Clinical trials: Ischemic Brain
Acute Ischemic Stroke
Comparative Effectiveness of Neuroprotectants on Acute Ischemic Stroke
The primary objective of this study is to compare effectiveness of five different neuroprotectants, including butylphthalide, edaravone, citicoline, cerebrolysin, and piracetam, among patients with acute ischemic stroke.
- Trial name
- CER (NCT01556854)
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- yongjun wang
Vertebral Artery Stenosis
Drug Eluting Stenting and Short Dual Antiplatelet Therapy for Preventing Recurrent Stroke in Vertebral Stenosis Registry Study
This is a prospective, multi-center, registry study exploring the duration of dual antiplatelet therapy (DAPT) after drug-eluting stent(DES) treatment of symptomatic vertebral artery atherosclerotic stenosis.
- Trial name
- M Short DAPT (NCT06683300)
- Testing
- DAPT for 3 months after vertebral artery stenting
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Beijing Tiantan Hospital
Tetraplegia, Spinal Cord Injury
ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis
The purpose of this research study is to demonstrate that individuals with upper limb paralysis due to spinal cord injury, brachial plexus injury, amyotrophic lateral sclerosis and brain stem stroke can successfully achieve…
- Conditions
- Tetraplegia, Spinal Cord Injury, Brachial Plexus Injury, Muscular Dystrophy
- Trial name
- NCT01393444
- Testing
- Implantation of ECoG sensors on the brain surface
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Pittsburgh
Transient Ischemic Attack
Post-emergency Management of Patients With Transient Ischemic Attack
A transient ischemic attack (TIA) is a momentary neurological dysfunction due to a brief cessation of blood flow to a region of the brain, resulting in typical signs of stroke (hemiplegia, aphasia, dysarthria), but whose clinical…
- Trial name
- NCT06170034
- Testing
- Satisfaction questionnaire, Medical care questionnaire
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Centre Hospitalier Henri Duffaut - Avignon
Ischemic Stroke
Safety, Tolerability and Pharmacokinetics of SP-8203
Phase I study in health volunteers to assess the safety, tolerability and pharmacokinetics of escalating single doses and multiple doses of SP-8203
- Trial name
- NCT01757795
- Testing
- SP-8203
- Where
- South Korea
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Stroke, Acute
Evaluation of 4D Magnetic Resonance Angiography (K-t Blast) of Supraortic Vessels in Acute Ischemic Stroke Patients
The Magnetic Resonance angiography (MRA) of supraaortic vessels is essential for the etiologic of stroke. However, the techniques usually used provide only static evaluation (degree of stenosis, occlusion) but not dynamic.
- Trial name
- NCT01311544
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Rennes University Hospital
Acute Ischemic Stroke
Efficacy and Safety of PCSK9 Inhibitors in Patients With Large-Artery Atherosclerosis (LAA) Ischemic Stroke
This prospective multicenter cohort study aims to evaluate the effectiveness and safety of early PCSK9 inhibitor therapy in patients with large-artery atherosclerotic ischemic stroke.
- Trial name
- NCT07540741
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Hypoxic Ischemic Encephalopathy, Umbilical Cord Milking
Umbilical Cord Milking for Neonates With Hypoxic Ischemic Encephalopathy
The objective of this pilot study is to investigate the feasibility of performing umbilical cord milking in neonates who are depressed at birth.
- Trial name
- NCT02287077
- Testing
- Umbilical Cord Milking
- Where
- India
- Volunteers
- 101 people
- Sponsor
- Thomas Jefferson University
Stroke, Acute, Hyperglycemia
Pioglitazone Treatment for Hyperglycemic Acute Ischemic Stroke
Study objective is to determine whether Pioglitazone (PGZ) can improve clinical outcomes in hyperglycemic acute ischemic stroke (IS).
- Conditions
- Stroke, Acute, Hyperglycemia, Diabetes
- Trial name
- NCT04123067
- Testing
- Pioglitazone 45 mg
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Milton S. Hershey Medical Center
Stroke, Acute
Endovascular Treatment in Ischemic Stroke Follow-up Evaluation
Study like register with biomarkers samples for patient experiencing acute ischemic stroke, to assess clinical outcomes and different factors that may affect the clinical outcomes.
- Trial name
- ETIS (NCT03776877)
- Where
- 16 sites in France
- Volunteers
- 4,000 people
- Sponsor
- Hopital Foch
Stroke, Acute Ischemic Stroke
The MRI-based Evaluation of Safety and Efficacy of EVT and SMT: A Retrospective, Multicenter Study
Acute Basilar Artery Occlusion (ABAO), a condition with a high risk of mortality or disability (up to 80%). The safety and efficacy of endovascular thrombectomy (EVT) in ABAO remains uncertain due to inconsistent evidence from…
- Conditions
- Stroke, Acute Ischemic Stroke, Ischemic Stroke
- Trial name
- NCT06236828
- Testing
- Mechanical Thrombectomy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Myocardial Infarction, Stroke
Using AtorVASTatin to Prevent VAscular Inflammatory OccLUSion in the Critically Ill
Patients are admitted to the critical care unit of the hospital because of medical conditions that have a high likelihood of causing severe problems with blood flow, breathing, or brain function.
- Conditions
- Myocardial Infarction, Stroke, Renal Failure
- Trial name
- VASTVALUS (NCT01073800)
- Testing
- atorvastatin 80 mg per os daily
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Alberta
Stroke, Acute
Stroke Treatment With Acute Reperfusion and Simvastatin
The purpose of this study is to determine whether simvastatin treatment started within the first 12 hours from stroke onset improves neurological and functional outcomes, evaluated at seventh day/discharge or at the third month.
- Trial name
- NCT01073007
- Testing
- Simvastatin
- Where
- 20 sites in Spain
- Volunteers
- 104 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Ischemic Stroke
Intravenous Thrombolysis Registry for Acute Ischemic Stroke in China
To analyze the real situation of intravenous thrombolysis in acute ischemic stroke in China
- Trial name
- NCT03997292
- Testing
- Alteplase, Urokinase
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- General Hospital of Shenyang Military Region
Stroke, Cerebrovascular Disorders
Precision Medicine in Stroke
PROMISE aims at identifying novel diagnostic and prognostic circulating biomarkers for patients with acute stroke and at informing on crucial yet undetected pathophysiological mechanisms driving outcome after stroke by enriching…
- Conditions
- Stroke, Cerebrovascular Disorders, Brain Diseases, Central Nervous System Diseases
- Trial name
- PROMISE (NCT05815836)
- Volunteers
- 787 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Acute Stroke, Transient Ischemic Attack
Motivational Interviewing for Stroke
Motivational interviewing (MI) is a style of communication designed to elicit a person's own reasons for change to drive commitment toward a goal.
- Trial name
- NCT06195007
- Testing
- Motivational Interview
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Florida
Stroke, Ischemic, Small Vessel Cerebrovascular Disease
Antiplatelet Therapy and Endothelial-stabilizing Agents in Cerebral Small Vessel Diseases
Cerebral small vessel disease (cSVD) is a common accompaniment of aging. Recent small subcortical (or lacunar) infarcts (i.e. symptomatic cSVD) and white matter hyperintensities are typical cSVD lesions on neuroimaging.
- Conditions
- Stroke, Ischemic, Small Vessel Cerebrovascular Disease, White Matter Hyperintensity
- Trial name
- Athena-cSVD (NCT06715007)
- Testing
- Clopidogrel, Aspirin, Cilostazol + Isosorbide Mononitrate
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Acute Ischemic Stroke
Effect of DIRECT Transfer to ANGIOsuite on Functional Outcome in Severe Acute Stroke
Rationale: Acute large-vessel strokes, requiring endovascular treatment, are currently being managed through radiology department before being transferred to the angiography room.
- Trial name
- DIRECTANGIO (NCT03969511)
- Testing
- direct angio-suite admission, standard management
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Central Hospital, Nancy, France
Ischemic Stroke, Acute, Malignant Cerebral Edema
Expansion-floating Craniotomy for the Treatment of Malignant Cerebral Edema Caused by Acute Ischemic Stroke
This clinical study investigates Expansion-floating Craniotomy (EC), a novel surgical technique for treating life-threatening malignant cerebral edema following large hemispheric infarction (commonly known as massive stroke).
- Trial name
- ECAIS (NCT07195786)
- Testing
- Expansion-floating Craniotomy, decompressive craniectomy, drug conservative therapeutic
- Volunteers
- 356 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Antiplatelet Therapy, Hemorrhagic Infarction
Early Antiplatelet Therapy After Hemorrhagic Infarction in Acute Ischemic Stroke Treated With Intravenous Thrombolysis (HITs)
Previous study showed that the proportions of hemorrhagic Infarction after intravenous thrombolysis were 24.2% and 32.5% in the control group and the alteplase group, and most of them were asymptomatic.
- Trial name
- NCT04624295
- Testing
- Early aspirin Therapy, Non-Early aspirin Therapy
- Where
- China
- Volunteers
- 294 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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