Clinical trials: Ischemic Lesions
Coronary Artery Disease, Atherosclerotic Plaque
STabilization of Atheroma by Lipid-reducing Effect of Drug-Coated Balloon (STABLE-DCB)
This study aims to investigate whether DCB angioplasty, compared to statin-based medical treatment alone, will lead to more reduction in plaque lipid burden as assessed by near infrared spectroscopy (NIRS) at 6-9 months following…
- Conditions
- Coronary Artery Disease, Atherosclerotic Plaque, De Novo Stenosis
- Trial name
- STABLE-DCB (NCT05438121)
- Testing
- SeQuent Please Neo
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Korea University Ansan Hospital
Stroke
Troponin Elevation in Acute Ischemic Stroke (TRELAS)
The primary objective of the prospective observational trial TRELAS (TRoponin ELevation in Acute ischemic Stroke) is to elucidate the underlying pathomechanism of cTnT elevation in acute ischemic stroke.
- Trial name
- TRELAS (NCT01263964)
- Testing
- coronary angiogram
- Where
- 2 sites in Germany
- Volunteers
- 58 people
- Sponsor
- Charite University, Berlin, Germany
Coronary Artery Disease
The Effectiveness and Safety of the Coronary Artery Serrated Cutting Balloon Dilation Catheter in the Pre-dilation of Coronary Artery Stenosis Lesions
To evaluate the effectiveness and safety of the coronary serrated cutting balloon dilation catheter for the pre-dilation of coronary artery stenosis lesions.
- Trial name
- NCT06926400
- Testing
- Coronary artery sawtooth cutting balloon dilation catheter, Cutting balloon catheter
- Volunteers
- 182 people
- Sponsor
- JW Medical Systems Ltd
Coronary Artery Disease, Coronary Bifurcation Lesions
Progress Bifurcation Global Registry
Coronary bifurcation lesions are lesions (or blockages) that occur at or near the intersection of a major coronary artery and one of the arteries' side branches.
- Trial name
- NCT05100992
- Testing
- Percutaneous Coronary Interbention
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- Minneapolis Heart Institute Foundation
Coronary Heart Disease
The Study of Active Transfer of Plaque Technique for Unprotected Distal Left Main Bifurcation Lesions
A Prospective Multi-center Randomized Trial Assessing the Efficacy and Safety of Active Transfer of Plaque vs. Provisional T Stenting for the Treatment of Unprotected Distal Left Main Bifurcation Lesions
- Trial name
- NCT02127138
- Testing
- Sirolimus eluting Drug stent
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Atherosclerosis
Comparison of the Conor Sirolimus-eluting Coronary Stent to the Taxus Liberte Paclitaxel-eluting Coronary Stent in the Treatment of Coronary Artery Lesions
The purpose of this study is to evaluate the safety and effectiveness of the Conor Sirolimus-eluting Coronary Stent System in the treatment of coronary artery disease (a single atherosclerotic lesion) in native coronary arteries.
- Trial name
- NEVO RES-I (NCT00606333)
- Testing
- NEVO™ Sirolimus-eluting Coronary Stent System, Drug-eluting stent (TAXUS Liberte Paclitaxel-eluting Coronary Stent System)
- Where
- 2 sites in Brazil, New Zealand
- Volunteers
- 394 people
- Sponsor
- Cordis US Corp.
Coronary Artery Disease
Drug-coated Balloons Versus Drug-eluting Stents for de Novo Small-vessel Coronary Artery Disease
This prospective, multicenter observational study will compare the safety and clinical outcomes of drug-coated balloon angioplasty and second-generation drug-eluting stent implantation in patients undergoing percutaneous coronary…
- Trial name
- DCB-SVD (NCT07839806)
- Testing
- Drug coated balloon, Drug Eluting stent
- Where
- Greece
- Volunteers
- 230 people
- Sponsor
- National and Kapodistrian University of Athens
LAD (Left Anterior Descending) Coronary Artery Stenosis
Reconstruction of Diffusely Diseased Left Anterior Descending with Left Internal Mammary Artery On-lay Patch or Saphenous Vein Patch Without Endarterectomy by Opening the Whole Wall of the Diseased Segment(s) Has Less Risk and Fewer Complications Compared to Endarterectomy Technique
The objective of this study is to compare different surgical strategies for management of severely diseased LAD artery during CABG i.e. LIMA on-lay patch vs.
- Trial name
- NCT06835114
- Testing
- CABG, LIMA on lay patch, Safenous vein patch
- Volunteers
- 90 people
- Sponsor
- Assiut University
Fibrillation, Atrial, Coronary Artery Disease
Atrial Fibrillation and Non-obstructive Coronary Lesions
Atrial fibrillation (AF) is the most common cardiac arrhythmia associated with excessive risk of ischemic stroke and heart failure as well as reduced life expectancy.
- Conditions
- Fibrillation, Atrial, Coronary Artery Disease, Chronic Kidney Diseases
- Trial name
- AF-CAD (NCT04537507)
- Testing
- Coronary angiography
- Where
- 5 sites in Poland, Russia and 1 more
- Volunteers
- 8,000 people
- Sponsor
- Medical University of Bialystok
Coronary Artery Disease
Resolute Integrity US Extended Length Sub-Study(RI US XL)
Prospective, multi-center, non-randomized, single-arm, open-label study to assess the safety and efficacy of the Resolute Integrity Stent for the treatment of de novo lesions in native coronary arteries with a reference vessel…
- Trial name
- RI-US XL (NCT01913600)
- Testing
- Resolute Integrity Stent
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Medtronic Vascular
Chronic Limb-threatening Ischemia, Endovascular Therapy
Prospective Multicenter Registry on the Endovascular Treatment in Critical Limb Threatening Ischemia With Below the Knee Lesions With Wound, Ischemia, and Foot Infection (WIFI) Assessment
This is a prospective multicenter clinical study that used WIFI grading scores at different periods to evaluate the therapeutic value of endovascular therapy and this grading system for Chronic limb-threatening ischemia.
- Trial name
- NCT04710420
- Testing
- Endovascular therapy
- Where
- China
- Volunteers
- 842 people
- Sponsor
- Xuanwu Hospital, Beijing
Arterial Occlusion, Angina Pectoris
Comparing TR Band to Statseal in Conjunction With TR Band
The primary objectives of this study are to evaluate the performance of StatSeal Advanced used in conjunction with the TR Band (SSA) as compared to the TR Band without SSA (TRB) relative to: the incidence of peri-procedural…
- Conditions
- Arterial Occlusion, Angina Pectoris, Cardiovascular Diseases, Atherosclerosis
- Trial name
- NCT03028025
- Testing
- StatSeal, TR Band
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- VA Long Beach Healthcare System
Coronary Diseases, Left Main Coronary Artery Disease
Clinical Efficacy and Safety of a Prospective, Multicenter Drug Coated Balloon for Left Main Artery Disease in China
This is a prospective and observational study. Patients with primary mediana 010 or 001 left main bifurcation lesions were treated with drug ball coated balloon from November 2018 to November 2020 in four hospitals in Huaihai…
- Conditions
- Coronary Diseases, Left Main Coronary Artery Disease, Bifurcation Lesions
- Trial name
- NCT04641468
- Testing
- DCB
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xuzhou Third People's Hospital
Drug-Coated Balloon, De Novo Stenosis
Safety and Efficacy of Drug-Coated Balloon for De-novo Lesions in Patients With Acute Coronary Syndromes (DCB-ACS)
The DCB-ACS trial is a prospective, multi-center, non-inferiority, randomized controlled trail. The purpose of this trial is to evaluate the safety and efficacy of drug-coated balloon(DCB) in de novo lesions for acute coronary…
- Conditions
- Drug-Coated Balloon, De Novo Stenosis, Acute Coronary Syndromes, ACS
- Trial name
- DCB-ACS (NCT04937803)
- Testing
- Drug-coated balloon, Zotarolimus-Eluting Coronary Stent
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Harbin Medical University
Acute Ischemic Stroke, Pneumonia
Predictors of Early Chest Infection in Acute Ischemic Stroke
Pneumonia is a frequent complication of acute stroke and is associated with increased mortality and long-term impairment in the affected subjects.
- Trial name
- PRECAST (NCT00906542)
- Where
- Germany
- Volunteers
- 530 people
- Sponsor
- University of Rostock
Coronary Artery Disease
Intimal Hyperplasia Evaluated by Optical Coherence Tomography (OCT) in de Novo Coronary Lesions Treated by Drug-eluting Balloon and Bare-metal Stent
Restenosis due to neointimal hyperplasia causes repeat target vessel revascularization in a relevant number of patients undergoing percutaneous coronary interventions (PCI).
- Trial name
- IN-PACT CORO (NCT01057563)
- Testing
- drug (paclitaxel)-eluting balloon (DEB), bare-metal stent (BMS)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Catholic University of the Sacred Heart
NSTEMI - Non-ST Segment Elevation MI, Multi Vessel Coronary Artery Disease
Culprit Lesions in NSTEMI With Multi Vessel Disease (NSTEMI-CULPRIT)
Acute myocardial infarction owes to a plaque rupture resulting in total (STEMI) or partial occlusion (NSTEMI) of the coronary artery.
- Trial name
- NS-CULPRIT (NCT03479593)
- Testing
- CMR and OCT in NSTEMI patients with MVD
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
ST-elevation Myocardial Infarction, Multi Vessel Disease
Primary PCI in Patients With ST-elevation Myocardial Infarction and Multivessel Disease: Treatment of Culprit Lesion Only or Complete Revascularization
In patients with ST-elevation myocardial infarction (STEMI) the primary treatment is acute angioplasty of the acute occlusion (culprit lesion).
- Trial name
- PRIMULTI (NCT01960933)
- Testing
- Percutaneous coronary intervention, FFR
- Where
- 2 sites in Denmark
- Volunteers
- 650 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Safety Issues, Efficacy, Self
The Lower Silesia Shockwave Registry
Lower Silesia Shockwave Registry (LSSR), is a observational registry collecting all consecutive cases of percutaneous coronary intervention (PCI) performed with the support of shockwave intravascular lithotripsy in two…
- Trial name
- LSSR (NCT05916898)
- Testing
- PCI with support of Shockwave Intravascular Lithotripsy
- Where
- 2 sites in Poland
- Volunteers
- 400 people
- Sponsor
- Miedziowe Centrum Zdrowia SA
Coronary Artery Disease, Myocardial Ischemia
AngioSculpt® Coronary Bifurcation Study
The purpose of this study is to evaluate a new angioplasty catheter, AngioSculpt® for the treatment of bifurcation lesions (blockages occurring at branch points) in coronary arteries.
- Trial name
- AGILITY (NCT00686647)
- Testing
- AngioSculpt® Scoring Balloon Catheter, AngioSculpt Scoring Balloon Catheter
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- AngioScore, Inc.