Clinical trials: Ischemic Brain
Embolic Stroke
Study of the Efficacy, Safety and Tolerability of Low Molecular Weight Heparin vs. Unfractionated Heparin in Stroke
Patients with Atrial fibrillation (AF) make a unique group of ischemic stroke, mostly caused by emboli from the left atrial appendage.
- Trial name
- NCT02159287
- Testing
- Enoxaparin, Heparin
- Where
- 2 sites in Iran
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shiraz University of Medical Sciences
Acute Ischemic Stroke
Buyang Huanwu Decoction With Wuling Powder for Acute Ischemic Stroke
Acute ischemic stroke is a common cause of disability. Standard Western medical treatment is widely used, but some patients continue to have neurological impairment and difficulty with daily activities after stroke.
- Trial name
- BYHW-WL (NCT07687043)
- Testing
- Standard Western Medical Treatment, Serum Sample Collection for Metabolomics Only, Buyang Huanwu Decoction Combined With Wuling Powder
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Liaoning University of Traditional Chinese Medicine
Carotid Arteries
Carotid Web Associated With Cerebral Infarctions
Carotid Web located at the bulb level is a rare condition and is often associated with severe cerebral infarction in the carotid territory. This condition has been described predominantly in the black population.
- Trial name
- CAROWEB (NCT04431609)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Bordeaux
Acute Ischemic Stroke
Qingre Huatan Formula for the Prevention of Early Neurological Deterioration in Acute Ischemic Stroke
The purpose of this study is to assess the effectiveness and safety of Qingre Huatan formula versus placebo on preventing early neurological deterioration in patients with acute ischemic stroke within 48 hours after onset.
- Trial name
- QUIET (NCT06857487)
- Testing
- Qingre Huatan Formula, Guidelines-based standard care
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Dongzhimen Hospital, Beijing
Stroke
Alteplase Treatment in Elderly Acute Ischaemic Stroke (AIS) Patients
The objective of this study is to find out if Chinese Acute Ischaemic Stroke (AIS) patients older than 80 years benefit from intravenous (IV) Recombinant Tissue Plasminogen Activator (rt-PA) treatment within 4.5 hours of symptom…
- Trial name
- NCT05401149
- Testing
- rt-PA
- Where
- China
- Volunteers
- 3,058 people
- Sponsor
- Boehringer Ingelheim
Hypoxic-Ischemic Encephalopathy
School-aged Outcomes Post Hypoxic Ischaemic Encephalopathy
Neonatal HIE increases the risk for cognitive impairments in childhood. Neonatal MRI brain scans are a strong predictor for outcome, however a normal scan has only a 35% sensitivity and 85% specificity for a normal outcome.
- Trial name
- SOPHIE (NCT07770035)
- Where
- Ireland
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- University College Cork
Stroke, Ischemic, Cardiac Complication
Cardiomyocyte Injury Following Acute Ischemic Stroke
The primary goal of the CORONA-IS study is to characterize stroke-associated acute myocardial injury (elevated hs-cardiac troponin) using different diagnostic examinations in order get a better understanding of it's underlying…
- Trial name
- CORONA-IS (NCT03892226)
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Hemorrhagic Unilateral Cortico-subcortical Hemispheric Stroke, Ischemic Stroke
Impact of a Self-rehabilitation and Tele-rehabilitation Program on the Post-stroke Care Pathway
The AutonHome® clinical investigation, proposed by Dr Charles FATTAL (coordinator of this study), and carried out by the Association Approche (delegated promoter), aims to use the AutonHome® selfeducation device for the…
- Trial name
- AUTONHOME (NCT06443840)
- Testing
- AutonHome® device
- Where
- 4 sites in France
- Volunteers
- 40 people
- Sponsor
- Association APPROCHE
Dysphagia Following Cerebrovascular Accident
Effect of Home Based Swallowing Exercise in Stroke Patients With Dysphagia
Dysphagia is a common problem in post-stroke patients and greatly impaired quality of life. Among them, the strength of tongue and lip muscles played a key role in the oral phase of swallowing and many stroke survivors suffered…
- Trial name
- NCT05758350
- Testing
- home based IOPI swallow training
- Volunteers
- 100 people
- Sponsor
- Taichung Veterans General Hospital
Ischemic Stroke
Efficacy of BNG-1 to Treat Acute Ischemic Stroke
The objective of this study is to investigate the efficacy and safety of BNG-1 in patients with ischemic stroke. The efficacy assessment will be based on the functional outcome while the safety will be reviewed by the adverse…
- Trial name
- BNG-1 (NCT01675115)
- Testing
- BNG-1, Aspirin
- Where
- Taiwan
- Volunteers
- 129 people
- Sponsor
- Chang Gung Memorial Hospital
Ischemic Stroke, Hemorrhagic Stroke
Safety of Autologous M2 Macrophage in Treatment of Non-Acute Stroke Patients
The purpose of this study is to determine whether M2 macrophages are safe and feasible in the treatment of non-acute stroke patients
- Trial name
- NCT01845350
- Testing
- M2 macrophage introduction
- Where
- Russia
- Volunteers
- 13 people
- Sponsor
- Siberian Branch of the Russian Academy of Medical Sciences
Stroke, Ischemic, Smartpose
The Effect of Rehabilitative Games With SmartPose on Upper Extremity Recovery in Stroke Patients
The goal of this clinical trial is to investigate the effects of SmartPose games on upper extremity motor, functional, and sensory recovery in patients with stroke.
- Conditions
- Stroke, Ischemic, Smartpose, Telerehabilitation
- Trial name
- NCT06778525
- Testing
- Exercise, SmartPose
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Istanbul University - Cerrahpasa
Atrial Fibrillation, Stroke
"Cryptogenic Stroke and Atrial Fibrillation Detection Through Implantable Loop Recorder (ILR)"
STUDY TYPE: Prospective, national , multicenter, and observational study. OBJECTIVE: To assess the incidence of AF in patients with cryptogenic stroke who have implanted an AF detection device during a period of 2 years.
- Trial name
- CRYPTONITE (NCT01025947)
- Where
- 2 sites in Spain
- Volunteers
- 100 people
- Sponsor
- University of Valencia
Acute Ischemic Stroke, Physical Activity
Physical Activity Immediately After Acute Cerebral Ischemia
Stroke is the leading cause of adult disability in Europe and United States and the second leading cause of death worldwide and affects more than 10,000 Danes each year.
- Conditions
- Acute Ischemic Stroke, Physical Activity, Accelerometer
- Trial name
- NCT01594190
- Testing
- physical activity 15 minutes/day, physical activity, 2 x 30 minutes/day
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Hillerod Hospital, Denmark
Ischemic Stroke
Efficacy and Safety of SP-8203 in Patients With Ischemic Stroke Requiring rtPA
This clinical trial is designed to evaluate the efficacy and safety of the combination therapy of SP-8203 (Otaplimastat) and recombinant tissue Plasminogen Activator (rtPA) standard of care.
- Trial name
- SP-8203-2002 (NCT04479449)
- Testing
- SP-8203
- Where
- South Korea
- Volunteers
- 178 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Stroke, Stroke Mimic(Conditions Presenting With Stroke-like Conditions)
BRAIN (Biomarker Rapid Assessment of Ischemic iNjury)
This project is designed to evaluate the clinical utility of a novel blood test, the Triage Stroke Panel, as an aid in the diagnosis and assessment of stroke.
- Trial name
- NCT00206908
- Where
- 22 sites in United States, Canada and 3 more
- Volunteers
- 900 people
- Sponsor
- Abbott RDx Cardiometabolic
Secondary Prevention, Stroke
Epidemiological Study on the Safety of Aspirin in The Health Improvement Network (THIN)
To investigate the risk of major bleeding (including gastrointestinal and intracranial bleeding episodes) among new users of low-dose acetylsalicylic acid (ASA) in clinical practice
- Conditions
- Secondary Prevention, Stroke, Ischemic Heart Disease, Coronary Heart Disease
- Trial name
- EPISAT (NCT02550717)
- Testing
- Acetylsalicylic Acid (Aspirin, BAYE4465), Clopidogrel, Oral Anticoagulants, NSAIDs and SSRIs
- Where
- United Kingdom
- Volunteers
- 398,158 people
- Sponsor
- Bayer
Stroke, Acute Ischemic
EXtending the Time Window for Thrombolysis in Posterior Circulation Stroke Without Early CT Signs
The primary hypothesis being tested in this trial is that ischemic stroke patients in posterior circulation at 4.5 - 24 hours post onset of stroke will have improved clinical outcomes when given intravenous tissue plasminogen…
- Trial name
- NCT05429476
- Testing
- Tissue Plasminogen Activator (Alteplase)
- Where
- 27 sites in China
- Volunteers
- 234 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ischemic Stroke, Stroke
A Functional MRI Study: Assessing Brain Function in Post Stoke Patients
This is a prospective, single center, observational clinical study containing two cohorts the healthy cohort and post stroke cohort. A total of 13 subjects will be enrolled.
- Conditions
- Ischemic Stroke, Stroke, Acute Ischemic Stroke
- Trial name
- NCT06573840
- Testing
- NeuroGlove
- Volunteers
- healthy volunteers welcome
- Sponsor
- NeuroGlove LLC
Acute Ischemic Stroke, Cerebral Autoregulation
Ultra-early Identification of Futile Recanalization After Reperfusion Therapy in Acute Ischemic Stroke Based on Cerebral Autoregulation
This multicenter, prospective, observational diagnostic accuracy study enrolls patients undergoing thrombectomy with intraoperative cerebral autoregulation monitoring and follows them up at predefined time points up to 90 days…
- Trial name
- CAREFUL-CA (NCT07556068)
- Testing
- diagnostic accuracy study
- Where
- 4 sites in China
- Volunteers
- 129 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University