Clinical trials: Ischemic Lesions
ST-Segment Elevation Myocardial Infarction, Multivessel Coronary Artery Disease
The FAVOR V AMI Trial
The FAVOR V AMI study is a prospective, multicenter, blinded, randomized, sham-controlled trial comparing the long-term clinical outcomes of the "Functional and Angiography-derived Strain inTegration (FAST)" technique…
- Conditions
- ST-Segment Elevation Myocardial Infarction, Multivessel Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- NCT05669222
- Testing
- FAST Technique, Angiography
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease
NeoVas Bioresorbable Coronary Scaffold Registry Study
The NeoVas Bioresorbable Coronary Scaffold Registry Trial is a prospective, multi-center, single arm registry trial based on the NeoVas FIM study which verified the safety and effectiveness of NeoVas initially.
- Trial name
- NCT02305472
- Testing
- NeoVas BCS
- Where
- 27 sites in China
- Volunteers
- 825 people
- Sponsor
- Lepu Medical Technology (Beijing) Co., Ltd.
Ischemic Heart Disease
Registry of Comprehensive Imaging and Physiological Evaluation of Deferred Lesions Based on FFR
1. To compare the risk of atherosclerotic lesion progression and subsequent patient-oriented composite outcomes (all-cause mortality, any MI, or any Ischemia-driven repeat revascularization) between deferred lesions with or…
- Trial name
- IMPACT-FFR (NCT03030495)
- Testing
- Comprehensive physiologic evaluation, Intravascular imaging devices
- Where
- 4 sites in South Korea
- Volunteers
- 1,400 people
- Sponsor
- Samsung Medical Center
Critical Limb Ischemia, Peripheral Arterial Occlusive Disease
Cryoplasty CLIMB-registry
In 5 Belgian hospitals, the data of 100 CLI-patients receiving the cryoplasty technique to treat their infrapopliteal arterial lesions will be collected.
- Trial name
- CLIMB (NCT00459888)
- Testing
- PolarCath Peripheral Dilatation System (Boston Scientific)
- Where
- 4 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Flanders Medical Research Program
Coronary Artery Disease, Left Main Coronary Artery Disease
IVUS VS CAG Guided PCI for Patients With LMB Lesion
To compare the 3 - year clinical follow - up results of patients with left main bifurcation lesions treated by intravascular ultrasound(IVUS) - guided and coronary angiography(CAG) - guided percutaneous coronary…
- Trial name
- Infinite (NCT04072003)
- Testing
- intravascular ultrasound (IVUS), coronary angiography
- Volunteers
- 616 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Disease
Intracoronary Stenting and Additional Results Achieved by ShockWAVE Coronary Lithotripsy
The clinical trial is intended to evaluate the efficacy, safety and economic benefit of coronary lithotripsy compared to other additional procedures (cutting or super high pressure balloon angioplasty, ablative procedures) in…
- Trial name
- ISAR-WAVE (NCT06369142)
- Testing
- Intravascular lithotripsy (IVL), Standard non-IVL methods
- Where
- 22 sites in Germany
- Volunteers
- 666 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Coronary Heart Disease, Coronary Restenosis
Study of Oral Rapamycin Plus Bare Metal Stents vs Drug Eltuting Stents
In a previous randomized comparison oral sirolimus plus bare metal stent compared to bare metal stent implantation alone demonstrated at one year of follow up a significant reduction of angiographic and clinical parameters of…
- Trial name
- ORAR III (NCT00552669)
- Testing
- Oral sirolimus, Drug Eluting stent
- Where
- 3 sites in Argentina
- Volunteers
- 200 people
- Sponsor
- Centro de estudios en Cardiologia Intervencionista
Coronary Artery Disease
Resting Full-cycle Ratio in Side Branch
The goal of this observational study is to evaluate diagnostic performance of resting full-cycle rate (RFR) in side branch lesion.
- Trial name
- NCT06075173
- Testing
- Resting full-cycle ration (RFR) measurments
- Where
- South Korea
- Volunteers
- 286 people
- Sponsor
- Sejong General Hospital
Coronary Artery Disease
Coronary Bifurcation Lesions Treated With Biguard Stent System
This study is designed to test the hypothesis that the Biguard stent system will lead to fewer target lesion failure compared to regular stent system in patients with coronary bifurcation lesions at one year.
- Trial name
- BIGUARD (NCT02597283)
- Testing
- Biguard sirolimus-eluting bifurcation stent system, Sirolimus-eluting stent system
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Artery Disease
Intra-Individual Comparison of Sirolimus and Paclitaxel Coated Stent (FRE-RACE Study)
The main objective of this study is to assess the safety and effectiveness of the Sirolimus eluting Cypher Select(TM) stent in reducing angiographic in-stent late loss in de novo native coronary lesions as compared to the…
- Trial name
- NCT00130546
- Testing
- Paclitaxel-eluting TAXUS(TM), Sirolimus eluting Cypher Select(TM)
- Where
- Germany
- Volunteers
- 112 people
- Sponsor
- University Hospital Freiburg
Coronary Occlusion
Supplemental Study to Evaluate the Safety and Effectiveness of the NovaCross™ Micro-catheter
This study will include up to 60 eligible male and female subjects. The purpose of this trial is to evaluate the safety and effectiveness of the NovaCross™ micro-catheter when used to facilitate crossing of Chronic Total…
- Trial name
- NCT03717675
- Testing
- NovaCross™ Chronic Total Occlusion micro-catheter
- Where
- 3 sites in Israel, Poland and 1 more
- Volunteers
- 40 people
- Sponsor
- Nitiloop Ltd.
Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)
IVUS-Guided Sirolimus-Coated Balloon Versus Sirolimus-Eluting Stent for De Novo Large Vessel Lesions in ACS
The goal of this interventional study is to evaluate the efficacy and safety of an intravascular ultrasound (IVUS)-guided sirolimus-coated balloon (SCB)-based strategy versus planned sirolimus-eluting stent (SES) implantation in…
- Trial name
- IVUS-SCB (NCT07796412)
- Testing
- IVUS-Guided Sirolimus-Coated Balloon, IVUS-Guided Sirolimus-Eluting Stent
- Where
- China
- Volunteers
- 150 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease
The TRIMAXX Coronary Stent Trial
The primary objective of the trial is to demonstrate the safety and feasibility of treating coronary artery lesions which have not been previously treated with the TRIMAXX Coronary stent system as compared to the reported results…
- Trial name
- NCT00596661
- Testing
- TriMaxx Coronary Stent placement
- Where
- 3 sites in Brazil, Germany
- Volunteers
- 100 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Disease
Clinical Trial of Cilostazol Eluting Stent System (CES-1) in De Novo Coronary Artery Lesions
The purpose of the this trial is to evaluate the clinical safety and efficacy of Cilostazol eluting stent system (CES-1) for the treatment of single de novo lesions in native coronary arteries.
- Trial name
- NCT03189641
- Testing
- Cilostazol eluting stent system (CES-1)
- Where
- 6 sites in Japan
- Volunteers
- 30 people
- Sponsor
- JIMRO Co., Ltd.
Ischemic Attack, Transient
Acute MRI in Transient Ischemic Attack
The purpose of this study is to detect acute ischemic lesions in patients admitted with symptoms of transient ischemic attack (TIA).
- Trial name
- NCT01531946
- Testing
- MRI Scan
- Where
- Denmark
- Volunteers
- 199 people
- Sponsor
- Bispebjerg Hospital
Coronary Artery Disease
Feasibility of Orbital Atherectomy System in Calcified Bifurcation Lesion
ORBID-OA is a single-center, observational study in 30 patients with stable coronary artery disease. The aim of the study is to analyze the outcomes of main vessel stenting on side branch in calcified bifurcation lesion and…
- Trial name
- ORBID-OA (NCT03058510)
- Testing
- Frequency domain optical coherence tomography
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Smoking Cessation
The Safety of Transdermal Nicotine Immediately Following an Acute Coronary Syndrome
Continuing to smoke after having a heart attack greatly increases the risk of death and cardiac illness. The nicotine patch is a commonly used pharmacotherapy for smoking cessation and has great potential to help heart attack…
- Trial name
- STADIA (NCT00990197)
- Testing
- Transdermal nicotine patch
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Acute Myocardial Infarction, Coronary Artery Disease
Complete vs Culprit-only Revascularization to Treat Multi-vessel Disease After Early PCI for STEMI
To determine whether, on a background of optimal medical therapy, including ticagrelor, opening of all suitable narrowings or blockages found at the time of primary PCI for an acute heart attack is better than treating only the…
- Trial name
- COMPLETE (NCT01740479)
- Testing
- Complete Revascularization Strategy
- Where
- Canada
- Volunteers
- 4,042 people
- Sponsor
- Population Health Research Institute
Coronary Angioplasty, Restenosis
Optimal Strategy to Correct Stent underexpAnsion in Resistant Lesions
Percutaneous coronary intervention (PCI) for in-stent restenosis (ISR) accounts for 5-10% of PCI. ISR may be linked to mechanical complications mainly under-expansion (UE), neointimal hyperplasia and/or neoatherosclerosis.
- Conditions
- Coronary Angioplasty, Restenosis, Lithotripsy, Restenosis of Coronary Artery Stent
- Trial name
- OSCAR (NCT07316504)
- Testing
- Intravascular lithotripsy, Balloon
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Unstable Angina (UA)
Scientific Rationale and Design for a Prospective Study to Codify Coronary Lesions Based on Fluid Mechanics and Acoustic Mechanisms
From January 2020 to June 2025, patients coming to the cardiac catheterization laboratories (CCL) for out-patient coronary angiography with diagnosis of unstable angina were screened for inclusion.
- Trial name
- NCT06868225
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tan Tao University, School of Medicine