Clinical trials: Ischemic Brain
Ischemic Stroke
HEMS for Mechanical Thrombectomy
Elapsed time from the onset of stroke symptoms to the point of revascularization is the key determinant of the optimal outcome of acute ischemic stroke.
- Trial name
- NCT04834284
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Tampere University Hospital
Ischemic Stroke, Intracranial Arteriosclerosis
Pair Antiplatelet THerapy in Ischemic Stroke With Intracranial Artery Stenosis
The goal of this clinical trial is to learn about efficacy and safety of dual antiplatelet therapy in ischemic stroke with intracranial artery stenosis.
- Conditions
- Ischemic Stroke, Intracranial Arteriosclerosis, Secondary Prevention, Antiplatelet Drug
- Trial name
- PATH-ICAS (NCT06243133)
- Testing
- clopidogrel for 90 days combined with aspirin for 90 days, clopidogrel for 30 days combined with aspirin for 90 days
- Where
- China
- Volunteers
- 1,100 people
- Sponsor
- Sichuan Provincial People's Hospital
Ischemic Stroke
Ticagrelor Versus Cilostazol in Minor Ischemic Stroke or TIA
Along with the current clinical trial, the efficacy and safety of ticagrelor and aspirin administered within the first 24 hours of first-ever ischemic stroke compared to cilostazol and aspirin were assessed through NIHSS, mRS…
- Trial name
- NCT06196047
- Testing
- Ticagrelor 90 MG, Cilostazol 100 MG
- Where
- Egypt
- Volunteers
- 900 people
- Sponsor
- Kafrelsheikh University
Acute Ischemic Stroke
Safety, Tolerability, and Preliminary Efficacy of HRS-7450 Injection in the Treatment of Acute Ischemic Stroke: a Multi-center, Randomized, Double-blind, Double-dummy, Placebo-controlled Clinical Trial
This study is a multi-center, randomized, double-blind, double-dummy, placebo-controlled, single dose escalation study aimed at evaluating the overall safety, tolerability, and preliminary efficacy of HRS-7450 in patients with…
- Trial name
- NCT06447415
- Testing
- HRS-7450, 0.9% sodium chloride injection
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Cardiovascular Diseases, Coronary Disease
Dietary Patterns and Risk of Cardiovascular Disease
To study, prospectively, the association between dietary patterns and risk of coronary heart disease (CHD), ischemic stroke, and hemorrhagic stroke in cohort studies of 121,700 women age 30 to 55 years at baseline in 1976 (the…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Cerebrovascular Disorders, Heart Diseases
- Trial name
- NCT00005514
- Volunteers
- 120,000 people
- Sponsor
- Harvard School of Public Health (HSPH)
Neurologic Manifestations, Premature Birth
The Neu-Prem Trial: Neuromonitoring of Preterm Newborn Brain During Birth Resuscitation
The purpose of this study is to characterize the normal brain function of premature infants (23 to 31+6 weeks GA) during birth transition and through the first 72 hours of life.
- Conditions
- Neurologic Manifestations, Premature Birth, Hypoxia-Ischemia, Brain
- Trial name
- Neu-Prem (NCT02605733)
- Testing
- EEG, NIRS
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Sharp HealthCare
Nervous System Diseases, Stroke
Safety and Long-term Effectiveness of High Frequency Repetitive Transcranial Magnetic Stimulation of Stroke (RAICup)
The aim of the study is to determine if 2-week repetitive transcranial magnetic stimulation at the subacute phase of stroke (between day 7 and day 14) improves significantly arm motility at 3 months with remaining effect at one…
- Conditions
- Nervous System Diseases, Stroke, Cerebrovascular Disorders, Brain Infarction
- Trial name
- RAICup (NCT01059149)
- Testing
- repetitive transcranial magnetic stimulation
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neurologic Disorder, Disorder of Consciousness
Prognostic Factors to Regain Consciousness
The study aims to identify factors that predict the medium and long-term outcome of patients with disorders of consciousness (DOC) undergoing early neurological rehabilitation.
- Conditions
- Neurologic Disorder, Disorder of Consciousness, Traumatic Brain Injury, Stroke
- Trial name
- NCT04445649
- Testing
- Coma-Recovery-Scale-Revised (CRS-R)
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
s100b, Hypoxia-Ischemia, Brain
Cord Blood S100B Protein Concentration in Neonates With Fetal Growth Restriction
S100B protein is a biomarker that increases following central nervous system (CNS) damage. Measuring this protein's levels may allow for the early identification of infants at high risk for developmental abnormalities, such as…
- Conditions
- s100b, Hypoxia-Ischemia, Brain, Fetal Growth Restriction (FGR)
- Trial name
- NCT06893926
- Testing
- Prenatal ultrasound examination with blood flow analysis, Umbilical cord blood gas analysis, Umbilical cord blood S100B protein level
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Institute of Mother and Child, Warsaw, Poland
Vertebrobasilar Artery Occlusion, Endovascular Treatment
Randomized Clinical Trial of Endovascular Treatment for Progressive Stroke With Vertebrobasilar Artery Occlusion
This multicenter, prospective, open-label randomized controlled trial with blinded assessment was designed to assess the efficacy and safety of endovascular treatment for progressive stroke due to vertebrobasilar artery occlusion.
- Trial name
- NCT07557485
- Testing
- Endovascular Recanalization, Medical Therapy Alone
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Feng Gao
Acute Ischemic Stroke
Study of the Effects of the Non-invasive Trigeminal Nerve Stimulation on Ischemic Stroke Patients
In patients with ischemic stroke, the primary focus revolves around enhancing the neuroprotective and rehabilitative effects of external trigeminal nerve stimulation (eTNS) and elucidating its underlying central mechanisms.
- Trial name
- NCT06540417
- Testing
- External trigeminal nerve stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xidian University
Ischemic Stroke
Superselective Citicoline and Verapamil for Ischemic Neuroprotection and Greater Effective Response
This is a phase 1, blinded-outcome, randomized, placebo controlled study to investigate the safety and feasibility of super-selective intra-arterial administration of verapamil and citicoline immediately following successful…
- Trial name
- SCAVINGER (NCT02823106)
- Testing
- Verapamil and Citicoline
- Where
- United States
- Sponsor
- Justin Fraser
Stroke, Cerebral Infarction
For Patients With Ischemic Stroke, Clinically Study the Effectiveness and Safety of Butylphthalide.
This is a prospective, open, single-arm, the real world of clinical trials. The researchers plan to recruit 300 eligible patients.
- Conditions
- Stroke, Cerebral Infarction, Brain Infarction, Brain Ischemia
- Trial name
- NCT05068349
- Testing
- Butylphthalide
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Qianfoshan Hospital
Stroke, Ischemic, Atrial Fibrillation
Atrial CMR in Patients With CVA of Unknown Source and no Known AF
This research study will investigate a new method for identifying which patients should be offered blood thinners or therapies to reverse the underlying causes after stroke.
- Trial name
- CARM-AF (NCT04555538)
- Testing
- Cardiac MRI
- Where
- 3 sites in United Kingdom
- Volunteers
- 92 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Stroke, Acute, Progressing Stroke
Safety and Efficacy of Therapeutic INduced HYPERTENSION in Acute Non-cardioembolic Ischemic Stroke (SETIN-HYPERTENSION)
The purpose of this study is to evaluate the safety and efficacy of the induced hypertension using phenylephrine in patients with noncardioembolic ischemic stroke.
- Trial name
- NCT01600235
- Testing
- Phenylephrine
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- Samsung Medical Center
Hypoxic-Ischemic Encephalopathy, Neonatal Encephalopathy
The Impact of Holding on Stress and Bonding in Mother-Infant Pairs During Therapeutic Hypothermia
This research is being done to try to improve the experience of mothers and babies during therapeutic hypothermia. Currently, mothers are not able to hold their baby during hypothermia treatment.
- Trial name
- NCT03837717
- Testing
- Holding, Saliva collection, No Holding
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- MaineHealth
Cerebral Infarction
"Evaluation by Transcranial Magnetic Stimulation of the Benefit of Fluoxetine on Motor Recovery After Stroke"
The objective of this study is to better characterize the mechanisms of action of fluoxetine in motor recovery and more specifically to identify the neurophysiological substrate underlying fluoxetine-induced motor recovery in…
- Trial name
- EFLUSTIM (NCT02063425)
- Testing
- Fluoxetine
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Centre Hospitalier St Anne
Subacute Stroke, Ischemic Stroke
Segmental Vibrator With NMES on Lower Limb Function in Subacute Stroke
Stroke is one of the world's leading causes of death and disability. It can cause a variety of motor disorders, such as apraxia, sensory deficits, abnormal muscle tone, inadequate weight transfer, lack of fine motor skills…
- Trial name
- NCT06927206
- Testing
- Experimental Group A: Segmental vibrator only on dorsiflexor, Experimental Group B: Segmental vibrator + Electrical stimulation on dorsiflexors
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Ischemic Stroke, Dysphagia
Effect of Specific Mode Electroacupuncture Stimulation Combined with NGF on Dysphagia After Ischaemic Stroke: a Pilot Randomized Controlled Trial
Ischemic stroke is a common clinical disease, often accompanied by dysphagia. At present, clinical treatment for patients with dysphagia after ischemic stroke is limited.
- Trial name
- NCT06737549
- Testing
- Nerver growth factor (NGF) injection, EA intervention, Acupuncture intervention
- Where
- China
- Volunteers
- 144 people
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Ischemic Cerebrovascular Accident
Mechanical Opening Device Implantation Following Intravenous r-tPA for Recanalization in Acute Ischemic Stroke
This study is to test a hypothesis that temporary implantation of JRecanTM blood flow recanalisation device within 6.5 hours of symptom onset of acute ischemic stroke due to a major intracranial artery occlusion following IV…
- Trial name
- NCT02347358
- Testing
- JRecanTM blood FR device, IV r-tPA
- Volunteers
- 100 people
- Sponsor
- The Second Artillery General Hospital
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