Clinical trials: Ischemic Brain
Stroke
Reduce Inefficiencies in Management of Spasticity
The purpose of this study is to evaluate the effectiveness of a spasticity screener and to determine if the spasticity screener results are useful to healthcare providers and impact clinical decision making
- Trial name
- ReIMage (NCT07639632)
- Testing
- Screener, Standard of care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center, Houston
Ischemic Stroke
A Randomized Controlled Study of the Effectiveness of Scalp Electroacupuncture in Improving Upper Limb Motor Function in Convalescent Phase of Ischemic Stroke.
This research is primary to compare effectiveness of scalp electroacupuncture and scalp acupuncture on motor function of the upper limb(UL) in convalescence phase of ischemic stroke.
- Trial name
- NCT02850198
- Testing
- scalp electroacupuncture
- Volunteers
- 328 people
- Sponsor
- Shaanxi Hospital of Traditional Chinese Medicine
Ischemic Stroke
Discovering Patterns in the Gut Microbiota Associated With the Risk of Stroke and the Outcome After a Stroke and Integration of These Data With Genomic Information to Find New Drug Targets and New Treatments to Improve Neurological Evolution and Functional Status of Stroke Patients.
The composition of the intestinal microbiota is associated with the risk of stroke and with post-stroke neurological evolution. At the same time, the genetics and epigenetics of each patient are associated with the composition of…
- Trial name
- MAESTRO (NCT04795687)
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Ischemic Attack, Transient, Transient Ischemic Attack
Pocket Sized Carotid Stenosis Screening by Junior Doctors
Among patients admitted with cerebral ischemia (stroke and transitory ischemic attack (TIA)) it is important to reveal the underlying cause of the disease.
- Conditions
- Ischemic Attack, Transient, Transient Ischemic Attack, Stroke, Cerebrovascular Accident
- Trial name
- NCT02992821
- Testing
- Bed-side pocket size ultrasound imaging, High frame rate tracking doppler
- Where
- 2 sites in Norway
- Volunteers
- 75 people
- Sponsor
- Helse Nord-Trøndelag HF
Mild Cognitive Impairment, Dementia
Remote Ischemic Conditioning of the Human Brain in Dementia Patients
The study investigates the incidence of remote ischemic conditioning in mild cognitive impairment and dementia patients
- Conditions
- Mild Cognitive Impairment, Dementia, Intermittent Claudication
- Trial name
- RICBDE (NCT04168021)
- Testing
- Leg ischemia
- Volunteers
- 90 people
- Sponsor
- Aristotle University Of Thessaloniki
Cerebral Infarction
Safty and Feasibility Study of Therapeutic Cooling in Acute Ischemic Stroke (COOLAID Øresund)
This study is designed to investigate the safty and feasibility of therapeutic hypothermia in acute stroke patients. Soon after arrival in the stroke unit patients are randomized to either hypothermia in the intensive care unit…
- Trial name
- NCT01500421
- Testing
- TH - Endovascular alone (Alsius®, Zoll, USA), TH - Endovascular + nasopharyngeal induction (Alsius®, Zoll, USA) (Rhinochill®, Benechill, USA), Intravenous cold saline and surface cooling (Arctic Sun, Medivance, USA)
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- Bispebjerg Hospital
Ischemic Stroke, Acute, Myocardial Injury
Safety and Efficacy of Remote Ischemic Conditioning in Patients With Acute Myocardial Injury Following Acute Ischemic Stroke
Introduction: The management of acute myocardial injury following acute ischemic stroke (AMI-AIS), a frequent complication that severely worsens prognosis, is challenging.
- Trial name
- NCT07531394
- Testing
- Remote Ischemic Conditioning
- Volunteers
- 580 people
- Sponsor
- Capital Medical University
Hypercholesterolemia
Evaluation of the Safety & Efficacy of a Combination of Niacin ER & Simvastatin in Patients With Dyslipidemia (OCEANS)
The purpose of this 24 week study is to compare the effectiveness and safety of different doses of Niacin ER/Simvastatin (NS) in subjects with elevated fat levels in their blood (dyslipidemia).
- Trial name
- NCT00080275
- Testing
- Niacin Extended-Release and simvastatin Tablets
- Volunteers
- 600 people
- Sponsor
- Kos Pharmaceuticals
Ischemic Stroke, Atherosclerosis
COlchicine iN Circulating Inflammatory Markers After StrokE (CONCISE)
The goal of this phase 2, before-and-after interventional study is to investigate the effect of colchicine treatment on serum biomarkers of inflammation in patients with a history of stroke and atherosclerosis.
- Trial name
- CONCISE (NCT06062277)
- Testing
- Colchicine 0.5 MG
- Where
- Ireland
- Volunteers
- 91 people
- Sponsor
- University College Dublin
Acute Ischemic Stroke
Extending the Time Window for Intravenous Tenecteplase in Patients With Distal Medium Vessel Occlusions Stroke
To assess the safety and efficacy of beyond time window TNK intravenous thrombolysis for distal Medium Vessel Occlusion (MeVO) related stroke in a prospective randomized clinical trial.
- Trial name
- NCT06559436
- Testing
- Intravenous thrombolysis, Standard medical management
- Where
- China
- Volunteers
- 560 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Transient Ischemic Attack
Evaluation of the Effectiveness of a City Hospital Care Network for the Care of Patients With Transient Ischemic Accident (TIA)
Transient ischemic accidents (TIA) are a frequent resort to hospitalization in the emergency department and are serious events in terms of recurrence and handicap.
- Trial name
- AIT-AMBU-GRE (NCT05216198)
- Testing
- Check of the different exams performed at the emergencies
- Where
- France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Grenoble
Cardiac Surgery, Neural Injury
Cerebral Oximetry in Cardiac Surgery to Reduce Neurological Impairment and Hospital Length-of-stay
Cerebral oximetry using near-infrared spectroscopy (NIRS) has been shown to reduce the incidence of neurological dysfunction and hospital length-of-stay in adult cardiac surgery though not all studies agree.
- Conditions
- Cardiac Surgery, Neural Injury, Cerebral Ischemia
- Trial name
- NCT04463563
- Testing
- Physiological
- Volunteers
- 182 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Ischemic Stroke
Computational Assessment of Hand Motor Skills in Stroke Patients
This is a two phase prospective observational study that aims to validate the use of a motion capture software (Leap Motion) to measure and quantify functional deficits of the hand in stroke patients using a standard battery of…
- Trial name
- NCT05487287
- Testing
- Kinematic computational analysis of the hand (Leap Motion device)
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Cerebral Infarction
Yiqi Huoxue Demolition and Recipes on Recovery Stage of Cerebral Infarction
This clinical research is based on the fundamentals of using Chinese medicine, which will improve Qi and promote blood circulation, to treat patients in the recuperating stages of cerebral infarction with deficiency in Qi and…
- Trial name
- NCT02846207
- Testing
- Yiqi huoxue, Yiqi group, Huoxue group
- Where
- 3 sites in China
- Volunteers
- 360 people
- Sponsor
- Dongfang Hospital Beijing University of Chinese Medicine
CADASIL
Safety and Efficacy of Edaravone Dexborneol Sublingual Tablets for Blood-Brain Barrier Dysfunction in CADASIL
This study is a single-center, prospective, single-arm, self-controlled clinical trial designed to assess the safety and efficacy of edaravone dexborneol sublingual tablets for blood-brain barrier (BBB) dysfunction in patients…
- Trial name
- NCT07692399
- Testing
- Edaravone Dexborneol Sublingual Tablets
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huashan Hospital
Acute Ischemic Stroke
Efficacy and Safety of Tenecteplase Intravenous Thrombolysis in Acute Posterior Circulation Ischemic Stroke Within 4.5-24 Hours After Onset
This study aims to evaluate the efficacy and safety of tenecteplase (TNK) intravenous thrombolysis within the extended time window (4.5 to 24 hours) in patients with acute posterior circulation ischemic stroke.
- Trial name
- NCT07094763
- Testing
- TNK plus standard medical treatment, standard medical management
- Where
- China
- Volunteers
- 406 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Ischemic Stroke, Cognitive Decline
Austrian Polyintervention Study to Prevent Cognitive Decline After Ischemic Stroke
Aim of this randomized controlled study is to test if intensive polyintervention therapy including life style modifications targeting at reduction of modifiable risk factors of stroke can reduce the risk of post-stroke cognitive…
- Conditions
- Ischemic Stroke, Cognitive Decline, Dementia
- Trial name
- ASPIS (NCT01109836)
- Testing
- Motivation and lifestyle intervention
- Where
- 5 sites in Austria
- Volunteers
- 202 people
- Sponsor
- Danube University Krems
Acute Ischemic Stroke
Predictive Factors of Outcome of Mechanical Thrombectomy After Acute Ischemic Stroke
Predictive factors of outcome of mechanical thrombectomy after acute ischemic stroke
- Trial name
- NCT03608644
- Volunteers
- 40 people
- Sponsor
- Assiut University
Stroke
CHinese Acute Tissue-Based Imaging Selection for Lysis In Stroke -Tenecteplase II
To explore the efficacy and safety of tenecteplase for acute ischemic stroke patients (onset time 4.5-24h) of large vessel occlusion using early combined CT/MR imaging outcomes
- Trial name
- CHABLIS-T II (NCT04516993)
- Testing
- Tenecteplase, The best treatment selected by local doctors(Aspirin, Recombinant Tissue Plasminogen Activator, Urokinase, Thrombectomy)
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Huashan Hospital
Subarachnoid Hemorrhage, Brain Ischemia
Dapsone Use in Patients With Aneurysmal Subarachnoid Hemorrhage.
Dapsone is a drug that has been used clinically for several decades due to its anti-infective effect, making it widely available. Its neuroprotective effects have been found through its glutamate receptors antagonistic effect.
- Conditions
- Subarachnoid Hemorrhage, Brain Ischemia, Subarachnoid Hemorrhage, Aneurysmal, Aneurysmal Subarachnoid Hemorrhage
- Trial name
- NCT05131295
- Testing
- Dapsone, Aluminum Hydroxide Gel
- Where
- Mexico
- Volunteers
- 49 people
- Sponsor
- El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
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