Clinical trials: Ischemic Heart Disease
Coronary Artery Disease
Novel Treatment for Coronary Artery Disease
Treatment of coronary artery disease is a major health care problem across the entire word, and the United States. Unfortunately, despite a number of medical advances, diagnostic procedure, or epidemiological studies, the…
- Trial name
- NCT01228214
- Testing
- amiloride
- Where
- Venezuela
- Volunteers
- 100 people
- Sponsor
- University of Carabobo
Cardiovascular Diseases, Heart Diseases
Vascular Disease--Structure/Function
To investigate the relationship of non-invasively measured flow-mediated brachial artery dilation with coronary artery disease (CAD).
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- NCT00005506
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Myocardial Infarction (AMI)
Artificial Intelligence Scalable Solution for ST Myocardial Infarction
The ASSIST clinical study is an observational, multicenter study to assess the performance of a cloud-based and AI-powered electrocardiogram (ECG) analysis platform, named Willem™, developed to detect Acute Myocardial Infarction…
- Trial name
- ASSIST (NCT06939738)
- Where
- 5 sites in Portugal, Spain
- Volunteers
- 489 people
- Sponsor
- Idoven 1903 S.L.
Coronary Artery Disease
Coroflex ISAR NEO "All Comers" Post Market Clinical Follow-up (PMCF)
The aim of the study is to assess the safety and efficacy of the device to treat coronary de novo and restenotic lesions.
- Trial name
- NCT03809715
- Testing
- Coroflex® ISAR NEO coronary stent system
- Where
- France
- Volunteers
- 3,520 people
- Sponsor
- B. Braun Melsungen AG
Type 2 Diabetes Mellitus (T2DM), Coronary Artery Disease (CAD)
Multiple Electrode Aggregometry & Clopidogrel Resistance
Antiplatelet therapy with aspirin-clopidogrel reduces the risk of cardiovascular episodes after percutaneous coronary intervention (PCI) in patients with acute coronary syndromes.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Coronary Artery Disease (CAD), Myocardial Infraction
- Trial name
- NCT01991093
- Where
- 3 sites in Greece
- Volunteers
- 280 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Unstable Angina Pectoris
Comparison of Administration Strategies of Ticagrelor in Patients With Unstable Angina Pectoris, a Pharmacokinetic / Pharmacodynamic Study
The purpose of this study is to evaluate the differences in pharmacokinetics and pharmacodynamics of ticagrelor and its active metabolite depending on the strategy of the drug administration in patients with unstable angina…
- Trial name
- NCT02612116
- Testing
- Pulverized ticagrelor sublingually, Pulverized ticagrelor orally, Integral ticagrelor
- Where
- Poland
- Volunteers
- 49 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Coronary Artery Disease
Assessment of Coronary Artery Lesion Using Optical Coherence Tomography Versus IntraVascular Ultrasound for BiorEsorbable Vascular Scaffold Implantation
The primary objective is to determine whether IVUS- (vs. OCT-) guided BVS implantation is non-inferior to achieve a large in-scaffold minimal lumen area (primary endpoint) measured by OCT at 1-year follow-up.
- Trial name
- ACTIV-BVS (NCT02814578)
- Testing
- Optical coherent tomography, IntraVascular UltraSound
- Where
- 3 sites in South Korea
- Volunteers
- 9 people
- Sponsor
- Young-Hak Kim, MD, PhD
Coronary Artery Disease
TAXUS PERSEUS Workhorse
The purpose of the TAXUS PERSEUS Workhorse trial is to evaluate the safety and efficacy of the next-generation Boston Scientific TAXUS paclitaxel-eluting coronary stent system (TAXUS® ElementTM) for the treatment of de novo…
- Trial name
- PERSEUS WH (NCT00484315)
- Testing
- Percutaneous coronary intervention (PCI) with paclitaxel-eluting stent (TAXUS Element) implantation, Percutaneous coronary intervention (PCI) with paclitaxel-eluting stent (TAXUS Express) placement
- Where
- 90 sites in United States, Australia and 2 more
- Volunteers
- 1,264 people
- Sponsor
- Boston Scientific Corporation
Coronary Artery Bypass, Atherosclerosis
Study of the Xience V Everolimus-eluting Stent in Saphenous Vein Graft Lesions
The specific aim of the SOS-Xience V study is to examine the 12-month incidence of binary angiographic in-stent restenosis after implantation of the Xience V stent in aortocoronary saphenous vein bypass graft lesions.
- Trial name
- SOS-Xience V (NCT00911976)
- Testing
- Xience V coronary stent
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- North Texas Veterans Healthcare System
Acute Coronary Syndrome
Deciphering the Salutogenic Effects of Close Relationships: Psycho-physiological Coregulation Processes and Their Outcomes in Couples Coping With Cardiovascular Disease
The established attachment theory elucidates how early human bonds bring about functional neurophysiological alterations influencing the lifelong capacity for self and co- regulation within relationships.
- Trial name
- NCT05341440
- Where
- Israel
- Volunteers
- 81 people
- Sponsor
- Bar-Ilan University, Israel
Stable Angina or Acute Coronary Syndrome Considered for Percutaneous Coronary Intervention With Dyslipidemia or Hypertension
Neointimal Coverage After Implantation of Biolimus Eluting Stent With Biodegradable Polymer: Optical Coherence Tomographic Assessment According to the Treatment of Dyslipidemia and Hypertension and the Types of Implanted Drug-eluting Stents
There has been little research on neointimal coverage and malapposition after BES implantation using OCT in human coronary artery. Furthermore, specific drug may possibly influence the vascular healing after stent implantation.
- Trial name
- NCT01502904
- Testing
- Sirolimus-eluting stent, Biolimus-eluting stents, pravastatin 20mg/day after DES implantation
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Yonsei University
Coronary Occlusion
Decision Aid in Chronic Total Occlusion (CTO) Patients
The aim of this study is to assess the feasibility and validity of patient-level randomization (vs. cluster randomization) in pilot trials of decision aid efficacy.
- Trial name
- NCT02963584
- Testing
- decision aid
- Volunteers
- 160 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Atherosclerosis, Cardiovascular Diseases
Epidemiology of Carotid IMT Progression in MESA - Ancillary Study
To determine the factors associated with progression of sub-clinical atherosclerosis and to evaluate the associations between the progression of sub-clinical atherosclerosis and the development of clinically manifest…
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Carotid Artery Diseases
- Trial name
- NCT00063440
- Volunteers
- 5,610 people
- Sponsor
- Tufts Medical Center
Coronary Artery Disease
Effect of Cocoa Flavanols on Vascular Function
Endothelial dysfunction is associated with a higher incidence of adverse cardiovascular events in patients with coronary artery disease (CAD).
- Trial name
- Cocoa (NCT00553774)
- Testing
- Cocoa Flavanols
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Francisco
Coronary Artery Disease
Comparison of Intravenous Adenosine Infusion With Regadenoson Bolus for Inducing Maximal Coronary Hyperemia
The purpose of this study is to determine if regadenoson is as safe and effective as adenosine when used in the cardiac catheterization lab during measurement of coronary flow reserve and fractional flow reserve.
- Trial name
- NCT01161121
- Testing
- adenosine, regadenoson
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- St. Louis University
Coronary Artery Stenosis, Coronary Artery Bypass Graft Surgery
Steroid-induced Reduction of Surgical Stress Study
The stress response as induced by myocardial cellular damage during cardiac surgery may lead to myocardial stunning and apoptosis, and could therefore impair postoperative patient recovery.
- Trial name
- STRESS (NCT00807521)
- Testing
- Dexamethasone
- Where
- Netherlands
- Sponsor
- Amsterdam UMC, location VUmc
Sudden Cardiac Death, Implantable Defibrillator User
Implantable Cardioverter Defibrillators - Improving Risk Stratification
Worldwide three million people a year die from sudden cardiac death (SCD). In most cases there is no warning and the heart is stopped by a sudden arrhythmia.
- Conditions
- Sudden Cardiac Death, Implantable Defibrillator User, Myocardial Infarction, Arrhythmias, Cardiac
- Trial name
- ICD-IRS (NCT01944514)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Cardiovascular Diseases, Coronary Disease
Physical Activity and Cardiovascular Disease Prevention
To provide new scientific information regarding the role of physical activity in primary and secondary disease prevention, particularly coronary heart disease (CHD).
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Infarction
- Trial name
- NCT00005447
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Comparison of UFR With QFR in Stable Coronary Artery Disease
Quantitative flow reserve (QFR), derived from coronary angiography, has shown high accuracy in detecting significant lesions. Ultrasonic flow ratio (UFR), a new development from IVUS, integrates physiological estimation with…
- Trial name
- NCT06322355
- Testing
- Coronary angiography, Fractional Flow Reserve measurement, Intravascular ultrasound
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shanghai Zhongshan Hospital
Heart Failure Due to Coronary Artery Disease, Valvular Cardiomyopathy
Delayed Initiation of ARNI and SGLT2i in Heart Failure With Corrected Aetiology (DELAY-HF), Pilot Study
In patients with heart failure due to a reversible underlying cause-such as valvular heart disease or coronary artery disease-surgical or procedural correction of the underlying lesion (valve repair/replacement, TAVI, PCI, or…
- Conditions
- Heart Failure Due to Coronary Artery Disease, Valvular Cardiomyopathy, Heart Failure
- Trial name
- NCT07572032
- Testing
- Sacubitril / Valsartan, SGLT-2 inhibitor, SGLT2 Inhibition
- Where
- 4 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Kyungsub Song
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