Clinical trials: Ischemic Brain
Cardiovascular Diseases, Heart Diseases
Epidemiology of Cardiovascular and Non-Cardiovascular Risk In Chicago
To continue the comprehensive research program on the epidemiology of cardiovascular and other major chronic diseases, including cancer and diabetes, in four Chicago population cohorts.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Cerebrovascular Disorders
- Trial name
- NCT00005140
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Brain Ischemia, Adverse Effect of Thrombolytic Drugs
Pre-stroke Cognitive Status and Thrombolytic Therapy
At the acute stage of cerebral ischaemia, the only effective drug that increases the proportion of patients who survive without dependency is thrombolytic therapy by intravenous (i.v.) tissue-plasminogen activator (t-PA).
- Conditions
- Brain Ischemia, Adverse Effect of Thrombolytic Drugs, Impaired Cognition, Dementia
- Trial name
- OPHELIE-COG (NCT01713491)
- Where
- 9 sites in France, Japan
- Volunteers
- 205 people
- Sponsor
- University Hospital, Lille
Ischemic Stroke, Patent Foramen Ovale
Patent Foramen Ovale Closure or Anticoagulants Versus Antiplatelet Therapy to Prevent Stroke Recurrence
A patent foramen ovale (PFO) is found more frequently in patients with an ischemic stroke than in control subjects. Therapeutic options to prevent stroke recurrence include antiplatelet drugs, oral anticoagulants, and…
- Conditions
- Ischemic Stroke, Patent Foramen Ovale, Atrial Septal Aneurysm, Migraine
- Trial name
- CLOSE (NCT00562289)
- Testing
- aspirin, Antivitamins K or rivaroxaban or dabigatran or apixaban, Devices for PFO closure
- Where
- France
- Volunteers
- 664 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Delirium, Cerebral Infarction
the Incidence and the Association Between Motor Subtypes and Outcome of Delirium in Ischemic Stroke Patients
this study examines the incidence of newly developed delirium in patients who admit to university hospital stroke unit for cerebral infarction, and analyze the association between delirium motor subtypes and short-term outcome in…
- Trial name
- NCT03317106
- Where
- South Korea
- Volunteers
- 943 people
- Sponsor
- Chungnam National University Hospital
Neurological Diseases, Ischemic Stroke
Establishment of Clinical Basis for Hematopoietic Growth Factors Therapy in Brain Injury
The purpose of our study is to determine the safety and efficacy of the combination of erythropoietin (EPO) and granulocyte-colony stimulating factors (G-CSF) in patients with neurological diseases.
- Conditions
- Neurological Diseases, Ischemic Stroke, Hemorrhagic Stroke, Cerebral Palsy
- Trial name
- NCT02018406
- Testing
- Combination injection of EPO and G-CSF, Injection of normal saline
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Ischemic Stroke, CYP2C19 Polymorphism
Implementation of Onsite Rapid CYP2C19 Assay for Genotype Guided Dual Antiplatelet Therapy After Acute Ischemic Stroke
The goal of this observational study is to use a genetic test to help doctors prescribe the most effective medications after a patient has a stroke. One type of stroke is caused by a blood clot in brain vessels.
- Trial name
- ORCA-AIS (NCT06292117)
- Testing
- CYP2C19 Genotype
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of Virginia
Coronary Artery Disease, Carotid Artery Diseases
Carotid Plaque Characteristics by MRI in AIM-HIGH (Carotid MRI Substudy)
Heart attacks and strokes caused by the unstable atherosclerotic plaques remain the leading cause of death in the United States. Unstable plaques often have more fat than stable plaques.
- Conditions
- Coronary Artery Disease, Carotid Artery Diseases, Atherosclerosis
- Trial name
- NCT01178320
- Testing
- Simvastatin, simvastatin plus extended-release niacin
- Where
- 19 sites in United States, Canada
- Volunteers
- 230 people
- Sponsor
- University of Washington
Stroke
Preventing Recurrence of Thromboembolic Events Through Coordinated Treatment in the District of Columbia
The purpose of this study is to refine and evaluate the Preventing Recurrence of Thromboembolic Events through Coordinated Treatment in the District of Columbia (PROTECT DC) intervention.
- Trial name
- PROTECT DC (NCT00703274)
- Testing
- PROTECT DC
- Where
- 6 sites in United States
- Volunteers
- 230 people
- Sponsor
- Georgetown University
Middle Cerebral Artery Stroke
The Efficacy and Safety of MK0724 IV for Improvement of Neurological Damage and Recovery From Middle Cerebral Artery Ischemic Stroke (0724-018)
The safety and efficacy of MK0724 will be assessed in patients with acute middle cerebral artery stroke using the Action Reach Arm Test (ARAT).
- Trial name
- NCT00401310
- Testing
- Comparator: MK0724
- Volunteers
- 150 people
- Sponsor
- Merck Sharp & Dohme LLC
Ischemic Stroke
A Study to Evaluate the Efficacy and Safety of TF0023 Spray on Subjects With Ischemic Strokes
This is a phase 2, multicenter, randomized, double-blind (within dose), placebo controlled, parallel-group, dose-range finding study to evaluate the efficacy and safety of TF0023 spray versus placebo in functional improvement of…
- Trial name
- TF0023 (NCT02785120)
- Testing
- TF0023
- Where
- 24 sites in United States
- Volunteers
- 225 people
- Sponsor
- Techfields Inc
Coronary Heart Disease, Stroke
Examining the Long-Term Risks of Oophorectomy
At the time of hysterectomy for benign disease, the overall health benefits of preserving ovarian function in a large population of women have not been established.
- Conditions
- Coronary Heart Disease, Stroke, Breast Cancer, Ovarian Cancer
- Trial name
- NCT00655447
- Where
- United States
- Volunteers
- 32,175 people, healthy volunteers welcome
- Sponsor
- Parker, William H., M.D.
Ischemic Stroke
SMART-EST(Specialized Multi-center Attributed Registry of sTroke - EndovaScular or Thrombolytic Therapy)
Use of intravenous(IV) thrombolysis and intra-arterial(IA) recanalization treatment has been rapidly increasing, However, despite of the treatment, recanalization rates are 22.6 - 70% and only 30-50% of patients show meaningful…
- Trial name
- NCT04066556
- Testing
- Brain CT imaging
- Where
- South Korea
- Volunteers
- 5,000 people
- Sponsor
- Yonsei University
Acute Ischemic Stroke
Rescue Distal Thrombectomy in Treatment for Persistent Distal Occlusions
The goal of this clinical trial is to determine whether rescue distal mechanical thrombectomy can improve outcomes in patients with persistent distal occlusions after successful proximal mechanical thrombectomy for acute ischemic…
- Trial name
- 2BE3-PhaseII (NCT07533253)
- Testing
- Proximal mechanical thrombectomy, Rescue distal mechanical thrombectomy, Conservative management
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Ischemic Stroke
Correlation Between Brain Structure and Activity and Spontaneous Recovery of Motor Function Following Brain Ischemic Stroke
The investigator aims to find a correlation between brain structure and activity and spontaneous recovery of motor function following brain ischemic stroke by Analysis of MRI scans.
- Trial name
- NCT05889429
- Testing
- MRI scans, clinical assessments
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Technion, Israel Institute of Technology
Stroke, Atrial Fibrillation (AF)
Early Anticoagulation Therapy After Endovascular Treatment for Acute Ischemic Stroke With Atrial Fibrillation
The goal of this clinical trial is to learn whether starting a direct oral anticoagulant (DOAC) early after endovascular treatment works to improve outcomes in patients with ischemic stroke related to atrial fibrillation.
- Trial name
- EATAF (NCT07849777)
- Testing
- Early Initiation of DOAC Therapy, Antiplatelet Bridging Followed by DOAC Therapy
- Where
- 2 sites in China
- Volunteers
- 474 people
- Sponsor
- The Fourth Affiliated Hospital of Soochow University
Stroke, Lacunar
Effect of Remote Ischemic Conditioning on Vascular Health in Stroke Patients
The main aim of the current study is to assess cardiovascular effects of remote ischemic conditioning in patients who have suffered from stroke.
- Trial name
- VISP (NCT03635177)
- Testing
- Remote ischemic conditioning
- Where
- 2 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- University of Copenhagen
Stroke, Myocardial Infarctions
Aspirin Resistance and Stroke Risk: Platelet Function Analysis in Patients With Ischemic Events
The purpose of this study is to determine if PFA results correlate with ischemic event outcomes as well as bleeding complications.
- Trial name
- NCT01586975
- Testing
- Clopidogrel, Aspirin 81 mg, Aspirin >300 mg
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Northwestern University
Acute Cerebrovascular Accident, Cerebral Edema
Histamine Glutamate Antagonism in Stroke
Stroke is the 4th leading cause of death in United States with an estimated 1 death every 4 minutes. On average, someone suffers from stroke in United States every 40th second. Stroke recurs in 1 out of 4 stroke patients.
- Trial name
- NCT02142712
- Testing
- Diphenhydramine, Pantoprazole, Famotidine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Florida
Brain Injuries, Acute, Brain Injuries, Traumatic
Antiseizure Medication in Seizure Networks at Early Acute Brain Injury
The goal of this clinical trial is to explore the effect of FDA-approved antiseizure drugs in the brain connectivity patterns of severe and moderate acute brain injury patients with suppression of consciousness.
- Conditions
- Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia
- Trial name
- NCT06081283
- Testing
- Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Acute Stroke
Early Administration of PCSK9 Inhibitors After Thrombectomy for Atherosclerotic Acute Ischemic Stroke: A Randomized Controlled Trial
This study (EPOCH-TECT) was a single-center, randomized, open-label, blinded, endpoint-assessing controlled trial conducted at the Affiliated Hospital of Xuzhou Medical University.
- Trial name
- EPOCH-TECT (NCT07295366)
- Testing
- Evolocumab(420 mg injections)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
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