak Heart Centre
Stroke, Ischemic, Inflammatory Response
TSPO PET as a Measure of Post-stroke Brain Inflammation: a Natural History Cohort
DESIGN: exploratory, prospective, natural history, imaging cohort study BACKGROUND: Stroke causes a strong inflammatory response in the brain which is thought to contribute to permanent brain damage in stroke patients.
- Conditions
- Stroke, Ischemic, Inflammatory Response, Stroke, Acute
- Trial name
- NCT03662750
- Testing
- Brain Imaging
- Where
- United Kingdom
- Volunteers
- 3 people
- Sponsor
- Imperial College London
Diabetes Mellitus, Hypertension
Integrated Primary Care for Diabetes and Cardiovascular Disease
This study will evaluate a complex intervention based on a patient management tool (PMT), combined with educational outreach to primary care doctors, nurses and other health workers, in the Brazilian city of Florianopolis.
- Conditions
- Diabetes Mellitus, Hypertension, Heart Failure, Ischemic Heart Disease
- Trial name
- PACKBrazDCVD (NCT02795910)
- Testing
- Outreach education training, No outreach education training
- Where
- Brazil
- Volunteers
- 40,577 people
- Sponsor
- University of Sao Paulo General Hospital
Stroke, Acute Stroke
The Study of Efficacy and Safety of Dimephosphon® in Acute Ischemic Stroke
A multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of Dimephosphon® in acute ischemic stroke
- Conditions
- Stroke, Acute Stroke, Ischemic Stroke, Cerebrovascular Disorders
- Trial name
- NCT07167550
- Testing
- Dimephosphon®
- Where
- 6 sites in Russia
- Volunteers
- 184 people
- Sponsor
- Tatchempharmpreparaty, JSC
Chronic Cerebral Ischemia
Safety and Efficacy of Sequential Therapy With Mexidol® in Patients With Chronic Cerebral Ischemia
The purpose of this study is to evaluate safety and efficacy of sequential treatment with Mexidol® in patients with chronic cerebral ischemia (CCI).
- Trial name
- MEMO (NCT06834490)
- Testing
- Mexidol
- Where
- 14 sites in Russia, Uzbekistan
- Volunteers
- 318 people
- Sponsor
- Pharmasoft
Stroke, Hemiparesis
Mechanisms of Arm Recovery in Stroke Patients With Hand Paralysis
This study examines the effect of non-invasive brain stimulation targeting different brain areas on movement of the affected arm post-stroke.
- Conditions
- Stroke, Hemiparesis, Cerebral Vascular Accident, Stroke, Ischemic
- Trial name
- NCT03067818
- Testing
- Unaffected Transcranial Magnetic Stimulation, Affected Transcranial Magnetic Stimulation, Control Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- George Mason University
Ischemic Stroke
Pilot Study of Aspirin Versus Warfarin for Cervicocephalic Arterial Dissection
Pilot Study of Aspirin Versus Warfarin for Cervicocephalic Arterial Dissection.
- Trial name
- NCT00265408
- Testing
- aspirin, warfarin
- Where
- United States
- Sponsor
- University of California, San Diego
Acute Ischemic Stroke
Mesenchymal Stem Cells for The Treatment of Acute Ischemic Stroke
The clinical study with UMC119-06 is designed to investigate the safety in patients with acute ischemic stroke ("AIS"). This will be a dose escalation, open-label, single-center study in adult with acute ischemic stroke.
- Trial name
- NCT04097652
- Testing
- UMC119-06
- Where
- Taiwan
- Volunteers
- 9 people
- Sponsor
- Meridigen Biotech Co., Ltd.
Acute Ischemic Stroke, Endovascular Thrombectomy
A Predictive Model and Scoring System for Severe Complications After Endovascular Thrombectomy
To establish a predictive model and scoring system for predicting severe complications after thrombectomy. This scoring system can be used to identify high-risk patients after endovascular thrombectomy, guide the early use of…
- Conditions
- Acute Ischemic Stroke, Endovascular Thrombectomy, Symptomatic Intracranial Hemorrhage, Malignant Cerebral Edema
- Trial name
- NCT06290076
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Xuanwu Hospital, Beijing
Cadasil
CERebrolysin In CADASIL
The objective of this trial is the global risk-benefit assessment of Cerebrolysin as compared to Placebo in patients with genetically proven CADASIL.
- Trial name
- CERICA (NCT05755997)
- Testing
- Cerebrolysin, 0.9 % NaCl
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- Ever Neuro Pharma GmbH
Ischemic Stroke, Acute, Myocardial Injury
Safety and Efficacy of Remote Ischemic Conditioning in Patients With Acute Myocardial Injury Following Acute Ischemic Stroke
Introduction: The management of acute myocardial injury following acute ischemic stroke (AMI-AIS), a frequent complication that severely worsens prognosis, is challenging.
- Trial name
- NCT07531394
- Testing
- Remote Ischemic Conditioning
- Volunteers
- 580 people
- Sponsor
- Capital Medical University
Cardiovascular Diseases, Heart Diseases
Minnesota Heart Survey - Risk Factor Survey
To continue surveillance of cardiovascular disease risk factors in the seven-county area of Minneapolis-St. Paul.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Cerebrovascular Accident, Coronary Disease
- Trial name
- MHS (NCT00005145)
- Sponsor
- University of Minnesota
Aneurysmal Subarachnoid Hemorrhage
Cerebral Hemodynamic Optimization by Milrinone to Prevent Delayed Cerebral Ischemia
The present study is a randomized, multi-center, double-blind, prospective study that tests the efficacy of intravenous milrinone to optimize cerebral hemodynamic and prevent delayed cerebral ischemia (DCI) during the high-risk…
- Trial name
- OPTIMIL (NCT04282629)
- Testing
- Milrinone Injection
- Where
- 5 sites in France
- Volunteers
- 234 people
- Sponsor
- University Hospital, Toulouse
Stroke, Ischemic
Thrombolysis Combined With Edaravone Dexborneol on Hemorrhagic Transformation for Acute Ischemic Stroke
To explore the safety and efficacy of edaravone dexborneol for the treatment of acute ischemic stroke patients who received thrombolysis.
- Trial name
- NCT05035953
- Testing
- Edaravone Dexborneol
- Volunteers
- 200 people
- Sponsor
- Huashan Hospital
Ischemic Stroke
Algorithm Development Through AI for the Triage of Stroke Patients in the Ambulance With EEG
Endovascular thrombectomy (EVT) enormously improves the prognosis of patients with large vessel occlusion (LVO) stroke, but its effect is highly time-dependent.
- Trial name
- AI-STROKE (NCT05437237)
- Testing
- Dry electrode EEG
- Where
- Netherlands
- Volunteers
- 1,192 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Hemiparesis, Ischemic Stroke
Dynamic Stabilometry Combined With Transcranial Direct Current Stimulation for Balance and Motor Recovery After Ischemic Stroke
The goal of this clinical trial is to learn if balance training on a moving (dynamic) platform with visual and sound feedback, combined with weak electrical brain stimulation, helps people recover balance and movement after an…
- Conditions
- Hemiparesis, Ischemic Stroke, Stroke Rehabilitation, Postural Balance
- Trial name
- STAB-tDCS (NCT07912151)
- Testing
- Dynamic Stabilometry With Biofeedback, Static Stabilometry, Anodal tDCS
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- Samara State Medical University
Post Stroke Recovery
Efficacy and Safety Trial With S 44819 After Recent Ischemic Cerebral Event
The purpose of this study is to assess the efficacy and safety of S 44819 in enhancing functional recovery after an ischemic stroke.
- Trial name
- NCT02877615
- Testing
- S 44819 150 mg twice a day, S 44819 300 mg twice a day
- Where
- 121 sites in Australia, Belgium and 13 more
- Volunteers
- 585 people
- Sponsor
- Institut de Recherches Internationales Servier
Stroke, Cerebral Venous System
Study of Cerebral Venous System in Acute Ischemic Stroke Patients Receiving Reperfusion Therapy
The VAST study is a single-center prospective observational study that enrolled individuals with acute ischemic stroke (AIS) within 24 hours onset.
- Conditions
- Stroke, Cerebral Venous System, Reperfusion Injury
- Trial name
- VAST (NCT03838289)
- Testing
- multimodal magnetic resonance imaging or computed tomography
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Aneurysmal Subarachnoid Hemorrhage, Delayed Cerebral Ischemia
Improving Outcome in Subarachnoid Hemorrhage wIth Nadroparine
Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) was long thought to be caused by subarachnoid blood-induced vasospasm.
- Trial name
- ISCHEMIA (NCT04507178)
- Testing
- Nadroparin Injectable Product
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
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