Clinical trials: Ischemic Brain
Pediatric Stroke, Arteriopathy
Focal Cerebral Arteriopathy Steroid Trial
This comparative effectiveness trial (CET) in children with suspected focal cerebral arteriopathy (FCA) presenting with arterial ischemic stroke (AIS) or transient ischemic attack (TIA) will compare the use of early…
- Conditions
- Pediatric Stroke, Arteriopathy, Arterial Ischemic Stroke
- Trial name
- FOCAS (NCT06040255)
- Testing
- methylprednisolone, prednisolone, prednisone
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, San Francisco
Ischemic Stroke, Transient Ischemic Attack
Regular Physical Exercise in Patients With Symptomatic Intracranial Arterial Stenosis
The objective of this study is to evaluate the effectiveness and safety of regular physical exercise in preventing ischemic stroke events in patients with symptomatic intracranial arterial stenosis.
- Trial name
- RESIST (NCT06615726)
- Testing
- Regular physical exercise, Control group
- Where
- 58 sites in China
- Volunteers
- 1,300 people
- Sponsor
- Capital Medical University
Ischemic Stroke
Allogeneic Mesenchymal Stem Cells for the Survivors of Ischemic Stroke Trial (ASSIST)
The purpose of this study is to evaluate the safety, tolerability, and preliminary efficacy of single injection of it-hMSC in patients with ischemic stroke in a multicenter, blind, randomized, placebo controlled trial
- Trial name
- NCT04590118
- Testing
- it-hMSC
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jiuzhitang Maker (Beijing) Cell Technology Co.,Ltd.
Heart Attack, Stroke
CV Wizard: Does a Clinical Decision Support Tool Improve CVD Risk Factor Control in Safety Net Clinics?
This project aims to reduce disparities in cardiovascular disease (CVD) risk factor control and in rates of heart attacks and strokes among the low-income, racially / ethnically diverse Americans who receive primary care at…
- Conditions
- Heart Attack, Stroke, Cardiovascular Diseases
- Trial name
- CV_WIZARD (NCT03001713)
- Testing
- CV WIZARD
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Ischemic Cerebrovascular Disease, Blood Pressure Variability
Blood Pressure Variability in Non-hypertensive Patients With Ischemic Cerebrovascular Disease
This study is a single-center prospective cohort of patients with ischemic cerebrovascular disease (ICVD) who have not met the diagnostic criteria for hypertension.
- Trial name
- BPV-NhICVD (NCT05232240)
- Testing
- blood pressure variability measured by ambulatory 24-hour blood pressure monitoring
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xuanwu Hospital, Beijing
Ischemic Stroke
Study Evaluating The Safety And Efficacy Of PF-03049423 In Subjects With Ischemic Stroke
The purpose of this study is to evaluate the safety and tolerability of PF-03049423 following multiple dose administration to subjects with ischemic stroke.
- Trial name
- NCT01208233
- Testing
- PF-03049423
- Where
- 70 sites in United States, Bulgaria and 8 more
- Volunteers
- 181 people
- Sponsor
- Pfizer
Cerebrovascular Disease, Stroke
Remote Ischemic Limb Preconditioning In Healthy Volunteers
The investigators would like to determine if remote ischemic leg preconditioning in healthy volunteers improves cerebral vasomotor reactivity as measured by breath holding and transcranial doppler vasomotor reactivity.
- Trial name
- NCT02553655
- Testing
- 4x 5min Limb Preconditioning, 3x 10min Limb Preconditioning
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Miami
Stroke, Acute
Solitaire FR Thrombectomy for Acute Revascularisation
The objective of this study was to obtain prospective clinical data on the safety and efficacy of the Solitaire™ FR device for patients diagnosed with acute ischemic stroke.
- Trial name
- STAR (NCT01327989)
- Testing
- Solitaire™ FR device
- Where
- 2 sites in Switzerland
- Volunteers
- 202 people
- Sponsor
- Medtronic Neurovascular Clinical Affairs
Coronary Artery Disease
Brain-heart Interaction in Coronary Plaque Stability and Cardiovascular Events
The effect of brain-heart interaction remains unclear. The study aims to investigate the biological interconnection between brain neural activity and coronary plaque morphological and inflammatory features, as well as their…
- Trial name
- Blueprint (NCT05545618)
- Testing
- CCTA and 18F-FDG-PET/CT
- Where
- 4 sites in China
- Volunteers
- 300 people
- Sponsor
- Shanghai Zhongshan Hospital
Stroke, Ischemic
The Effect of The Ten-Session Dual-tDCS On Lower-Limb Performance in Sub- Acute and Chronic Stroke
The present study aims to determine the effect of the ten-session dual tDCS combine with physical therapy on gait performance, balance, and lower limbs muscle strength in patients with subacute and chronic stroke.
- Trial name
- NCT04687033
- Testing
- Transcranial direct current stimulation
- Where
- Thailand
- Volunteers
- 34 people
- Sponsor
- Mahidol University
Acute Stroke, Thrombolytic Therapy
Evaluation of the Effectiveness of Thrombolytic Therapy in Acute Ischemic Stroke Patients Using NIRS
Investigators aim to study effectiveness of systemic thrombolytic therapy on acute ischemic stroke patients with near infrared spectroscopy.
- Conditions
- Acute Stroke, Thrombolytic Therapy, Stroke, Ischemic
- Trial name
- E-NESE (NCT03621917)
- Testing
- Near-infrared spectroscopy reading
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Dokuz Eylul University
Acute Ischemic Stroke
Dynamic Changes in Human Microbiome Predict the Risk of Adverse Outcomes in Patients With Acute Ischemic Stroke: a Multicenter Prospective Cohort Study
(1) The main purpose To explore the predictive value of human microbiome and its metabolome for adverse prognosis in patients with acute ischemic stroke (AIS). (2) Secondary purposes 1.
- Trial name
- NCT06240468
- Testing
- not have
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Venous Thrombosis, Pulmonary Embolism
Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands)
This prospective cohort study will provide information about: characteristics of Rivaroxaban use in patients who are prescribed Rivaroxaban for the first time compared to patients who are prescribed Acenocoumarol for the first…
- Conditions
- Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation, Acute Coronary Syndrome
- Trial name
- NCT01947985
- Testing
- Rivaroxoban (Xarelto, Bay59-7939), Standard of care
- Where
- Netherlands
- Volunteers
- 208,958 people
- Sponsor
- Bayer
Stroke
Intravenous Thrombolysis With Tenecteplase Plus Thrombectomy Versus Thrombectomy Alone In Patients With A Large Ischemic Stroke: A Multicenter Randomized Controlled Trial (IVT-ALL-IN)
Stroke is a frequent and severe disease worldwide, representing the second leading cause of death and the leading cause of acquired disability.
- Trial name
- IVT-ALL-IN (NCT07603440)
- Testing
- Intravenous administration, MT alone
- Where
- 36 sites in France
- Volunteers
- 486 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ischemic Stroke, Vagus Nerve Stimulation
Effect Of Robotic Rehabilitation And Vagus Nerve Stimulation In Ischemia Stroke Patients
This study was conducted in patients with ischemic stroke; This study was conducted to examine the effect of robotic rehabilitation and transcutaneous auricular vagal nerve stimulation applied in addition to robotic…
- Conditions
- Ischemic Stroke, Vagus Nerve Stimulation, Robotic Rehabilitation, Autonomic Nervous System
- Trial name
- ERRVNS (NCT06381089)
- Testing
- Robotic Rehabilitation, Transcutaneous Auricular Vagal Nerve Stimulation
- Volunteers
- 40 people
- Sponsor
- SEFA HAKTAN HATIK
Acute Stroke, Hyperglycemia
SELESTIAL: Trial of Insulin to Control Blood Sugar After Acute Stroke Using Magnetic Resonance Imaging (MRI) End-Points
High blood sugar (hyperglycaemia) affects 40% of acute stroke patients and has a major adverse effect on survival and recovery. Increased production of lactic acid in brain tissue that has a poor blood supply is postulated to be…
- Trial name
- NCT00124826
- Testing
- Insulin
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Glasgow
Cerebrovascular Accident
Transient Ischemic Attack (TIA) Triage and Evaluation of Stroke Risk
Transient ischemic attack (TIA) is a transient neurological deficit (speech disturbance, weakness…), caused by temporary occlusion of a brain vessel by a blood clot that leaves no lasting effect.
- Trial name
- NCT01423201
- Where
- 3 sites in United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Stanford University
Depression, Pain
Efficacy of Pain Treatment on Depression in Patients With Dementia
The purpose of this study is to determine whether pain treatment can reduce symptoms of depression in patients suffering from dementia and depression. Depression is commonly diagnosed in patients with dementia.
- Conditions
- Depression, Pain, Dementia
- Trial name
- DEP-PAIN-DEM (NCT02267057)
- Testing
- Paracetamol, Buprenorphine
- Where
- Norway
- Volunteers
- 163 people
- Sponsor
- University of Bergen
Subclavian Steal
Differential Diagnosis for the Causes of Subclavian Steal for Patients With Vascular Access in the Forearm
Subclavian steal phenomenon is normally observed in patients with stenosis of subclavian artery proximal to orifice of vertebral artery(V0).
- Trial name
- NCT01263301
- Testing
- carotid duplex
- Where
- Taiwan
- Volunteers
- 16 people
- Sponsor
- Mennonite Christian Hospital
Sleep-Disordered Breathing, Sleep Architecture
Screening of OSA in Hospitalized Stroke Patients Using BSP
Obstructive sleep apnea (OSA) is prevalent in patients with stroke and has a negative effect on outcomes by predisposing them to recurrent stroke, increasing mortality, and so forth.
- Conditions
- Sleep-Disordered Breathing, Sleep Architecture, Stroke, Acute
- Trial name
- NCT05466864
- Testing
- Belun Sleep platform
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
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