Clinical trials: Ischemic Brain
Ischemic Stroke
Tenecteplase Thrombolytic Therapy for Acute Ischemic Stroke in China
The objective of the study is to investigate the effectiveness and safety of rhTNK-tPA in acute ischemic stroke patients within 4.5 hours of symptom onset in a real-world clinical setting.
- Trial name
- TTT-AIS CHINA (NCT06078995)
- Testing
- Tenecteplase, Alteplase
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Huashan Hospital
Atrial Fibrillation (AF), Hypertension
Integrated Approach in Frail Older People with Atrial Fibrillation
The study will verify if a structured multidisciplinary approach (called iABC), aimed to improve the appropriate management of elderly AF patients with multimorbidity (the i-ABC group), would provide a clear evidence of an…
- Conditions
- Atrial Fibrillation (AF), Hypertension, Coronary Arterial Disease (CAD), Heart Failure
- Trial name
- AFFIRMO (NCT06775028)
- Testing
- iABC platform use
- Where
- 50 sites in Bulgaria, Denmark and 4 more
- Volunteers
- 1,250 people
- Sponsor
- Heart Care Foundation
Ischemic Stroke, Transient Ischemic Attack
Treat Stroke to Target
The aim of this study is the evaluation of two usual care strategies after stroke or TIA : achieved target LDL-C of 100 mg/dL (+/-10 mg/dL) or less than 70 mg/dL.
- Conditions
- Ischemic Stroke, Transient Ischemic Attack, Atherosclerotic Stenosis
- Trial name
- TST (NCT01252875)
- Testing
- Target : 100 mg/dL (+/-10 mg/dL), 70 mg/dL
- Where
- 2 sites in France
- Volunteers
- 2,873 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Ischemic Stroke
Aleeto in Acute ISchemic Stroke：A RandomISed Controlled Clinical Trial
This study is a prospective, double-blind, 1:1:1 randomized controlled study aimed at evaluating the efficacy and safety of Aleeto treatment compared to placebo in improving the NIHSS score at 14 days in patients with moderate to…
- Trial name
- ASSIST (NCT06759753)
- Testing
- Aleeto
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Study to Assess the Safety and Efficacy of THR-18 When Administered to Patients Suffering Acute Ischemic Stroke and Treated With Tissue Plasminogen Activator (tPA)
This will be a randomized, double-blind, placebo-controlled, multi-center, multi-national, escalating dose, pilot study comparing two doses of THR-18 to placebo when administered to patients suffering acute ischemic stroke and…
- Trial name
- NCT01253512
- Testing
- THR-18
- Where
- Israel
- Volunteers
- 22 people
- Sponsor
- Thrombotech Ltd.
Stroke, Stroke Ischemic
duoABLE for People With Stroke and Their Caregivers
The goal of this intervention study is to test whether a behavioral program that involves people with stroke and their caregivers is acceptable, safe, and can promote physically active lifestyles using enjoyable activities.
- Conditions
- Stroke, Stroke Ischemic, Stroke Hemorrhagic, Stroke Sequelae
- Trial name
- NCT05964400
- Testing
- duoABLE
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Minnesota
Inflammatory Arthritis, Rheumatoid Arthritis
The Relationship Between Inflammatory ARTritis and CArdiac DIseAse
The goal of this prospective cohort study is to investigate cardiac comorbidity in a random sample of approximately 1200 patients from a population of outpatients with rheumatoid arthritis and axial spondyloarthritis referred to…
- Conditions
- Inflammatory Arthritis, Rheumatoid Arthritis, Spondylitis, Ankylosing, Axial Spondyloarthritis
- Trial name
- ARTCADIA (NCT05647577)
- Where
- Denmark
- Volunteers
- 1,285 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Stroke
The Influence of day-to Day BPV on Long-term Adverse Outcomes in Patients Ischemic Stroke
Stroke is one of the most devastating disorder worldwide. Hypertension has been confirmed to be a major modifiable risk factor for stroke.Even the casual visit hypertension has been managed ideally,there is still surplus risk for…
- Trial name
- NCT02663557
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Zhu Shi
Stroke, Ischemic
A Phase Ⅱb Study of XY03-EA Tablets in Acute Ischemic Stroke
This was a multicenter, randomized, double-blind, placebo-controlled, parallel-group Phase Ⅱb/Ⅲ clinical study to evaluate the efficacy and safety of XY03-EA tablets, a novel oral neuroprotective agent, and explore the…
- Trial name
- XY03-EA (NCT06755944)
- Testing
- XY03-EA 150 mg (per dose), XY03-EA 300 mg (Regimen A), XY03-EA 300 mg (Regimen B)
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Shijiazhuang Yiling Pharmaceutical Co. Ltd
Acute Ischemic Stroke
Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial
The primary objective is to establish the efficacy of intra-arterial (IA) mechanical thrombectomy (MT) with extracranial proximal carotid artery acute stenting versus non-stenting approaches in patients with acute ischemic stroke…
- Trial name
- PICASSO (NCT05611242)
- Testing
- MT+CAS with IV-AP, MT+CAS with PO-AP, MT+CAT with PO-AP
- Where
- 60 sites in United States
- Volunteers
- 404 people
- Sponsor
- Mercy Health Ohio
Cardiovascular Diseases, Heart Diseases
Novel Hemostatic Cardiac Risk Factors in Framingham
To investigate hemostatic variables in relation to cardiovascular risk in the Framingham Offspring Study cohort.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Death, Sudden, Cardiac, Myocardial Infarction
- Trial name
- NCT00005356
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Stroke
Mechanical Recanalization With Flow Restoration in Acute Ischemic Stroke
The objective of this study is to collect data on the use of the SOLITAIR FR device for treatment of acute ischemic stroke with large artery occlusion i.e.
- Trial name
- ReFlow (NCT01210729)
- Testing
- Solitaire FR, ev3
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Universität des Saarlandes
Acute Ischemic Stroke
Heart Evaluation of Acute Ischemic Stroke With Reperfusion Therapy
Heart Evaluation of Acute ischemic stroke with Reperfusion Therapy (HEART) is a single-center observational registry evaluating the heart of patients hospitalized for acute ischemic stroke with reperfusion therapy.
- Trial name
- HEART (NCT06882577)
- Testing
- observational only- no intervention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Soochow University
Stroke With Hemiparesis
Transfer of Grasp Control Across Hands After Stroke
The purpose of this study is to examine if the strong hand can assist in the recovery of muscle function in the weak hand after a stroke.
- Trial name
- NCT00589368
- Testing
- Transfer of grasp control across hands
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
CADASIL
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study
This is an observational study to better understand the risk factors and progression of CADASIL, a leading cause of vascular cognitive impairment and dementia (VCID).
- Trial name
- NCT05677880
- Testing
- Study Procedures
- Where
- 12 sites in United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Acute Ischemic Stroke
Neurocognitive Impairment After Ischemic Stroke
Affecting more than 150,000 patients in France, stroke is a major public health issue and a leading cause of disability worldwide. In western countries, 80-85% of strokes are of ischemic subtype.
- Trial name
- COG-TRA-Y MRI (NCT06262529)
- Testing
- Cerebral MRI
- Where
- 2 sites in France
- Volunteers
- 16 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Acute Ischemic Stroke, Hemorrhagic Stroke
Mapping the Natural History of Parenychymal and Cerebral Perfusion Changes in Acute Ischemic and Hemorrhagic Strokes
Study using ultrasound of the brain as a diagnostic tool to differentiate between ischemic stroke and hemorrhagic stroke. Correlation of brain perfusion and size of stroke in relation to systemic hemodynamic targets will be…
- Trial name
- NCT05865795
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Wake Forest University Health Sciences
Acute Ischemic Stroke
The Correlation Between CITED2 and Collateral Circulation in Acute Ischemic Stroke
Evaluating the collateral circulation of acute ischemic stroke (AIS) mainly depends on the imaging examination. At present, there is no effective and sensitive biomarker for collateral circulation.
- Trial name
- NCT05345366
- Testing
- non-applicable
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Zhujiang Hospital
Ischemic Stroke, Remote Ischaemic Preconditioning
Effect of Remote Ischemic Preconditioning on Early Neurological Deterioration in Acute Perforating Artery Infarction
This study aims to conduct a prospective, randomized, double-blind, multicenter, parallel-controlled, group-sequential trialto scientifically evaluate the safety and efficacy of remote ischemic preconditioning (RIC) in preventing…
- Trial name
- RIC-END (NCT07237542)
- Testing
- remote ischemic preconditioning
- Where
- China
- Volunteers
- 910 people
- Sponsor
- Jinling Hospital, China
Chronic Cerebral Ischemia, Intracranial Atherosclerosis
Optimized Remote Ischemic Conditioning (RIC) Treatment for Patients With Chronic Cerebral Ischemia
This prospective, randomized, single-center clinical trial is designed to figure out the most optimal algorithm of remote ischemic conditioning on patients with chronic cerebral ischemia.
- Trial name
- NCT03105141
- Testing
- Remote ischemic conditioning
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- Capital Medical University
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